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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Brain Cancers: Molecular Diagnostic and Therapeutic Approaches

edited by

Carmine Antonio Donofrio

submission deadline 20 Sep 2025 | Viewed by 204 | Submission Open

Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenesis and Treatment of Prostate Cancer

edited by

Vincenzo Fiorentino

submission deadline 20 Sep 2025 | Viewed by 203 | Submission Open

Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Therapeutical Advances in Multiple Sclerosis

edited by Arturo Mangas and

Rafael Coveñas Rodríguez

submission deadline 20 Sep 2025 | Viewed by 202 | Submission Open

Keywords: multiple sclerosis; neurodegenerative disease; chronic disease; autoimmune disease; biological markers; new drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

A New Era for Structures and Functions of Amyloid Fibrils in Neurodegenerative Diseases

edited by Masahiro Enomoto

submission deadline 20 Sep 2025 | Viewed by 201 | Submission Open

Keywords: neurodegenerative disease; structural mechanisms; super-resolution microscopy; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET)

(This special issue belongs to the Section Molecular Neurobiology)

Discovery of Proteins Leading to New Asthma Treatments

edited by

Alberto Spisni

and

Elena Ferrari

submission deadline 20 Sep 2025 | Viewed by 197 | Submission Open

Keywords: asthma; allergens; proteomic analysis; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immune Regulation in Lung Diseases

edited by

Chiara Colarusso

and

Rosalinda Sorrentino

submission deadline 20 Sep 2025 | Viewed by 194 | Submission Open

Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Advances in Research of Neuroendocrine Tumors

edited by Tania Amin

submission deadline 20 Sep 2025 | Viewed by 193 | Submission Open

Keywords: neuroendocrine tumors; drug resistance; personalized treatment; molecular subtypes

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Pathogen Dynamics: Enhancing One Health Surveillance

edited by

Franklin W.N. Chow

and

Chi-Ching Tsang

submission deadline 20 Sep 2025 | Viewed by 193 | Submission Open

Keywords: pathogens; pathogen dynamics; infectious diseases; molecular omics; wet lab experiments; phenotypic analyses; bacterial; viral; fungal; parasitic pathogens; zoonotic diseases; vector-borne Diseases; antimicrobial resistance; interplay between pathogens and hosts/environment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

T Cells in Immune Diseases: Regulation and Function

edited by Chia-Rui Shen

submission deadline 20 Sep 2025 | Viewed by 191 | Submission Open

Keywords: T cell function; T cells in immune diseases; regulation and function

(This special issue belongs to the Section Molecular Immunology)

Research on Signal Transduction Mechanisms of Cancer Cells

edited by

Anuraag Shrivastav

submission deadline 20 Sep 2025 | Viewed by 186 | Submission Open

Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation

(This special issue belongs to the Section Molecular Oncology)

Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease

edited by

Eva Kiss

submission deadline 20 Sep 2025 | Viewed by 186 | Submission Open

Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein

(This special issue belongs to the Section Molecular Neurobiology)

Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia

edited by Fabrizio Barbetti

submission deadline 20 Sep 2025 | Viewed by 180 | Submission Open

Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanoparticle Systems for Cancer Phototherapy

edited by

Maria Raposo

submission deadline 20 Sep 2025 | Viewed by 177 | Submission Open

Keywords: nanoparticles; phototherapy; cancer; photodynamic therapy; photosensitiser molecules; biomolecules damage; DNA-intercalators; oxidative stress; cell/tissue specificity; drug delivery systems

(This special issue belongs to the Section Molecular Oncology)

Role of Glia in Human Health and Disease

edited by

Daniele Lana

and

Hajime Hirase

submission deadline 20 Sep 2025 | Viewed by 166 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

From Macrophage Biology to Cell and EV-Based Immunotherapies

edited by

Katarzyna Nazimek

and

Krzysztof Bryniarski

submission deadline 20 Sep 2025 | Viewed by 165 | Submission Open

Keywords: macrophage-based; macrophage-targeting; cancer immunotherapies; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

The Function of Glial Cells in the Nervous System: 2nd Edition

edited by Krista Minéia Wartchow

submission deadline 20 Sep 2025 | Viewed by 165 | Submission Open

Keywords: glial cells; glial– neuronal interaction; glial biomarkers; neurodegenerative diseases; therapeutic approaches

(This special issue belongs to the Section Molecular Neurobiology)

Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease

edited by Janette Bester

submission deadline 20 Sep 2025 | Viewed by 163 | Submission Open

Keywords: red blood cell; inflammation; infection; metabolic disease; hemodynamics

(This special issue belongs to the Section Molecular Biology)

New Insights into Ubiquitination and Deubiquitination in Plants

edited by

Hongyong Fu

submission deadline 20 Sep 2025 | Viewed by 161 | Submission Open

Keywords: ubiquitin; E1; E2; E3; deubiquitination; proteolysis; plants

(This special issue belongs to the Section Biochemistry)

Molecular Research on the Regulation of Expression Associated with the Mechanism of Multidrug Resistance in Mycobacterium tuberculosis

edited by Maria Del Carmen Muñoz-Egea

submission deadline 20 Sep 2025 | Viewed by 150 | Submission Open

Keywords: multidrug resistance; MDR; XDR; Mycobacterium tuberculosis; molecular research; gene expression; genome sequencing

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathology, Diagnostics, and Therapeutics in Optic Neuropathies

edited by Tsz Kin Ng

submission deadline 20 Sep 2025 | Viewed by 138 | Submission Open

Keywords: optic neuropathies; glaucoma; optic nerve; retinal ganglion cells; neuroprotection; biomarkers; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

From Plant Genomics Investigations to Plant Biotechnology Exploitation

edited by

Maria R. Ercolano

submission deadline 20 Sep 2025 | Viewed by 129 | Submission Open

Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries

(This special issue belongs to the Section Molecular Plant Sciences)

Glioblastoma: Molecular Pathogenesis and Treatment

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 20 Sep 2025 | Viewed by 106 | Submission Open

Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Forest Tree Genetics, Breeding and Environmental Adaption

edited by

Jingli Yang

and

Huiyu Li

submission deadline 20 Sep 2025 | Viewed by 96 | Submission Open

Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 20 Sep 2025 | Viewed by 94 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Upper and Lower Airway Diseases in Allergy and Immunology: From Bench to Bedside

edited by

Giovanni Paoletti

Giulia Costanzo

and

Enrico Marco Heffler

submission deadline 20 Sep 2025 | Viewed by 88 | Submission Open

Keywords: unified airway disease; allergic rhinitis; asthma; chronic rhinosinusitis; eosinophilic; airway inflammation; airway epithelial barrier; immune dysregulation; respiratory microbiome; biomarkers; allergy and immunology

(This special issue belongs to the Section Molecular Immunology)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 20 Sep 2025 | Viewed by 73 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

Plant Breeding and Genetics: New Findings and Perspectives

edited by

Andrés J. Cortés

submission deadline 20 Sep 2025 | Viewed by 72 | Submission Open

Keywords: quantitative genetics; classical plant breeding; marker-assisted selection; genomic selection; speed breeding; gene editing and biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Artificial Intelligence in Molecular Biomarker Screening

edited by

Tony Hsiu-Hsi Chen

submission deadline 20 Sep 2025 | Viewed by 66 | Submission Open

Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse

(This special issue belongs to the Section Molecular Informatics)

The Role of Transcription Factors in Cancer

edited by

Tomasz Wilanowski

submission deadline 20 Sep 2025 | Viewed by 64 | Submission Open

Keywords: transcription factor; oncogene; tumor suppressor; nuclear receptor; genetic regulation; post-translational regulation; biomarker; drug target

(This special issue belongs to the Section Molecular Oncology)

Immunological Regulation as Determinant of Outcomes in Critically Sick Patients

edited by

Krzysztof Laudanski

submission deadline 20 Sep 2025 | Viewed by 62 | Submission Open

Keywords: critical illness; outcome; immune system; inflammation; homeostasis; epigenetic; microbiome; central nervous system; dysregulation; recovery

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Pathogenesis to Innovative Treatments

edited by Volker Adams and

Ephraim Bernhard Winzer

submission deadline 20 Sep 2025 | Viewed by 59 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; comorbidities; pathophysiology; treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Molecular-Scale and Nano-Scale Materials: Design, Characterization and Application

edited by Xiaogang Li

submission deadline 20 Sep 2025 | Viewed by 56 | Submission Open

Keywords: molecular scale; nano scale; material design and preparation; characterization; regulation; application

(This special issue belongs to the Section Molecular Nanoscience)

The Future of Biomaterials in Dentistry: Innovations in Drug Delivery and Regenerative Medicine

edited by

Victor Martin

submission deadline 20 Sep 2025 | Viewed by 54 | Submission Open

Keywords: dentistry; regenerative medicine; drug delivery; tissue engineering; biomaterials; tooth; periodontal

(This special issue belongs to the Section Materials Science)

Mechanosensitive Ion Channels in the Nervous System

edited by

Rashid Giniatullin

submission deadline 20 Sep 2025 | Viewed by 47 | Submission Open

Keywords: mechanosensitive ion channels; Piezo1; Piezo2; mechanosensitive K2P channels; mechanical pain; pulsating blood flow; tissue stiffness; mechanobiology of glymphatic system; chemical agonists of mechanosensitive channels; mechanosensitive TRP channels; neuron; glial cells

(This special issue belongs to the Section Molecular Neurobiology)

Fundamental and Translational Insights into Colorectal Cancer

edited by Giuseppe Broggi

submission deadline 20 Sep 2025 | Viewed by 46 | Submission Open

Keywords: colorectal cancer (CRC); molecular pathways; translational research; immune checkpoint inhibitors; drug resistance

(This special issue belongs to the Section Molecular Oncology)

Damage to Plants and Microorganisms Caused by Heavy Metal Toxicity

edited by

Xiaomeng Chen

submission deadline 20 Sep 2025 | Viewed by 44 | Submission Open

Keywords: metal; oxidative stress; stress response; molecular function; gene regulation; metabolic regulation; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives

edited by

Katarzyna E. Stȩpnik

submission deadline 20 Sep 2025 | Viewed by 42 | Submission Open

Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Targeting Tyrosine Kinase Receptors in Cancer: Mechanisms, Resistance and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 20 Sep 2025 | Viewed by 40 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

RNA in Biology and Medicine (2nd Edition)

edited by

Roberto Patarca

and William A. Haseltine

submission deadline 20 Sep 2025 | Viewed by 39 | Submission Open

Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function

(This special issue belongs to the Section Molecular Biology)

Genetic and Molecular Susceptibility in Human Diseases: 3rd Edition

edited by

Roberto Madeddu

submission deadline 20 Sep 2025 | Viewed by 28 | Submission Open

Keywords: genetic susceptibility; proteomics; gene expression; apoptosis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Reproduction and Reproductive Diseases

edited by

Sung Tae Kim

submission deadline 22 Sep 2025 | Viewed by 58 | Submission Open

Keywords: reproduction; implantation; fertilization; gametogenesis; preimplantation genetic testing; in vitro fertilization; infertility; miscarriage; reproductive aging; endometriosis; premature ovarian failure; menopause; preeclampsia; preterm birth; placenta; testis; azoospermia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Products in Lifestyle-Related Diseases: Molecular Mechanisms, Prevention and Treatments

edited by

Takanobu Takata

submission deadline 25 Sep 2025 | 2 articles | Viewed by 3567 | Submission Open

Keywords: natural products; crude drugs; lifestyle-related diseases; diabetes mellitus; cardiovascular disease; non-alcoholic hepatosteatosis; cancer; sarcopenia; Alzheimer’ s disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Periodontal Disease, Association with Systemic Conditions and Periodontal Pathogens: 2nd Edition

edited by Evangelos Papathanasiou

submission deadline 25 Sep 2025 | 1 articles | Viewed by 1678 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal medicine; periodontal– systemic interactions; immune response; periodontal pathogens

(This special issue belongs to the Section Molecular Immunology)

Antitumor Activity of Natural Products

edited by

Spiro Mihaylov Konstantinov

submission deadline 25 Sep 2025 | 1 articles | Viewed by 960 | Submission Open

Keywords: natural compounds and extracts with antitumor activity; studies on molecular mechanisms; signal transduction modulation in tumor cells; immunomodulating activity; mitosis inhibition; cell differentiation; cell death induction (apoptosis/autophagy)

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unveiling Molecular Mysteries of Brain Barriers

edited by Ana Catarina Duarte

submission deadline 25 Sep 2025 | Viewed by 118 | Submission Open

Keywords: blood– brain barrier; blood– cerebrospinal fluid barrier; arachnoid barrier; transport mechanisms; drug delivery; drug metabolism; ATP-binding cassete (ABC) transporters

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Epigenetic Mechanisms in Cognition

edited by Sabrina Venditti

submission deadline 25 Sep 2025 | Viewed by 102 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Magnetic Materials: Synthesis, and Applications

edited by Artur Chrobak

submission deadline 25 Sep 2025 | Viewed by 93 | Submission Open

Keywords: magnetic materials; properties; synthesis; applications

(This special issue belongs to the Section Materials Science)

Molecular Insights in Neurodegeneration

edited by

Oscar Arias-Carrión

submission deadline 25 Sep 2025 | Viewed by 79 | Submission Open

Keywords: neurodegeneration; molecular mechanisms; protein aggregation; neuroinflammation; oxidative stress; mitochondrial dysfunction; Alzheimer’ s disease; Parkinson’ s disease; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Accelerating Therapeutic Innovation: Advances in Computer-Aided Drug Discovery

edited by Pietro Delre and