Novel Studies and Therapeutic Options for Skin Disease

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Personalized Therapy and Drug Delivery".

Deadline for manuscript submissions: closed (20 May 2026) | Viewed by 1231

Editors


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Guest Editor
Department of Dermatology, Medical University of Warsaw, Warsaw, Poland
Interests: atopic dermatitis; inflammatory skin diseases; microbiome; pediatric dermatology

Special Issue Information

Dear Colleagues,

The skin is a sophisticated organ whose homeostasis may be disturbed by a wide range of pathological processes. Our understanding of the complexity of the skin’s structure and immunology has significantly expanded in recent years. Translational medicine is currently entering the field of dermatology, providing novel, personalized solutions to patients with cutaneous disorders. In this context, the aim of this Special Issue is to highlight late-breaking developments in the diagnosis and treatment of skin diseases.

We look forward to your submissions.

Dr. Leszek Blicharz
Dr. Mohamad Goldust
Guest Editors

Manuscript Submission Information

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Keywords

  • dermatology
  • genodermatoses
  • inflammatory skin diseases
  • personalized treatment
  • skin
  • skin cancer

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Published Papers (1 paper)

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Review

12 pages, 897 KB  
Review
Facial Discoid Dermatosis Imaging with Line-Field Confocal Optical Coherence Tomography and Reflectance Confocal Microscopy—A Case Report and Literature Review
by Joanna Zygadło, Leszek Blicharz, Joanna Czuwara, Joanna Nowaczyk, Karolina Makowska, Małgorzata Olszewska and Lidia Rudnicka
J. Pers. Med. 2026, 16(7), 360; https://doi.org/10.3390/jpm16070360 - 1 Jul 2026
Viewed by 197
Abstract
Background/Objectives: Facial discoid dermatosis is a rare inflammatory dermatosis presenting with round, superficial erythematous lesions located on the face. Diagnosis may be challenging and often requires careful clinicopathological correlation due to overlapping clinical and histopathological features. Skin lesions are typically resistant to [...] Read more.
Background/Objectives: Facial discoid dermatosis is a rare inflammatory dermatosis presenting with round, superficial erythematous lesions located on the face. Diagnosis may be challenging and often requires careful clinicopathological correlation due to overlapping clinical and histopathological features. Skin lesions are typically resistant to a wide range of topical and systemic treatments. From the perspective of personalized medicine, improved phenotyping of rare inflammatory dermatoses may support more precise diagnosis, individualized therapeutic decisions, and non-invasive disease monitoring. This study aimed to characterize facial discoid dermatosis using line-field confocal optical coherence tomography and reflectance confocal microscopy and to discuss its differential diagnosis and therapeutic implications. Methods: We report a case of facial discoid dermatosis in a 35-year-old patient examined with line-field confocal optical coherence tomography and reflectance confocal microscopy. The imaging findings were interpreted in correlation with clinical and histopathological features. A literature review was performed to summarize differential diagnoses, therapeutic perspectives, and the proposed relationship between facial discoid dermatosis and pityriasis rubra pilaris. Results: Non-invasive imaging revealed morphological features consistent with a psoriasiform inflammatory dermatosis and provided additional in vivo information supporting the diagnosis. The literature review showed limited evidence for a direct association between facial discoid dermatosis and pityriasis rubra pilaris, with only isolated reports suggesting possible overlap or progression. Conclusions: Facial discoid dermatosis appears to represent a distinct psoriasiform dermatosis. Line-field confocal optical coherence tomography and reflectance confocal microscopy may contribute to a personalized diagnostic approach by supporting differential diagnosis and potentially guiding individualized monitoring in rare inflammatory facial dermatoses. Full article
(This article belongs to the Special Issue Novel Studies and Therapeutic Options for Skin Disease)
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