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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endothelial Cells in Health and Disease

edited by

Alessia Ricci

and

Amelia Cataldi

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8382 | Submission Open

Keywords: endothelial cells; vascular homeostasis; tissue homeostasis; endothelial cell biology; endothelial cells dysfunction; oxidative stress; redox signaling; aging; endothelial regulation of tissue repair

(This special issue belongs to the Section Molecular Biology)

Bone Development and Regeneration—4th Edition

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7648 | Submission Open

Keywords: osteoblast; osteocyte; osteoclast; mesenchymal stem cell; cell differentiation; epigenetics; omics; integrative analysis; biomaterials

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Biomarkers in Cancer and Metabolic Diseases

edited by

José Antonio Morales-González

and

Angel Morales-González

submission deadline 30 Sep 2026 | 4 articles | Viewed by 6902 | Submission Open

Keywords: biomarkers; cancer; metabolic disease; diagnosis; prognosis; treatment

(This special issue belongs to the Section Molecular Biology)

Erythrocyte Cell Death: Molecular Insights

edited by

Anton Tkachenko

submission deadline 30 Sep 2026 | 4 articles | Viewed by 5856 | Submission Open

Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death

(This special issue belongs to the Section Molecular Biology)

Molecular Biology of Hypoxia: 2nd Edition

edited by Yuji Arai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 2971 | Submission Open

Keywords: hypoxia; HIFs; normoxic environment

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanisms of Taste and Smell: From Physiology to Pathology

edited by

Mariano Mastinu

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1855 | Submission Open

Keywords: taste; olfaction; taste/smell processing; chemosensory dysfunction; genetic variations; neurodegeneration; perireceptor space; sensory nutrition; hypogeusia and hyposmia

(This special issue belongs to the Section Molecular Biology)

Current Trends and Future Directions in Antimicrobial Peptide Research

edited by

Sara Elsa Aita

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1779 | Submission Open

Keywords: antimicrobial peptides (AMPs); host defense; structure-function; antimicrobial agents; biomedical applications; antibiotic alternatives; antibiotic resistance

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Forensic Odontology, Legal Medicine, and Forensic Sciences

edited by

Ricardo Henrique Alves Da Silva

submission deadline 30 Sep 2026 | 2 articles | Viewed by 1247 | Submission Open

Keywords: forensic odontology; legal medicine; forensic sciences; forensic genetics; human identification; criminal database; quality assurance; age assessment; sex estimation; ancestry; time of death

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Aquatic Animal Reproduction, Breeding Strategies and Genetic Improvement

edited by

Jixing Zou

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1076 | Submission Open

Keywords: reproductive biology; aquaculture genetics; fish breeding; genomic selection; marker-assisted selection; genome editing; hybridization; genetic improvement; molecular breeding; sustainable animal production

(This special issue belongs to the Section Molecular Biology)

Glial Cells in Brain and Eye: Emerging Mechanisms and Functions in Health and Disease

edited by

Mario E. Guido

submission deadline 30 Sep 2026 | 1 articles | Viewed by 981 | Submission Open

Keywords: glial cells; brain & eye (retina); health & disease; neuronal regulation; therapeutic strategies; CNS; glia biology; cellular interactions

(This special issue belongs to the Section Molecular Biology)

Production and Biomedical Translation of Functional Biomolecules

edited by

Loredana Capobianco

and

Giorgia Natalia Iaconisi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 747 | Submission Open

Keywords: functional biomolecules; recombinant production; molecular engineering; structural characterization

(This special issue belongs to the Section Molecular Biology)

Molecular and Immunological Mechanisms Associated with Exercise

edited by

Sebastian Del Rosso

submission deadline 30 Sep 2026 | Viewed by 627 | Submission Open

Keywords: signaling pathways; exercise training adaptation; exercise and mitochondrial health; skeletal muscle secretome; exercise and extracellular vesicles; myokines; exerkines; molecular immune responses to exercise

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Physiology and Pathophysiology

edited by

Yonghui Zhao

and

Tarek Mohamed Abd El-Aziz

submission deadline 30 Sep 2026 | Viewed by 545 | Submission Open

Keywords: ion channels; physiology; pathophysiology; channelopathies; membrane proteins; cellular signaling; electrophysiology; structural biology; inflammation; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Novel Insights into Vascular Biology

edited by

Cristina Ribas Fürstenau

submission deadline 30 Sep 2026 | 1 articles | Viewed by 534 | Submission Open

Keywords: interorgan vascular communication; vascular immunology; endothelial metabolism; mechanotransduction; vascular plasticity

(This special issue belongs to the Section Molecular Biology)

Molecular Advances of Gut–Brain Communications

edited by

Walter Pirovano

submission deadline 30 Sep 2026 | Viewed by 482 | Submission Open

Keywords: gut-brain axis; microbiome; molecular profiling; omics/multi-omics data; functional measurements; analytical methods; computational methods; neurological disorders; neuropsychiatric disorders

(This special issue belongs to the Section Molecular Biology)

Cellular Pathways and Cytokine Networks in Tuberous Sclerosis: Mechanisms and Therapeutic Targets

edited by Uchenna John Unachukwu

submission deadline 30 Sep 2026 | Viewed by 480 | Submission Open

Keywords: mTOR signaling dysregulation; neurocristopathy; cytokine crosstalk; TSC1/TSC2 complex; epigenetic modifiers; metabolic reprogramming; molecular biomarkers; spatial transcriptomics

(This special issue belongs to the Section Molecular Biology)

Patient-Derived iPSC Models in Chronic Disease Research

edited by

Valentina Parra

submission deadline 30 Sep 2026 | Viewed by 421 | Submission Open

Keywords: induced pluripotent stem cells; patient-derived iPSCs; chronic diseases; disease modeling; molecular mechanisms; stem cell differentiation; gene editing; organoids; personalized medicine; multi-omics

(This special issue belongs to the Section Molecular Biology)

Molecular Interplay: Natural Antioxidants as Modulators of Redox Homeostasis

edited by

Giovanni Pratelli

and

Daniela Carlisi

submission deadline 30 Sep 2026 | Viewed by 362 | Submission Open

Keywords: natural antioxidants; oxidative stress; chronic diseases; molecular mechanisms; cancer; neurodegenerative diseases; metabolic disorders; redox biology; omics; precision medicine

(This special issue belongs to the Section Molecular Biology)

Novel Insights into Endothelial Cell Biology

edited by

Takato Hara

and

Toshiyuki Kaji

submission deadline 30 Sep 2026 | Viewed by 350 | Submission Open

Keywords: endothelial cell heterogeneity; mechanotransduction; endothelial–immune interactions; endothelial senescence; vascular barrier regulation; extracellular vesicles; angiogenesis and vascular remodeling; endothelial metabolism; endothelial regulation of the fibrinolytic system

(This special issue belongs to the Section Molecular Biology)

Molecular Studies of Cartilage Deformation

edited by

Kazuo Yudoh

submission deadline 30 Sep 2026 | Viewed by 331 | Submission Open

Keywords: osteoarthritis; chondrocyte; mitochondria function; mechanical stress; oxidative stress; cartilage metabolism

(This special issue belongs to the Section Molecular Biology)

MicroRNAs in Cancer: Molecular Mechanisms and Regulatory Networks

edited by

Yarely M. Salinas-Vera

submission deadline 30 Sep 2026 | Viewed by 294 | Submission Open

Keywords: microRNAs; cancer; non-coding RNAs; gene regulation; tumor microenvironment; transcriptomics; cancer signaling

(This special issue belongs to the Section Molecular Biology)

TRIM Family Proteins and Beyond: Molecular Mechanisms in Tissue Homeostasis and Disease

edited by

Chuanxi Cai

submission deadline 30 Sep 2026 | Viewed by 290 | Submission Open

Keywords: TRIM family proteins; E3 ubiquitin ligases; protein homeostasis; autophagy and selective autophagy; innate immunity and antiviral defense; signal transduction; post-translational modifications; phase separation; tissue homeostasis; cancer biology; heart failure; neurodegeneration; inflammation and immunity; molecular mechanisms of disease; biomarkers and therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Effects of Radiation on Biomolecules and Cells: Mechanisms, Responses, and Biological Implications

edited by

Sachin Gulati

submission deadline 30 Sep 2026 | Viewed by 274 | Submission Open

Keywords: radiation biology; biomolecular damage; cellular responses; DNA damage and repair; oxidative stress; radioprotection; radiotherapy; dosimetry; molecular mechanisms; radiation-induced toxicity

(This special issue belongs to the Section Molecular Biology)

Advanced In Vitro Models: Integrating the 3Rs in Translational Science

edited by Glaucia Maria Machado-Santelli

submission deadline 30 Sep 2026 | Viewed by 257 | Submission Open

Keywords: 3Rs principles; advanced in vitro models; molecular mechanisms; cell signaling; organoids; organ-on-chip; translational research; molecular profiling; tissue engineering; redox biology; microphysiological systems; translational research; alternative methods to animal testing; nanotechnology in biomedicine; tissue engineering; drug discovery platforms

(This special issue belongs to the Section Molecular Biology)

Metabolic Reprogramming in Cancer: Non-Coding RNAs as Regulators and Biomarkers

edited by

Christos Papaneophytou

submission deadline 30 Sep 2026 | Viewed by 208 | Submission Open

Keywords: metabolic enzymes; circulating biomarkers; non-coding RNAs; circulating free DNA; liquid biopsy; metabolic reprogramming; artificial intelligence; biomarker discovery; precision medicine

(This special issue belongs to the Section Molecular Biology)

Quantitative Physiology of Mitochondria: Integration of Theory, Computation and High-Throughput Experimentation

edited by

Tsz-Leung To

submission deadline 30 Sep 2026 | Viewed by 196 | Submission Open

Keywords: mitochondria; systems biology; quantitative physiology; multi-omics; computational modeling; bioenergetics; thermodynamics and kinetics; metabolic networks; physicochemical modeling; virtual cells

(This special issue belongs to the Section Molecular Biology)

The Na, K-ATPase in Health and Disease: 2nd Edition

edited by

Liora Shoshani

submission deadline 30 Sep 2026 | Viewed by 192 | Submission Open

Keywords: Na+,K+-ATPase; α-subunit; β-subunit; γ subunits; FXYD

(This special issue belongs to the Section Molecular Biology)

Protease Inhibitors: Their Impact on Inflammatory Pathologies and Cancer

edited by

Sergio Daishi Sasaki

submission deadline 30 Sep 2026 | Viewed by 184 | Submission Open

Keywords: protease inhibitors; matrix metalloproteinases (MMPs); cathepsins (cysteine proteases); serine proteases; metastasis and invasion; chronic inflammation; angiogenesis; protease activated receptor (PAR)

(This special issue belongs to the Section Molecular Biology)

Mesenchymal Stem Cells and Their Derivatives in Tissue Regeneration

edited by Vladislav Volarevic

submission deadline 30 Sep 2026 | Viewed by 173 | Submission Open

Keywords: mesenchymal stem cells; exosomes; extracellular vesicles; immunomodulation; tissue regeneration; stem cell-based therapy

(This special issue belongs to the Section Molecular Biology)

Mitochondria: Central Players in Cancer

edited by

Annamaria Piscazzi

and

Domenica Mangieri

submission deadline 20 Oct 2026 | 4 articles | Viewed by 15535 | Submission Open

Keywords: mitochondria; cancer; tumorigenesis; oxidative phosphorylation; glycolysis; Warburg effect; reactive oxygen species (ROS); apoptosis; mitochondrial dysfunction; metabolic reprogram-ming; cancer therapy

(This special issue belongs to the Section Molecular Biology)

Macro- and Micronutrients in Health and Diseases

edited by

Karolina Orywal

and Mariusz Gryko

submission deadline 20 Oct 2026 | 4 articles | Viewed by 11004 | Submission Open

Keywords: macronutrients; micronutrients; vitamins; macrominerals; trace elements; cancer; obesity; cardiovascular diseases; diabetes; osteoporosis; immune disorders; neurodegenerative diseases

(This special issue belongs to the Section Molecular Biology)

Sperm Oxidative Stress and Male Infertility

edited by

Kamil Gill

submission deadline 20 Oct 2026 | 5 articles | Viewed by 9998 | Submission Open

Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into the Role of Exercise in Disease and Health, 2nd Edition

edited by

Brisamar Estébanez

, María José Cuevas-González and Chun-Jung Huang

submission deadline 20 Oct 2026 | 3 articles | Viewed by 6694 | Submission Open

Keywords: physical activity; molecular mechanisms; disease prevention; metabolic health; cardiovascular diseases; neurodegenerative diseases; sarcopenia; immune function; healthy aging; epigenetics

(This special issue belongs to the Section Molecular Biology)

RNA in Human Diseases: Challenges and Opportunities: 2nd Edition

edited by

Nicoletta Potenza

submission deadline 20 Oct 2026 | 7 articles | Viewed by 5396 | Submission Open

Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification

(This special issue belongs to the Section Molecular Biology)

Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security

edited by

Bruno Lapied

and David Barry Sattelle

submission deadline 20 Oct 2026 | 2 articles | Viewed by 3667 | Submission Open

Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies

(This special issue belongs to the Section Molecular Biology)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 20 Oct 2026 | 2 articles | Viewed by 2350 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Amyloid-β: An Antimicrobial Defense Peptide

edited by

Anna Lia Asti

submission deadline 20 Oct 2026 | 1 articles | Viewed by 788 | Submission Open

Keywords: amyloid (Aß); aggregation prone regions (ARPs); lipopolysaccharide (LPS); amphipathic molecules; LL-37 peptide; neurodegeneration; aggregation inhibition; Alzheimer's disease (AD)

(This special issue belongs to the Section Molecular Biology)

Molecular and Neuromuscular Mechanisms in Skeletal Muscle Aging, 2nd Edition

edited by

Rosa Mancinelli

submission deadline 23 Oct 2026 | 5 articles | Viewed by 12472 | Submission Open

Keywords: aging; sarcopenia; neuromuscular junction; molecular muscle modifications; myokines

(This special issue belongs to the Section Molecular Biology)

Radiobiology—New Advances

edited by

Marco Calvaruso

and

Luigi Minafra

submission deadline 23 Oct 2026 | 3 articles | Viewed by 6126 | Submission Open

Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy

(This special issue belongs to the Section Molecular Biology)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 23 Oct 2026 | Viewed by 537 | Submission Open

Keywords: zinc finger proteins: structure, function and properties, applications; protein folding and dynamics; environmental contaminants and metal ions exposure, uptake, toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Intermittent Hypoxia: Physiological and Biomedical Perspectives

edited by

Teresa Carbonell Camós

Olga Tura-Ceide

and Norma Alva

submission deadline 30 Oct 2026 | 4 articles | Viewed by 3385 | Submission Open

Keywords: altitude training; cardiovascular adaptation; endothelial dysfunction; EPO; intermittent hypoxia conditioning programs; HIF-1; neuroplasticity; obstructive sleep apnea; oxidative stress; pulmonary hypertension

(This special issue belongs to the Section Molecular Biology)

Focus on the Tryptophan Pathway

edited by

Burkhard Poeggeler

submission deadline 30 Oct 2026 | 2 articles | Viewed by 3294 | Submission Open

Keywords: aging; indole-3-propionic acid; kynurenic acid; melatonin; serotonin; tryptophan

(This special issue belongs to the Section Molecular Biology)

Stem Cells in Development and Regenerative Medicine: Molecular Insights

edited by

Jesus Chimal-Monroy

submission deadline 30 Oct 2026 | 1 articles | Viewed by 519 | Submission Open

Keywords: stem cells; cell differentiation; tissue regeneration; regenerative medicine; signaling pathways; gene expression

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 30 Oct 2026 | Viewed by 447 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease

edited by

Tania Fiaschi

submission deadline 30 Oct 2026 | Viewed by 435 | Submission Open

Keywords: lactate; GPR81 receptor; signaling cascade

(This special issue belongs to the Section Molecular Biology)

Zebrafish Models of Human Disease: Uncovering Immunometabolic Mechanisms and Therapeutic Targets

edited by Juliana Moreira Mendonça Gomes

submission deadline 30 Oct 2026 | Viewed by 214 | Submission Open

Keywords: zebrafish; immunometabolism; metabolism; inflammation; cancer; obesity; diabetes; cardiovascular disease; MASH; disease modeling

(This special issue belongs to the Section Molecular Biology)

Design of Bioactive Agents and Interaction with Biological Systems

edited by

Josef Jampilek

submission deadline 31 Oct 2026 | 3 articles | Viewed by 5897 | Submission Open

Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry

(This special issue belongs to the Section Molecular Biology)

Bone and Cartilage Injury and Repair: Molecular Aspects

edited by Silvia María Díaz-Prado

submission deadline 31 Oct 2026 | 2 articles | Viewed by 5695 | Submission Open

Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Reproduction and Fertility of Aquatic Animals: 3rd Edition

edited by

Hui Qiao

and Hongtuo Fu

submission deadline 31 Oct 2026 | 5 articles | Viewed by 5180 | Submission Open

Keywords: reproduction; aquatic animals; sex determination; gonadal development; steroid hormones; sex-related genes; monosex culture

(This special issue belongs to the Section Molecular Biology)

Advancements in Pathogen Detection, Microdevice Technologies and AI-Driven Analysis

edited by

Younseong Song

submission deadline 31 Oct 2026 | 3 articles | Viewed by 4565 | Submission Open

Keywords: pathogen detection; microfluidic; microdevice; AI analysis; virus; bacteria; point-of-care testing; infectious disease; nanotechnology

(This special issue belongs to the Section Molecular Biology)

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