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Molecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Bioactive Components in Plants: Extraction, Characterization and Antioxidant Activity
edited by
submission deadline 15 Dec 2026 | 1 articles | Viewed by 2002 | Submission Open
Keywords: bioactive compounds; plant extracts; extraction of bioactives; polyphenols; chemical characterization; antioxidant activity; green chemistry
(This special issue belongs to the Section Natural Products Chemistry)
NMR Spectroscopy in Medical Diagnosis and Precision Medicine: Current Trends and Future Directions submission deadline 15 Dec 2026 | Viewed by 725 | Submission Open
Keywords: NMR spectroscopy; metabolomics; lipidomics; biomarkers; medical diagnosis; precision medicine
(This special issue belongs to the Section Applied Chemistry)
Characterization, Quality, and Authenticity of Olive Products: A Themed Issue in Honor of Professor Emerita Maria Z. Tsimidou submission deadline 15 Dec 2026 | Viewed by 598 | Submission Open
Keywords: olive oil; table olives; olive by-products; bioactive compounds; authenticity and quality markers; molecular and metabolomics characterization; food contaminants (MOHs and PAHs); analytical methods; antioxidant activity; food fraud; climate change effects; valorization
(This special issue belongs to the Section Food Chemistry)
Bioactive Compounds and Biological Activity of Plants from the Cerrado and Amazon
edited by Paula Becker Pertuzatti, and Julia Teixeira De Paula
submission deadline 15 Dec 2026 | Viewed by 383 | Submission Open
Keywords: Cerrado plants; Amazon plants; natural products; sustainable biodiversity; health benefits; extraction and characterization
(This special issue belongs to the Section Natural Products Chemistry)
Biologically Active Nitrogen-Containing Heterocyclic Compounds
edited by and Sara Janowska
submission deadline 15 Dec 2026 | Viewed by 374 | Submission Open
Keywords: nitrogen-containing heterocyclic compounds; biological activity; drug design; molecular docking; synthesis; structure–activity relationship (SAR); medicinal chemistry; bioactive molecule
(This special issue belongs to the Section Medicinal Chemistry)
Featured Review Papers in Green Chemistry
edited by
submission deadline 15 Dec 2026 | Viewed by 323 | Submission Open
Keywords: green catalysts; green extraction and processing; chemistry based on natural products; bio-based solvents with sub- and super-critical fluids; microwave and ultrasound; organic reaction in green solvents; bioconversion of biomass and sustainable biomaterials; creating fine chemicals and polymers from renewable resources; green nanotechnology; green analytical chemistry; green degradation process
(This special issue belongs to the Section Green Chemistry)
Perovskite-Based Mixed Oxide Catalysts for Environmental and Industrial Applications submission deadline 15 Dec 2026 | Viewed by 111 | Submission Open
Keywords: perovskite-type materials; heterogeneous catalysis; environmental remediation; energy conversion and storage
(This special issue belongs to the Section Materials Chemistry)
Oxidative Stress and Cancer Therapy: Molecular Mechanisms, Drug Delivery, and Therapeutic Response
edited by
submission deadline 16 Dec 2026 | 1 articles | Viewed by 1208 | Submission Open
Keywords: oxidative stress; reactive oxygen species; ROS; cancer therapy; anticancer agents; lipid peroxidation; ferroptosis; chemoresistance; drug resistance; antioxidant defense; redox signaling; redox homeostasis; drug delivery; nanomedicine; targeted delivery; combination therapy; immunogenic cell death; redox active compounds; natural products; therapeutic response
(This special issue belongs to the Section Chemical Biology)
Bioactive Natural Products: The Potential Sources of New Drugs submission deadline 20 Dec 2026 | 3 articles | Viewed by 4828 | Submission Open
Keywords: bioactive natural compounds; chemical characterization and optimization; bioactive natural products’ safety; cytotoxicity; bioactive natural products’ mechanisms of action; biological activities in vitro and in vivo; chronic diseases; bioactive natural product in non-communicable diseases-chronic inflammation/chronic stress/drug discovery/anticancer
(This special issue belongs to the Section Natural Products Chemistry)
Characterization of Organic Ligands: Correlations Between Results by Electrochemistry and Other Methods
edited by Eleonora-Mihaela Ungureanu
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1689 | Submission Open
Keywords: connections; electrochemical experiments; characterization of organic ligands; DFT calculations of ligand properties; optical methods; electrochemical methods; surface characterization methods (SEM, AFM, Raman, etc.); analytical methods
(This special issue belongs to the Section Applied Chemistry)
Elemental Analysis and Determination for Food and Environmental Samples
edited by Kelly das Graças Fernandes Dantas and
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1027 | Submission Open
Keywords: spectroanalytical techniques; mineral composition; sample preparation; essential elements; toxic elements; food safety; nutritional analysis; environmental monitoring
(This special issue belongs to the Section Analytical Chemistry)
AI in Materials Design and Discovery
edited by Guanjie Wang
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1021 | Submission Open
Keywords: materials informatics; materials large language model and agent; explainable machine learning; computational materials science; high-throughput screening; molecules inverse design; structure–property relationships; data-driven discovery
(This special issue belongs to the Section Materials Chemistry)
Rare Earth Materials: From Design to Applications
edited by Meng Ju
submission deadline 20 Dec 2026 | 1 articles | Viewed by 524 | Submission Open
Keywords: rare earth; crystal structure; spectral characteristic; luminescence; energy conversion; electronic properties; optical communications
(This special issue belongs to the Section Applied Chemistry)
Terpenoids: Chemistry, Structural Diversity, and Biological Activities
edited by and Valentina Parisi
submission deadline 20 Dec 2026 | Viewed by 213 | Submission Open
Keywords: terpenoids; chemical diversity; specialised metabolites; drug discovery; plant-derived compounds; biological activity; biotechnology; metabolomics
(This special issue belongs to the Section Natural Products Chemistry)
Functional Supramolecular Gels: Design, Dynamics, and Applications submission deadline 20 Dec 2026 | Viewed by 187 | Submission Open
Keywords: hydrogels; organogels; ionogels; hybrid supramolecular gels; gel properties; gel applications
(This special issue belongs to the Section Materials Chemistry)
Nanomaterials in Photochemical Devices: Advances and Applications submission deadline 30 Dec 2026 | 3 articles | Viewed by 5087 | Submission Open
Keywords: nanomaterials; photochemistry; photocatalysis; nanoparticles; energy conversion; environmental remediation; biomedical applications; photoacoustic imaging
(This special issue belongs to the Section Photochemistry)
Advancement in Natural and Novel Antimicrobial Agents submission deadline 30 Dec 2026 | 3 articles | Viewed by 1842 | Submission Open
Keywords: bacterial priority list; antimicrobial resistance; natural compounds; novel antibacterial agents; synthetic antimicrobial compounds; extraction; synthesis; antimicrobial activity
(This special issue belongs to the Section Medicinal Chemistry)
Recent Research Advances in Green Extraction of Natural Products submission deadline 30 Dec 2026 | 1 articles | Viewed by 832 | Submission Open
Keywords: sustainable chemistry; natural products; bio-based solvents; process intensification; sustainable extraction technologies; biomass valorization
(This special issue belongs to the Section Natural Products Chemistry)
Phenolic Composition and Antioxidant Activity of Natural Products submission deadline 30 Dec 2026 | 1 articles | Viewed by 788 | Submission Open
Keywords: metabolomics; extracts; phenolic compounds; antioxidants; plants; fungi; lichens; phytotherapy
(This special issue belongs to the Section Natural Products Chemistry)
Ab-Initio Molecular Dynamics Studies of Chemical Reactions in the Gas Phase, Condensed Phases and Interfaces
edited by Robert Benny Gerber and Imon Mandal
submission deadline 30 Dec 2026 | 1 articles | Viewed by 674 | Submission Open
Keywords: ab initio molecular dynamics; chemical reactions; reaction mechanism and dynamics; potential energy surfaces; trajectories
(This special issue belongs to the Section Computational and Theoretical Chemistry)
Bioactive Ingredients in Foods: Delivery, Stabilization, and Functionality submission deadline 30 Dec 2026 | Viewed by 298 | Submission Open
Keywords: antioxidant capacity; bioactive compounds; bioactive nutrients; carotenoids; food matrix; functional food; health benefits; natural sources; phytochemicals; polyphenols
(This special issue belongs to the Section Food Chemistry)
Advanced Techniques for the Chemical Analysis and Removal of Environmental Pollutants
edited by Anca-Iulia Stoica
submission deadline 30 Dec 2026 | Viewed by 143 | Submission Open
Keywords: pollutant monitoring; emerging contaminants; advanced techniques; removal of pollutants; eco-friendly treatments; nature-based solutions; environmental management
Drug Discovery Based on Non-Mammalian Models
edited by
submission deadline 30 Dec 2026 | Viewed by 143 | Submission Open
Keywords: disease models; drug discovery; zebrafish; drosophila melanogaster; caenorhabditis elegans
(This special issue belongs to the Section Medicinal Chemistry)
Sustainable Electrochemical Platforms for Clinical and Environmental Determination submission deadline 30 Dec 2026 | Viewed by 142 | Submission Open
Keywords: sustainable electrochemistry; electrochemical biosensors; environmental monitoring; green synthesis; point-of-care diagnostics; biomass-derived carbon; emerging pollutants; nanocomposites; screen-printed electrodes; molecular detection
(This special issue belongs to the Section Electrochemistry)
Novel Polymer Materials for Environmental Applications submission deadline 30 Dec 2026 | Viewed by 138 | Submission Open
Keywords: bioplastics; polymer biocomposites; ecological packaging; polymer waste recovery; microplastics; photocatalytic polymers; conductive polymers; polymeric membranes; biodegradation of polymers
(This special issue belongs to the Section Materials Chemistry)
30th Anniversary of Molecules—Recent Advances in Organic Chemistry
edited by , Antonia Di Mola and
submission deadline 31 Dec 2026 | 23 articles | Viewed by 35752 | Submission Open
Keywords: organic synthesis; organic chemistry research; theoretical study; reaction mechanisms; catalysis
(This special issue belongs to the Section Organic Chemistry)
30th Anniversary of Molecules—Recent Advances in Chemical Biology submission deadline 31 Dec 2026 | 13 articles | Viewed by 29218 | Submission Open
Keywords: bioorthogonal chemistry; peptides; nucleic acids; proteins; analytical methods; chemical inhibitors; chemical probe; ubiquitination; structure-activity relationship
(This special issue belongs to the Section Chemical Biology)
30th Anniversary of Molecules: Recent Advances and the Next in Macromolecular Chemistry submission deadline 31 Dec 2026 | 10 articles | Viewed by 28342 | Submission Open
Keywords: macromolecular chemistry; synthetic polymers; natural polymers; polymerization mechanisms and kinetics; supramolecular self-assembly; biological macromolecules
(This special issue belongs to the Section Macromolecular Chemistry)
30th Anniversary of Molecules—Recent Advances in Food Chemistry
edited by and Marta Coelho
submission deadline 31 Dec 2026 | 22 articles | Viewed by 26723 | Submission Open
Keywords: functional foods; nutraceuticals; bioactive compounds; analytical techniques; by-products; food chemistry
(This special issue belongs to the Section Food Chemistry)
Featured Review Papers in Food Chemistry—2nd Edition
edited by
submission deadline 31 Dec 2026 | 7 articles | Viewed by 23479 | Submission Open
Keywords: food analysis; food additives; food supplements; functional foods; physicochemical properties; agro-food wastes recycling; bioaccessibility and bioavailability; food stability; food security
(This special issue belongs to the Section Food Chemistry)
Advances in Coordination Chemistry, 3rd Edition
edited by Juan Niclós-Gutiérrez and
submission deadline 31 Dec 2026 | 8 articles | Viewed by 20970 | Submission Open
Keywords: synthesis strategies for novel coordination compounds; coordination compounds with tailor-made ligands for specific applications; coordination compounds with multitopic ligands; single-crystal XRD structures and dimensionality of metal complexes; metal–organic frameworks and their applications; molecular recognition in mixed ligand–metal complexes at the molecular and/or supra-molecular levels; model metal complexes from the bioinorganic frontier of biological chemistry; DFT and other theoretical approaches for inter-ligand interactions in metal complexes
(This special issue belongs to the Section Inorganic Chemistry)
Biologically Active Molecules: Extraction Strategies, Therapeutic Potential and Biomedical Perspective
edited by
submission deadline 31 Dec 2026 | 10 articles | Viewed by 19917 | Submission Open
Keywords: natural bioactive components; extraction techniques; therapeutic and biomedical profiling
(This special issue belongs to the Section Medicinal Chemistry)
30th Anniversary of Molecules—Recent Advances in Applied Chemistry submission deadline 31 Dec 2026 | 12 articles | Viewed by 19358 | Submission Open
Keywords: applied chemistry; new molecules and natural materials; analytical methods and techniques; electrochemistry and energy; biodegradable materials and medicines; environment and green chemistry; theoretical chemistry
(This special issue belongs to the Section Applied Chemistry)
Review Papers in Analytical Chemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 4 articles | Viewed by 18729 | Submission Open
Keywords: analytical chemistry; analytical spectroscopy; environmental sciences; medical science; forensic science; cultural heritage; food analysis
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Inorganic Chemistry submission deadline 31 Dec 2026 | 10 articles | Viewed by 16620 | Submission Open
Keywords: inorganic chemistry; coordination chemistry; solid-state chemistry; nanomaterials; organometallics; transition and main group metal chemistry; catalysis; bioinorganic chemistry
(This special issue belongs to the Section Inorganic Chemistry)
The 30th Anniversary of Molecules—Recent Advances in Natural Products Chemistry submission deadline 31 Dec 2026 | 8 articles | Viewed by 14781 | Submission Open
Keywords: natural compounds; bioactive molecules; drug discovery; pharmacological activity; formulations, drug delivery systems; food applications and additives; cosmetic applications; synthesis
(This special issue belongs to the Section Natural Products Chemistry)
30th Anniversary of Molecules—Recent Advances in Analytical Chemistry submission deadline 31 Dec 2026 | 7 articles | Viewed by 12055 | Submission Open
Keywords: chromatography and advanced mass spectrometry; atomic spectroscopy and elemental mass spectrometry; molecular spectroscopy; miniaturization of analytical instruments; ohmics; nanomaterials and sensors; automation and high-throughput screening; single-cell analysis; non-invasive analysis/techniques; green analytical chemistry
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Bioorganic Chemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 10924 | Submission Open
Keywords: bioorganic chemistry; chemoenzymatic synthesis; biocatalysis; biomimetic synthesis; biomolecular interactions; functional biomolecules; molecular recognition
(This special issue belongs to the Section Bioorganic Chemistry)
Applied Chemistry in Europe, 2nd Edition
edited by and Gianluca D'Abrosca
submission deadline 31 Dec 2026 | 9 articles | Viewed by 10871 | Submission Open
Keywords: nano-materials; environmental chemistry; chemical synthesis; green chemistry; theoretical chemistry analytical methods
(This special issue belongs to the Section Applied Chemistry)
Advances and Opportunities of Natural Products in Drug Discovery submission deadline 31 Dec 2026 | 9 articles | Viewed by 10800 | Submission Open
Keywords: natural products; drug discovery; pharmacological activity; biological activity; new compounds
(This special issue belongs to the Section Natural Products Chemistry)
Modern Trends and Solutions in Analytical Chemistry in Poland
edited by
submission deadline 31 Dec 2026 | 9 articles | Viewed by 10085 | Submission Open
Keywords: analytical and physical chemistry; separation sciences; chromatographic methods and related techniques (HPLC, SPE, SFC, GC, CZE, UPLC, GC × GC, and others); sample preparation and extraction techniques (SPE, QuEChERS/d-SPE, SPME, SBSE, HFLPME, DLLME, FUSLE, and others); detection techniques (DAD, FLD, MS, MS/MS, and others); spectrometry; bioanalytics; proteomics, metabolomics, and lipidomics; nanotechnology; environmental sciences; natural product chemistry (isolation, identification and quantification of bioactive compounds, and in vitro and then in vivo investigations on their biological activity); food analysis and food safety; xenobiotics analysis in environmental, biological, and food samples; chemometrics and statistical analysis
(This special issue belongs to the Section Analytical Chemistry)
Back to Nature: Pharmacological Activities of Phytochemicals Isolated from Medicinal Plants
edited by and Ludmila Yarmolinsky
submission deadline 31 Dec 2026 | 9 articles | Viewed by 9325 | Submission Open
Keywords: medicinal plant; pharmacological activity; phytochemical; disease; drug; therapeutic; polyphenol; terpene; carotenoid; saponin; alkaloid; thiophene; sugar; fatty oil; resin; phytosterol; protein; peptide; anti-inflammatory; antidiabetic; neuroprotective; anticancer; antioxidative; antimicrobial; antiviral; antifungal
(This special issue belongs to the Section Natural Products Chemistry)
Chemical Analysis of Pollutant in the Environment submission deadline 31 Dec 2026 | 5 articles | Viewed by 9046 | Submission Open
Keywords: inorganic and organic pollutants; persistent organic pollutants; heavy metals; nano- and microplastics; chemical methods; instrumental methods; validation
(This special issue belongs to the Section Green Chemistry)
Advance in Radiochemistry, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 6 articles | Viewed by 8897 | Submission Open
Keywords: radiochemistry; radionuclide (radioisotopes); radiolabeling; radiopharmaceutical (radiotracer); nuclear medicine; theranostics (diagnostics and therapeutics); molecular imaging
(This special issue belongs to the Section Medicinal Chemistry)
Innovative Approaches to Sustainable Wastewater Treatment—Recent Developments in Hazardous Pollutants Removal submission deadline 31 Dec 2026 | 7 articles | Viewed by 8793 | Submission Open
Keywords: wastewater treatment; industrial wastewater; physical methods; chemical methods; biological methods; emerging micropollution; dyes; heavy metals; removal; (bio)sorbent; ion exchange resin
(This special issue belongs to the Section Green Chemistry)
Novel Neuroprotective Agents: Design, Synthesis, and Biological Evaluation submission deadline 31 Dec 2026 | 3 articles | Viewed by 8604 | Submission Open
Keywords: neurodegenerative diseases; heterocyclic compounds; rational design; enzyme inhibitors; structure–activity relationship; structural characterization
(This special issue belongs to the Section Medicinal Chemistry)
Chromatography—The Ultimate Analytical Tool, 3rd Edition submission deadline 31 Dec 2026 | 6 articles | Viewed by 8386 | Submission Open
Keywords: chromatography; high-performance liquid chromatography; ultra-high-performance liquid chromatography; gas chromatography; two-dimensional gas chromatography; two-dimensional liquid chromatography; paper chromatography; liquid chromatography; preparative chromatography; supercritical fluid chromatography; thin-layer chromatography
(This special issue belongs to the Section Analytical Chemistry)
30th Anniversary of Molecules—Recent Advances in Electrochemistry submission deadline 31 Dec 2026 | 9 articles | Viewed by 8344 | Submission Open
Keywords: electrochemical science; energy conversion; charge transfer; voltammetry; magnetoelectrochemistry/spin; redox chemistry
(This special issue belongs to the Section Electrochemistry)
30th Anniversary of Molecules: Recent Advances in Photochemistry submission deadline 31 Dec 2026 | 6 articles | Viewed by 8151 | Submission Open
Keywords: organic photochemistry synthetic photochemistry; photocatalysis; photofunctionalization; photobiology; medicinal photochemistry; computational photochemistry; photoelectrochemistry; solar energy conversion; condensed and gas phase photochemistry; polymer photochemistry; supramolecular photochemistry; photochromism; luminescent sensors; photochemistry for environmental remediation
(This special issue belongs to the Section Photochemistry)
Recent Advances in Porous Materials, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 5 articles | Viewed by 8105 | Submission Open
Keywords: porous carbon; adsorption; catalysis; supercapacitor; biomass; energy storage; zeolite; fuel cell; molecular sieves; metal–organic frameworks; porous metal oxide; mesoporous silicon; macroporous resin; aerogel; separation; porous composites; covalent organic frameworks
(This special issue belongs to the Section Materials Chemistry)
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