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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Challenges and Innovations in Modern Arthroplasty: State of the Art and Perspectives
edited by Suenghwan Jo and Jungmo Hwang
submission deadline 20 May 2027 | Viewed by 2 | Submission Open
Keywords: knee arthroplasty; hip arthroplasty; complications; robotic surgery; artificial intelligence
(This special issue belongs to the Section Orthopedics)
Tumor Microenvironment in Translational Oncology: Histopathological Biomarkers and Therapeutic Targets
edited by Valeria Zuccalà
submission deadline 21 May 2027 | Viewed by 75 | Submission Open
Keywords: tumor microenvironment; translational pathology; tumor budding; invasive front; cancer-associated fibroblasts; tumor-associated macrophages; angiogenesis; lymphangiogenesis; mast cells; immune landscape; immunohistochemistry; digital pathology; spatial pathology; predictive biomarkers; therapeutic targets
(This special issue belongs to the Section Oncology)
Recent Clinical Advances and Challenges in Oral and Maxillofacial Surgery
edited by Majeed Rana and
submission deadline 25 May 2027 | Viewed by 399 | Submission Open
Keywords: oral and maxillofacial surgery; virtual surgical planning; patient-specific implants; 3D printing and additive manufacturing; computer-assisted surgery; artificial intelligence; orthognathic surgery; craniomaxillofacial reconstruction
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
From Psychological Distress to Well-Being: Prevention and Interventions Across Clinical and Applied Settings
edited by Dominika Wilczyńska
submission deadline 25 May 2027 | Viewed by 167 | Submission Open
Keywords: psychological well-being; mental health; psychological distress; depression; high-functioning depression; burnout; resilience; physical activity; exercise interventions; positive psychology
(This special issue belongs to the Section Mental Health)
Symptoms and Treatment of Parkinson’s Disease: 2nd Edition
edited by and Nikolaos Papagiannakis
submission deadline 25 May 2027 | Viewed by 63 | Submission Open
Keywords: Parkinson’s disease; non-motor symptoms; clinical progression; cognitive assessment; genetics; remote monitoring; biomarkers; personalized medicine; device-aided treatments; disease-modifying therapies
(This special issue belongs to the Section Clinical Neurology)
Clinical Advances in Dyslipidemia
edited by Beatriz Candás-Estébanez
submission deadline 25 May 2027 | Viewed by 55 | Submission Open
Keywords: characterization of lipoproteins; cardiovascular risk; individualized approach; risk stratification tools; novel biomarkers; dyslipidemia; atherosclerosis; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Advances in Cardiothoracic Surgery: Current Techniques and Future Innovations
edited by Hari R. Mallidi
submission deadline 25 May 2027 | Viewed by 52 | Submission Open
Keywords: heart transplantation; donation after circulatory death; ex vivo perfusion; mechanical circulatory support; left ventricular assist device; ECMO; coronary artery bypass grafting; aortic surgery; small aortic root; valve surgery; minimally invasive cardiac surgery; robotic surgery; lung transplantation; enhanced recovery after surgery; outcomes research
(This special issue belongs to the Section Cardiology)
Innovations in Sports Medicine: From Surgical Treatment to Return to Play
edited by Luigi Cianni and Maristella Francesca Saccomanno
submission deadline 25 May 2027 | Viewed by 31 | Submission Open
Keywords: sports medicine; shoulder surgery; arthroscopy; shoulder instability; rotator cuff; knee surgery; sports traumatology; orthobiologics; return to play; joint preservation
(This special issue belongs to the Section Sports Medicine)
Ocular Surface, Retina, and Choroid as Mirrors of Systemic and Genetic Diseases: 2nd Edition submission deadline 28 May 2027 | Viewed by 69 | Submission Open
Keywords: ocular surface; retina; choroid; systemic diseases; genetic conditions; biomarkers; diagnostic imaging; neuroretina; infectious diseases
(This special issue belongs to the Section Ophthalmology)
Aortic Aneurysms: Recent Advances in Diagnosis and Treatment: 2nd Edition
edited by Marco Virgilio Usai, Giuseppe Asciutto and Michele Piazza
submission deadline 31 May 2027 | 1 articles | Viewed by 401 | Submission Open
Keywords: aortic aneurysms; abdominal aortic; thoraco-abdominal aortic aneurysms (TAAAs); complex aortic anatomies; endovascular abdominal aortic aneurysm repair (EVAR); endovascular thoracic aortic aneurysm repair (TEVAR); endovascular treatment
(This special issue belongs to the Section Cardiovascular Medicine)
Current Concepts and Updates in Eye Diseases
edited by Wiktor Stopyra, and Anna Machalinska
submission deadline 1 Jun 2027 | 4 articles | Viewed by 5526 | Submission Open
Keywords: corneal disease; glaucoma; cataract, uveitis; ocular oncology; retinal disorder; ocular treatment; eye surgery; ocular diagnostics
(This special issue belongs to the Section Ophthalmology)
Cutting-Edge Research on Thrombosis and Antithrombotic Therapy
edited by
submission deadline 1 Jun 2027 | Viewed by 120 | Submission Open
Keywords: thrombosis; antithrombotic therapy; anticoagulation; thrombolysis; venous thromboembolism; arterial thrombosis; pulmonary embolism; myocardial infarction; stroke; peripheral artery disease; cardiovascular medicine; artificial intelligence; precision medicine; cardiovascular outcomes research
(This special issue belongs to the Section Cardiovascular Medicine)
Recent Advances in Refractive Surgery and Intraocular Lens Implantation
edited by Antonio Leccisotti
submission deadline 5 Jun 2027 | 3 articles | Viewed by 1929 | Submission Open
Keywords: refractive surgery; intraocular lens implantation; keratectomy; cornea; ocular surgery; optical coherence tomography; laser surgery; KLEx (keratorefractive lenticule extraction); femtolasik
(This special issue belongs to the Section Ophthalmology)
Infectious Disease Epidemiology: Current Updates and Perspectives submission deadline 10 Jun 2027 | 8 articles | Viewed by 12312 | Submission Open
Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments
(This special issue belongs to the Section Infectious Diseases)
The Development and Challenges of Spinal Surgery in Minimally Invasive Surgery, Spinal Endoscopy Robotics, Navigation and Augmented Reality
edited by
submission deadline 10 Jun 2027 | Viewed by 138 | Submission Open
Keywords: spinal endoscopy; robotics; spinal tumor surgery; spinal deformity; spinal
(This special issue belongs to the Section Orthopedics)
Advances in Oral and Maxillofacial Surgery: Clinical Practice, Innovation and Future Perspectives submission deadline 10 Jun 2027 | Viewed by 58 | Submission Open
Keywords: oral surgery; implant dentistry; reconstructive surgery; dental materials; surgical complications; surgical innovation; healthcare innovation; autologous platelets concentrates; clinical research
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Updates on Rheumatoid Arthritis: 3rd Edition
edited by Francesca Bandinelli
submission deadline 10 Jun 2027 | Viewed by 54 | Submission Open
Keywords: rheumatoid arthritis; rheumatology; treatment; diagnosis; biomarkers; rheumatic disease
(This special issue belongs to the Section Immunology & Rheumatology)
Beyond Decompensation: Emerging Concepts in Advanced Cirrhosis and Its Complications submission deadline 10 Jun 2027 | Viewed by 8 | Submission Open
Keywords: cirrhosis; decompensated cirrhosis; acute kidney injury; acute kidney disease; chronic kidney disease; hepatorenal syndrome; bacterial infections; further decompensation; recompensation; acute-on-chronic liver failure
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Hypertrophic Cardiomyopathy: Diagnosis, Risk Stratification and Management
edited by
submission deadline 15 Jun 2027 | Viewed by 66 | Submission Open
Keywords: hypertrophic cardiomyopathy; risk stratification; sudden cardiac death; genetics; arrhythmias; precision medicine; catheter ablation
(This special issue belongs to the Section Cardiology)
Transforming Medical Imaging with Artificial Intelligence: Innovations and Clinical Applications
edited by Anna Colarieti
submission deadline 17 Jun 2027 | Viewed by 44 | Submission Open
Keywords: artificial intelligence; radiomics; quantitative imaging; magnetic resonance imaging; precision oncology; imaging biomarkers
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Clinical Perspective in Endocrinology Across the Contemporary Era: From Challenges to Future Directions
edited by
submission deadline 18 Jun 2027 | Viewed by 44 | Submission Open
Keywords: thyroid; adrenal; parathyroid; pituitary; neuroendocrine; biomarker; gene; hormone; endocrine surgery; irisin; primary hyperparathyroidism; osteoporosis; DXA; endocrine tumor; hyper/hypothyroidism
(This special issue belongs to the Section Endocrinology & Metabolism)
Innovations in Perioperative Anesthesia: Advancing Non-Operating Room Anesthesia (NORA) and Regional Techniques
edited by Francesco Coppolino and
submission deadline 20 Jun 2027 | 4 articles | Viewed by 9979 | Submission Open
Keywords: perioperative medicine; non-operating room anesthesia (NORA); ultrasound-guided regional anesthesia; fascial plane blocks; postoperative pain management
(This special issue belongs to the Section Anesthesiology)
Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 20 Jun 2027 | 7 articles | Viewed by 9636 | Submission Open
Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation
(This special issue belongs to the Section Orthopedics)
Clinical Management of Frailty: 2nd Edition
edited by Walter Sepulveda-Loyola, and
submission deadline 20 Jun 2027 | Viewed by 96 | Submission Open
Keywords: frailty; comprehensive geriatric assessment; assessment; monitoring; functional decline; physical performance; exercise interventions; nutritional strategies; interventions; adverse outcomes
(This special issue belongs to the Section Geriatric Medicine)
Emerging Technologies in Plastic and Reconstructive Surgery: Digital Innovation, Surgical Strategies and Precision Reconstruction
edited by Edward M. Kobraei and Patryk Ostrowski
submission deadline 20 Jun 2027 | Viewed by 68 | Submission Open
Keywords: plastic and reconstructive surgery; emerging technologies; regenerative medicine; microsurgery; peripheral nerve repair; artificial intelligence; digital surgery; virtual surgical planning; three-dimensional printing; patient-specific reconstruction; precision reconstruction; surgical robotics; augmented reality
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Psychological Distress During Pregnancy, Childbirth and Postnatal Period submission deadline 20 Jun 2027 | Viewed by 66 | Submission Open
Keywords: pregnancy; childbirth; postpartum period; psychological distress; maternal mental health; fear of child-birth; body image; anxiety; depression
(This special issue belongs to the Section Mental Health)
Advances in Sleep-Disordered Breathing: Emerging Diagnostics, Innovative Therapies, and Special Populations
edited by
submission deadline 20 Jun 2027 | Viewed by 59 | Submission Open
Keywords: sleep-disordered breathing; obstructive sleep apnea; central sleep apnea; precision medicine; artificial intelligence; wearable technologies; digital health; phenotyping; hypoglossal nerve stimulation; GLP-1 receptor agonists; cardio-vascular disease; obesity; diabetes; neurological disorders; women's health; pediatric sleep medicine; telemedicine; multimorbidity
(This special issue belongs to the Section Respiratory Medicine)
The Role of Endoscopy in the Clinical Diagnosis and Treatment of Gastrointestinal Diseases
edited by Steven P. Shamah and Ariel A. Benson
submission deadline 20 Jun 2027 | Viewed by 44 | Submission Open
Keywords: third-space endoscopy; therapeutic EUS; endobariatrics; POEM; advanced resections; artificial Intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Clinical Treatments and Challenges for Cardiovascular Diseases: 2nd Edition
edited by Georgios Bouras and
submission deadline 20 Jun 2027 | Viewed by 44 | Submission Open
Keywords: heart failure; coronary artery disease; acute coronary syndromes; atrial fibrillation; arrhythmias; cardiomyopathies; hypertension; valvular heart disease; pulmonary hypertension; cardiogenic shock; cardiovascular prevention; dyslipidemia; cardiovascular pharmacotherapy; cardiac imaging; cardiovascular risk stratification; cardiovascular outcomes
(This special issue belongs to the Section Cardiovascular Medicine)
Spontaneous Pneumothorax: Disease Concepts, Etiologies, and Clinical Management of Primary and Secondary Forms submission deadline 20 Jun 2027 | Viewed by 43 | Submission Open
Keywords: spontaneous pneumothorax; primary spontaneous pneumothorax; secondary spontaneous pneumothorax; thoracic surgery; COPD; interstitial lung disease; catamenial pneumothorax; thoracic endometriosis-related pneumothorax; Birt-Hogg-Dubé syndrome; lymphangioleiomyomatosis; pleurodesis; recurrence prevention; multidisciplinary management
(This special issue belongs to the Section Respiratory Medicine)
Lung Transplantation: Clinical Innovations and Future Directions
edited by Shambhu Aryal
submission deadline 20 Jun 2027 | Viewed by 40 | Submission Open
Keywords: lung transplantation; chronic lung allograft dysfunction; primary graft dysfunction; ex vivo lung perfusion; organ allocation; interstitial lung disease; immunosuppression; donor optimization
(This special issue belongs to the Section Respiratory Medicine)
Sports Medicine: Recent Advances in Sports Injuries and Rehabilitation
edited by Roxana Ramona Onofrei
submission deadline 20 Jun 2027 | Viewed by 39 | Submission Open
Keywords: sports injuries; injury prevention; risk factors; overuse injuries; rehabilitation; return to play; athletic performance; wearable technologies
(This special issue belongs to the Section Sports Medicine)
Advances in the Treatment and Management of Gastrointestinal Cancers
edited by
submission deadline 20 Jun 2027 | Viewed by 36 | Submission Open
Keywords: gastrointestinal oncology; colorectal cancer; gastric cancer; pancreatic cancer; immunotherapy; targeted therapy; precision oncology; molecular biomarkers; liquid biopsy; drug resistance
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Advances in Otolaryngology-Head and Neck Surgery
edited by
submission deadline 20 Jun 2027 | Viewed by 35 | Submission Open
Keywords: rhinology; laringology; otology; sleep disorders; head and neck surgery
(This special issue belongs to the Section Otolaryngology)
Advances and Current Clinical Challenges in Neonatal and Perinatal Care
edited by and Georgios Mitsiakos
submission deadline 20 Jun 2027 | Viewed by 34 | Submission Open
Keywords: neonatology; perinatal medicine; neonatal intensive care; prematurity; extremely preterm infants; neonatal morbidity; high-risk neonates; neurodevelopment; precision medicine; neonatal technologies; clinical challenges
(This special issue belongs to the Section Clinical Pediatrics)
Endometriosis and Endometrial Cancer: Molecular Insights, Clinical Management and Challenges
edited by Lucia Lazzeri and
submission deadline 20 Jun 2027 | Viewed by 34 | Submission Open
Keywords: endometriosis; endometrial cancer; gynecologic ultrasound; pelvic imaging; minimally invasive gyneco-logic surgery
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Practice and Future Perspectives of Breast Reconstruction
edited by Florian Falkner and Alexander Haumer
submission deadline 20 Jun 2027 | Viewed by 30 | Submission Open
Keywords: breast reconstruction; reconstructive microsurgery; autologous breast reconstruction; implant-based breast recon-struction; DIEP flap; perforator flaps; robotic surgery; breast neurotization; artificial intelligence; lipografting; onco-plastic breast surgery
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Innovations in Maxillofacial Surgery: 2nd Edition
edited by , and Ana María López López
submission deadline 20 Jun 2027 | Viewed by 25 | Submission Open
Keywords: orthognathic surgery; sleep apnea; 3D technologies; regenerative medicine; reconstructive surgery; facial trauma; minimally invasive surgery; oncology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Adverse Pregnancy Outcomes: Current Status, Challenges and Future Directions—2nd Edition
edited by , Iuliana Ceausu and
submission deadline 20 Jun 2027 | Viewed by 24 | Submission Open
Keywords: great obstetrical syndromes; adverse pregnancy outcomes; screening; prediction; prophylaxis; diagnosis; long-term follow-up; perinatal management; intrapartum management
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Surgical Management of Corpus Callosum Glioma submission deadline 20 Jun 2027 | Viewed by 24 | Submission Open
Keywords: glioma; neuro-oncology; awake surgery; high-grade glioma; low-grade glioma
(This special issue belongs to the Section Clinical Neurology)
Cardiac Intensive Care: Clinical Advances and Prospects
edited by Robert Zilberszac and
submission deadline 20 Jun 2027 | Viewed by 18 | Submission Open
Keywords: cardiac intensive care; cardiogenic shock; acute heart failure; mechanical circulatory support; VA-ECMO; extracorporeal cardiopulmonary resuscitation; cardiac arrest; post-resuscitation care; hemodynamic moni-toring; critical care echocardiography; valvular heart disease
(This special issue belongs to the Section Intensive Care)
Contemporary Coronary Interventions: From Guideline-Directed Revascularization to Complex PCI
edited by Andreas Synetos
submission deadline 20 Jun 2027 | Viewed by 17 | Submission Open
Keywords: coronary artery disease; myocardial infarction; complex, chronic total occlusions; bifurcation lesions; calcium modification
(This special issue belongs to the Section Cardiology)
Advances in Cardiac Arrhythmias: Diagnosis and Management
edited by and Paschalis Karakasis
submission deadline 20 Jun 2027 | Viewed by 15 | Submission Open
Keywords: atrial fibrillation; cardiac electrophysiology; catheter ablation; pulsed field ablation; ventricular arrhythmias; cardiac pacing; conduction system pacing; electroanatomic mapping; digital health; precision medicine
(This special issue belongs to the Section Cardiology)
New Perspectives in Pediatric Epilepsy: From Mechanisms to Clinical Care
edited by
submission deadline 20 Jun 2027 | Viewed by 14 | Submission Open
Keywords: pediatric epilepsy; drug-resistant epilepsy; precision medicine; epilepsy genetics; neuroimaging; neuromodulation; epilepsy surgery
(This special issue belongs to the Section Clinical Pediatrics)
Epidemiology of Hyperglycemia in Pregnancy and Its Maternofetal Adverse Outcomes: 2nd Edition
edited by
submission deadline 20 Jun 2027 | Viewed by 11 | Submission Open
Keywords: gestational diabetes; diabetes in pregnancy; risk factors; epidemiology; maternofetal adverse outcomes in pregnancies with hypergliycemia; temporal trends
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in Keratoconus: Emerging Treatments and Surgical Innovation
edited by Artemis Matsou and Miltos O. Balidis
submission deadline 20 Jun 2027 | Viewed by 10 | Submission Open
Keywords: corneal cross-linking; corneal biomechanics; intracorneal ring segments; stromal augmentation; corneal transplantation; visual rehabilitation
(This special issue belongs to the Section Ophthalmology)
Major Depressive Disorder: Clinical Advances and Management Strategies
edited by Paolo Olgiati
submission deadline 20 Jun 2027 | Viewed by 1 | Submission Open
Keywords: major depressive disorder; clinical management; pharmacotherapy; psychotherapy; treatment-resistant depression; precision psychiatry; digital interventions; neuromodulation; suicidality; integrated interventions
(This special issue belongs to the Section Mental Health)
Management of Helicobacter pylori-Related Gastric Lesions: From Chronic Inflammation to Bleeding and Cancer Risk
edited by and Simona Grad
submission deadline 20 Jun 2027 | Viewed by 1 | Submission Open
Keywords: Helicobacter pylori infection; chronic gastritis; atrophic gastritis; intestinal metaplasia; peptic ulcer bleeding; gastric cancer; eradication therapy; screen-and-treat strategy; artificial intelligence-assisted endoscopy; gastric cancer pre-vention; Correa cascade; non-invasive biomarkers
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Neuromodulation and Rehabilitative Interventions in Spasticity: From Cryoneurolysis to Emerging Technologies
edited by Luigi Di Lorenzo and Fabio Tortora
submission deadline 24 Jun 2027 | Viewed by 5 | Submission Open
Keywords: cryoneurolysis; spasticity; botulinum; neuromodulation; rehabilitative interventions
(This special issue belongs to the Section Clinical Rehabilitation)
Contemporary and Emerging Strategies for Cardiac Arrhythmia Management submission deadline 25 Jun 2027 | Viewed by 42 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; atrial tachyarrhythmias; ventricular arrhythmias; cardiac electrophysiology; catheter ablation; pulsed-field ablation; electroanatomical mapping; sudden cardiac death; cardiac implantable electronic devices; conduction system pacing; leadless pacing; cardiac resynchronization therapy; implantable cardioverter-defibrillator; wearable devices; remote monitoring; artificial intelligence; digital health; cardiac imaging; biomarkers; precision medicine; rhythm control; antiarrhythmic therapy; risk stratification; clinical outcomes
(This special issue belongs to the Section Cardiology)
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