Special Issue "Advances in Research of Short Peptides"
Deadline for manuscript submissions: 31 December 2020.
Interests: bio-supramolecular chemistry of oligopeptides; polymorphism; biologically active substances; drug design
Interests: X-ray crystallography; supramolecular chemistry; crystal engineering; peptides; medicinal chemistry; coordination chemistry; solid-state synthesis; analytical chemistry
Interests: theoretical chemistry; research of drugs; drug-receptor interactions; structure of intermolecular complexes; peptides
Interests: bioinformatics; theoretical molecular biophysics; biochemistry of proteins
Interests: biocrystallography, drug design; peptide chemistry
Interests: peptide chemistry; synthesis of medicinal compounds; peptidomimetics; neuropeptides
Interests: peptide chemistry; peptide synthesis; unusual amino acids; peptide bond motifs
It is a great honor for us to invite you to a Special Issue of “Molecules” focusing on short peptides, which have attracted increasing interest due to their many advantages and applications, inter alia anticancer therapies or hydrogels. They represent an unique class of biopharmaceuticals, including cosmeceuticals, with improved pharmacological profiles. Oligopeptides fill the gap between classical small molecules and mature proteins. Amino acids carry the prime structural information and are building blocks of higher level species, which architecture is mainly controlled by intermolecular interactions, which just like a virtuoso play a symphony of life. Therefore, detailed knowledge on interactions either at a molecular or supramolecular level is essential in the development of innovative medical therapies or smart functional biomaterials. Notably, small molecules and proteins have a natural synergy. The Cambridge Structure Database (CSD) collects over one million crystal structures of small molecules and is the world`s largest source of precise information geometry of either bonding or non-bonding interactions. The latter may be systematized into the libraries of supramolecular synthons, which can be further transferred to the macromolecular environment. The CSD data may be used for screening of ligand-target binding affinities. New computational methods for characterizing molecular shapes, electrostatic complementarity and the intercontacts surfaces as related to their environment, like Hirshfeld surface analysis, can be effective tools in the drug discovery. The combination of information from the CSD and the RCSB Protein Data Bank yield thorough foundation for the smart structure and ligand based design.
We cordially invite scientists from various fields to submit research articles, reviews or communications concerning molecular and supramolecular aspects of short peptides and modified amino acids investigated by either experimental or/and in silico methods. Findings leading to novel therapeutics and functional materials are particularly welcome.
Dr. Joanna Bojarska
Prof. Dr. Wojciech M. Wolf
Prof. Dr. Milan Remko
Prof. Dr. Piotr Zielenkiewicz
Prof. Dr. Michele Saviano
Prof. Dr. Janusz Zabrocki
Dr. Krzysztof Kaczmarek
Prof. Dr. Michele Saviano
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- oligopeptide-based therapeutic agents and functional biomaterials
- molecular and supramolecular features
- drug design
- drug-receptor interactions
- synthesis of oligopeptides and modified amino acids