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Medicina
Special Issues
Early Diagnosis and Treatment of Cardiovascular Disease: 2nd Edition
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Early Diagnosis and Treatment of Cardiovascular Disease: 2nd Edition

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (31 July 2026) | Viewed by 821

Editors

Dr. Mihaela-Viviana Ivan

E-Mail Website
Guest Editor
Department of Internal Medicine II, Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timisoara, Romania
Interests: cardiovascular disease; cardiology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Elena Bobescu

E-Mail Website
Guest Editor
1. Faculty of Medicine, Transilvania University of Brasov, Brasov, Romania
2. County Emergency Hospital of Brasov, Brasov, Romania
Interests: atrial fibrillation; supraventricular arrhythmia; cardiovascular risk; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our Special Issue “Early Diagnosis and Treatment of Cardiovascular Disease: 2nd Edition”, which will be published in Medicina.

This Special Issue addresses the continuous development and research of cardiovascular diseases and comorbidities that influence prognosis and treatment, aiming to provide a significant perspective upon early diagnosis and treatment in different conditions. New guidelines on heart failure draw attention to the significant impact of early complete treatment and early diagnosis on cardiac disease. Patients with diabetes mellitus, chronic kidney disease, and anemia must be checked for cardiac conditions, and diagnosis and active treatment should address all risk factors. New data also show the utmost importance of inflammation in cardiac diseases. Moreover, novel biomarkers have emerged to improve diagnosis accuracy. In recent years, evidence has increased regarding the diagnosis and involvement of comorbidities in cardiac function. Furthermore, the recent COVID-19 pandemic showed the importance of thorough follow-up of all data known to influence treatment and prognosis and, of course, the cardiac structures themselves.

This Special Issue aims to offer a complex and current overview of new research related to cardiac disease, expanding our current knowledge and adding important insights related to its management.

Dr. Mihaela-Viviana Ivan
Prof. Dr. Elena Bobescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary artery disease
  • heart failure
  • comorbidities
  • chronic kidney disease
  • anemia
  • diabetes mellitus
  • arrhythmias
  • hypertension
  • dyslipidemia
  • novel biomarkers

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Published Papers (1 paper)

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Research

15 pages, 1405 KB  
Article
Enhancing Cardiopulmonary Function Through Spasticity Reduction—Effects of Botulinum Toxin A After Stroke: A Prospective Before–After Study
by Laura Marieta Alexa, Alexandru-Cosmin Palcău, Livia Florentina Păduraru, Daniel Alexa, Claudia Andreea Palcău, Maria Magdalena Leon, Mihai Roca, Adriana Mihaela Ilieșiu and Lucia Corina Dima-Cozma
Medicina 2026, 62(6), 1066; https://doi.org/10.3390/medicina62061066 - 31 May 2026
Viewed by 436
Abstract
Background and Objectives: Post-stroke spasticity is a frequent complication that contributes to impaired mobility, reduced functional independence, and decreased exercise tolerance. While botulinum toxin A (BoNT-A) is widely used to improve muscle tone, its effects on cardiopulmonary exercise capacity remain insufficiently characterized. [...] Read more.
Background and Objectives: Post-stroke spasticity is a frequent complication that contributes to impaired mobility, reduced functional independence, and decreased exercise tolerance. While botulinum toxin A (BoNT-A) is widely used to improve muscle tone, its effects on cardiopulmonary exercise capacity remain insufficiently characterized. This study aimed to evaluate the impact of BoNT-A treatment on cardiopulmonary performance and functional outcomes in patients with post-stroke spasticity. Materials and Methods: A prospective before–after study was conducted including 50 patients with post-stroke spasticity. Cardiopulmonary exercise testing was performed before and after BoNT-A administration. The primary outcome was peak oxygen consumption (VO2 peak), while secondary outcomes included anaerobic threshold (AT), exercise duration, maximal workload, 10 m walk test time, Barthel Index, and modified Rankin Scale (mRS). Paired comparisons and multivariable linear regression analyses were performed to assess changes and associated factors. Results: VO2 peak increased significantly following treatment (12.96 ± 2.70 vs. 13.55 ± 2.85 mL/kg/min; mean change 0.59 mL/kg/min, 95% CI 0.36–0.82; p < 0.001). Similar improvements were observed for AT (10.47 ± 2.77 vs. 10.97 ± 2.97 mL/kg/min; p < 0.001), exercise duration (6.70 ± 1.48 vs. 7.11 ± 1.55 min; p < 0.001), and maximal workload (44.70 ± 10.97 vs. 48.06 ± 12.60 W; p < 0.001). Functional performance improved, as indicated by reduced 10 m walk time (18.33 ± 4.67 vs. 17.36 ± 4.82 s; p < 0.001) and increased Barthel Index (57.62 ± 19.18 vs. 61.92 ± 21.10; p < 0.001). A modest but significant reduction in disability was observed on the mRS (p = 0.003). Baseline values were the strongest predictors of post-treatment outcomes, while smoking status was associated with worse walking performance. Conclusions: BoNT-A treatment was associated with modest but consistent improvements in cardiopulmonary exercise capacity and functional performance in patients with post-stroke spasticity. These findings suggest that spasticity management may be associated with functional and exercise-related benefits extending beyond local neuromuscular effects, although causal relationships cannot be established based on the present study design. Further controlled studies are needed to confirm these findings and evaluate their long-term clinical significance. Full article
(This article belongs to the Special Issue Early Diagnosis and Treatment of Cardiovascular Disease: 2nd Edition)
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