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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Clinical Updates in Stem Cell Transplants
edited by Daniele Avenoso and Michele Malagola
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2434 | Submission Open
Keywords: AML; CML; lymphoma; allo-HSCT; GVHD; MDS; AA
(This special issue belongs to the Section Hematology)
Clinical Translation of Technological Innovations in Diabetes Therapeutics
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2216 | Submission Open
Keywords: diabetes management; remote patient monitoring (RPM); artificial intelligence (AI); machine learning (ML); wearable sensors; point-of-care diagnostics; centrifugal microfluidics; glucose monitoring
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Updates and Personalized Medicine in Hepatocellular Carcinoma and Liver Transplantation
edited by Adriano Pellicelli
submission deadline 20 Feb 2026 | 1 articles | Viewed by 2167 | Submission Open
Keywords: hepatocellular carcinoma; transarterial chemoembolization (TACE); transarterial radioembolization (TARE); liver transplant; immune checkpoint inhibitors (ICI); tyrosine kinase inhibitor; liver function assessment; Child-Pugh score; bridging to liver transplantation; immuno escape
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Integrating Psychological Science into Chronic Pain Management: Emerging Approaches and Insights
edited by Scott G. Ravyts and Margot De Kooning
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2032 | Submission Open
Keywords: chronic primary pain; nociplastic pain; coping strategies; depression; anxiety; trauma
(This special issue belongs to the Section Mental Health)
Clinical Insights and Emerging Strategies in Chronic Pain Management
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1764 | Submission Open
Keywords: chronic pain; neuropathic pain; multimodal pain management; digital health; real-world evidence; interdiscipli-nary care
(This special issue belongs to the Section Anesthesiology)
Rising Star: Advanced Physical Therapy and Expansion
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 1731 | Submission Open
Keywords: physical therapy; digital therapeutic technology; geriatric diseases; pediatric; psychology of physical therapies; clinical approach
(This special issue belongs to the Section Clinical Rehabilitation)
Innovations in Personalized Therapy and Clinical Outcomes for Myopia and Ocular Disorders
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1690 | Submission Open
Keywords: myopia; refractive errors; visual development; childhood eye disorders; vision screening; diagnostic tools in optometry; vision-related quality of life; therapeutic strategies in optometry; artificial intelligence; public health; eye care innovation; multidisciplinary vision science
(This special issue belongs to the Section Ophthalmology)
Cardio-Oncology: Clinical Advances in Cardiotoxicity Detection, Imaging and Therapeutic Strategies submission deadline 20 Feb 2026 | 2 articles | Viewed by 1675 | Submission Open
Keywords: cardio-oncology; cardiovascular toxicity; targeted therapies; echocardiography; PET/CT
(This special issue belongs to the Section Cardiology)
Breakthroughs in Spine Biomechanics: Diagnostics and Treatment Approaches for Body Posture, Scoliosis and Chronic Back Pain submission deadline 20 Feb 2026 | 1 articles | Viewed by 1667 | Submission Open
Keywords: spinal biomechanics; spinal pathologies; idiopathic scoliosis; postural abnormalities; spinal pain syndromes; spinal deformities; chronic spinal pain
(This special issue belongs to the Section Orthopedics)
Breast Cancer: Symptoms, Types, Causes & Treatment
edited by Min-Jeong Cho and Sara Myers
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1646 | Submission Open
Keywords: ductal carcinoma in situ (DCIS); breast cancer; breast cancer prevention; minimally invasive surgery; innovative imaging technologies
(This special issue belongs to the Section Obstetrics & Gynecology)
New Insights in Cognitive Aging and Mild Cognitive Impairment submission deadline 20 Feb 2026 | 2 articles | Viewed by 1493 | Submission Open
Keywords: cognitive aging; mild cognitive impairment; normative aging; neuropsychological assessment; diagnosis; gerontology; prevention; intervention; multidisciplinary approach; measurement
(This special issue belongs to the Section Geriatric Medicine)
Orthopedic Trauma: Diagnosis, Treatment and Rehabilitation
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1378 | Submission Open
Keywords: orthopedic trauma; fragility fractures; biomechanics; bone defect; pelvic ring; acetabular fractures; amputation; re-habilitation
(This special issue belongs to the Section Orthopedics)
Advances and Updates in Migraine
edited by and Carl H. Göbel
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1295 | Submission Open
Keywords: migraine; chronic migraine; headache disorders; CGRP antibodies; gepants; ditans; triptans; precision medicine; neuromodulation; comorbidities; disability burden; pediatric migraine; ICHD-3 classification; neurotransmitters; preventive therapy; translational headache research
(This special issue belongs to the Section Clinical Neurology)
Advances in the Field of Cutaneous Malignancies: Background and Clinical Management submission deadline 20 Feb 2026 | 2 articles | Viewed by 1284 | Submission Open
Keywords: dermatology; skin cancer; diagnosis; melanoma; basal cell carcinoma; squamous cell carcinoma; imaging; artificial intelligence; dermoscopy; treatment
(This special issue belongs to the Section Dermatology)
Deep Vein Thrombosis and Pulmonary Embolism: Clinical Treatment and Management—Second Edition submission deadline 20 Feb 2026 | 1 articles | Viewed by 1263 | Submission Open
Keywords: pulmonary embolism; thrombophilia; deep vein thrombosis; venous thromboembolism; anticoagulation therapy; thrombectomy; bleeding; cancer-associated thrombosis
(This special issue belongs to the Section Hematology)
Novel Developments in Digestive Endoscopy
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1234 | Submission Open
Keywords: endoscopy for IBD; AI in endoscopy; therapeutic endoscopy; EUS; interventional EUS; AI in digestive endoscopy; quality in endoscopy
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Opinion of Reconstructive and Aesthetic Breast Surgery
edited by , Konstantin Frank and Vanessa Brébant
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1223 | Submission Open
Keywords: reconstructive breast surgery; lipofilling; microsurgery; aesthetic breast surgery; PROM; digital anthropometry; autologous fat transfer; ADM; synthetic mesh; BIA-ALCL; BII
(This special issue belongs to the Section General Surgery)
Cancer Immunotherapy: Recent Advances and Clinical Challenges
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1214 | Submission Open
Keywords: immune checkpoint inhibitors; solid tumors; early-stage disease; metastatic disease; prognostic factors; biomarkers; resistance mechanisms
(This special issue belongs to the Section Oncology)
Clinical Applications of Cardiac Imaging: 2nd Edition
edited by Maria Concetta Pastore
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1200 | Submission Open
Keywords: cardiac imaging; echocardiography; magnetic resonance imaging; computed tomography; nuclear imaging; heart failure; valvular heart disease; congenital heart disease
(This special issue belongs to the Section Cardiology)
Updates on Neurosurgical Techniques, Management, and Outcomes for Intracranial Hemorrhages
edited by Bruno Splavski
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1133 | Submission Open
Keywords: minimally invasive neurosurgery; neuro-intervention endovascular techniques; intracranial hemorrhage; stroke; hemorrhagic; ischemic; neurosurgical decision-making; long-term outcomes in neurosurgery
(This special issue belongs to the Section Clinical Neurology)
Hepatobiliary Surgery: State of the Art and Future Perspectives
edited by and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1102 | Submission Open
Keywords: hepatobiliary surgery; cholangiocarcinoma; hepatocellular carcinoma; liver metastases; benign liver lesions
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Opinion in Dental Implant Surgery and Peri-Implant Disease
edited by and Giovanni Corrocher
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1096 | Submission Open
Keywords: dental implant surgery; dental implantology; peri-implant disease; oral surgery; dental implantology
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Treatment and Long-Term Outcome of Fracture
edited by , and Fabrizio Quattrini
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1043 | Submission Open
Keywords: traumatology; osteosynthesis; plating; nailing; osteosynthesis devices; surgical technique; approach
(This special issue belongs to the Section Orthopedics)
Advances in Maternal–Fetal Medicine
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 968 | Submission Open
Keywords: maternal– fetal medicine; obstetric ultrasound; preterm birth; preeclampsia; pregnancy complications; artificial intelligence
(This special issue belongs to the Section Obstetrics & Gynecology)
Diagnosis and Treatment of Gastrointestinal Malignancies
edited by and Gianmauro Numico
submission deadline 20 Feb 2026 | 2 articles | Viewed by 954 | Submission Open
Keywords: gastrointestinal cancers; immunotherapy; targeted therapy; chemotherapy; microsatellite instability; driver mutations
(This special issue belongs to the Section Oncology)
Age-Related Macular Degeneration: Challenges and Opportunities
edited by Deepayan Kar
submission deadline 20 Feb 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: age-related macular degeneration; imaging biomarkers; visual function testing; optical coherence tomography; anti-VEGF; complement; artificial intelligence
(This special issue belongs to the Section Ophthalmology)
New Insights into Orthodontic Treatment
edited by Federico Brugnami and Simonetta Meuli
submission deadline 20 Feb 2026 | 1 articles | Viewed by 850 | Submission Open
Keywords: digital orthodontics; clear aligners; artificial intelligence; digital superimpositions; cone beam computed tomography; growing patients; periodontal patients; maxillofacial surgery; long-term stability; prediction of orthodontic movements
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Minimally Invasive Surgery for Gastrointestinal Disorder submission deadline 20 Feb 2026 | 1 articles | Viewed by 848 | Submission Open
Keywords: minimally invasive surgery; gastrointestinal disorder; laparoscopy; robotic surgery; colorectal surgery; gastric surgery; endoscopic technique; oncological outcomes; surgical innovation
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current Challenges and Innovations in Emergency Medicine: From Prehospital Care to Critical Decision-Making in the Emergency Department
edited by , Barbara P. Fyntanidou and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 811 | Submission Open
Keywords: emergency medicine; prehospital care; triage strategies; acute care; point-of-care diagnostics; artificial intelligence; telemedicine; emergency department; patient flow; healthcare systems; burnout in emergency care
(This special issue belongs to the Section Emergency Medicine)
Diagnosis and Treatment of Cardiovascular Diseases in the Elderly submission deadline 20 Feb 2026 | 1 articles | Viewed by 731 | Submission Open
Keywords: cardiovascular diseases; elderly population; diagnosis and management; age-related pathophysiology; frailty and cognitive impairment
(This special issue belongs to the Section Geriatric Medicine)
Cardiac Anesthesia: Current Research and Future Prospects
edited by and Lorenzo Stephan Cesare Grazioli
submission deadline 20 Feb 2026 | 1 articles | Viewed by 678 | Submission Open
Keywords: cardiac anesthesia; cardiac surgery; echocardiography; interventional cardiology; anesthesia; cardiology
(This special issue belongs to the Section Anesthesiology)
Clinical Update on Cardiac Rehabilitation
edited by
submission deadline 20 Feb 2026 | Viewed by 642 | Submission Open
Keywords: cardiac rehabilitation; cardiovascular disease; physiotherapy; interprofessional intervention; exercise training; nutritional counseling; psychosocial support; secondary prevention; rehabilitation modalities; rehabilitation tools
(This special issue belongs to the Section Clinical Rehabilitation)
Novel Research in Pediatric Dentistry: 2nd Edition
edited by Christian Hirsch and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 551 | Submission Open
Keywords: early childhood caries; primary teeth; caries prevention; caries treatment; behavioral management; molar incisor hypomineralization; dental trauma; sedation; oral health-related quality of life
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
State of the Art in Interventional Cardiology
edited by Antonios Karanasos
submission deadline 20 Feb 2026 | Viewed by 476 | Submission Open
Keywords: interventional cardiology; intravascular imaging; structural interventions; TAVI; vascular access; percutaneous coronary intervention; coronary stenting; cardiovascular diseases
(This special issue belongs to the Section Cardiology)
Advances in the Personalized Management of Chronic Obstructive Pulmonary Disease (COPD)
edited by and Georgios Hillas
submission deadline 20 Feb 2026 | 1 articles | Viewed by 447 | Submission Open
Keywords: artificial intelligence; biologics; biomarkers; diagnostics; oscillometry; COPD pharmacotherapy; imaging
(This special issue belongs to the Section Respiratory Medicine)
Advances in Posttraumatic Stress Disorder (PTSD): Clinical Update
edited by An-Fu Hsiao and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 408 | Submission Open
Keywords: PTSD; stellate ganglion block; transcranial magnetic stimulations; neurobiology; trauma disorders; mind– body medicine; psychophysiology
(This special issue belongs to the Section Mental Health)
Current and Emerging Treatment Options in Atrial Fibrillation: 2nd Edition submission deadline 20 Feb 2026 | Viewed by 359 | Submission Open
Keywords: atrial fibrillation; left atrial appendage closure; ablation techniques; personalized medicine in AF treatment; cardioversion methods
(This special issue belongs to the Section Cardiology)
Disease Modifying Activity in Psoriasis and Atopic Dermatitis submission deadline 20 Feb 2026 | Viewed by 327 | Submission Open
Keywords: atopic dermatitis; biologics; psoriasis; disease-modifying treatment; small molecules; type 2 inflammation
(This special issue belongs to the Section Dermatology)
Novel Insights for Imaging and Therapy in Maternal and Fetal Medicine
edited by Xin Kang
submission deadline 20 Feb 2026 | Viewed by 282 | Submission Open
Keywords: prenatal imaging; prenatal diagnosis; fetal virtual autopsy; preeclampsia; macrosomia; preterm birth; pelvic floor
(This special issue belongs to the Section Obstetrics & Gynecology)
Endocrine Disorders in Children: 2nd Edition submission deadline 20 Feb 2026 | Viewed by 210 | Submission Open
Keywords: endocrinology; pediatrics; hormones; genetics; growth; nutrition; development  ; adolescence  ; prevention
(This special issue belongs to the Section Clinical Pediatrics)
Recent Advances and Future Perspectives on Spinal Surgeries
edited by
submission deadline 20 Feb 2026 | Viewed by 196 | Submission Open
Keywords: minimally invasive spine procedures; robotic-assisted spine surgery; image-guided navigation; spinal implants and biomaterials; artificial intelligence in spinal care; regenerative spine therapies; clinical outcomes in spine surgery; future trends in spinal interventions
(This special issue belongs to the Section Orthopedics)
Progress and Innovation in the Clinical Management of Psychosis
edited by
submission deadline 20 Feb 2026 | Viewed by 193 | Submission Open
Keywords: psychosis; schizophrenia; clinical interventions; neurobiological mechanisms; early intervention
(This special issue belongs to the Section Mental Health)
Maxillofacial Surgery in the Modern Era: Surgical Advances and Clinical Innovation submission deadline 20 Feb 2026 | Viewed by 192 | Submission Open
Keywords: maxillofacial surgery; oral surgery; craniofacial surgery; plastic surgery; bone
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Hypercholesterolemia: Update on Treatment Approaches and Outcomes
edited by and Lucia Barbieri
submission deadline 20 Feb 2026 | Viewed by 189 | Submission Open
Keywords: hypercholesterolemia; dyslipidemia; atherosclerosis; cardiovascular risk; LDL; HDL; lipoprotein(a)
(This special issue belongs to the Section Cardiovascular Medicine)
Advances and Innovations in Radiology: From Contrast-Enhanced Mammography to Artificial Intelligence and Beyond
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 188 | Submission Open
Keywords: contrast-enhanced mammography (CEM); artificial intelligence; radiomics; diagnostic imaging innovations; inter-ventional radiology
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Advances in the Diagnosis and Management of Atherosclerosis submission deadline 20 Feb 2026 | Viewed by 185 | Submission Open
Keywords: atherosclerosis; cardiovascular disease; coronary artery disease; endothelial function; acute coronary syndromes
(This special issue belongs to the Section Cardiology)
Innovations and Challenges in the Burden and Rehabilitation of Musculoskeletal Disorders submission deadline 20 Feb 2026 | Viewed by 179 | Submission Open
Keywords: musculoskeletal diseases; rehabilitation; physical therapy modalities; telemedicine; mobile applications; health information technology; patient-centered care; quality of life; health care innovation
(This special issue belongs to the Section Clinical Rehabilitation)
Myocarditis and Pericarditis: Clinical Advances and Current Challenges submission deadline 20 Feb 2026 | Viewed by 170 | Submission Open
Keywords: pericarditis; myocarditis; pericardial effusion; cardiac tamponade; interleukin-1 inhibitors; pericardium
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Updates on Acromegaly
edited by , Jowita Halupczok-Żyła, Aleksandra Gilis-Januszewska and Przemysław Witek
submission deadline 20 Feb 2026 | Viewed by 161 | Submission Open
Keywords: acromegaly; GH; IGH-1; growth hormone-secreting pituitary adenoma; pituitary adenoma
(This special issue belongs to the Section Endocrinology & Metabolism)
Rheumatoid Arthritis: Insights into Appropriate Diagnosis, Treatment and Management
edited by
submission deadline 20 Feb 2026 | Viewed by 155 | Submission Open
Keywords: rheumatoid arthritis; precision medicine; difficult-to-treat rheumatoid arthritis; late-onset rheumatoid arthritis; ageing society; comorbidities
(This special issue belongs to the Section Immunology & Rheumatology)
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