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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Amino Acid and Sugar Metabolism in Disease

edited by V. Tkach

submission deadline 31 Mar 2027 | 1 articles | Viewed by 967 | Submission Open

Keywords: metabolic diseases; metabolic disturbances; carbohydrate metabolism; aminoacid metabolism; artificial sweeteners; metabolic path alterations

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular and Histological Advance in Neural Regeneration

edited by Wiktor Pascal

submission deadline 31 Mar 2027 | 1 articles | Viewed by 951 | Submission Open

Keywords: neural regeneration; peripheral nerve injury; central nervous system; Schwann cells; axonal regeneration; stem cells; neurotrophic factors; biomaterials; histology; molecular mechanisms

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Molecular Research on Diabetes Pharmacology

edited by

Ioanna A. Anastasiou

submission deadline 31 Mar 2027 | 1 articles | Viewed by 944 | Submission Open

Keywords: diabetes; pharmacology; antidiabetic drugs; insulin therapy; SGLT2 inhibitors; GLP-1 receptor agonists; combination therapy; personalized medicine; drug development

(This special issue belongs to the Section Molecular Pharmacology)

Plant Responses to Abiotic Stress: Mechanisms and Adaptations

edited by

Shalini Tiwari

and

Lam-Son Phan Tran

submission deadline 31 Mar 2027 | Viewed by 941 | Submission Open

Keywords: salinity stress; heat and cold stress; oxidative stress; signal transduction; stress-responsive genes; antioxidant defence mechanisms; hormonal regulation; molecular adaptation; epigenetic regulation; plant-microbe interaction; crop improvement; stress-resilient plants

(This special issue belongs to the Section Molecular Plant Sciences)

Epitranscriptomics: RNA Modifications and Function

edited by Caroline Vissers

submission deadline 31 Mar 2027 | 1 articles | Viewed by 940 | Submission Open

Keywords: epitranscriptome; methylation; mRNA; rRNA; RNA modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Safety, Toxicity, and Therapeutic Potential of Natural Products and Complex Mixtures

edited by

Fotios Tekos

and Demetrios Kouretas

submission deadline 31 Mar 2027 | 1 articles | Viewed by 905 | Submission Open

Keywords: natural products; complex mixtures; toxicity; safety assessment; antioxidant activity; bioactivity; redox biology; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Artificial Intelligence in Drug Design: Molecular Aspects

edited by

Dorota Latek

submission deadline 31 Mar 2027 | 1 articles | Viewed by 899 | Submission Open

Keywords: artificial intelligence; machine learning; drug design; medical imaging; apoptosis; metastasis; anticancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Detrimental and Beneficial Roles of Glial Cells After Neural Disorders

edited by

Walace Gomes-Leal

submission deadline 31 Mar 2027 | Viewed by 892 | Submission Open

Keywords: neuroprotection; neuroinflammation; cell therapy; microglia; astrocytes; oligodendrocytes; Janus face; double-edged sword

(This special issue belongs to the Section Molecular Neurobiology)

Advancements in Prognostic and Predictive Biomarkers for Advanced Prostate Cancer

edited by

Daniel Khalaf

submission deadline 31 Mar 2027 | 2 articles | Viewed by 892 | Submission Open

Keywords: biomarkers; predictive biomarkers; prognostic biomarkers; genomic biomarkers; biomarker directed therapy; advanced prostate cancer; metastatic prostate cancer; circulating tumour DNA; precision oncology; systemic therapy

(This special issue belongs to the Section Molecular Oncology)

Advances in Microbial Strategies to Combat Antimicrobial Resistance

edited by

Chonticha Romyasamit

submission deadline 31 Mar 2027 | 1 articles | Viewed by 880 | Submission Open

Keywords: probiotics; postbiotics; antimicrobial resistance; bacteriophages; microbial bioactives; functional foods; molecular microbiology; biomedical innovation

(This special issue belongs to the Section Molecular Microbiology)

Mathematical Calculation and Modeling in Biology

edited by Nan Sheng

submission deadline 31 Mar 2027 | 1 articles | Viewed by 862 | Submission Open

Keywords: mathematical modeling; computational biology; machine/deep learning; molecular biology; molecular interactions; gene; protein; small molecule; computational drug design; multi-omics

(This special issue belongs to the Section Molecular Informatics)

Novel Metallic Biomaterials: From Research to Clinical Translation

edited by Ke Yang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 840 | Submission Open

Keywords: metallic biomaterials; bio-functionality; biocompatibility; mechanical properties; clinical application

(This special issue belongs to the Section Materials Science)

Molecular Targets in Reproductive Diseases

edited by

Changwon Yang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 839 | Submission Open

Keywords: reproductive diseases; endometriosis; polycystic ovary syndrome; infertility-related disorders; pregnancy complications; reproductive system cancers; reproductive medicine; precise diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Antiparasitic Agents

edited by Olga S. Koutsoni and

Maria Agallou

submission deadline 31 Mar 2027 | Viewed by 835 | Submission Open

Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite–host interactions; drug targets; mechanisms of drug resistance

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms in Glomerular and Renal Diseases

edited by Eleni Stamellou and

Evangelia Dounousi

submission deadline 31 Mar 2027 | 1 articles | Viewed by 835 | Submission Open

Keywords: glomerulonephritis (GN); podocytopathies; IgA (IgAN); chronic kindey disease (CKD); membra-nous nephropathy; focal segmental glomerulosclerosis (FSGS)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenic Escherichia coli: Cellular Biology, Mechanisms of Pathogenesis, Therapeutic Approaches and Strategies for Disease Intervention

edited by

Jorge Goldstein

submission deadline 31 Mar 2027 | 1 articles | Viewed by 778 | Submission Open

Keywords: enterohemorrhagic E. coli; EHEC; Shiga toxin-producing E. coli; STEC; HUS; inflammation; kidney; blood; brain; pathogenesis; antibodies; extraintestinal pathogenic E. coli; E. coli pathotypes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biomarkers in Airway Diseases: From Epigenetic Regulation to Cellular Stress Pathways

edited by

Giusy Daniela Albano

submission deadline 31 Mar 2027 | 1 articles | Viewed by 777 | Submission Open

Keywords: airway diseases; asthma; chronic obstructive pulmonary disease; chronic rhinosinusitis; virus-associated airway disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Immune Regulation in Prostate Cancer

edited by Nigel Peter Murray

submission deadline 31 Mar 2027 | 1 articles | Viewed by 772 | Submission Open

Keywords: prostate cancer; immunosupressision; molecular changes; tumour microenvironment; anti-tumour immune changes; next-generation methods of molecular investigation

(This special issue belongs to the Section Molecular Oncology)

Molecular and Cellular Mechanisms of Scaffold-Based Tissue Engineering

edited by

Inseon Kim

submission deadline 31 Mar 2027 | 1 articles | Viewed by 753 | Submission Open

Keywords: scaffold; tissue engineering; extracellular matrix; biomaterials; 3D bioprinting; mechanobiology; stem cell differentiation; cultivated meat

(This special issue belongs to the Section Molecular Biology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases: 2nd Edition

edited by

Niels Schaft

submission deadline 31 Mar 2027 | 1 articles | Viewed by 752 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by

Vladimir Simic

submission deadline 31 Mar 2027 | 1 articles | Viewed by 744 | Submission Open

Keywords: computational models; tumor growth; computational oncology; multiscale modeling; cancer progression; treatment response modeling; mathematical modeling

(This special issue belongs to the Section Molecular Informatics)

Bioactive Peptides: Function, Metabolism and Synthesis

edited by

Leandro Mantovani de Castro

submission deadline 31 Mar 2027 | Viewed by 729 | Submission Open

Keywords: bioactive peptides; antimicrobial peptides; antitumoral peptides; neurodegenerative diseases; metabolic diseases; chemical synthesis; cellular proteolysis; mass spectrometry; peptidomics; intracellular peptides; micropeptides

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathophysiology of Lung Diseases—2nd Edition

edited by

Theodoros Karampitsakos

and Vassilios Tzilas

submission deadline 31 Mar 2027 | Viewed by 682 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19; interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Pharmacological Targets and Therapeutic Strategies in Diabetes and Obesity

edited by

Roma Patel

submission deadline 31 Mar 2027 | 1 articles | Viewed by 681 | Submission Open

Keywords: diabetes; obesity; molecular pharmacology; therapeutic targets; insulin resistance; β-cell dysfunction; metabolic signaling pathways; adipose tissue biology; drug–target interactions

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

A Window to the Brain: From Retinal Cellular and Soluble Biomarkers Towards Neurodegeneration

edited by

Bijorn Omar Balzamino

Rosanna Squitti

and

Alessandra Micera

submission deadline 31 Mar 2027 | 1 articles | Viewed by 672 | Submission Open

Keywords: retinal signaling; oxidative stress; retinal neurodegeneration; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Single Cell Transcriptomics in Human Disease

edited by

Md. Mahmudul Hasan

submission deadline 31 Mar 2027 | 1 articles | Viewed by 670 | Submission Open

Keywords: single-cell RNA sequencing; brain aging; neurodegeneration; cellular heterogeneity; transcriptomics; neuronal aging; glial cells; senescence; cognitive decline; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Current Trends in Organometallic Chemistry and Its Applications

edited by

Senka Djaković

and Jasmina Lapić

submission deadline 31 Mar 2027 | 1 articles | Viewed by 656 | Submission Open

Keywords: (bio)organometallic chemistry; synthesis; application; structure–property relationships; computational modelling; ligand design; biomedical materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition

edited by

Michael Moustakas

submission deadline 31 Mar 2027 | 1 articles | Viewed by 649 | Submission Open

Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Kidney Transplantation: Current Framework and New Perspectives

edited by Alberto Rosati

submission deadline 31 Mar 2027 | 1 articles | Viewed by 640 | Submission Open

Keywords: renal transplantation; organ donation; living donation; transplant survival; organ preservation; healthcare costs; acute and chronic rejection; immune tolerance; xenotransplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research Progress in Food Packaging Materials

edited by

Anouar Mouhoub

submission deadline 31 Mar 2027 | 1 articles | Viewed by 637 | Submission Open

Keywords: molecular design; intermolecular interactions; structure–property relationships; bio-based polymers; controlled release systems; active packaging; sustainable materials

(This special issue belongs to the Section Materials Science)

Podocyte Research: Molecular Insights and Clinical Applications

edited by

Hans Lorenzo

submission deadline 31 Mar 2027 | Viewed by 621 | Submission Open

Keywords: podocytes; glomerular filtration barrier; slit diaphragm; podocyte injury; proteinuria; focal segmental glomerulosclerosis; nephrotic syndrome; cell death; non-coding RNAs; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Antibiotic Resistance: Recent Developments and Future Prospects

edited by

Awais Ghaffar

submission deadline 31 Mar 2027 | 1 articles | Viewed by 616 | Submission Open

Keywords: antimicrobial resistance detection; microbial ecology; shotgun metagenomics; genome-resolved metagenomics; microbiome analysis; resistome characterization; One Health

(This special issue belongs to the Section Molecular Pharmacology)

Cellular and Molecular Mechanisms of Biological Interactions with Carbon-Based Materials

edited by Ângela Almeida and

Francesca Coppola

submission deadline 31 Mar 2027 | 1 articles | Viewed by 610 | Submission Open

Keywords: carbon (nano)materials; (nano)toxicology; biomaterial interactions; biosensors; remediation; risk assessment

(This special issue belongs to the Section Molecular Nanoscience)

Transformation and Associated Isotope Kinetics of Halogenated Organic Pollutants in the Environment and Living Organisms

edited by Chenchen Huang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 592 | Submission Open

Keywords: halogenated organic pollutants; compound-specific isotope analysis; isotope fractionation; source apportionment; transformation discrimination; mechanism elucidation; biotic and abiotic transformation; transformation kinetics and pathways; environmental fate

(This special issue belongs to the Section Biochemistry)

Molecular Antimicrobial Resistance in Cancers

edited by Nicola Silvestris and Massimo Andreoni

submission deadline 31 Mar 2027 | Viewed by 577 | Submission Open

Keywords: antimicrobial resistance; host–pathogen interaction; immune dysfunction; immunosuppression; infection; biomarker; novel antimicrobials; cancer; frail patient

(This special issue belongs to the Section Molecular Oncology)

Periodontitis: From Cellular Mechanism to Therapy

edited by Mahmoud Elashiry

submission deadline 31 Mar 2027 | Viewed by 575 | Submission Open

Keywords: periodontitis; inflammatory bone disease; host–microbe interactions; innate and adaptive immunity; osteoimmunology; cellular signaling; immune dysregulation; tissue destruction; translational therapy; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 31 Mar 2027 | Viewed by 562 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Emerging Role of Heterogeneous Catalysis in Materials Science and Application

edited by Alejandro Pérez Larios and

Carlos Soto Robles

submission deadline 31 Mar 2027 | 1 articles | Viewed by 553 | Submission Open

Keywords: heterogeneous photocatalysis; photocatalytic materials; structure–property relationships; catalyst design; surface and interface engineering; operando characterization; charge transfer dynamics; sustainable photocatalysis; CO2 photoconversion; environmental photocatalysis

(This special issue belongs to the Section Materials Science)

Molecular and Nanoscience Approaches to Neurodevelopmental Disorders

edited by

Khairunnuur Fairuz Azman

submission deadline 31 Mar 2027 | Viewed by 553 | Submission Open

Keywords: neurodevelopment; molecular neuroscience; neurotrophic signaling; epigenetics; synaptic plasticity; neuroinflammation; neurodevelopmental disorders; biomarkers; nanoneuroscience; nanotechnology

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Animal Nutrition: Oxidative Stress, Polyphenols and Functional Feed Materials

edited by

Sotiria Makri

and

Dimitrios Kouretas

submission deadline 31 Mar 2027 | 1 articles | Viewed by 550 | Submission Open

Keywords: animal nutrition; oxidative stress; reactive oxygen species; polyphenols; feed materials; molecular nutrition; antioxidant defense; animal physiology; nutritional toxicology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Valorization of Agri-Food Wastes: Extraction, Characterization and Functional Applications of Bioactive Compounds

edited by Pittaya Chaikham

submission deadline 31 Mar 2027 | Viewed by 546 | Submission Open

Keywords: agri-food waste valorization; bioactive compounds; functional foods; green extraction; food sustainability; plant-based ingredients; antioxidants; circular economy; probiotics; food processing

(This special issue belongs to the Section Biochemistry)

Molecular Approaches to Aquatic Animal Health: Immunobiology, Infectious Diseases, Antimicrobial Resistance and One Health

edited by

Partho Debnath

submission deadline 31 Mar 2027 | 1 articles | Viewed by 543 | Submission Open

Keywords: aquatic animal health; molecular immunology; infectious diseases; antimicrobial resistance; One Health; whole-genome sequencing; host–pathogen interactions; comparative genomics; molecular diagnostics; molecular epidemiology

(This special issue belongs to the Section Molecular Immunology)

T Cell Receptor (TCR) Signaling at the Crossroads of Immunity, Tolerance, and Disease

edited by Amar Singh

submission deadline 31 Mar 2027 | Viewed by 533 | Submission Open

Keywords: T cell receptor (TCR) signaling; immune tolerance; effector T cell differentiation; regulatory T cells (Tregs, Tr1); T cell heterogeneity; metabolic reprogramming; T cell memory and exhaustion; TCR repertoire analysis; autoimmunity and inflammation; TCR-based immunotherapy; CAR-T cells

(This special issue belongs to the Section Molecular Immunology)

Advanced Strategies for Melanoma Immunotherapy

edited by

Andrzej Mackiewicz

and

Piotr Rutkowski

submission deadline 31 Mar 2027 | Viewed by 530 | Submission Open

Keywords: melanoma immunotherapy; immune Checkpoint Inhibitors; combination therapies; biomarkers; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Calcium Dynamics in Disease: Mechanisms and Therapeutic Opportunities

edited by

Valeria Magnelli

submission deadline 31 Mar 2027 | Viewed by 523 | Submission Open

Keywords: calcium signaling; homeostasis; deregulation; calcium imbalance

(This special issue belongs to the Section Biochemistry)

Depression: From Molecular Basis to Therapy—3rd Edition

edited by

Terezia Kiskova-Simkova

submission deadline 31 Mar 2027 | Viewed by 523 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches

edited by Yuehling Hsieh

submission deadline 31 Mar 2027 | Viewed by 496 | Submission Open

Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathogenesis and Treatments of Pediatric Leukemias

edited by

Joanna Zawitkowska

submission deadline 31 Mar 2027 | Viewed by 487 | Submission Open

Keywords: monoclonal antibodies; tyrosine kinase inhibitors; CAR-T; chemotherapy; drug induced toxicity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

DNA Damage and DNA Repair in Health and Diseases

edited by Silvina B. Nadin

submission deadline 31 Mar 2027 | Viewed by 482 | Submission Open

Keywords: genome instability; DNA damage response; DNA repair mechanisms; cancer; therapeutic targets; preclinical studies; translational studies; DNA repair and immune system; PARP inhibitors; BRCA1/2

(This special issue belongs to the Section Molecular Biology)

Unraveling the Host–Virus Interplay in Viral Infection: Molecular Mechanisms and Therapeutic Horizons

edited by