Advanced Scaffold Biomaterials in Tissue Engineering

Dear Colleagues,

Regenerative procedures in dental medicine have become increasingly popular for treating complex clinical situations in oral surgery, implantology, periodontics, endodontics, and other disciplines. The procedures aim to heal tissues and form new ones, such as healing bone defects and forming new bone, to revascularize pulp tissue, and to promote apexogenesis, among other objectives. All these procedures were critical, and many “conventional” approaches did not obtain satisfactory results. The principle of regenerative procedures is to introduce a scaffold that will enable cell migration in the desired environment, their differentiation, and vascularization, as well as the delivery of stem cells and growth factors. Laboratory techniques for developing scaffold matrices include the processing of autologous bone transplants, 3D printing, and the production of antibacterial scaffolds for periodontal and bone regeneration. Laboratory design enables the production of special types of scaffolds for specific purposes and can be highly individualized. Over the last ten years, many types of scaffolds have been introduced, ranging from bone scaffolds, biomatrices, platelet-based scaffolds, bioactive and biomimetic scaffolds, to hydro-soluble scaffolds and scaffold-free approaches, such as custom-made bio-based stem cells, molecular functionalization, and the introduction of exosomes and hypoxia-based stem cells. This Special Issue aims to gain insight into the current situation in laboratories and clinics and promote new techniques for treating critical clinical situations.

Prof. Dr. Domagoj Glavina
Guest Editor

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