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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Targeting Extravalvular Burden Associated with Valvular Heart Disease

edited by

Giovanni La Canna

submission deadline 20 Apr 2027 | Viewed by 276 | Submission Open

Keywords: valvular heart disease; systemic disorder; extravalvular burden; valve dysfunction; valve intervention; multimodality imaging

(This special issue belongs to the Section Cardiology)

Hypertension in Adults: Current Updates on Diagnosis, Treatment and Management—Second Edition

edited by Emelina Stambolliu and Antonios A. Argyris

submission deadline 20 Apr 2027 | Viewed by 270 | Submission Open

Keywords: essential hypertension; nighttime blood pressure; blood pressure measurement; blood pressure management; blood pressure medical treatment; hypertension thresholds

(This special issue belongs to the Section Vascular Medicine)

Advancements in Urolithiasis Surgery: Current Trends and Future Directions

edited by

Asaf Shvero

and Nir Kleinmann

submission deadline 20 Apr 2027 | 1 articles | Viewed by 257 | Submission Open

Keywords: urolithiasis; ureterocopy; laser; PCNL; ESWL; robotic surgery

(This special issue belongs to the Section Nephrology & Urology)

Innovations in Percutaneous Coronary Intervention

edited by Sachin Kumar and Amit Hooda

submission deadline 20 Apr 2027 | Viewed by 180 | Submission Open

Keywords: percutaneous coronary intervention; intravascular imaging; coronary physiology; complex coronary interventions; calcified coronary lesions; chronic total occlusion; atherectomy; bifurcation PCI; coronary CT angiography

(This special issue belongs to the Section Cardiology)

The New Frontier in Rheumatoid Arthritis: From Clinical Phenotypes to Precision Medicine

edited by Paula David and Amit Druyan

submission deadline 20 Apr 2027 | Viewed by 177 | Submission Open

Keywords: rheumatoid arthritis; precision medicine; musculoskeletal ultrasound; MRI; difficult-to-treat (D2T) RA; clinical phenotypes

(This special issue belongs to the Section Immunology & Rheumatology)

Burning Mouth Syndrome: Advances in Diagnosis and Patient-Centred Management

edited by Daniela Adamo and

Federica Canfora

submission deadline 20 Apr 2027 | Viewed by 167 | Submission Open

Keywords: oral medicine; oral pathology; burning mouth syndrome; orofacial pain; oral mucosal diseases; psychosomatic dentistry; pharmacological treatment; pharmacotherapy; topical therapy; systemic therapy; pain management; photo-biomodulation; laser therapy; neuromodulation; psychosomatic dentistry; patient-centred care; digital health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Strategies in Cataract and Refractive Management

edited by

Hadas Ben-Eli

and Arie Marcovich

submission deadline 20 Apr 2027 | Viewed by 150 | Submission Open

Keywords: cataract management; refractive management; cataract surgery; refractive surgery; intraocular lens (IOL); IOL power calculation; surgical planning; ocular biometry; anterior segment imaging; refractive outcomes; visual quality; ocular surface optimization; dry eye disease; surgical complications; patient-reported outcomes; clinical ophthalmology

(This special issue belongs to the Section Ophthalmology)

Evolving Imaging Techniques for the Tricuspid Valve and Right Ventricle: Challenges and Future Directions

edited by

Jose Alberto De Agustín

submission deadline 20 Apr 2027 | Viewed by 138 | Submission Open

Keywords: tricuspid valve disease; right ventricle; deformation imaging; cardiac imaging; right heart imaging

(This special issue belongs to the Section Cardiology)

Comorbidities and Challenges Throughout the Lifespan in Down Syndrome

edited by

Ann-Charlotte Granholm-Bentley

submission deadline 20 Apr 2027 | Viewed by 127 | Submission Open

Keywords: Down syndrome; comorbidities; neuropathology; imaging

(This special issue belongs to the Section Clinical Neurology)

Advances in AI-Powered Brain Screening and Clinical Neuroscience

edited by

Fusao Ikawa

submission deadline 20 Apr 2027 | Viewed by 122 | Submission Open

Keywords: artificial intelligence; brain screening; small vessel disease; unruptured cerebral aneurysm; stroke; dementia; prevention; clinical neuroscience

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)

Advanced Therapies and Circulatory Support for Cardiogenic Shock

edited by Ingo Voigt

submission deadline 20 Apr 2027 | Viewed by 121 | Submission Open

Keywords: cardiogenic shock; mechanical circulatory support; extracorporeal membrane oxygenation; ventricular assist devices; hemodynamic monitoring; shock team; myocardial recovery

(This special issue belongs to the Section Cardiology)

Bidirectional Interplay Between Hematological Malignancies and Comorbidities

edited by

Romeo-Gabriel Mihaila

and

Ovidiu Fratila

submission deadline 20 Apr 2027 | Viewed by 120 | Submission Open

Keywords: arrhythmias; cytokine release syndrome; heart failure; hepatitis; hypertension; leukemia; lymphoma; pulmonary fibrosis; renal dysfunction; second cancer

(This special issue belongs to the Section Hematology)

New Updates on Cochlear Implantation and Hearing Rehabilitation

edited by Davide Soloperto

submission deadline 20 Apr 2027 | Viewed by 119 | Submission Open

Keywords: pediatric audiology; cochlear implants; surgical strategies; robotic surgery; inner ear malformations; audiological outcomes evaluation

(This special issue belongs to the Section Otolaryngology)

Ileal and Bipartition Surgeries in the Era of Incretin-Based Therapies: Defining the Future of Metabolic Surgery

edited by

Patrick Noel

submission deadline 20 Apr 2027 | Viewed by 118 | Submission Open

Keywords: metabolic surgery; ileal and bipartition surgeries; incretin-based therapies; obesity; diabetes; type 2 diabetes; pharmacological treatment

(This special issue belongs to the Section General Surgery)

Advances in Clinical Anesthesia and Analgesia: Novel Approaches for Optimal Patient Safety and Comfort—2nd Edition

edited by Giuliano Lo Bianco and

Cesare Gregoretti

submission deadline 20 Apr 2027 | Viewed by 115 | Submission Open

Keywords: pain management; pain medicine; anesthesia; analgesia; anesthesiology; clinical anesthesia; regional anesthesia; perioperative medicine; multimodal analgesia; acute pain management; chronic pain management; enhanced recovery after surgery (ERAS); patient safety; opioid-sparing analgesia; ultrasound-guided regional anesthesia; airway management; anesthetic monitoring; hemodynamic monitoring; postoperative pain; precision anesthesia

(This special issue belongs to the Section Anesthesiology)

Oral Hygiene: Updates and Clinical Progress—3rd Edition

edited by

Frédéric Denis

submission deadline 20 Apr 2027 | Viewed by 113 | Submission Open

Keywords: oral hygiene; preventive dentistry; primary care; oral health promotion; public health; integrated care; digital health; oral–systemic health; global oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Cardiac Arrhythmia Treatment

edited by Nithi Tokavanich and Narut Prasitlumkum

submission deadline 20 Apr 2027 | Viewed by 108 | Submission Open

Keywords: arrhythmia; atrial fibrillation; atrial flutter; ventricular arrhythmia; premature ventricular contraction; sudden cardiac death; ventricular fibrillation; ablation; pulse field ablation; supraventricular tachycardia

(This special issue belongs to the Section Cardiology)

Evolution of Breast and Lymphatic Reconstruction: Current Techniques, Advances and Future Directions

edited by

Dung Nguyen

submission deadline 20 Apr 2027 | Viewed by 101 | Submission Open

Keywords: breast reconstruction; lymphedema; physiologic lymphatic surgery; robotic-assisted surgery; surgical innovation; surgical technology; microsurgery; supermicrosurgery

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Transformative Advances in Crohn’s Disease: Early Disease Intervention and Pre-Clinical Intervention

edited by

Maria Manuela Estevinho

and

Nurulamin M. Noor

submission deadline 20 Apr 2027 | Viewed by 88 | Submission Open

Keywords: inflammatory bowel disease; Crohn’s disease; early treatment; effective intervention; early disease; pre-clinical disease; early medical treatment; early surgical treatment; early patient management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Progress in Hemodialysis and Peritoneal Dialysis

edited by Jyoti Baharani

submission deadline 20 Apr 2027 | Viewed by 81 | Submission Open

Keywords: hemodialysis; peritoneal dialysis; home dialysis; vascular access; chronic kidney disease; shared decision-making

(This special issue belongs to the Section Nephrology & Urology)

Clinical Advances in Trauma and Emergency Medicine, 2nd Edition

edited by Viktoria Bogner-Flatz

submission deadline 20 Apr 2027 | Viewed by 77 | Submission Open

Keywords: resuscitation; trauma emergency management; disaster response; mild traumatic brain injury emergency management; critical emergency care

(This special issue belongs to the Section Emergency Medicine)

Transcatheter Aortic Valve Implantation (TAVI): Recent Advances and Future Prospects

edited by Suvitesh Luthra and Richard Jabbour

submission deadline 20 Apr 2027 | Viewed by 68 | Submission Open

Keywords: transcatheter; surgical; aortic valve; TAVI; aortic stenosis; clinical outcomes research

(This special issue belongs to the Section Cardiology)

New Frontiers in Kidney Transplantation: Innovation, Organ Preservation, and Clinical Outcomes

edited by Obi O. Ekwenna

submission deadline 20 Apr 2027 | Viewed by 62 | Submission Open

Keywords: kidney transplantation; robotic kidney transplantation; organ preservation; machine perfusion; living donor protection; deceased donor transplantation; xenotransplantation; cryobiology; biomimetic organ preserva-tion; transplant innovation; clinical outcomes; precision medicine; transplant immunology; health disparities

(This special issue belongs to the Section Nephrology & Urology)

Challenges and Advances in Thyroid and Parathyroid Surgery

edited by

Kwangsoon Kim

submission deadline 20 Apr 2027 | Viewed by 51 | Submission Open

Keywords: thyroid surgery; parathyroid surgery; surgical innovation; multigland disease; postoperative quality of life

(This special issue belongs to the Section General Surgery)

Current Trends in Minimally Invasive Gynecologic Surgery

edited by Raanan Meyer

submission deadline 20 Apr 2027 | Viewed by 49 | Submission Open

Keywords: minimally invasive gynecology; endometriosis; uterine fibroids; isthmocele; fertility sparing surgery; hysteroscopy; gynecological surgery; laparoscopic surgery; deeply infiltrating endometriosis; ERAS protocols; artificial intelligence in surgery; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Prediction, Prevention, and Management of Pregnancy and Childbirth Complications

edited by Ioannis Kyvernitakis

submission deadline 20 Apr 2027 | Viewed by 47 | Submission Open

Keywords: preterm birth; prevention; high-risk pregnancy; prediction; fetal medicine; fetal growth restriction; twin pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

The Evolving Landscape of Neuromodulation: From Technology to New Indications and Improved Outcomes

edited by Artur Vetkas and Pablo Andrade

submission deadline 20 Apr 2027 | Viewed by 33 | Submission Open

Keywords: deep brain stimulation; transcranial focused ultrasound; non-invasive neuromodulation, stereo-EEG; clinical neuroengineering; closed-loop stimulation; clinical translational neuroscience, patient outcomes

(This special issue belongs to the Section Clinical Neurology)

Urological Oncology: Clinical Diagnosis, Treatment, and Prognostic Management

edited by Matteo Vittori and Valerio Iacovelli

submission deadline 20 Apr 2027 | Viewed by 32 | Submission Open

Keywords: urological oncology; prostate cancer; bladder cancer; renal cell carcinoma; upper tract urothelial carcinoma; urological malignancies; biomarkers; imaging; precision oncology; risk stratification; prognostic factors; robotic surgery; minimally invasive surgery; systemic therapy; immunotherapy; artificial intelligence

(This special issue belongs to the Section Nephrology & Urology)

Current Advances in Glaucoma: From Pathophysiology to Clinical Management

edited by

Alon Zahavi

and

Nitza Goldenberg-Cohen

submission deadline 23 Apr 2027 | Viewed by 1 | Submission Open

Keywords: glaucoma; intraocular pressure; optic neuropathy; glaucoma diagnosis; ocular imaging; glaucoma treatment; glau-coma surgery; neuroprotection; clinical translational research; treatment adherence; real-world evidence; phar-macoepidemiology; artificial intelligence; quality of life

(This special issue belongs to the Section Ophthalmology)

Clinics and Management of Allergic and Inflammatory Skin Disorders

edited by

Andrzej Jaworek

and

Marta Szepietowska

submission deadline 25 Apr 2027 | 5 articles | Viewed by 6037 | Submission Open

Keywords: allergic dermatoses; chronic inflammatory dermatoses; atopic dermatosis; contact dermatitis; chronic urticria; rosacea; psoriasis; hidradenitis suppurativa; diagnosis; comorbidities; management

(This special issue belongs to the Section Dermatology)

Colorectal Cancer: Early Detection, Treatment Advances and Patient Outcomes

edited by

Damiano Caputo

Roberto Cammarata

and Federica Giordano

submission deadline 25 Apr 2027 | 3 articles | Viewed by 4548 | Submission Open

Keywords: colorectal cancer; early detection; prevention; innovation; screening; precision medicine; biomarkers; genetic profile

(This special issue belongs to the Section Oncology)

Helicobacter pylori-Associated Intestinal Diseases and Beyond

edited by

Antonio Facciorusso

submission deadline 25 Apr 2027 | 4 articles | Viewed by 4355 | Submission Open

Keywords: IBD; Hp; stomach; celiac disease; diverticulosis; diverticulitis

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Updates on Neuromuscular Diseases

edited by

Menachem Sadeh

submission deadline 25 Apr 2027 | 5 articles | Viewed by 2982 | Submission Open

Keywords: neuromuscualr disorders; myopathies; neuropathies; neuromuscualr junction disorders; neurogenetics

(This special issue belongs to the Section Clinical Neurology)

Personalized Therapy and Clinical Outcome for Vasculitis

edited by

Giulia Cassone

submission deadline 25 Apr 2027 | 2 articles | Viewed by 2810 | Submission Open

Keywords: immune-mediated systemic vasculitis; personalized therapy; treatment; outcome; biomarkers; risk factors; management; multidisciplinary care

(This special issue belongs to the Section Immunology & Rheumatology)

Chronic Obstructive Pulmonary Disease (COPD): Treatment and Management—Second Edition

edited by

Maurizio Marvisi

and Alfredo Antonio Chetta

submission deadline 25 Apr 2027 | 3 articles | Viewed by 2581 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); treatable traits; precision medicine; COPD comorbidities; COPD mortality

(This special issue belongs to the Section Respiratory Medicine)

Early Palliative Care for Patients with Advanced Cancer

edited by

Daryl Bainbridge

submission deadline 25 Apr 2027 | Viewed by 2121 | Submission Open

Keywords: palliative care; early integration; cancer care transitions; communication; symptom management; end of life

(This special issue belongs to the Section Oncology)

The New Perspective in Transcatheter Aortic Valve Implantation (TAVI)

edited by Salvatore Giordano, Arturo Giordano and Nicola Corcione

submission deadline 25 Apr 2027 | 3 articles | Viewed by 1964 | Submission Open

Keywords: transcatheter aortic valve implantation (TAVI); structural heart intervention; aortic stenosis; valve technology and durability; imaging and procedural optimization

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Advancements in Orthopedic Trauma Treatments

edited by

Alessandro Rava

submission deadline 25 Apr 2027 | 3 articles | Viewed by 1696 | Submission Open

Keywords: fractures; osteoporosis; fixation; trauma; fracture healing; osteosynthesis; pain

(This special issue belongs to the Section Orthopedics)

Knee Arthroplasty: Recent Advances and Future Challenges

edited by Matteo Marullo

submission deadline 25 Apr 2027 | 2 articles | Viewed by 1547 | Submission Open

Keywords: knee arthroplasty; implant design; robotic surgery; revision surgery; biomechanics; clinical outcomes; perioperative care; fast-track surgery; digital orthopedics; partial knee replacement

(This special issue belongs to the Section Orthopedics)

Advances in Anticoagulant and Antiplatelet Therapy for Coronary Artery Disease: 2nd Edition

edited by

Giuseppe De Luca

submission deadline 25 Apr 2027 | 1 articles | Viewed by 1366 | Submission Open

Keywords: platelet; anticoagulant therapy; antiplatelet therapy; coronary artery disease (CAD); atrial fibrillation (AF); thromboembolic events; myocardial ischemic; bleeding events; aspirin; clopidogrel; cardiovascular and cerebrovascular diseases; diagnosis and treatment; percutaneous coronary intervention; acute coronary syndrome

(This special issue belongs to the Section Cardiology)

Bariatric Surgery: Clinical Advances and Future Directions

edited by

Natalia Dowgiałło-Gornowicz

and

Mateusz Wityk

submission deadline 25 Apr 2027 | 1 articles | Viewed by 877 | Submission Open

Keywords: metabolic surgery; bariatric surgery; reflux; laparoscopy; conversion surgery; obesity

(This special issue belongs to the Section General Surgery)

Kidney Transplantation: From Donor Selection to Recipient Outcomes

edited by Basma Merhi and Reginald Gohh

submission deadline 25 Apr 2027 | 1 articles | Viewed by 821 | Submission Open

Keywords: kidney transplantation; end-stage renal disease (ESRD); living-donor kidney transplantation; deceased-donor kidney transplantation; organ shortage; dialysis waiting time; transplant candidate evaluation; immunosuppression

(This special issue belongs to the Section Nephrology & Urology)

Advances in Percutaneous Coronary Intervention: Techniques, Tools and Outcomes

edited by Takashi Ashikaga

submission deadline 25 Apr 2027 | 1 articles | Viewed by 732 | Submission Open

Keywords: percutaneous coronary intervention; orbital atherectomy; coronary artery calcification; intravascular ultrasound (IVUS); optical coherence tomography (OCT)

(This special issue belongs to the Section Cardiovascular Medicine)

Management of Complex Orthopaedic Trauma and Bone Infection

edited by

Georg Mattiassich

submission deadline 25 Apr 2027 | 1 articles | Viewed by 549 | Submission Open

Keywords: complex orthopaedic trauma; fracture-related infection (FRI); bone and implant-associated infection; chronic osteomyelitis; post-traumatic infection; biofilm-associated infection; advanced fracture management; limb reconstruction; nonunion and delayed union; multidisciplinary trauma care

(This special issue belongs to the Section Orthopedics)

Clinical Updates of Pediatric Craniofacial Surgery

edited by Federica Tosi

submission deadline 25 Apr 2027 | Viewed by 340 | Submission Open

Keywords: pediatric craniofacial surgery; craniosynostosis; near-infrared spectroscopy; blood transfusion; perioperative monitoring; pediatric anesthesia; hemodynamic management; tissue oxygenation

(This special issue belongs to the Section Clinical Pediatrics)

Percutaneous Coronary Interventions in Acute Coronary Syndromes: Techniques, Imaging and Clinical Outcomes

edited by Ioannis Skalidis

submission deadline 25 Apr 2027 | Viewed by 282 | Submission Open

Keywords: PCI; acute coronary syndrome; STEMI; NSTEMI; myocardial infarction; intravascular imaging; IVUS; OCT; coro-nary physiology; QFR; multivessel disease; antithrombotic therapy

(This special issue belongs to the Section Cardiology)

Advanced Diagnostics, Management, and Rare Unusual Clinical Consequences of Blunt or Penetrating Abdominal, Pelvic, Thoracic, and Vascular Injuries

edited by

Karol Kłosiński

and Zbigniew Pasieka

submission deadline 25 Apr 2027 | 1 articles | Viewed by 177 | Submission Open

Keywords: blunt trauma; penetrating trauma; abdominal injuries; thoracic injuries; pelvic fractures; arterial and vascular trauma; blunt aortic injury (BTAI); thoracic endovascular aortic repair (TEVAR); visceral macrovascular trauma; emergency surgery; damage control resuscitation

(This special issue belongs to the Section General Surgery)

New Insights into Physical Therapy: 2nd Edition

edited by

Patsaki Irini

and

George A. Koumantakis

submission deadline 25 Apr 2027 | Viewed by 156 | Submission Open

Keywords: physical rehabilitation; new technologies; virtual reality; augmented reality; telerehabilitation; clinical pilates; blood flow restriction; manual therapy; motor imagery; electrophysical modalities; therapeutic exercises; neurology; mus-culoskeletal; geriatric; respiratory; acute illness; cardiovascular

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Advances in Intracranial Tumors Surgery

edited by Michael J. Karsy and

Nasser K. Yaghi

submission deadline 25 Apr 2027 | Viewed by 127 | Submission Open

Keywords: intracranial tumors; surgical innovations; minimally invasive surgery; awake mapping; fluorescence-guided surgery; intraoperative imaging; robotic surgery; artificial intelligence; perioperative care; patient-centered outcomes

(This special issue belongs to the Section Clinical Neurology)

Advances and Updates in Fetal Medicine

edited by Roy Zigron and

Amihai Rottenstreich

submission deadline 25 Apr 2027 | Viewed by 109 | Submission Open

Keywords: fetal medicine; maternal medicine; obstetric ultrasound; twin pregnancy; pre-eclampsia; prematurity

(This special issue belongs to the Section Obstetrics & Gynecology)

Displaying special issue 1301-1350 on page 27 of 30.

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