Advances in Gas Chromatography–Mass Spectrometry-Based Targeted Metabolomics

Dear Colleagues,

Gas Chromatography–Mass Spectrometry has historically been a key technology in the field of metabolomics. It is a robust, reproducible, cost-effective platform that is capable of analysing both volatile and non-volatile metabolites. In recent years, there has been a greater shift toward the use of Liquid Chromatography–Mass Spectrometry. Despite this, there have been significant advances in targeted GC-MS metabolomics techniques, where the comprehensive targeted profiling of various metabolite classes enables high-throughput analysis with high-confidence metabolite annotation. This provides an excellent opportunity to observe global metabolic shifts in the biological system of interest, and the use of targeted methods can then be applied to further understand these dynamic metabolic changes through the use of stable isotope labelling techniques. It is for these reasons that it is important to highlight the place that GC-MS still has as a key technology in the field of metabolomics. Therefore, this Special Issue will aim to showcase the utility of targeted GC-MS metabolomics.

Dr. David P. De Souza
Dr. Sheik Nadeem Elahee Doomun
Guest Editors

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