Multifunctional Biomaterial Development and Biofabrication for Precision Regenerative Medicine

Dear Colleagues,

The field of regenerative medicine is rapidly advancing toward personalized and patient-specific therapeutic solutions. Central to this progress is the development of multifunctional biomaterials and next-generation biofabrication technologies capable of directing cell behavior, promoting tissue maturation, and enabling precise architectural control. This Special Issue aims to highlight cutting-edge research that integrates material functionality, biological responsiveness, and advanced fabrication strategies to engineer tissues with high fidelity and therapeutic relevance.

We welcome contributions focused on bioactive hydrogels, nanocomposite scaffolds, functional biomaterial coatings, smart or stimuli-responsive materials, and engineered bioinks designed to improve biocompatibility, mechanical performance, and biological signaling. Studies employing 3D bioprinting, organ-on-chip systems, dynamic culture platforms, mechanobiological stimulation, and controlled release systems to achieve precision tissue formation are of particular interest.

Applications may include bone, vascular, dental, musculoskeletal, and soft-tissue regeneration, as well as disease modeling, high-throughput screening, and translational approaches leveraging personalized biomaterial design.

This Special Issue aims to collate innovative methodologies and conceptual advances that bridge fundamental biomaterial research with translational regenerative medicine, offering new pathways toward highly functional, patient-tailored therapeutic constructs.

Dr. Varvara Platania
Dr. Isaac-Maximiliano Bugueno
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.