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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unveiling Mental Disorders: Molecular Mechanisms and Innovative Therapies

edited by Blerida Banushi

submission deadline 25 Jul 2025 | 2 articles | Viewed by 7583 | Submission Open

Keywords: molecular psychiatry; epigenetics; neurobiology; gene– environment interactions; neuroplasticity; psychopharmacology; neuromodulation; personalized medicine; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances and Emerging Trends in Marine Natural Products

edited by Rafael Félix and

Carina Félix

submission deadline 25 Jul 2025 | 2 articles | Viewed by 983 | Submission Open

Keywords: marine natural products; bioprospecting; circular bioeconomy; bioactive compounds; antioxidant; antimicrobial; anti-inflammatory; polymers; peptides; genome mining; enzyme inhibitors; plant priming; green extraction methodologies

(This special issue belongs to the Section Molecular Pharmacology)

Mesenchymal Stem Cell-Based Therapy: Cell Therapy vs. EV Therapy

edited by Masahito Nakazaki

submission deadline 25 Jul 2025 | Viewed by 340 | Submission Open

Keywords: mesenchymal stromal/stem cells; small extracellular vesicles; large extracellular vesicles; clinical trials; spinal cord injury; cerebrovascular disease

(This special issue belongs to the Section Biochemistry)

Design, Synthesis and Application of Drugs

edited by

Samir Chtita

submission deadline 25 Jul 2025 | Viewed by 304 | Submission Open

Keywords: drug design; drug synthesis; pharmaceutical applications; medicinal chemistry; pharmacology; drug development; molecular modeling; therapeutic agents; innovative therapies

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Immune Mechanisms in Pathogenic Mycobacteria Infections

edited by Fabiana Bigi and Federico Carlos Blanco

submission deadline 25 Jul 2025 | Viewed by 277 | Submission Open

Keywords: Mycobacterium tuberculosis; virulence; pathogens

(This special issue belongs to the Section Molecular Microbiology)

Advances in Plant Nematology Research

edited by

Sergei A. Subbotin

submission deadline 25 Jul 2025 | Viewed by 197 | Submission Open

Keywords: DNA barcoding; Molecular evolution; Genomes; Molecular systematics; Phylogenetics; Plant– nematode interactions; Transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

Host-Virus Interaction

edited by

Xiaohui Ju

and

Xupeng Hong

submission deadline 25 Jul 2025 | Viewed by 169 | Submission Open

Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies

(This special issue belongs to the Section Molecular Immunology)

Molecular Basic Research of Autoimmune Diseases

edited by

Shibei Wu

submission deadline 25 Jul 2025 | Viewed by 126 | Submission Open

Keywords: autoimmune diseases; immunogenetics; T cells; B cells; cytokines; therapeutic targets; biomarkers; environmental triggers; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hearing Loss: Recent Progress in Molecular Genomics

edited by

Chen-Chi Wu

submission deadline 28 Jul 2025 | 1 articles | Viewed by 558 | Submission Open

Keywords: hearing loss; high-throughput sequencing; prognostic analyses; translational medicine; gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Skin Diseases: Molecular Prediction, Diagnosis, Pathogenesis and Treatment

edited by

Youwen Zhou

submission deadline 28 Jul 2025 | Viewed by 99 | Submission Open

Keywords: molecular pathogenesis; pigmentation disorders; vitiligo; hair follicle biology; alopecia; androgenetic alopecia; acne; rosacea; Hidradenitis suppurativa; skin inflammation; genetic epidemiology; environmental triggers; translational dermatology; therapeutic innovation; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in DNA Nanotechnology

edited by Zhaoqi Yang

submission deadline 29 Jul 2025 | Viewed by 145 | Submission Open

Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Gestational Diabetes Mellitus

edited by Natasha Singh

submission deadline 30 Jul 2025 | 7 articles | Viewed by 11773 | Submission Open

Keywords: metabolome; placental insulin signaling; DNA methylation; mitochondrial oxidation; MTOR; amino acids lipidomics; proteomics; gluconeogenesis; GDM

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA Biology: Unraveling the Complex Interplay Between Proteins and RNAs in Gene Expression and Regulation

edited by

Rosemary Kiernan

submission deadline 30 Jul 2025 | 7 articles | Viewed by 10886 | Submission Open

Keywords: RNA biology; protein– RNA interplay; gene expression; post-transcriptional modifications; non-coding RNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Role of Inflammation in the Etiology of Precancerous Lesions, Carcinogenesis and Cancer Treatment

edited by

Boguslaw Nedoszytko

, Leszek Kalinowski and

Luigi Marano

submission deadline 30 Jul 2025 | 5 articles | Viewed by 9768 | Submission Open

Keywords: inflammation cascade in cancer initiation; progression and metastasis; inflammasome proteins; glycation; NOS isoforms; nitric oxide; oxidative and nitroxidative stress; DAMP; TLR; ferroptosis and necrosis in cancer etiology; COVID-19 infection; cancer and neurodegenerative isorders; inflammatory cells and cacer; primary and secondary inflammation cascade cytokines (IL-1; TNFα ; IL-18; IL-8; IL-6); chemokines; and growth factors in cancer; noncoding RNA and other epigenetic mechnisms in cancer; oxidative/nitroxidative-dependent cell signaling; breast; prostate; urogenital; renal; thyroiccolon and esophago-gastric cancers; melanomas; skin diseases associated with cancer; oncogenes; supressor genes; apoptosis; gene dysfunction and cancer; metabolomic; microbiotic; proteomic and genomic changes in cancer; biological drugs in inflammatory diseases and cancer treatment; effects of immunonutrition and microbiotic modulators on the inflammatory infiltration of the tumor microenvironment; neurodegenerative changes in cancer and after cancer treatmet; the regulatory feedback of inflammatory signaling and telomere/telomerase complex dysfunction in carcinogenesis and chronic inflammatory diseases

(This special issue belongs to the Section Molecular Immunology)

Innovative Molecular Strategies in Biomedicine

edited by

Rui Vitorino

submission deadline 30 Jul 2025 | 4 articles | Viewed by 8437 | Submission Open

Keywords: bioprinting; organ-on-chip; venom-derived therapeutics; 3D in vitro models; skeletal muscle models; toxic peptides; peptide expression; nanoparticles in medicine; protein and peptide drug delivery; peptide-based biomaterials; self-assembled hydrogels; molecular therapeutics; nanotechnology in drug delivery; regenerative medicine; tissue engineering

(This special issue belongs to the Section Materials Science)

Hearing Loss: Molecular Biological Insights

edited by María Beatriz Durán-Alonso

submission deadline 30 Jul 2025 | 5 articles | Viewed by 7824 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in Proteomics in Disease

edited by

Valeria Magnelli

submission deadline 30 Jul 2025 | 4 articles | Viewed by 7692 | Submission Open

Keywords: proteomics; protein; profile; molecular mechanism; biomarker; therapeutical agent

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors

edited by Lukasz Szafron

submission deadline 30 Jul 2025 | 5 articles | Viewed by 6919 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Stem Cells and Selected Papers Associated with 2023 STEMNET MEETING and Related Researchers

edited by

Katia Mareschi

and Ivana Ferrero

submission deadline 30 Jul 2025 | 4 articles | Viewed by 6915 | Submission Open

Keywords: mesenchymal stromal cell; advanced cell therapy; translational medicine; stem cell in veterinary; organoid; secretome

(This special issue belongs to the Section Biochemistry)

Advances in Plant Physiology, Biochemistry, and Biotechnology for Natural Product Synthesis

edited by

Farzana Sabir

submission deadline 30 Jul 2025 | 5 articles | Viewed by 6487 | Submission Open

Keywords: medicinal plants; natural products; phytomedicine

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of the Mitochondria in Human Health and Diseases

edited by

María Isabel Hernández-Alvarez

submission deadline 30 Jul 2025 | 2 articles | Viewed by 5333 | Submission Open

Keywords: mitochondria; mitochondria contact sites; metabolism; lipids; metabolites

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Product-Based Strategy for Skin Inflammatory Disorders and Regeneration

edited by

Mi Young Lee

submission deadline 30 Jul 2025 | 5 articles | Viewed by 5272 | Submission Open

Keywords: inflammatory skin disorders; skin wound healing and regeneration; skin aging; bioactive natural compound; derivative and conjugate; plant extract; beneficial effect and application; molecular mechanism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular and Cellular Mechanisms and the Pathophysiology of Skeletal Muscle Diseases

edited by

Gaetano Vattemi

submission deadline 30 Jul 2025 | 4 articles | Viewed by 4774 | Submission Open

Keywords: acquired muscle diseases; inherited muscle diseases; pathogenesis; molecular and cellular mechanisms; in vitro and in vivo models; treatment strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Topoisomerase Inhibitors: Future Perspectives and Challenges

edited by

Ben Bax

and Mark Mitton-Fry

submission deadline 30 Jul 2025 | 3 articles | Viewed by 4539 | Submission Open

Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety

(This special issue belongs to the Section Molecular Pharmacology)

Adsorption Materials and Adsorption Behavior: 3rd Edition

edited by

Jun Wang

submission deadline 30 Jul 2025 | 4 articles | Viewed by 4189 | Submission Open

Keywords: adsorption; adsorption materials; adsorption behavior; adsorption mechanisms; adsorption thermodynamics and kinetics; resource extraction; pollutant removal; separation

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Bone Biomaterials Research and 3D Spheroid Culture Systems in Osteogenesis

edited by

Chawon Yun

submission deadline 30 Jul 2025 | 1 articles | Viewed by 3705 | Submission Open

Keywords: osteogenic differentiation; 3D culture; bone regeneration; toxicological and pharmacological assessment; bone homeostasis; bone materials

(This special issue belongs to the Section Materials Science)

Protein Methyltransferases in Human Health and Diseases

edited by

Byron Baron

submission deadline 30 Jul 2025 | 1 articles | Viewed by 3067 | Submission Open

Keywords: lysine and arginine methylation; mass spectrometry; PTM cross talk; functional proteomics; cancer; neurological disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanism and Treatment of Allergic Asthma

edited by

Francesco Menzella

and Marcello Cottini

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2691 | Submission Open

Keywords: allergic asthma; epithelial barrier damage; protease allergen; type 2 inflammation

(This special issue belongs to the Section Molecular Immunology)

Antiviral Drugs Discovery

edited by

Dongwei Kang

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2566 | Submission Open

Keywords: antiviral agents; organic synthesis and medicinal chemistry; biological activity; drug design and computational chemistry; drug discovery and development

(This special issue belongs to the Section Molecular Pharmacology)

Pathogenicity and Antibiotic Resistance of Helicobacter pylori

edited by

Paweł Krzyżek

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2514 | Submission Open

Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors

(This special issue belongs to the Section Molecular Microbiology)

Current Insights into Nucleic Acids

edited by

David Stephen Pisetsky

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2269 | Submission Open

Keywords: nucleic acids; DNA; RNA; genome; gene function; gene regulation; gene structure

(This special issue belongs to the Section Molecular Genetics and Genomics)

Emerging Roles for Serotonin in Regulating Metabolism

edited by

Giuseppe Bruschetta

and

Patrizia Licata

submission deadline 30 Jul 2025 | 2 articles | Viewed by 2268 | Submission Open

Keywords: serotonin; cortisol; phospholipids; glycosaminoglycans; oxidative stress; veterinary anesthesia and analgesia

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Advances Related to Bone Regeneration

edited by

Gianluigi Pasta

and

Virginie Sottile

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2097 | Submission Open

Keywords: bone regeneration; bone extracellular matrix; regenerative medicine; biomaterials

(This special issue belongs to the Section Molecular Biology)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 30 Jul 2025 | 1 articles | Viewed by 2004 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Glycans in Immune Regulation

edited by Senlian Hong

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1774 | Submission Open

Keywords: glycoimmunology; glycotherapy; vaccines; glycan synthesis; immune tolerance

(This special issue belongs to the Section Molecular Immunology)

Advances in Design, Synthesis and Applications of Peptide Nucleic Acid

edited by

Maria Moccia

, Concetta Avitabile and

Annalisa Masi

submission deadline 30 Jul 2025 | 1 articles | Viewed by 1523 | Submission Open

Keywords: PNA; nucleic acid analog; molecular design; synthesis; delivery system; therapeutics; diagnostic

(This special issue belongs to the Section Molecular Biology)

Molecular and Structural Research Advances in Model Plants (Second Edition)

edited by

Ioannis-Dimosthenis Adamakis

submission deadline 30 Jul 2025 | 2 articles | Viewed by 1320 | Submission Open

Keywords: A. thaliana; plant biology; model organisms; plant models; non-model plant models

(This special issue belongs to the Section Molecular Plant Sciences)

Plant–Microbe Interactions: 2nd Edition

edited by Jian Jin

submission deadline 30 Jul 2025 | 2 articles | Viewed by 1085 | Submission Open

Keywords: plant; crop; rhizosphere microbiome; microbial colonization; quorum sensing; endophytic microbes

(This special issue belongs to the Section Molecular Plant Sciences)

Focus on Gastrointestinal Diseases: Inflammation, 3rd Edition

edited by

Marcello Candelli

submission deadline 30 Jul 2025 | Viewed by 1066 | Submission Open

Keywords: signal transduction; receptor signaling; infection and inflammation; protein interaction; tumor biology; growth factors; cytokines; cell death and differentiation; inflammation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

edited by Yang Mao-Draayer

submission deadline 30 Jul 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging

(This special issue belongs to the Section Molecular Neurobiology)

Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology

edited by

Giuseppe Murdaca

and

Sebastiano Gangemi

submission deadline 30 Jul 2025 | 1 articles | Viewed by 875 | Submission Open

Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies

(This special issue belongs to the Section Molecular Immunology)

The Role of Cytokines in Health and Diseases

edited by Hung-Jen Liu

submission deadline 30 Jul 2025 | 2 articles | Viewed by 852 | Submission Open

Keywords: cytokines; immune regulation; disease management; signaling pathways; translational research; clinical applications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Food-Derived Bioactive Peptides

edited by

Fidel Toldrá

and

Leticia Mora

submission deadline 30 Jul 2025 | 2 articles | Viewed by 611 | Submission Open

Keywords: peptides identification; peptides characterization; functional foods; biological activity; peptidomics; proteomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Hyperelastic Structures

edited by

Hossein Bakhshi Khaniki

and

Mergen Ghayesh

submission deadline 30 Jul 2025 | Viewed by 574 | Submission Open

Keywords: hyperelastic structures; biological properties; molecular properties; nonlinear elasticity; soft structures; material modeling

(This special issue belongs to the Section Materials Science)

Recent Advances in Molecular Mechanisms of Bacterial Resistance and Antibiotic Therapy

edited by

Xinyi Yang

submission deadline 30 Jul 2025 | 2 articles | Viewed by 554 | Submission Open

Keywords: bacterial resistance; antibiotics; antimicrobials; “ superbugs” ; clinical strains; laboratory induced-bacteria; antimicrobial peptides; antimicrobial combinations; hybrid antibiotics; repurposing drugs; anti-virulence agents; immune modulators; toxin neutralizers

(This special issue belongs to the Section Molecular Microbiology)

Molecular Diagnostic and Treatment Methods in Socially Significant Diseases in Urology

edited by

Elenko Popov

submission deadline 30 Jul 2025 | Viewed by 549 | Submission Open

Keywords: prostate cancer; bladder cancer; renal-cell cancer; risk stratification; urolithiasis; chronic UTIs; BPH; clinical decision-making

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer

edited by

Katharina M. Robertson

submission deadline 30 Jul 2025 | 1 articles | Viewed by 547 | Submission Open

Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Energy Metabolism and Obesity: 2nd Edition

edited by

Po-Shiuan Hsieh

submission deadline 30 Jul 2025 | Viewed by 466 | Submission Open

Keywords: energy metabolism; obesity; insulin resistance; glucose and lipid metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Radiation Resistance in Extremophile Bacteria: Unraveling the Molecular Mysteries

edited by

Sathiyaraj Srinivasan

submission deadline 30 Jul 2025 | Viewed by 455 | Submission Open

Keywords: extremophiles; radiation resistance; genome analysis; RNAseq; proteome studies; comparative analysis; molecular mechanisms; genetic adaptation; metabolic shifts; evolutionary insights; eukaryotic resistance

(This special issue belongs to the Section Molecular Microbiology)

Protein Kinase in Disease, 2nd Edition

edited by

Manae Suzuki Kurokawa

submission deadline 30 Jul 2025 | 1 articles | Viewed by 453 | Submission Open

Keywords: protein kinases; phosphorylation; cancers; inflammatory diseases; protein kinase inhibitors; anticancer drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1401-1450 on page 29 of 68.

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