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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Treatment of Chronic Kidney Disease
edited by Xinming Chen
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2006 | Submission Open
Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
Cellular Oxygen Homeostasis—3rd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2004 | Submission Open
Keywords: cellular oxygen homeostasis; redox signaling; cellular oxygen sensing; hypoxia; hyperoxia
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism of Extracellular Vesicles in Human Diseases
edited by Eszter Ágnes Tóth
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1617 | Submission Open
Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions
(This special issue belongs to the Section Molecular Biology)
Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1354 | Submission Open
Keywords: inflammation; autophagy; apoptosis; pyroptosis; necroptosis; PANoptosis; ferroptosis; cell death; cell survival
(This special issue belongs to the Section Molecular Biology)
miRNAs in Cancers: From Molecular Biology to Treatment
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 861 | Submission Open
Keywords: cancer; miRNA; epigenetic
(This special issue belongs to the Section Molecular Biology)
Extracellular Vesicles: Functions and Therapeutic Applications
edited by Deepshikha Tewari
submission deadline 20 Sep 2025 | Viewed by 841 | Submission Open
Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases
(This special issue belongs to the Section Molecular Biology)
Red Blood Cell Dysfunction and Hemodynamic Changes in Inflammation, Infection and Metabolic Disease
edited by Janette Bester
submission deadline 20 Sep 2025 | 1 articles | Viewed by 580 | Submission Open
Keywords: red blood cell; inflammation; infection; metabolic disease; hemodynamics
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Energy Metabolism in Cells and Tissues
edited by
submission deadline 20 Sep 2025 | Viewed by 368 | Submission Open
Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism
(This special issue belongs to the Section Molecular Biology)
Recent Progress in Extracellular Vesicles submission deadline 20 Sep 2025 | Viewed by 367 | Submission Open
Keywords: extracellular vesicles (EVs); macrovesicles; exosomes; cell– cell comunication
(This special issue belongs to the Section Molecular Biology)
Research on the Mechanism of Ferroptosis
edited by and
submission deadline 20 Sep 2025 | Viewed by 340 | Submission Open
Keywords: ferroptosis; programmed cell death; targeted drugs; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Molecular and Genomics Advances in Behaviours
edited by
submission deadline 20 Sep 2025 | Viewed by 314 | Submission Open
Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders
(This special issue belongs to the Section Molecular Biology)
Environmental Contributors to Oxidative Stress: Mechanisms and Effects
edited by Halina Tkaczenko and
submission deadline 20 Sep 2025 | Viewed by 313 | Submission Open
Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health
(This special issue belongs to the Section Molecular Biology)
Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health
edited by and Andrea Corsello
submission deadline 20 Sep 2025 | Viewed by 301 | Submission Open
Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome
(This special issue belongs to the Section Molecular Biology)
RNA in Biology and Medicine (2nd Edition)
edited by and William A. Haseltine
submission deadline 20 Sep 2025 | Viewed by 64 | Submission Open
Keywords: noncoding RNAs; coding RNAs; RNA-based therapy; RNA vaccine; RNA structure; RNA function
(This special issue belongs to the Section Molecular Biology)
Molecular Epigenetic Mechanisms in Cognition
edited by Sabrina Venditti
submission deadline 25 Sep 2025 | 1 articles | Viewed by 512 | Submission Open
Keywords: epigenetics; DNA methylation; histone modifications; noncoding RNAs; cognition; learning and memory; neuroplasticity; neurodegeneration; ASD; training
(This special issue belongs to the Section Molecular Biology)
Biomarker Discovery in Oral Diseases: Integrating Connected Health and Digital Biomarkers for Advanced Diagnostics and Personalized Care submission deadline 25 Sep 2025 | 1 articles | Viewed by 398 | Submission Open
Keywords: oral diseases; biomarker; proteomics; metabolomics
(This special issue belongs to the Section Molecular Biology)
Progress of Molecular Biology and Physiology in Lepidopteran Insects submission deadline 30 Sep 2025 | 7 articles | Viewed by 9385 | Submission Open
Keywords: silkworm; Bombyx mori; Lepidopteran insects; molecular biology; physiology; genome analysis; mode of action; genome editing
(This special issue belongs to the Section Molecular Biology)
New Advances in Erythrocyte Biology and Functions
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 2416 | Submission Open
Keywords: erythrocyte; red blood cells; red blood functions; vascular function; blood bank storage
(This special issue belongs to the Section Molecular Biology)
Hypoxia: Molecular Mechanism and Health Effects submission deadline 30 Sep 2025 | 1 articles | Viewed by 1768 | Submission Open
Keywords: hypoxia; inflammation; oxidative stress; metabolic conditions; hypoxia-inducible factors (HIFs); oxidative stress; mitochondrial dysfunction; angiogenesis; metabolic reprogramming; apoptosis
(This special issue belongs to the Section Molecular Biology)
Advancing Regenerative Medicine: Basic Research and Translation in Clinics
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 1102 | Submission Open
Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics
(This special issue belongs to the Section Molecular Biology)
Molecular Research in Obesity and Obesity Related Disorders: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 921 | Submission Open
Keywords: biochemistry and molecular medicine; molecular and cellular mechanisms of disease pathogenesis; pathogenesis of metabolic disorders; the role of interaction between genetic and environmental factors in the pathogenesis of non-communicable diseases; atherosclerosis; obesity; obesity-related metabolic diseases and cancers
(This special issue belongs to the Section Molecular Biology)
New Advances in Platelet Biology and Functions: 3rd Edition
edited by
submission deadline 30 Sep 2025 | 2 articles | Viewed by 892 | Submission Open
Keywords: platelet microparticles; thrombosis; inflammation; oxidative stress; antiplatelet drug; signal transduction; immunity; tumor growth
(This special issue belongs to the Section Molecular Biology)
Bone and Cartilage Injury and Repair: Molecular Aspects
edited by Silvia María Díaz-Prado
submission deadline 30 Sep 2025 | 2 articles | Viewed by 832 | Submission Open
Keywords: bone and cartilage repair; regenerative medicine; inflammation and immune response; stem cell therapy; extracellular matrix remodeling; biomaterials; drug delivery systems; therapeutic targets; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms and Functions of Extracellular Vesicles
edited by and Jameel M. Inal
submission deadline 30 Sep 2025 | 1 articles | Viewed by 696 | Submission Open
Keywords: extracellular vesicles; molecular mechanisms; biomarkers; liquid biopsy; cell-communication; cellular function; pathobiology; clinical
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Functions and Dynamics
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 655 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease
edited by
submission deadline 30 Sep 2025 | 1 articles | Viewed by 536 | Submission Open
Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanism of VCP/p97 in Health and Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 406 | Submission Open
Keywords: AAA ATPase; VCP/p97/cdc48/TER ATPase; AAA ATPase; protein unfolding; protein degradation; protein quality control; ERAD; mitochondria-associated degradation; lysosome degradation; ribosome-associated degradation; membrane fusion and trafficking; ubiquitin; TDP43; inclusion body myopathy (IBM); paget disease (PD); frontotemporal dementia (FD); MSP1; amyotrophic lateral sclerosis (ALS); charcot-marie-tooth disease 2Y; Parkinson’ s disease; intellectual development disabilities (IDDs); lysosomal diseases; tauopathies
(This special issue belongs to the Section Molecular Biology)
Molecular Forensics and the Genetic Foundations of Forensic Biology
edited by
submission deadline 30 Sep 2025 | Viewed by 183 | Submission Open
Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault
(This special issue belongs to the Section Molecular Biology)
Foundational Studies Using Model Systems for Molecular Insights into Metabolism, Aging, and Disease
edited by
submission deadline 30 Sep 2025 | Viewed by 136 | Submission Open
Keywords: Saccharomyces cerevisiae  and yeasts; Caenorhabditis elegans  and nematodes; Arabidopsis thaliana  and plants; Drosophila melanogaster; Mus musculus; established and emerging model systems  
(This special issue belongs to the Section Molecular Biology)
Psychobiotics as Next-Generation Probiotics: A Holistic Approach to Mental Health and Gut–Brain Axis Modulation submission deadline 30 Sep 2025 | Viewed by 134 | Submission Open
Keywords: probiotics; gut microbiota; gut– brain axis; mental health
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Assisted Reproductive Technologies
edited by
submission deadline 30 Sep 2025 | Viewed by 125 | Submission Open
Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology; morpho kinetics; in vitro gametogenesis; in vitro oocyte maturation; reproductive tissue cryopreservation; artificial intelligence (AI)
(This special issue belongs to the Section Molecular Biology)
Biological Effects of Radiation on Human Cells and Tissues submission deadline 30 Sep 2025 | Viewed by 122 | Submission Open
Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity
(This special issue belongs to the Section Molecular Biology)
Intercellular Adhesion and Inflammatory Response in Cancer
edited by Anna Pryczynicz
submission deadline 30 Sep 2025 | Viewed by 97 | Submission Open
Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment
(This special issue belongs to the Section Molecular Biology)
RNA in Human Diseases: Challenges and Opportunities: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 79 | Submission Open
Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms of Apoptosis and Aging Complexes
edited by
submission deadline 30 Sep 2025 | Viewed by 78 | Submission Open
Keywords: cell biology; antioxidants; transmembrane signalisation; actin cytoskeleton; anti-tumor therapy; cytotoxicity; apoptosis; aging; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Insights on Myogenic Progenitors: Regulation of Differentiation
edited by
submission deadline 30 Sep 2025 | Viewed by 73 | Submission Open
Keywords: myogenic progenitors; skeletal muscle; muscle regeneration; myogenesis
(This special issue belongs to the Section Molecular Biology)
Regulatory Mechanisms in Kidney Development and Function
edited by Gary F. Gerlach
submission deadline 30 Sep 2025 | Viewed by 67 | Submission Open
Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN
(This special issue belongs to the Section Molecular Biology)
The Role of Extracellular Vesicles in Disease and Therapeutic Applications
edited by Sunyoung Park
submission deadline 30 Sep 2025 | Viewed by 66 | Submission Open
Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Pathways Involved in Age-Related Musculoskeletal Disorders
edited by and Neha Dole
submission deadline 1 Oct 2025 | Viewed by 118 | Submission Open
Keywords: musculoskeletal disorders; cellular senescence; aging; genetic mutations; oxidative stress; mitochondrial dysfunction; bone homeostasis
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Allergy and Asthma: 3rd Edition submission deadline 20 Oct 2025 | 7 articles | Viewed by 12413 | Submission Open
Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology
(This special issue belongs to the Section Molecular Biology)
Research and Application of Platelet-Rich Plasma (PRP)
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 10897 | Submission Open
Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration
(This special issue belongs to the Section Molecular Biology)
Targeting RNA Molecules submission deadline 20 Oct 2025 | 3 articles | Viewed by 9677 | Submission Open
Keywords: riboswitch; noncoding RNA; antibiotics; resistance; bacteria; antimicrobial resistance
(This special issue belongs to the Section Molecular Biology)
Exosomes—3rd Edition
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7882 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes; cancer; sleep cardiovascular diseases; lung disease and upper airways; obesity; sleep and end-organ morbidity
(This special issue belongs to the Section Molecular Biology)
Molecular Research and Treatment in Multiple Sclerosis
edited by Nada Starčević Čizmarević and
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6430 | Submission Open
Keywords: multiple sclerosis; neuroinflammation; neurodegeneration; genetics; molecular research; biomarkers; neuroimaging; therapy
(This special issue belongs to the Section Molecular Biology)
Ion Channels as a Potential Target in Pharmaceutical Designs 2.0
edited by
submission deadline 20 Oct 2025 | 6 articles | Viewed by 6090 | Submission Open
Keywords: ion currents; current kinetics; gating properties; voltage-dependent hysteresis; frequency-dependent regulation; small-molecule modulator
(This special issue belongs to the Section Molecular Biology)
The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 5862 | Submission Open
Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Cancer and Molecular Imaging
edited by Mi-Ae Park
submission deadline 20 Oct 2025 | 3 articles | Viewed by 5516 | Submission Open
Keywords: molecular imaging; radiology; cancer detection; precision medicine; cancer mechanisms
(This special issue belongs to the Section Molecular Biology)
Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition
edited by
submission deadline 20 Oct 2025 | 2 articles | Viewed by 4768 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes; release; uptake; bio-distribution; methods; biomarkers; therapeutic applications
(This special issue belongs to the Section Molecular Biology)
Zebrafish as a Model for Biomedical Studies—2nd Edition submission deadline 20 Oct 2025 | 3 articles | Viewed by 4594 | Submission Open
Keywords: zebrafish; cancer; metabolic diseases; neurological disorders; infectious diseases; xenografts; drug discovery
(This special issue belongs to the Section Molecular Biology)
Molecular Aspects of Cartilage Biology
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 4321 | Submission Open
Keywords: cartilage biology; tissue regeneration; molecular mechanisms; chondrocytes; cartilage disorders; therapeutic interventions; biomaterials
(This special issue belongs to the Section Molecular Biology)
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