Challenges in COVID-19 and Related Complications

Dear Colleagues,

The coronavirus disease 2019 (COVID-19) pandemic has held the world in its thrall since early March 2020 and, unfortunately, it still represents a very difficult challenge.

COVID-19 manifests a spectrum of signs and symptoms from mild to critical illness with rapid clinical deterioration and death. Especially at the beginning of the pandemic, physicians were faced with the challenge of caring for infected patients in the complete absence of scientific evidence and guidelines. Therefore, they used drugs already approved for other diseases, often without assuring optimal therapeutic appropriateness.

Emerging evidence highlights societal and physical impacts of the ongoing pandemic that might worsen clinical conditions, mainly in elderly and frail subjects. Apart from the direct effects of SARS-CoV-2, it is evident that several mechanisms can influence COVID-19 prognosis and patient outcome. This syndrome is associated with several extra-pulmonary manifestations leading to dysfunction and damage to many parts of the body even after the recovery. As a matter of fact, terms such as “long COVID” and “chronic COVID syndrome” have been coined to define the persistence of clinical manifestations or laboratory abnormalities beyond the acute phase of the disease. Therefore, understanding the short- and long-term consequences of COVID-19 represents an urgent issue.

The purpose of this Special Issue is to provide an overview of several concerns related to COVID-19 syndrome and address questions regarding clinical management, including the proper utilization of healthcare resources.

Particular attention will be focused on therapeutic appropriateness and the use of pharmacological and complementary approaches useful to care for both infected patients and patients showing post-COVID sequelae.

This Special issue is open to both reviews and original research papers targeting any of these topics.

Prof. Dr. Amelia Filippelli
Dr. Valeria Conti
Guest Editors

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