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Periodontal Disease, Association with Systemic Conditions and Periodontal Pathogens 2.0

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 248

Special Issue Editor


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Guest Editor
Department of Periodontology, Tufts University School of Dental Medicine, Boston, MA 02111, USA
Interests: periodontitis; gingivitis; inflammation; antibodies; cytokines; immune response; antigens; bacteria
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Periodontitis is a chronic prevalent non-communicable disease (NCD) characterized by complex dynamic interactions among specific bacterial pathogens and the inflammatory destruction of the tooth-supporting tissues. In recent decades, a significant body of evidence supports independent associations between severe periodontitis and various systemic conditions, such as diabetes mellitus, cardiovascular disease, obesity, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis and adverse pregnancy outcomes. Consequently, the field of “periodontal medicine” has evolved, to study how periodontal infection/inflammation may impact extraoral health. While the field has significantly progressed, there is a need for continued extensive research on the associations between systemic conditions and the infectious, immune, inflammatory and systemic characteristics of periodontitis. Therefore, the aim of this Special Issue of the International Journal of Molecular Sciences is to provide an update on the current knowledge in the research field of “Periodontal Disease, Association with Systemic Conditions and Periodontal Pathogens”, and this Special Issue welcomes both original research articles and review papers that encompasses molecular biology studies on the etiology, diagnosis, prognosis and treatment of periodontitis and periodontal–systemic interactions.

Dr. Evangelos Papathanasiou
Guest Editor

Manuscript Submission Information

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Keywords

  • periodontal disease
  • periodontitis
  • periodontal medicine
  • periodontal–systemic interactions
  • immune response
  • periodontal pathogens

Published Papers (1 paper)

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Research

15 pages, 3266 KiB  
Article
Anti-Inflammatory Activity of No-Ozone Cold Plasma in Porphyromonas gingivalis Lipopolysaccharide-Induced Periodontitis Rats
by Kwang-Ha Park, Yoon-Seo Jang, Ji-Young Joo, Gyoo-Cheon Kim and Jeong-Hae Choi
Int. J. Mol. Sci. 2024, 25(11), 6161; https://doi.org/10.3390/ijms25116161 - 3 Jun 2024
Viewed by 101
Abstract
Periodontitis is an inflammatory disease caused by Porphyromonas gingivalis (P. gingivalis) in the oral cavity. This periodontal disease causes damage to the periodontal ligament and alveolar bone and can cause tooth loss, but there is no definite treatment yet. In this [...] Read more.
Periodontitis is an inflammatory disease caused by Porphyromonas gingivalis (P. gingivalis) in the oral cavity. This periodontal disease causes damage to the periodontal ligament and alveolar bone and can cause tooth loss, but there is no definite treatment yet. In this study, we investigated the possibility of using no-ozone cold plasma to safely treat periodontitis in the oral cavity. First, human gingival fibroblasts (HGFs) were treated with P. gingivalis-derived lipopolysaccharide (PG-LPS) to induce an inflammatory response, and then the anti-inflammatory effect of NCP was examined, and a study was conducted to identify the mechanism of action. Additionally, the anti-inflammatory effect of NCP was verified in rats that developed an inflammatory response similar to periodontitis. When NCP was applied to PG-LPS-treated HGFs, the activities of inflammatory proteins and cytokines were effectively inhibited. It was confirmed that the process of denaturing the medium by charged particles of NCP is essential for the anti-inflammatory effect of NCP. Also, it was confirmed that repeated treatment of periodontitis rats with NCP effectively reduced the inflammatory cells and osteoclast activity. As a result, this study suggests that NCP can be directly helpful in the treatment of periodontitis in the future. Full article
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