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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Repair Mechanisms of Stem Cells submission deadline 31 Dec 2026 | 1 articles | Viewed by 1558 | Submission Open
Keywords: stem cell biology; stem cells; stem cell therapy; tissue regeneration
(This special issue belongs to the Section Biochemistry)
Activity and Efficacy Evaluation of Natural Products submission deadline 31 Dec 2026 | 4 articles | Viewed by 1533 | Submission Open
Keywords: natural products; bioactivity; pharmacological efficacy; medicinal plants; marine bioresources; anticancer; anti-inflammatory; synergistic effects; AI-guided discovery; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into Neuroproteins
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1431 | Submission Open
Keywords: neuroproteins; S100B; glial fibrillary acidic protein; neuron-specific enolase; alpha-synuclein; amyloid proteins
(This special issue belongs to the Section Molecular Neurobiology)
New Perspectives of Colloids for Biological Applications, 2nd Edition submission deadline 31 Dec 2026 | 1 articles | Viewed by 1329 | Submission Open
Keywords: colloids; emulsions; dispersions, stability; size distribution; zeta potential; optical/rheological properties; medicine; pharmaceuticals; cosmetics
(This special issue belongs to the Section Materials Science)
Natural Products: Pharmacological Insights and Advances
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1311 | Submission Open
Keywords: natural products; biological activity; pharmacology; mechanism of action; molecular targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Emerging Roles of Phytochemicals in Cancer Chemoprevention and Treatment
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1309 | Submission Open
Keywords: natural products; phytochemicals; cancer; chemoprevention; cancer therapy; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Spermatogenesis and Male Infertility, 2nd Edition
edited by Wanxi Yang
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1290 | Submission Open
Keywords: male reproduction; hormone regulation; blood–testis barrier; male reproductive diseases; male infertility
(This special issue belongs to the Section Molecular Biology)
Next-Generation Natural Products in Drug Discovery: From Ethnopharmacology to Precision Medicine
edited by Idris Adewale Ahmed
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1264 | Submission Open
Keywords: phytochemicals; pharmacodynamics; pharmacokinetics; formulation strategies; commercialization; nanotechnology; delivery systems
(This special issue belongs to the Section Molecular Pharmacology)
Breast Cancer and Molecular-Based Treatments
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1221 | Submission Open
Keywords: breast cancer; immunotherapy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Host–Microorganism Interaction
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1174 | Submission Open
Keywords: host–microbe interaction; gut microbiota; molecular pathogenesis; metagenomics; immune modulation; microbial dysbiosis; gene expression; antimicrobial resistance; metabolic diseases; biofilm formation
(This special issue belongs to the Section Molecular Microbiology)
Multi-Omics Platforms for Comprehensive Biological Insights
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1171 | Submission Open
Keywords: allergen; animal; cancer biology; diseases; microbiology; plant; proteomics; post-translational modification; stress biology
(This special issue belongs to the Section Biochemistry)
Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside
edited by Antonio Arnaiz-Villena
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1147 | Submission Open
Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances in Obstetrical and Gynaecological Disorders: 2nd Edition submission deadline 31 Dec 2026 | 1 articles | Viewed by 1133 | Submission Open
Keywords: gynaecological disorders; obstetrical disorders; gynaecological diseases; genetic markers; molecular therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Medicinal Plants in the Treatment of Neurodegenerative Diseases: Advances, Challenges, and Future Perspectives submission deadline 31 Dec 2026 | 1 articles | Viewed by 1131 | Submission Open
Keywords: medicinal plants; neuroprotection; neurodegeneration; plant secondary metabolites; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Neuroregenerative Medicine: Molecular Mechanisms, Neuroinflammation, and Translational Approaches submission deadline 31 Dec 2026 | 1 articles | Viewed by 1108 | Submission Open
Keywords: neuroregeneration; neuroinflammation; regenerative medicine; mesenchymal stem cells; neural stem cells; Schwann cells; translational medicine; extracellular vesicles; peripheral nerve regeneration; 3D bioprinting
(This special issue belongs to the Section Molecular Neurobiology)
Integrative Perspectives on Plant Signaling Pathways: From Growth Regulation to Stress Resilience and Adaptive Responses
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1083 | Submission Open
Keywords: plant signaling; hormonal regulation; plant growth and development; plant-peptide signal transduction; abiotic/biotic stress resilience; omics; molecular mechanisms; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Telomere Dynamics in Aging and Disease: Biology, Regulation, and Pathogenesis
edited by Jidong Shan
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1077 | Submission Open
Keywords: telomeres; telomere length; telomerase; aging; diseases; disorders; cancer
(This special issue belongs to the Section Molecular Biology)
Addressing Autoimmunity in the 21st Century
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 1072 | Submission Open
Keywords: autoimmunity; autoimmune diseases; immune-mediated disorders; molecular mechanisms; molecular biomarkers; therapeutic strategies; immunomodulation; immune tolerance
(This special issue belongs to the Section Molecular Immunology)
Biological Activities and Applications of Marine Algae submission deadline 31 Dec 2026 | 1 articles | Viewed by 1071 | Submission Open
Keywords: marine algae; biological activity; bioactive compounds; antimicrobial; antioxidant; anticancer; sustainable natural resources; agriculture; health care; biotechnology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Design, Synthesis and Evaluations of Anticancer Activity of Multi-Target Inhibitors submission deadline 31 Dec 2026 | 1 articles | Viewed by 1042 | Submission Open
Keywords: synthesis of anticancer compounds; multi-target inhibitors; kinase inhibitors; apoptosis modulation; cancer signaling pathways; structure–activity relationships; molecular docking; hybrid molecules
(This special issue belongs to the Section Molecular Pharmacology)
Synthesis and Activity of Natural Products and Analogues
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 999 | Submission Open
Keywords: natural products; functional food; synthesis; high-resolution mass spectrometry; bioactive compound
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Application of Polysaccharides and Their Derivatives in Drug Delivery
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 992 | Submission Open
Keywords: polysaccharides; drug delivery; biomaterials; nanoparticles; controlled release; targeted delivery; hydrogels; biopolymers; drug carriers; biomedical applications
(This special issue belongs to the Section Macromolecules)
Exploring Molecular Mechanisms Involved in Head and Neck Cancer
edited by Jae Won Chang
submission deadline 31 Dec 2026 | 1 articles | Viewed by 952 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); molecular targeted therapy; tumor microenvironment (TME); therapeutic resistance; cancer stem cells (CSCs); immunotherapy; ferroptosis and cuproptosis; non-coding RNAs; microbiome and exosomes; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Cutting Edge Advances in Wound Healing
edited by Fui Ping Lim
submission deadline 31 Dec 2026 | 1 articles | Viewed by 926 | Submission Open
Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation
(This special issue belongs to the Section Molecular Biology)
Effects of Nutrients and Functional Foods on Immune and Inflammatory Responses
edited by and Wenjie Yan
submission deadline 31 Dec 2026 | 1 articles | Viewed by 903 | Submission Open
Keywords: nutrients and bioactive compounds; functional foods; immune response; chronic inflammation; inflammatory pathways; cytokines and chemokines; gut–immune axis; oxidative stress; immunomodulation; in vitro and in vivo models
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Plant Breeding and Genetics: New Findings and Perspectives, 2nd Edition
edited by
submission deadline 31 Dec 2026 | 2 articles | Viewed by 895 | Submission Open
Keywords: quantitative genetics; classical plant breeding; marker assisted selection; genomic selection; speed breeding; gene editing and biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Machine Learning and Advanced Feature Engineering: Deciphering the Complexity of Plant Functional Genomics
edited by and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 887 | Submission Open
Keywords: machine learning; deep learning; feature engineering; plant functional genomics; genomic elements; plant evolution; gene regulatory networks; multi-omics integration; sequence encoding; explainable AI (XAI)
(This special issue belongs to the Section Molecular Plant Sciences)
Bridging Molecular and Translational Research in Chronic Kidney Disease and Dysmetabolism
edited by , , Lida Tartaglione and
submission deadline 31 Dec 2026 | 2 articles | Viewed by 884 | Submission Open
Keywords: chronic kidney disease; translational research; dysmetabolism; biotechnologies; bone diseases; inflammation; oxidative stress; omics; personalize medicine; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Orthopedic Materials
edited by Seung Hun Lee
submission deadline 31 Dec 2026 | 1 articles | Viewed by 873 | Submission Open
Keywords: orthopedic biomaterials; bone regeneration; musculoskeletal system; muscle tissue engineering; 3D bioprinting; functional scaffolds; hydrogels; cell–material interaction; regenerative medicine; myogenic differentiation
(This special issue belongs to the Section Materials Science)
Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders
edited by
submission deadline 31 Dec 2026 | Viewed by 863 | Submission Open
Keywords: blood–brain barrier; neurodegenerative diseases; Alzheimer’s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow
(This special issue belongs to the Section Molecular Neurobiology)
Research Progress of Nanocarriers submission deadline 31 Dec 2026 | 1 articles | Viewed by 851 | Submission Open
Keywords: controlled release; drug delivery systems; multimodal nanoplatforms; nanoparticles; precision medicine; stimuli-responsive nanocarriers; theranostics; therapeutic delivery; translational na-nomedicine
(This special issue belongs to the Section Molecular Nanoscience)
Latest Research on Drug-Diagnostic Co-Development in Oncology submission deadline 31 Dec 2026 | Viewed by 851 | Submission Open
Keywords: companion diagnostics; tumor; drug–diagnostic co-development; molecular profiling; biomarker; theranostics
(This special issue belongs to the Section Molecular Oncology)
Environmental Microorganisms and Pathogen Infections submission deadline 31 Dec 2026 | 1 articles | Viewed by 845 | Submission Open
Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health
(This special issue belongs to the Section Molecular Microbiology)
Nanomaterials in Tissue Engineering and Regenerative Medicine: Recent Advances and Future Prospects
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 843 | Submission Open
Keywords: nanoparticles; nanofibers; nanotubes; nanocomposites; hydrogels; ceramics; bioactive glass nanoparticles; tissue engineering; regenerative medicine
(This special issue belongs to the Section Molecular Nanoscience)
Ion Channels in Human Health and Diseases
edited by and Jinghui Guo
submission deadline 31 Dec 2026 | 1 articles | Viewed by 828 | Submission Open
Keywords: ion channels; channelopathies; electrophysiology; organ systems; human diseases; membrane excitability; pharmacology and drug discovery; translational medicine
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Photodynamic Therapy for Antibacterial and Anticancer Applications submission deadline 31 Dec 2026 | Viewed by 817 | Submission Open
Keywords: photodynamic therapy (PDT); sonodynamic therapy (SDT); radiodynamic therapy (RDT); chemodynamic therapy (CDT); photosensitizers; sonosensitizers; radiosensitizers; antimicrobial PDT; antimicrobial SDT; antimicrobial RDT; anticancer therapy; drug resistance; bacterial biofilms; reactive oxygen species; nanocarriers; nanoscale metal–organic frameworks; immunogenic cell death; targeted drug delivery; combination therapeutics
(This special issue belongs to the Section Molecular Biology)
Individualised Therapies for Rare Disorders
edited by Paul Gissen
submission deadline 31 Dec 2026 | 1 articles | Viewed by 812 | Submission Open
Keywords: individualised therapies; personalised medicine; rare diseases; omics; gene therapy; molecular pathways; mechanistic discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Biomaterials for Neural Regeneration and Axogenesis: From Cellular Support to Functional Recovery
edited by Noela Rodríguez-Losada
submission deadline 31 Dec 2026 | Viewed by 787 | Submission Open
Keywords: neural regeneration; axogenesis; neurorepair; neuroprotection; biocompatible materials; extracellular matrix mimetics; graphene-based scaffolds; conductive polymers; hybrid hydrogels; carbon nanomaterials; neuroengineering
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Engineering of Biomaterials for Advanced Additive Manufacturing submission deadline 31 Dec 2026 | 1 articles | Viewed by 775 | Submission Open
Keywords: molecular engineering; biomaterials; polymer chemistry; additive manufacturing; 3D printing; supramolecular interactions; surface chemistry; biocompatibility; degradation mechanisms; functional polymers; bioactive materials; computational modeling; tissue engineering; regenerative medicine
(This special issue belongs to the Section Materials Science)
Azoles and Fused Heterocycles in Antimicrobial Drug Discovery: Synthesis, Mechanisms, and Applications
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 758 | Submission Open
Keywords: drug design and discovery; bioactive molecules; azoles and fused heterocycles; antimicrobials
(This special issue belongs to the Section Molecular Pharmacology)
Metallopharmaceuticals: Current Trends and Future Perspectives in Cancer Immunoediting submission deadline 31 Dec 2026 | Viewed by 740 | Submission Open
Keywords: metal-based drugs; anticancer activity; mechanisms of action; tumor microenvironment; immune cell regulation; cancer immunity; metal–protein interactions; metal–nucleic acid interactions
(This special issue belongs to the Section Molecular Pharmacology)
Decoding Animal Reproduction: From Molecular Mechanisms to Breeding Innovations
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 736 | Submission Open
Keywords: embryo; epigenetics; multi-omics; breeding
(This special issue belongs to the Section Molecular Biology)
Pancreatic Cancer: Biomarkers and New Drug Development
edited by Yi-Ming Arthur Chen
submission deadline 31 Dec 2026 | 1 articles | Viewed by 735 | Submission Open
Keywords: pancreatic ductal adenocarcinoma; biomarkers; transcriptomic subtypes; new drug development; target therapy; immunotherapy; KRAS inhibitors; precision medicine; health supplements
(This special issue belongs to the Section Molecular Oncology)
Metal Toxicity and Particle Toxicity
edited by Alicja Piotrowska-Niczyporuk
submission deadline 31 Dec 2026 | 1 articles | Viewed by 731 | Submission Open
Keywords: metals; particles; toxicity; microplastic; environment pollution; animals; plants; algae
(This special issue belongs to the Section Molecular Toxicology)
Research Progress of Orthopedic Materials
edited by Robert Karpiński
submission deadline 31 Dec 2026 | Viewed by 727 | Submission Open
Keywords: biocompatibility; biomaterials; orthopedic implants; hydroxyapatite; biodegradable polymers; tissue engineering; bioactive surfaces; bone cements; bone regeneration; antibacterial coatings
(This special issue belongs to the Section Materials Science)
Molecular Mechanisms of Adipose Tissue Dysfunction in Obesity and Metabolic Diseases
edited by Andressa Bolsoni-Lopes
submission deadline 31 Dec 2026 | Viewed by 689 | Submission Open
Keywords: adipose tissue dysfunction; obesity; metabolic diseases; insulin resistance; adipose tissue inflammation; lipid metabolism; fatty acid signaling; extracellular matrix remodeling; metabolic dysfunction-associated steatotic liver disease (MASLD); G protein-coupled receptors (GPCRs)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Targeted Anticancer Therapeutics: Mechanisms, Resistance, Tumor Microenvironment, and Translational Advances
edited by Shakti Prasad Pattanayak
submission deadline 31 Dec 2026 | 1 articles | Viewed by 661 | Submission Open
Keywords: cancer metabolism; drug resistance; tumor microenvironment; immunometabolism; targeted therapy; anticancer therapeutics; autophagy; oxidative stress; cancer immunotherapy; translational oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Neuroendocrine Regulations in Health and Pathology submission deadline 31 Dec 2026 | 1 articles | Viewed by 645 | Submission Open
Keywords: neuroendocrine system; brain; hypothalamus; adenohypophysis; endocrine glands; (neuro)hormones; ontogenesis; neuroendocrine disorders
(This special issue belongs to the Section Molecular Neurobiology)
Research Progress on Cancer Biomarkers and Molecular Targets
edited by
submission deadline 31 Dec 2026 | 1 articles | Viewed by 636 | Submission Open
Keywords: cancer biomarkers; molecular targets; cellular senescence; autophagy; epigenetics; prognosis; tumor microenvironment; therapy resistance; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Enzyme Inhibitory Assessment and Molecular Docking Studies of Natural and Synthetic Heterocyclic Compounds
edited by
submission deadline 31 Dec 2026 | Viewed by 612 | Submission Open
Keywords: heterocycles; enzyme inhibition; docking studies; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
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