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Review: Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin

Biology Department, Acadia University, Wolfville, NS B4P 2R6, Canada
Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada
Author to whom correspondence should be addressed.
Academic Editors: Joanna Bojarska, Wojciech M. Wolf, Milan Remko, Piotr Zielenkiewicz, Michele Saviano, Janusz Zabrocki and Krzysztof Kaczmarek
Molecules 2020, 25(22), 5436;
Received: 1 November 2020 / Revised: 17 November 2020 / Accepted: 17 November 2020 / Published: 20 November 2020
(This article belongs to the Special Issue Advances in Research of Short Peptides)
Host defense peptides (HDPs) are a group of antimicrobial peptides (AMPs) that are crucial components of the innate immune system of many different organisms. These small peptides actively kill microbes and prevent infection. Despite the presence of AMPs in the amphibian immune system, populations of these organisms are in decline globally. Magainin is an AMP derived from the African clawed frog (Xenopus laevis) and has displayed potent antimicrobial effects against a wide variety of microbes. Included in this group of microbes are known pathogens of the African clawed frog and other amphibian species. Arguably, the most deleterious amphibious pathogen is Batrachochytrium dendrobatidis, a chytrid fungus. Investigating the mechanism of action of magainin can help understand how to effectively fight off infection. By understanding amphibian AMPs’ role in the frog, a potential conservation strategy can be developed for other species of amphibians that are susceptible to infections, such as the North American green frog (Rana clamitans). Considering that population declines of these organisms are occurring globally, this effort is crucial to protect not only these organisms but the ecosystems they inhabit as well. View Full-Text
Keywords: antimicrobial peptide; magainin; African clawed frog; North American green frog antimicrobial peptide; magainin; African clawed frog; North American green frog
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McMillan, K.A.M.; Coombs, M.R.P. Review: Examining the Natural Role of Amphibian Antimicrobial Peptide Magainin. Molecules 2020, 25, 5436.

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