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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Atrial Fibrillation and Heart Failure: Diagnosis, Risk Stratification, and Clinical Management
edited by Christian Grebmer
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1538 | Submission Open
Keywords: atrial fibrillation; heart failure; clinical management; risk stratification; anticoagulation; catheter ablation; guide-line-directed therapy; clinical outcomes
(This special issue belongs to the Section Cardiology)
State-of-the-Art Advances in Bloodstream Infections submission deadline 20 Dec 2026 | 2 articles | Viewed by 1522 | Submission Open
Keywords: bloodstream infections; sepsis; antimicrobial resistance; rapid diagnostics; metagenomics; antimicrobial treatment; antimicrobial stewardship; artificial intelligence; precision medicine
(This special issue belongs to the Section Infectious Diseases)
Applications of Artificial Intelligence in Cardiology: New Tools to Transform Care submission deadline 20 Dec 2026 | 1 articles | Viewed by 1513 | Submission Open
Keywords: artificial intelligence in cardiology; machine learning; deep learning; AI-driven ECG analysis; cardiovas-cular imaging and AI; predictive analytics in cardiology; mHealth and wearables; clinical decision support systems; ethics and AI in healthcare; digital health and remote monitoring
(This special issue belongs to the Section Cardiology)
Clinical Applications of Artificial Intelligence and Machine Learning in Diagnosis and Therapy
edited by Christian Salvatore, Valentina Chiappa and Gennaro D’Anna
submission deadline 20 Dec 2026 | 3 articles | Viewed by 1357 | Submission Open
Keywords: artificial intelligence in clinical medicine; machine learning in clinical medicine; medical imaging analysis; digital biomarkers; explainable artificial intelligence (XAI); precision medicine; human–AI interaction in healthcare
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
New Insights into Regional Anesthesia and Pain Management submission deadline 20 Dec 2026 | 3 articles | Viewed by 1254 | Submission Open
Keywords: regional anesthesia; pain management; ultrasound-guided techniques; erector spinae plane block; pericapsular nerve group (PENG) block; interfascial plane blocks; multimodal analgesia; opioid-sparing analgesia; postoperative pain; inflammatory response; enhanced recovery after surgery (ERAS); pediatric anesthesia; geriatric anesthesia; orthopedic anesthesia; randomized controlled trials
(This special issue belongs to the Section Anesthesiology)
Advancements in Diagnosing, Management and Treatment of Gynecologic Oncology submission deadline 20 Dec 2026 | 3 articles | Viewed by 1228 | Submission Open
Keywords: gynecologic oncology; ovarian cancer; endometrial cancer; cervical cancer; breast cancer; peritoneal metastasis; biomarkers; cytoreductive surgery; HIPEC; targeted therapy; immunotherapy; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
Advancing Personalized and Precision Medicine with Large Language Models
edited by
submission deadline 20 Dec 2026 | 2 articles | Viewed by 1170 | Submission Open
Keywords: large language models; precision medicine; clinical decision support; electronic health records; phenotyping; multimodal data integration; explainable artificial intelligence; clinical summarization; biomedical data interpretation; digital health
(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Clinical Medicine)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Dec 2026 | 1 articles | Viewed by 1084 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Schizophrenia and Psychotic Disorders: Clinical Updates submission deadline 20 Dec 2026 | 1 articles | Viewed by 946 | Submission Open
Keywords: schizophrenia spectrum disorder; mobile health apps; antipsychotics; repetitive transcranial magnetic stimulation; artificial intelligence; machine learning; augmented reality; neuroimaging; treatment resistance; quality of life; comorbidities
(This special issue belongs to the Section Mental Health)
Advances in Spinal Deformity: Current Challenges and Future Directions
edited by and Sam Yeol Chang
submission deadline 20 Dec 2026 | 2 articles | Viewed by 943 | Submission Open
Keywords: spinal deformity; adult spinal deformity; pediatric scoliosis; minimally invasive spine surgery; navigation and robotics; spinal alignment; surgical outcomes
(This special issue belongs to the Section Orthopedics)
Clinical Diagnosis and Treatment of Demyelinating Diseases
edited by and John S. Tzartos
submission deadline 20 Dec 2026 | 1 articles | Viewed by 745 | Submission Open
Keywords: demyelinating diseases of the CNS; demyelinating diseases of the PNS; multiple sclerosis; neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); clinical diagnosis; biomarkers; therapeutics
(This special issue belongs to the Section Clinical Neurology)
Advances in Laparoscopic, Robotic, and Minimally Invasive Gastrointestinal Surgery submission deadline 20 Dec 2026 | 1 articles | Viewed by 722 | Submission Open
Keywords: minimally invasive surgery; laparoscopy; robotic surgery; gastrointestinal surgery; surgical innovation; patient outcomes; enhanced recovery; clinical research
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Advances in Critical Care Cardiology
edited by Marc-Olivier Fischer
submission deadline 20 Dec 2026 | 1 articles | Viewed by 709 | Submission Open
Keywords: antiplatelets drugs; arrhythmia ablations; cardiology; catecholamines; sodium-glucose cotransporter type 2 inhibitors; critical care; cardiogenic shock; echocardiography; ECLS; ECMO; inotropic drugs; vasopressors drugs
(This special issue belongs to the Section Intensive Care)
Moving Forward to New Trends in Pulmonary Diseases: 2nd Edition submission deadline 20 Dec 2026 | 1 articles | Viewed by 684 | Submission Open
Keywords: pulmonary tuberculosis; chronic obstructive airway diseases; bronchiectasis; COVID-19; sleep apnea; ultrasound; lung cancer; pulmonary rehabilitation
(This special issue belongs to the Section Respiratory Medicine)
Advances in Endoscopy for the Diagnosis and Treatment of Gastrointestinal Diseases submission deadline 20 Dec 2026 | 1 articles | Viewed by 670 | Submission Open
Keywords: gastrointestinal endoscopy; early gastrointestinal neoplasia; endoscopic imaging; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic full-thickness resection (EFTR); pancreatic and biliary diseas-es; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); small bowel pathology; video capsule endoscopy (VCE); artificial intelligence (AI)
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Colorectal Disorder: Latest Advances and Prospects
edited by Pietro Fransvea
submission deadline 20 Dec 2026 | 1 articles | Viewed by 643 | Submission Open
Keywords: colorectal surgery; emergency surgery; artificial intelligence; minimally invasive surgery; colorectal cancer; sepsis; gut microbiome; intestinal failure
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Heart Failure in the Elderly: Diagnosis, Treatment and Prognosis
edited by Francesco Curcio and Francesco Cacciatore
submission deadline 20 Dec 2026 | 1 articles | Viewed by 580 | Submission Open
Keywords: heart failure; elderly; aging; frailty; HFpEF; multimorbidity; biomarkers; precision medicine; aortic stenosis; trans-thyretin amyloidosis; cardiac amyloidosis
(This special issue belongs to the Section Cardiology)
Clinical Advances in Obstructive Sleep Apnea submission deadline 20 Dec 2026 | 1 articles | Viewed by 560 | Submission Open
Keywords: obstructive sleep apnea; sleep apnea syndromes; precision medicine; treatment outcome; diagnosis
(This special issue belongs to the Section Respiratory Medicine)
Advanced Strategy for Diagnosis and Treatment of Obstructive Sleep Apnea Syndrome (OSAS)—Second Edition
edited by
submission deadline 20 Dec 2026 | 1 articles | Viewed by 559 | Submission Open
Keywords: obstructive sleep apnea syndrome; diagnosis; obesity; treatment; CPAP; comorbidities; cardiovascular risk
(This special issue belongs to the Section Respiratory Medicine)
Exploring Cardiomyopathy: Comprehensive Guide to Causes, Symptoms and Care
edited by
submission deadline 20 Dec 2026 | Viewed by 553 | Submission Open
Keywords: cardiomyopathy; heart failure; genetics; hypertrophic cardiomyopathy; dilated cardiomyopathy; left ventricular noncompaction; pediatric cardiomyopathies; cardiac imaging
(This special issue belongs to the Section Cardiology)
Chronic Kidney Disease: Treatment, Nutritional Intervention and Renal Transplantation
edited by Hülya Taşkapan
submission deadline 20 Dec 2026 | 1 articles | Viewed by 484 | Submission Open
Keywords: chronic kidney disease; renal insufficiency; nutritional therapy; dietary intervention; CKD management; treatment strategies; nephrology; dialysis; kidney transplantation
(This special issue belongs to the Section Nephrology & Urology)
Artificial Intelligence in Craniofacial Surgery: An Emerging Challenge submission deadline 20 Dec 2026 | 1 articles | Viewed by 470 | Submission Open
Keywords: artificial intelligence; craniofacial surgery; surgical simulation; machine learning; deep learning; predictive modeling; 3D reconstruction; intraoperative guidance; patient-specific planning; clinical validation; surgical innovation; precision medicine
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Cardiovascular Imaging: Opportunities and Challenges in Clinical Application: 4th Edition
edited by and Panagiota Christia
submission deadline 20 Dec 2026 | 1 articles | Viewed by 459 | Submission Open
Keywords: echocardiography; cardiovascular magnetic resonance imaging; cardiovascular computed tomography imaging; nuclear cardiology imaging; stress test with imaging; multimodality cardiovascular imaging; cardiomyopathy; coronary artery disease; microvascular disease; valvular heart disease
(This special issue belongs to the Section Cardiology)
Liver Failure: Current Status and Future Opportunities
edited by
submission deadline 20 Dec 2026 | Viewed by 449 | Submission Open
Keywords: acute liver failure; acute-on-chronic liver failure; portal hypertension; hepatic encephalopathy; pathogenesis; management
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Surgical Treatment of Urinary System Cancers
edited by Roderick K. Clark and Matthew G. Kaag
submission deadline 20 Dec 2026 | 1 articles | Viewed by 385 | Submission Open
Keywords: urologic oncology; multimodal cancer treatment; perioperative management; oncologic outcomes; surgical innovation; minimally invasive surgery
(This special issue belongs to the Section Nephrology & Urology)
Surgical Management of Vascular Diseases: Challenges and Innovations in the 21st Century
edited by Reinhardt T. Grundmann
submission deadline 20 Dec 2026 | Viewed by 362 | Submission Open
Keywords: abdominal aortic aneurysm; carotid stenosis; peripheral vascular disease; endovascular therapy; open surgery; vascular disease and cancer outcomes; clinical trial; meta-analysis; surgical innovation
(This special issue belongs to the Section Cardiovascular Medicine)
Skin Cancer: From Diagnosis to Personalized Treatment
edited by
submission deadline 20 Dec 2026 | Viewed by 356 | Submission Open
Keywords: immunotherapy; neoadjuvant; melanoma; cutaneous sarcoma; merkel cel tumor; risk assessment; combination therapy; surgery
(This special issue belongs to the Section Dermatology)
The Association Between Cancer and Cardiovascular Diseases: Insights After a Quarter of the Century
edited by Tomer Ziv-Baran and Elena Izkhakov
submission deadline 20 Dec 2026 | Viewed by 345 | Submission Open
Keywords: cancer survivors; cardiovascular disease; cardio-oncology; chemotherapy; radiation therapy; immunotherapy; multidisciplinary approach
(This special issue belongs to the Section Epidemiology & Public Health)
Advances in Orthopedic Trauma Surgery: From Surgical Techniques to Patient Outcomes submission deadline 20 Dec 2026 | Viewed by 310 | Submission Open
Keywords: trauma; fractures; clinical outcome; surgical techniques; complications; innovation; patient management
(This special issue belongs to the Section Orthopedics)
Clinical Advances in Cardio-Obstetrics on Labor and Delivery
edited by Diana S. Wolfe
submission deadline 20 Dec 2026 | Viewed by 282 | Submission Open
Keywords: cardio-obstetrics; maternal medicine; high risk pregnancy; perinatology; cardiology
(This special issue belongs to the Section Obstetrics & Gynecology)
Clinical Management and Advances in Hereditary Hemorrhagic Telangiectasia
edited by Hanny Al-Samkari
submission deadline 20 Dec 2026 | Viewed by 271 | Submission Open
Keywords: hereditary hemorrhagic telangiectasia; epistaxis; gastrointestinal bleeding; women’s health; arteriovenous mal-formation; AVM; anemia; iron deficiency; vasculopathy; angiogenesis; novel therapy
(This special issue belongs to the Section Hematology)
Cardiogenic Shock: Multidisciplinary Approaches in Acute Cardiac Care submission deadline 20 Dec 2026 | Viewed by 249 | Submission Open
Keywords: cardiogenic shock; acute cardiac care; emergency department; intensive care unit; acute coronary syndromes; shock team; mechanical circulatory support; ECMO; hemodynamic monitoring
(This special issue belongs to the Section Emergency Medicine)
Beyond Full Weight-Bearing Alone: Innovative, Individualized and Holistic Rehabilitation in Geriatric Orthopedic Trauma submission deadline 20 Dec 2026 | Viewed by 242 | Submission Open
Keywords: geriatric trauma; orthogeriatrics; rehabilitation; weight-bearing; partial weight-bearing; full weight-bearing; fracture healing; frailty; sarcopenia; mobilization; tele-rehabilitation; digital health; wearable sensors; biofeedback; exoskeleton; robotics; neuromuscular electrical stimulation; multimodal rehabilitation; individualized care; postoperative aftercare
(This special issue belongs to the Section Clinical Rehabilitation)
Artificial Intelligence in Orthopedics: Current Advancements and Future Perspectives
edited by Koroush Kabir
submission deadline 20 Dec 2026 | Viewed by 238 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; orthopedics; trauma surgery; spinal surgery; arthroplasty; clin-ical guidelines
(This special issue belongs to the Section Orthopedics)
Current Treatments for Mitral Valve Regurgitation and Aortic Valve Stenosis submission deadline 20 Dec 2026 | Viewed by 232 | Submission Open
Keywords: mitral and aortic valve disease; transcatheter valve intervention; cardiac surgery; minimally invasive cardiac surgery; valve disease management
(This special issue belongs to the Section Cardiology)
Transdiagnostic Insights to Eating Disorders: Bridging Cognitive Processes and Clinical Outcomes
edited by and Patrizia Todisco
submission deadline 20 Dec 2026 | Viewed by 212 | Submission Open
Keywords: eating disorders; cognitive processes; emotional regulation; social cognition; neurocognitive functioning; interoception; body representation; clinical outcomes; psychopathology
(This special issue belongs to the Section Mental Health)
Pulmonary Embolism and Pulmonary Hypertension: From Diagnosis to Treatment
edited by Remigiusz Kazimierczyk
submission deadline 20 Dec 2026 | Viewed by 196 | Submission Open
Keywords: pulmonary hypertension; pulmonary embolism; CTEPH; PET/MRI; catheter-directed therapies
(This special issue belongs to the Section Cardiology)
Kidney Cancer: From Diagnostic to Therapy—2nd Edition
edited by Devin N. Patel, Ithaar H. Derweesh and
submission deadline 20 Dec 2026 | Viewed by 194 | Submission Open
Keywords: biomarkers; clinical practice patterns; diagnosis; kidney cancer; metastasis; renal cell carcinoma; renal mass; staging; systemic therapy; surveillance
(This special issue belongs to the Section Nephrology & Urology)
Recent Advances in Inflammatory and Infectious Skin Diseases (Third Edition) submission deadline 20 Dec 2026 | Viewed by 190 | Submission Open
Keywords: atopic dermatitis; eczematous diseases; inflammatory skin diseases; chronic skin diseases; human herpesvirus; roseola syphilitica; psoriasis; bacterial infections and mycoses; sexually transmitted diseases, bacterial; sexually transmitted diseases, viral; Papillomavirus infections
(This special issue belongs to the Section Dermatology)
Vulnerability and Resilience in the Perinatal Period: Focus on Maternal and Paternal Mental Health
edited by
submission deadline 20 Dec 2026 | Viewed by 175 | Submission Open
Keywords: perinatal mental health; maternal mental health; paternal mental health; resilience; perinatal wellbeing; dyadic processes; parent–infant relationship; perinatal affective disorders; perinatal psychiatry
(This special issue belongs to the Section Mental Health)
Transforming the Diagnosis and Management of Retinal Diseases: Integrating Imaging, Modeling, and Digital Innovation submission deadline 20 Dec 2026 | Viewed by 174 | Submission Open
Keywords: retinal diseases; choroidal diseases; multimodal imaging; optical coherence tomography; OCT angiography; adaptive optics; artificial intelligence; imaging biomarkers; predictive modelling; precision medicine; digital ophthalmology; clinical management
(This special issue belongs to the Section Ophthalmology)
Advancing Autism Care: Early Diagnosis and Care Pathways for Autistic Children
edited by Laura Maria Fatta
submission deadline 20 Dec 2026 | Viewed by 173 | Submission Open
Keywords: early diagnosis; developmental outcomes; integrated care pathways; real-world clinical care; care coordination; evidence-based interventions; family support systems
(This special issue belongs to the Section Mental Health)
Rethinking Renal Pathways: Recent Advances in Diagnosis, Vascular Access, and Targeted Therapy in Chronic Kidney Disease (CKD)
edited by Alina Ramona Potra, Ina Maria Kacsò and
submission deadline 20 Dec 2026 | Viewed by 172 | Submission Open
Keywords: chronic kidney disease; biomarkers in kidney disease; precision nephrology; artificial intelligence in nephrology; vascular access for dialysis; targeted therapies in CKD; malnutrition and protein-energy wasting in CKD; renal fibrosis and disease progression; translational nephrology research
(This special issue belongs to the Section Nephrology & Urology)
Shoulder and Elbow Surgery: Clinical Updates and Digital Transformation submission deadline 20 Dec 2026 | Viewed by 169 | Submission Open
Keywords: shoulder surgery; elbow surgery; digitalization; patient pathway; clinical decision support systems; artificial intelligence; machine learning; radiological imaging; 3D planning; navigation; robotics; augmented reality; PROMs; wearables; big data; registries; outcome prediction; digital twins; large language models (LLMs); digital health; personalized medicine
(This special issue belongs to the Section Orthopedics)
Clinical Updates in Treating Orthopaedic Deformities of the Foot submission deadline 20 Dec 2026 | Viewed by 166 | Submission Open
Keywords: foot deformity; hallux valgus; progressive collapsing foot deformities; ankle arthroplasty; minimally invasive surgery; diabetic foot; trauma; reconstructive surgery; clinical outcomes
(This special issue belongs to the Section Orthopedics)
Hip Surgery: Recent Clinical Advances
edited by Sujith Konan
submission deadline 20 Dec 2026 | Viewed by 165 | Submission Open
Keywords: total hip replacement; revision hip replacement; bearing surfaces; instability; dislocation; fixation of hip implants; large heads; dual mobility; aces in hip surgery
(This special issue belongs to the Section Orthopedics)
Modern Diagnosis and Management of Coronary Artery Disease
edited by
submission deadline 20 Dec 2026 | Viewed by 152 | Submission Open
Keywords: coronary artery disease; myocardial revascularization; percutaneous coronary intervention; cardiac surgery; coronary artery bypass graft; intravascular ultrasound; fractional flow reserve; instantaneous wave-free ratio; angiogenesis
(This special issue belongs to the Section Cardiology)
Sexually Transmitted Infections as a Challenge of Modern Society: Old Problems and Modern Solutions—2nd Edition
edited by Mauro Zaccarelli and
submission deadline 20 Dec 2026 | Viewed by 150 | Submission Open
Keywords: sexually transmitted infections (STIs); human papilloma virus (HPV); syphilis; gonorrhea; chlamydia trachomatis; HIV infection; PrEP; chemsex; doxycicline prophylaxis; gonococcal resistance
(This special issue belongs to the Section Infectious Diseases)
Thoracic Organ Transplantation: From Diagnosis to Long-Term Outcomes
edited by Sławomir Zeglen
submission deadline 20 Dec 2026 | Viewed by 149 | Submission Open
Keywords: lung transplantation; heart transplantation; thoracic organ transplantation; transplantation candidate evaluation; transplant out-comes; immunosuppressive therapy; graft dysfunction; chronic lung allograft dysfunction (CLAD); artificial intelligence in preopera-tive medicine; physical activity in transplant candidates and recipients
(This special issue belongs to the Section General Surgery)
Innovative Therapeutic Strategies for Retinal Diseases
edited by Akihiro Ohira
submission deadline 20 Dec 2026 | Viewed by 145 | Submission Open
Keywords: retinal diseases; innovative therapies; clinical research; drug delivery; imaging biomarkers; real-world evidence; clinical application
(This special issue belongs to the Section Ophthalmology)
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