Novel Strategies for Enhancing Oral Bioavailability and/or Biopharmaceutics-Related Research
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 32861
Special Issue Editors
Interests: pharmacokinetics; biopharmaceutics; absorption; drug transporters; metabolic enzymes; drug delivery; nanoparticles
Special Issues, Collections and Topics in MDPI journals
Interests: bioanalysis; biopharmaceutics; DMPK; PBPK/PD modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Poor oral absorption is likely due to low aqueous or gastrointestinal solubility and poor intestinal membrane permeability. Additionally, drug candidates are often optimized with respect to intestinal and/or hepatic metabolic stability in the drug discovery and development stage, suggesting that the first-pass effect can govern oral bioavailability (BA) in vivo.
Thus, strategies to enhance the oral bioavailability of new drug candidates and prescription drugs are necessary. Various oral formulation technologies have been developed for poorly water-soluble drugs, such as nanosuspensions, solid dispersions, self-nanoemulsifying drug delivery systems (SNEDDSs), and so on. In addition, research on intestinal absorption to avoid efflux transporters such as P-glycoprotein, breast cancer resistance protein (BCRP), and multidrug-resistance-associated proteins (MRPs), using specific inhibitors; to utilize absorption-mediated influx transporters; and to increase passive diffusion via paracellular pathways by various formulations and/or nontoxic surfactants are scientifically meaningful to understand the mechanisms related to absorption.
This Special Issue focuses on novel strategies for enhancing oral bioavailability, such as oral formulations and/or biopharmaceutics-related approaches, to elucidate possible mechanisms responsible for poor oral bioavailability. We would like to invite original and review articles of novel and innovative research on drugs, drug candidates, nutrients, and other natural products in the fields of Pharmaceutics and Biopharmaceutics.
Prof. Dr. Han-Joo Maeng
Prof. Dr. In-Soo Yoon
Guest Editors
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Keywords
- oral absorption
- poorly water-soluble
- bioavailability
- permeability
- solid dispersions
- nanosuspension
- self-nanoemulsifying drug delivery system
- oral formulation technology
- transporters
- natural products
- nutrients
- first pass effect
- biopharmaceutics
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