Role of Angiotensin II in Cardiac Fibrosis and Heart Failure
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 31
Special Issue Editor
Interests: cardiovascular endocrinology; renin–angiotensin–aldosterone system (RAAS); metabolic risk biomarkers; molecular epidemiology; genomic and metabolomic regulation
Special Issue Information
Dear Colleagues,
Angiotensin II (Ang II) is a central effector peptide of the renin–angiotensin–aldosterone system (RAAS), playing a critical role in cardiovascular homeostasis and pathology. Chronically elevated Ang II levels trigger a cascade of pathological events, including oxidative stress, chronic inflammation, and fibroblast activation, leading to excessive extracellular matrix deposition. This progressive cardiac fibrosis disrupts myocardial architecture, increases ventricular stiffness, and ultimately drives the transition from compensatory hypertrophy to heart failure. Understanding the intricate molecular pathways, genomic variations, and cellular interactions mediated by Ang II is essential for identifying novel therapeutic targets and biomarkers to mitigate adverse cardiac remodeling.
This Special Issue aims to gather cutting-edge research that elucidates the mechanisms by which Ang II promotes cardiac fibrosis and accelerates heart failure. We welcome original research articles, comprehensive reviews, and short communications spanning basic, translational, and clinical studies. Key areas of focus include genomic and metabolomic signatures associated with RAAS dysregulation, signaling pathways in myofibroblast differentiation, and innovative therapeutic strategies targeting Ang II. By bridging molecular insights with clinical outcomes, this Special Issue seeks to advance our current understanding of cardiovascular pathology within the journal's scope and improve patient management strategies.
Dr. Nancy Martínez-Rodríguez
Guest Editor
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Keywords
- angiotensin II
- cardiac fibrosis
- heart failure
- renin–angiotensin–aldosterone system (RAAS)
- extracellular matrix remodeling
- myofibroblast activation
- cardiovascular genomics
- molecular biomarkers
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