The PCSK9 Story: Advances in Cholesterol Metabolism, Cardiovascular Complications and Beyond

Dear Colleagues,

Since our first identification in 2003 of PCSK9 and its natural mutations causing familial hypercholesterolemia and its relationship to cardiovascular complications, a huge field of research on PCSK9 has emerged leading to clinical prescriptions of a new class of lipid lowering drugs. Anti-PCSK9 antibodies are now very efficient in fighting hypercholesterolemia and cardiovascular diseases. The PCSK9 story is an amazing example of successful translational research that revolutionized the field of LDL-cholesterol. However, many aspects of the PCSK9 biology still need to be elucidated, which may lead to new and exciting applications.

This Special Issue of Metabolites, “The PCSK9 Story: Advances in Cholesterol Metabolism, Cardiovascular Complications, and Beyond” will be dedicated to PCSK9 and to anti-PCSK9 therapies, notably antibodies and siRNA, in cholesterol and cardiovascular diseases.

This issue will include PCSK9 hepatic but also extrahepatic functions and their implications in atherosclerosis through LDL-cholesterol homeostasis or beyond. Additionally, it will cover the role of PCSK9 in cancer, inflammation, infectious, and neurological diseases. It will provide new insights into genetics, molecular, biochemical, cellular, animal, pharmacological, and clinical studies from fundamental and applied research angles, as well as the various roles of PCSK9, the measurement of its various forms, and its modulation by nutritional or therapeutic approaches.

Dr. Marianne Abifadel
Prof. Dr. Catherine Boileau
Dr. Nabil G. Seidah
Guest Editors

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