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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 20 May 2026 | 4 articles | Viewed by 8604 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

Effect of Long-Term Insomnia on Mental Health—2nd Edition

edited by

Aleksandra Rogowska

submission deadline 20 May 2026 | 1 articles | Viewed by 8378 | Submission Open

Keywords: anxiety; alcohol and substance use disorders; behavioral addiction; burnout; cognitive dysfunction; depression; eating disorders; gaming addiction; problematic internet/social media use; insomnia; long-term insomnia; mood disorders; post-traumatic stress disorder; stress

(This special issue belongs to the Section Mental Health)

State of the Art in Neuromodulation or Spinal Cord Stimulation Therapy

edited by Marco Mercieri

submission deadline 20 May 2026 | 3 articles | Viewed by 8327 | Submission Open

Keywords: neuromodulation; spinal cord stimulation; chronic pain management; stimulation waveforms; long-term efficacy; loss of efficacy; outcome prediction; opioid-sparing techniques; neurostimulation mechanisms; psychological predictors; therapeutic targets

(This special issue belongs to the Section Clinical Neurology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 20 May 2026 | 7 articles | Viewed by 7764 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Transcatheter Aortic Valve Implantation: Recent Advances and Future Directions

edited by

Alon Shechter

and Pablo Codner

submission deadline 20 May 2026 | 6 articles | Viewed by 7166 | Submission Open

Keywords: transcatheter aortic valve implantation; transcatheter aortic valve replacement; aortic valve stenosis; aortic valve regurgitation; aoric valve disease; cardiac imaging; artifical intelligence; machine learning

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Myasthenia Gravis

edited by Shingo Konno

submission deadline 20 May 2026 | 3 articles | Viewed by 5508 | Submission Open

Keywords: myasthenia gravis; clinical trials; translational research; drug repurposing; biological markers; experimental autoimmune myasthenia gravis

(This special issue belongs to the Section Clinical Neurology)

Neural Application of Artificial Intelligence in Clinical Neuroscience

edited by Saurabh J. Singhal

submission deadline 20 May 2026 | 3 articles | Viewed by 5205 | Submission Open

Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction

(This special issue belongs to the Section Clinical Neurology)

Updates on Cardiac Pacing and Electrophysiology

edited by

Axel Brandes

submission deadline 20 May 2026 | 4 articles | Viewed by 4249 | Submission Open

Keywords: pacemaker; conduction system pacing; leadless pacemaker; implantable cardioverter– defibrillator; ICD; extravascular ICD; S-ICD; lead extraction; supraventricular tachycardia; ventricular tachycardia; cardio-neuro ablation

(This special issue belongs to the Section Cardiology)

Advances in Retinal Diseases—Mechanisms, Diagnostics, and Emerging Therapies

edited by

Minzhong Yu

submission deadline 20 May 2026 | 3 articles | Viewed by 4248 | Submission Open

Keywords: inherited retinal diseases; age-related macular degeneration; diabetic retinopathy; multimodal retinal imaging; treatment

(This special issue belongs to the Section Ophthalmology)

New Advances in Uterus and Ovarian Transplantation: 2nd Edition

edited by

Elliott G. Richards

submission deadline 20 May 2026 | 2 articles | Viewed by 3880 | Submission Open

Keywords: uterus transplantation; gynaecological surgery; endometriosis; IVF; fibroids; reproductive medicine; laparoscopic surgery; assisted reproductive technology; reproductive endocrinology

(This special issue belongs to the Section Obstetrics & Gynecology)

Challenges in Reproductive Health

edited by

Loris Marin

and Guido Ambrosini

submission deadline 20 May 2026 | 2 articles | Viewed by 3802 | Submission Open

Keywords: fertility preservation; oocytes cryopreservation; embryo cryopreservation; ovarian tissue transplantation; gonadotoxic therapy

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Prostate Cancer: Diagnosis, Clinical Management and Prognosis

edited by Giovanni Muto

submission deadline 20 May 2026 | 3 articles | Viewed by 3626 | Submission Open

Keywords: prostate cancer; diagnosis; clinical management; prognosis; treatments

(This special issue belongs to the Section Nephrology & Urology)

Clinical Update in Pulmonary Rehabilitation

edited by Akira Tamaki

submission deadline 20 May 2026 | 3 articles | Viewed by 3309 | Submission Open

Keywords: pulmonary rehabilitation; chronic obstructive pulmonary disease; interstitial lung disease; sarcopenia; respiratory sarcopenia; respiratory muscle training; nutritional intervention

(This special issue belongs to the Section Respiratory Medicine)

Clinical Application of Knee Arthroscopy

edited by

Francesco Bosco

and Alessandro Carrozzo

submission deadline 20 May 2026 | 3 articles | Viewed by 2535 | Submission Open

Keywords: knee surgery; arthroscopy; orthopedics; sport medicine; clinical outcomes; ligament reconstruction; meniscal repair; cartilage; postoperative rehabilitation; knee joint; tissue repair; joint preservation

(This special issue belongs to the Section Orthopedics)

Targeted Diagnosis and Treatment of Shoulder and Elbow Disease: 2nd Edition

edited by

Teresa Paolucci

and

Massimiliano Mangone

submission deadline 20 May 2026 | 2 articles | Viewed by 2392 | Submission Open

Keywords: anterolateral deltoid split; joint pain; axillary nerve injury; rotator cuff injuries; shoulder arthroplasty; shoulder impingement syndrome; proximal humeral fracture; rehabilitation; exercise; physiotherapy; rehabilitative relapses

(This special issue belongs to the Section Orthopedics)

Cirrhosis and Its Complications: Prognosis and Clinical Management

edited by

Ana-Maria Singeap

submission deadline 20 May 2026 | 2 articles | Viewed by 2352 | Submission Open

Keywords: cirrhosis; complications; spontaneous bacterial peritonitis; portal hypertension; ascites; hepatorenal syndrome; hepatic encephalopathy; liver transplantation; acute-on-chronic liver failure; hepatocellular carcinoma; quality of life; prognosis; clinical management

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Research Progress in Pediatric Endocrinology

edited by

Federico Baronio

submission deadline 20 May 2026 | 2 articles | Viewed by 2009 | Submission Open

Keywords: pediatric endocrinology; rare endocrine disorders; precision medicine; congenital adrenal hyperplasia (CAH); short stature genetics; severe childhood obesity; glp-1 receptor agonists; endocrine disruptors; artificial intelligence (AI) in endocrinology; newborn screening

(This special issue belongs to the Section Clinical Pediatrics)

Clinical Management and Long-Term Prognosis in Intensive Care

edited by

Wioletta Mędrzycka-Dąbrowska

and

Sandra Lange

submission deadline 20 May 2026 | 3 articles | Viewed by 1385 | Submission Open

Keywords: intensive care; post-intensive care syndrome; patient safety; improved survival; mental health; mechanical ventilation

(This special issue belongs to the Section Intensive Care)

Acute Ischemic Stroke: Current Status and Future Challenges—2nd Edition

edited by

Lucio D'Anna

submission deadline 20 May 2026 | 2 articles | Viewed by 1321 | Submission Open

Keywords: acute ischemic stroke; atrial fibrillation; endovascular thrombectomy; intravenous thrombolysis; direct oral anticoagulants

(This special issue belongs to the Section Clinical Neurology)

Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 20 May 2026 | 1 articles | Viewed by 1128 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

Diagnosis and Treatment of Ocular Surface Diseases

edited by

Stuti Misra

and

Sònia Travé-Huarte

submission deadline 20 May 2026 | 1 articles | Viewed by 1122 | Submission Open

Keywords: dry eye disease; ocular surface; anterior segment imaging; biomarkers; artificial intelligence; diagnostic tools; novel therapeutic agents; anterior eye care

(This special issue belongs to the Section Ophthalmology)

Current Advances and Future Perspectives in Interventional Cardiology

edited by

Jacob Zeitani

submission deadline 20 May 2026 | 1 articles | Viewed by 1107 | Submission Open

Keywords: trans-catheter valve repair and replacement; advanced coronary intervention; AI in decision making for trans-catheter aortic root and arch replacement; LAA occlusion; anti-arrhythmic therapy; right side of the heart

(This special issue belongs to the Section Cardiology)

Challenges and Opportunities in Application of Laparoscopic, Robotic and Other Technological Advances in Gastrointestinal Surgery

edited by

Gianluca Cassese

and Fabrizio Panaro

submission deadline 20 May 2026 | 1 articles | Viewed by 1058 | Submission Open

Keywords: robotic surgery; laparoscopic surgery; artificial intelligence; technological advances

(This special issue belongs to the Section General Surgery)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 20 May 2026 | 1 articles | Viewed by 1049 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Minimally Invasive Otolaryngology: Precision Techniques and Functional Outcomes

edited by Giovanni Colombo and

Matteo Di Bari

submission deadline 20 May 2026 | 2 articles | Viewed by 1012 | Submission Open

Keywords: advances in otolaryngology; endoscopic surgery; head and neck surgery; functional outcomes; quality of life

(This special issue belongs to the Section Otolaryngology)

New Updates in Pediatric Gastroenterology

edited by

Laura Trandafir

, Alina Stanescu-Popp and Oana Belei

submission deadline 20 May 2026 | Viewed by 947 | Submission Open

Keywords: pediatric gastroenterology and hepatology; inflammatory bowel disease; celiac disease; gastrointestinal diseases; esophageal diseases; endoscopy; gut microbiome; inflammatory bowel disease; functional GI disorders; nutritional management; precision medicine; gut– brain axis; transitional care

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Percutaneous Coronary Intervention: Latest Advances and Future Prospects

edited by

Alessandro Mandurino-Mirizzi

submission deadline 20 May 2026 | 1 articles | Viewed by 780 | Submission Open

Keywords: percutaneous coronary intervention; coronary artery disease; intravascular imaging; intracoronary physiology; high-risk percutaneous coronary intervention; calcified coronary stenosis; chronic total occlusion; bifurcation disease

(This special issue belongs to the Section Cardiology)

Advances in Clinical Rheumatology—2nd Edition

edited by

Jacopo Ciaffi

submission deadline 20 May 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: rheumatoid arthritis; spondylarthritis; interventional; osteoporosis; complex regional pain syndrome

(This special issue belongs to the Section Immunology & Rheumatology)

Physiotherapy in Clinical Practice: From Assessment to Rehabilitation

edited by

Inés Llamas Ramos

and

Rocío Llamas-Ramos

submission deadline 20 May 2026 | 1 articles | Viewed by 687 | Submission Open

Keywords: clinical assessment; rehabilitation; clinical practice; patient-centered care; physiotherapy innovation

(This special issue belongs to the Section Clinical Rehabilitation)

Surgical Management of Complex Spinal Pathologies: Challenges and Innovations

edited by

Spyridon Komaitis

submission deadline 20 May 2026 | 2 articles | Viewed by 657 | Submission Open

Keywords: complex spinal surgery; adult spinal deformity; complex degenerative pathologies; revision spine surgery; spinal oncology; robotics; navigation; surgical outcomes

(This special issue belongs to the Section Orthopedics)

Clinical Diagnosis and Management of Obstructive Sleep Apnea Syndrome

edited by

Graziano Montaruli

Domenico Ciavarella

and

Michele Tepedino

submission deadline 20 May 2026 | 1 articles | Viewed by 595 | Submission Open

Keywords: obstructive sleep apnea (OSA); apnea-hypopnea index (AHI); oxygen desaturation index (ODI); mandibular advancement device (MAD); polysomnography; upper airway; continuous positive airway pressure (C-PAP)

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Cardiac Imaging in Cardiovascular Disorders

edited by Leif-Christopher Engel

submission deadline 20 May 2026 | Viewed by 572 | Submission Open

Keywords: coronary CT angiography; cardiac magnetic resonance imaging; molecular imaging; echocardiography; stress echocardiography; myocardial perfusion imaging

(This special issue belongs to the Section Cardiology)

Cutting Edge Research on Total Knee Arthroplasty

edited by

Nahum Rosenberg

submission deadline 20 May 2026 | 1 articles | Viewed by 530 | Submission Open

Keywords: total knee arthroplasty; robotic-assisted surgery; computer-navigated arthroplasty; implant design; kinematic alignment; enhanced recovery pathways; patient-reported outcomes; artificial intelligence in orthopedics; revision surgery

(This special issue belongs to the Section Orthopedics)

Total Joint Arthroplasty: Innovations, Outcomes, and Challenges—Second Edition

edited by Hendrik Kohlhof

submission deadline 20 May 2026 | 1 articles | Viewed by 494 | Submission Open

Keywords: knee and hip replacements; joint replacement; biomechanics; revision arthroplasty; orthogeriatrics and perioperative management

(This special issue belongs to the Section Orthopedics)

Clinical Updates of Physical Therapy in Rehabilitation

edited by

Sofia Xergia

submission deadline 20 May 2026 | Viewed by 371 | Submission Open

Keywords: neurological rehabilitation; musculoskeletal rehabilitation; special populations; new technology in physical therapy

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Therapeutic and Management Strategies of Epilepsy—Social and Neuropsychological Aspects

edited by

Hideaki Kanemura

submission deadline 20 May 2026 | Viewed by 364 | Submission Open

Keywords: quality of life (QOL); cognition; behavior; stigma; seizure severity; interictal epileptiform discharge (IED); social

(This special issue belongs to the Section Clinical Neurology)

New Therapies for Diabetic Foot Ulcer Management

edited by

Irene Sanz-Corbalan

and

Raúl J. Molines Barroso

submission deadline 20 May 2026 | Viewed by 330 | Submission Open

Keywords: diabetic foot disease; diabetic foot ulcers; wound healing; biomarkers; telemedicine; artificial intelligence; preven-tive strategies; advanced therapies; amputation prevention; diabetes complications; novel treatments

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Updates in Transfusion Medicine and Patient Blood Management

edited by

Carlos Jerico

and

José Antonio García-Erce

submission deadline 20 May 2026 | Viewed by 263 | Submission Open

Keywords: anaemia; bleeding; blood transfusion; patient blood management; transfusion medicine

(This special issue belongs to the Section Hematology)

Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest

edited by

Erik Roman-Pognuz

submission deadline 20 May 2026 | Viewed by 259 | Submission Open

Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical Research in Vascular Access Devices

edited by

Antonio Gidaro

submission deadline 20 May 2026 | Viewed by 255 | Submission Open

Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation

(This special issue belongs to the Section Vascular Medicine)

Key Quality Indicators in Diagnosis and Treatment of Respiratory Diseases

edited by

Fotios Sampsonas

submission deadline 20 May 2026 | Viewed by 213 | Submission Open

Keywords: key quality indicators; respiratory disorders; audit; quality improvement; real-life data

(This special issue belongs to the Section Respiratory Medicine)

Interventional Cardiology: Clinical Advances and Future Perspectives

edited by Antonio Landi and

Andrea Milzi

submission deadline 20 May 2026 | Viewed by 209 | Submission Open

Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome

(This special issue belongs to the Section Cardiology)

New Horizons in Aortic Valve Replacement

edited by Abdellaziz Dahou

submission deadline 20 May 2026 | Viewed by 203 | Submission Open

Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement

(This special issue belongs to the Section Cardiology)

Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives

edited by Balakrishnan M. Mahesh

submission deadline 20 May 2026 | Viewed by 189 | Submission Open

Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion

(This special issue belongs to the Section Cardiology)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 20 May 2026 | Viewed by 180 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Novel Approaches in Cataract and Refractive Surgery

edited by Stephen T. Armenti

submission deadline 20 May 2026 | Viewed by 177 | Submission Open

Keywords: cataract surgery; complex cataract surgery; secondary intraocular lens surgery; refractive surgery (LASIK; PRK; SMILE); astigmatism correction; multifocal intraocular lenses; femtosecond laser; dropless cataract surgery

(This special issue belongs to the Section Ophthalmology)

Artificial Intelligence in Exercise, Rehabilitation and Health Promotion: A Clinical Perspective

edited by

Ki-Hyuk Lee

and

Koji Koyama

submission deadline 20 May 2026 | Viewed by 132 | Submission Open

Keywords: artificial intelligence; machine learning and deep learning; large language models (LLMs); explainable AI; exercise and physical activity; rehabilitation and sports medicine; clinical applications; chronic disease and preventive health; digital health and big data analytics

(This special issue belongs to the Section Sports Medicine)

Surgery in the Era of Neoadjuvant Immune Checkpoint Inhibitors Therapy for Thoracic Oncology

edited by

Mohsen Ibrahim

submission deadline 20 May 2026 | Viewed by 127 | Submission Open

Keywords: neoadjuvant therapy; immune checkpoint inhibitors; unresectable disease; lung cancer; locally advanced lung cancer

(This special issue belongs to the Section General Surgery)

Spine Surgery: Current Challenges and Opportunities

edited by Kambiz Sarahrudi

submission deadline 20 May 2026 | Viewed by 118 | Submission Open

Keywords: vertebral fracture; spine trauma; spinal cord injury; adjacent segment degeneration; infection; spondylodiscitis; verte-bral metastasis; osteoporotic fracture; fracture of sacrum; disk degeneration; degenerative spine surgery; minimally invasive spine surgery

(This special issue belongs to the Section Orthopedics)

Current Challenges in Oral and Maxillofacial Surgery

edited by

Federica Canfora

and Lucia Memé

submission deadline 20 May 2026 | Viewed by 112 | Submission Open

Keywords: oral and maxillofacial surgery; surgical management; virtual surgical planning; postoperative management; orthog-nathic surgery; reconstructive techniques; minimally invasive surgery; digital technologies; 3D printing

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Displaying special issue 1101-1150 on page 23 of 32.

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