Drug Repurposing as a Synergistic Therapeutic Strategy for the Treatment of Various Diseases

Dear Colleagues,

Drug repurposing has emerged as a powerful and cost-effective strategy for accelerating therapeutic innovation by identifying new clinical applications for existing drugs with well-established safety profiles. Beyond therapeutic repositioning alone, the development and preparation of repurposed drugs in advanced dosage forms—including nanocarriers, targeted delivery systems, modified-release formulations, and combination dosage forms—have opened up new avenues in enhancing drug synergy, bioavailability, and tissue specificity while minimizing toxicity.

This Special Issue will highlight recent advances in drug repurposing as a synergistic therapeutic strategy, with a particular focus on formulation science, advanced drug delivery technologies, and translational applications across various diseases, including cancer and infectious, neurological, and metabolic disorders. We welcome original research articles, reviews, and perspectives addressing formulation design, manufacturing strategies, pharmacokinetic and pharmacodynamic optimization, and clinical evaluation of repurposed drugs in innovative dosage forms. By integrating drug repurposing with advanced pharmaceutical technologies, this Special Issue will bridge the gap between bench-scale discoveries and clinically viable therapies, ultimately contributing to more effective, safe, and accessible treatment strategies.

Topics of interest include (but are not limited to) the following:

- Synergistic drug combinations involving repurposed agents;

- Mechanistic studies on drug–drug interactions;

- Nanotechnology or targeted delivery systems for combination therapy;

- Drug repurposing for cancer treatment (e.g., statins, antiparasitics, antifungals);

- Repurposed drugs in neurological and neurodegenerative diseases;

- Antimicrobial and antiviral synergy using existing medications;

- Computational approaches for predicting synergistic combinations;

- In vivo and clinical studies evaluating repurposed drug synergy;

- Formulation strategies (nanoparticles, liposomes, spanlastics, etc.) used to enhance combination efficacy;

- Safety, toxicity, and pharmacokinetic considerations in drug combination therapy.

Prof. Dr. Rehab Abdelmonem
Guest Editor

Manuscript Submission Information

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• drug repurposing
• drug synergy
• combination therapy
• advanced and targeted drug delivery
• drug–drug interactions
• pharmacokinetics and pharmacodynamics
• translational therapeutics
• safety and toxicity