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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Developments on Diagnosis and Treatment of Gastrointestinal Cancer
edited by Bhaumik Patel
submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open
Keywords: colorectal cancer; gastric cancer; biomarker; novel therapy; immune microenvironment; gut microbiota; molecular mechanisms
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Research in Vascular Access Devices
edited by
submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open
Keywords: short peripheral catheters; long peripheral catheters; midline; peripherally inserted central catheters (PICCs); femoral-inserted central catheters (FICCs); centrally inserted central catheters (CICCs); totally implantable venous access devices (TIVAD); catheter-related bloodstream infection (CRBSI); catheter-associated bloodstream infection (CABSI); central line-associated bloodstream infection (CLABSI); catheter-related thrombosis (CRT); fibroblastic sleeve; infiltration; extravasation
(This special issue belongs to the Section Vascular Medicine)
Novel Insights into the Clinical Management of Retinal Detachment
edited by Francesco Sabatino
submission deadline 30 Nov 2025 | Viewed by 84 | Submission Open
Keywords: retinal detachment; oil toxicity; gas tamponade; pars plana vitrectomy; scleral buckle; pneumatic retinopexy; surgical techniques; retinal imaging; retinal displacement
(This special issue belongs to the Section Ophthalmology)
Interventional Cardiology: Clinical Advances and Future Perspectives
edited by Antonio Landi and
submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: percutaneous coronary intervention; myocardial infarction; interventional cardiology; cardiac catheterization; coronary artery disease; antithrombotic therapy; intravascular imaging; acute coronary syndrome; chronic coronary syndrome
(This special issue belongs to the Section Cardiology)
Challenges in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 30 Nov 2025 | Viewed by 82 | Submission Open
Keywords: glaucoma diagnosis; glaucoma progression; glaucoma biomarkers; intraocular pressure (IOP) management; corneal hysteresis; machine learning in glaucoma detection; neuroprotection in glaucoma; surgery and laser therapy
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Neuroprognostication and Outcome Prediction After Cardiac Arrest
edited by
submission deadline 30 Nov 2025 | Viewed by 77 | Submission Open
Keywords: neuroprognostication; cardiac arrest; neurological outcome prediction; biomarkers in brain injury; multimodal prog-nostic tools; EEG monitoring; somatosensory evoked potentials (SSEPs); magnetic resonance imaging (MRI) in prognos-tication; post-cardiac arrest care; hypoxic– ischemic brain injury; withdrawal of life-sustaining treatment (WLST); inten-sive care prognostic strategies
(This special issue belongs to the Section Cardiovascular Medicine)
Kidney Transplantation: Recent Advances and Challenges
edited by Jose Torrealba
submission deadline 30 Nov 2025 | Viewed by 63 | Submission Open
Keywords: kidney allograft; pathology; HLA and antibodies; management
(This special issue belongs to the Section Nephrology & Urology)
Thrombotic Risk and Its Management Across Diverse Clinical Settings
edited by Samuel Bogdan Todor and Ana Maria Vlǎdǎreanu
submission deadline 30 Nov 2025 | Viewed by 59 | Submission Open
Keywords: thrombosis; thrombotic risk; hematologic disorders; thrombophilia; myeloproliferative neoplasms; antithrombotic therapy; cardiovascular diseases; biomarkers
(This special issue belongs to the Section Hematology)
Transcatheter Aortic Valve Implantation- Clinical Management and Future Challenges
edited by Mohamed Farag
submission deadline 30 Nov 2025 | Viewed by 55 | Submission Open
Keywords: transcatheter aortic valve implantation; TAVI; bicuspid aortic valve; small annulus; prosthesis– patient mismatch; coronary reaccess; valve-in-valve TAVI; leaflet modification
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in the Management and Treatment of Obesity
edited by
submission deadline 5 Dec 2025 | 1 articles | Viewed by 2345 | Submission Open
Keywords: obesity; therapy; weight loss; diet; surgery; exercise; personalized medicine
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
AI in Maternal Fetal Medicine and Perinatal Management
edited by Ariel Many
submission deadline 5 Dec 2025 | 1 articles | Viewed by 408 | Submission Open
Keywords: maternal fetal medicine; high-risk pregnancy; perinatal management; artificial intelligence (AI) in obstetrics; fetal growth abnormalities; preterm labor prediction
(This special issue belongs to the Section Obstetrics & Gynecology)
Comprehensive Approaches in Plastic and Reconstructive Surgery
edited by Michael Alfertshofer
submission deadline 7 Dec 2025 | 3 articles | Viewed by 2572 | Submission Open
Keywords: plastic surgery; reconstructive surgery; regenerative medicine; advanced surgical planning; trauma reconstruction; patient-specific solutions; multidisciplinary care
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Clinical Challenges in Obstetrics and Gynecology: Interactions Between Gynecological and Obstetric Disorders, Quality of Life, and Mental Health in Women
edited by and Daniel María Lubián López
submission deadline 10 Dec 2025 | 4 articles | Viewed by 4179 | Submission Open
Keywords: perinatal mental health; gynecological disorders; sexual disorders; women’ s quality of life; obstetric complications; women’ s health; women’ s psychological well-being
(This special issue belongs to the Section Obstetrics & Gynecology)
Kidney Transplantation and Rehabilitation: Current Updates and Perspectives
edited by Zoltán Sándor
submission deadline 10 Dec 2025 | 2 articles | Viewed by 3788 | Submission Open
Keywords: chronic kidney disease; kidney transplantation; transplant rehabilitation; transplant care; physical therapy; occupational therapy; intervention; recovery; quality of life; aftercare
(This special issue belongs to the Section Nephrology & Urology)
State of the Art: Updates in Preterm Labor and Preterm Birth
edited by and Moti Gulersen
submission deadline 10 Dec 2025 | 3 articles | Viewed by 3314 | Submission Open
Keywords: prenatal diagnosis; preterm birth; antenatal corticosteroids; cerclage; multiple gestations
(This special issue belongs to the Section Obstetrics & Gynecology)
Advances in the Prevention, Diagnosis, and Rehabilitation of Sports Injuries
edited by Kevin Laudner
submission deadline 10 Dec 2025 | 2 articles | Viewed by 2746 | Submission Open
Keywords: orthopedics; prevention; rehabilitation; management; sports injuries
(This special issue belongs to the Section Sports Medicine)
Cardiac Arrhythmias: Current Status and Future Directions
edited by
submission deadline 10 Dec 2025 | 1 articles | Viewed by 2233 | Submission Open
Keywords: ventricular tachycardia; atrial fibrillation; catheter ablation; novel therapies; complex arrhythmias
(This special issue belongs to the Section Cardiology)
Clinical Advances in Arthroscopic Shoulder Surgery
edited by Anup Ajit Shah, Michael J. O’Brien and Asheesh Bedi
submission deadline 10 Dec 2025 | Viewed by 333 | Submission Open
Keywords: rotator cuff; biologic tuberoplasty; lower trapezius tendon transfer; arthroscopic Latarjet; arthroscopic bone block; augmentation of the cuff
(This special issue belongs to the Section Orthopedics)
Latest Research on Male Infertility submission deadline 10 Dec 2025 | Viewed by 320 | Submission Open
Keywords: testis; sperm; seminal plasma; spermatogenesis; fertilization; omics; proteomics; oxidative stress; sperm DNA fragmentation; varicocele; male infertility; testicular cancer; infertility management; ART
(This special issue belongs to the Section Reproductive Medicine & Andrology)
Innovative Endodontics
edited by
submission deadline 10 Dec 2025 | Viewed by 48 | Submission Open
Keywords: regenerative endodontics; bioceramics; guided endodontics; AI in endodontics; pericervical dentine; reduced taper; irrigation adjuvant; pulp regeneration
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Updates on Geriatric Oncology
edited by Cherif N. Boutros
submission deadline 12 Dec 2025 | Viewed by 59 | Submission Open
Keywords: geriatric oncology; cancer in elderly; geriatric cancer care; frailty; access to cancer care
(This special issue belongs to the Section Geriatric Medicine)
Aortic Pathologies: Aneurysm, Atherosclerosis and More
edited by Alexander Gombert and Panagiotis Doukas
submission deadline 15 Dec 2025 | 4 articles | Viewed by 4725 | Submission Open
Keywords: aorta; aortic aneurysm; thoracoabdominal aortic aneurysm; fenestrated endovascular aortic repair (FEVAR); branched endovascular aortic repair (BEVAR); spinal cord ischemia; coral reef aorta; surgery; endovascular aortic surgery
(This special issue belongs to the Section Cardiovascular Medicine)
Physical Activity, Exercise and Health: Clinical Management and Research submission deadline 15 Dec 2025 | 4 articles | Viewed by 4128 | Submission Open
Keywords: physical activity; exercise; exercise physiology; exercise prescription; aging; women’ s health; chronic disease
(This special issue belongs to the Section Epidemiology & Public Health)
Coronary Heart Disease: Causes, Diagnosis and Management
edited by
submission deadline 15 Dec 2025 | 3 articles | Viewed by 4020 | Submission Open
Keywords: coronary heart disease; coronary revascularization; coronary artery disease; ischemic heart disease; atherosclerosis
(This special issue belongs to the Section Cardiology)
Evidence-Based Clinical Management of Orthopaedic Trauma: 25 Years in Retrospect, and a Forecast of 25 Years to Come
edited by Dirk Stengel and
submission deadline 15 Dec 2025 | 3 articles | Viewed by 3229 | Submission Open
Keywords: evidence-based medicine; orthopaedic surgery; clinical trials; systematic reviews; patient outcomes; multiple trauma; artificial intelligence; injuries
(This special issue belongs to the Section Orthopedics)
Spine Surgery: Clinical Advances and Future Directions
edited by and Eun-Sang Kim
submission deadline 15 Dec 2025 | 3 articles | Viewed by 2030 | Submission Open
Keywords: spine surgery; back pain; endoscopic spine surgery; cage implantation; neck pain
(This special issue belongs to the Section Clinical Neurology)
Neural Application of Artificial Intelligence in Clinical Neuroscience
edited by Saurabh J. Singhal
submission deadline 15 Dec 2025 | 1 articles | Viewed by 1368 | Submission Open
Keywords: artificial intelligence (AI); clinical neuroscience; neuroimaging; brain– computer interfaces (BCIs); neuroprosthetics; EEG/EMG analysis; robotic surgery; deep brain stimulation (DBS); drug discovery; telemedicine; neurorehabilitation; stroke detection; Alzheimer’ s disease; brain tumors; seizure prediction
(This special issue belongs to the Section Clinical Neurology)
Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition submission deadline 15 Dec 2025 | 1 articles | Viewed by 798 | Submission Open
Keywords: gynecological cancers; e.g.; endometrial; cervical; ovarian; and vulvar cancer; urogenital tract cancers in men; e.g.; bladder; prostate; penis; and testicular cancer; gastrointestinal cancers; complications of oncological treatment; e.g.; pelvic floor disfunction: incontinence and POP; patients’ quality of life and possibilities of its improvement; oncofertility; physiotherapy; oncology treatment (modern surgical approach; including robotics; chemotherapy; radiotherapy; immunotherapy; targeted therapy); biological basis of pathogenesis and cancer progression; biological markers; anticancer agents; cancer prophylaxis and prevention— current trends and opportunities
(This special issue belongs to the Section Oncology)
Clinical Advancements in Intraocular Lens Power Calculation Methods
edited by and Thomas Kohnen
submission deadline 15 Dec 2025 | 1 articles | Viewed by 719 | Submission Open
Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry
(This special issue belongs to the Section Ophthalmology)
Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives
edited by Janusz Skrzypecki
submission deadline 15 Dec 2025 | Viewed by 540 | Submission Open
Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery
(This special issue belongs to the Section Ophthalmology)
Clinical Advances in Cardio-Rheumatology submission deadline 15 Dec 2025 | 1 articles | Viewed by 540 | Submission Open
Keywords: cardio-rheumatology; autoimmune diseases; cardiac imaging; cardiovascular disease; autoimmune rheumatic diseases
(This special issue belongs to the Section Cardiology)
Rheumatoid Arthritis: Challenges, Innovations and Outcomes
edited by
submission deadline 15 Dec 2025 | 1 articles | Viewed by 499 | Submission Open
Keywords: rheumatoid arthritis; pathogenesis; treatments; outcomes; autoimmunity
(This special issue belongs to the Section Immunology)
Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 351 | Submission Open
Keywords: cardiac arrhythmias; cardiac implantable electronic device; catheter ablation; sudden cardiac death; lead extraction; atrial fibrillation; ventricular tachycardia; defibrillator therapy
(This special issue belongs to the Section Cardiology)
Blood Cancer: Current Status and Future Challenges in Acute Myeloid Leukemia (AML)
edited by and Massimo Breccia
submission deadline 15 Dec 2025 | Viewed by 326 | Submission Open
Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders
(This special issue belongs to the Section Hematology)
Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition
edited by Senthil Sambandam
submission deadline 15 Dec 2025 | 1 articles | Viewed by 240 | Submission Open
Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement
(This special issue belongs to the Section Orthopedics)
Advances in the Diagnosis and Treatment of Glaucoma
edited by
submission deadline 15 Dec 2025 | Viewed by 169 | Submission Open
Keywords: OCT; glaucoma; MIGS; neuroprotection; drug delivery systems; artificial intelligence; pharmacologic agents; per-sonalized medicine
(This special issue belongs to the Section Ophthalmology)
Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors
edited by Eleni T. Timotheadou and Emmanouil Saloustros
submission deadline 15 Dec 2025 | Viewed by 129 | Submission Open
Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA
(This special issue belongs to the Section Obstetrics & Gynecology)
Latest Advances in Pediatric Surgery
edited by Francesco Macchini and Andrea Zanini
submission deadline 15 Dec 2025 | Viewed by 127 | Submission Open
Keywords: pediatric surgery; innovations; fluorescence-guided surgery; pediatric robotic surgery; minimally invasive surgery
(This special issue belongs to the Section General Surgery)
Male Sexual and Reproductive Health: Clinical Aspects, Metabolic Profile, Environmental Factors and Lifestyle: 2nd Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 112 | Submission Open
Keywords: male sexual dysfunction; reproductive health; erectile dysfunction; premature ejaculation; infertility; epidemiology; causes; diagnosis; treatments; environmental factors; lifestyle
(This special issue belongs to the Section Reproductive Medicine & Andrology)
New Clinical Advances in Pediatric Asthma
edited by
submission deadline 15 Dec 2025 | Viewed by 102 | Submission Open
Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life
(This special issue belongs to the Section Clinical Pediatrics)
Key Advances in the Treatment of the Critically Ill: 3rd Edition submission deadline 15 Dec 2025 | Viewed by 76 | Submission Open
Keywords: respiration; artificial ventilation; prone positioning; respiratory distress syndrome; respiratory insufficiency; cardiac arrest; induced hypothermia; amiodarone; vasopressin; steroids; epinephrine; trauma; injuries; tranexamic acid; sepsis; antibiotics; extracorporeal membrane oxygenation; extracorporeal CPR; blood purification
(This special issue belongs to the Section Intensive Care)
New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases: 2nd Edition submission deadline 15 Dec 2025 | Viewed by 72 | Submission Open
Keywords: therapeutic drug monitoring; inflammatory bowel diseases; immune mediated inflammatory diseases; pharmacokinetics; anti-TNF; vedolizumab; ustekinumab; risankizumab; point-of-care assays; model informed precision dosing
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment
edited by Massimiliano Mariani
submission deadline 15 Dec 2025 | Viewed by 66 | Submission Open
Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies
(This special issue belongs to the Section Cardiology)
Thoracic Surgery: Current Practice and Future Directions: 2nd Edition
edited by
submission deadline 15 Dec 2025 | Viewed by 57 | Submission Open
Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS
(This special issue belongs to the Section Respiratory Medicine)
Clinical Advances in Cancer Imaging submission deadline 15 Dec 2025 | Viewed by 57 | Submission Open
Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging
(This special issue belongs to the Section Oncology)
Novel Prognostic Risk Factors in Acute Coronary Syndrome submission deadline 15 Dec 2025 | Viewed by 56 | Submission Open
Keywords: acute coronary syndrome; risk stratification; biomarkers; cardiovascular imaging; inflammation; genetics; heart– kidney interaction; cardio-pulmonary complications; neurological dysfunction; precision medicine
(This special issue belongs to the Section Cardiology)
Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies
edited by Claus Schildberg and Frank Meyer
submission deadline 15 Dec 2025 | Viewed by 47 | Submission Open
Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Emergency Surgery: Clinical Updates and New Perspectives
edited by
submission deadline 15 Dec 2025 | Viewed by 45 | Submission Open
Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach
(This special issue belongs to the Section Emergency Medicine)
Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders
edited by Natalia Motas and Veronica Manolache
submission deadline 17 Dec 2025 | Viewed by 71 | Submission Open
Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule
(This special issue belongs to the Section Respiratory Medicine)
Clinical and Surgical Insights on Lung Cancer Treatment
edited by and Marco Schiavon
submission deadline 18 Dec 2025 | 1 articles | Viewed by 757 | Submission Open
Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; clinical trials; robotic surgery; diagnosis; multimodal treatment; outcomes; targeted therapy
(This special issue belongs to the Section Respiratory Medicine)
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