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Molecular Advances Related to Bone Regeneration
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Molecular Advances Related to Bone Regeneration

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 2079

Special Issue Editors

Dr. Gianluigi Pasta

E-Mail Website
Guest Editor
Department of Orthopedic Surgery, IRCCS Fondazione Policlinico San Matteo, 27100 Pavia, Italy
Interests: orthopedic surgery; regenerative medicine; rare diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Virginie Sottile

E-Mail Website
Guest Editor
Immunology and General Pathology Unit, Department of Molecular Medicine, University of Pavia, 27100 Pavia, Italy
Interests: regenerative medicine; stem cells; biomaterials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bone is a dynamic tissue and the molecular mechanisms underlying its remodeling and regeneration are numerous. In orthopedic and maxillofacial surgery, bone tissue regeneration remains a major challenge. Bone defects can be caused by several adverse events (trauma, cancer, infections, congenital diseases or abnormal skeletal development). Several factors involved in bone regeneration process are able to regulate signaling cascades modifying cellular responses such as differentiation and proliferation. Particular interest is focused on the characteristics of bone extracellular matrix and the pathways related to its synthesis.

Nevertheless, there are still many aspects and new pathways to be clarified that could open new perspectives to new therapies aimed at regulating and stimulating bone regeneration.

Moreover, bone regeneration has to be considered part of regenerative medicine, with studies of new biomaterials and effects of physical stimuli such as electomagnetic waves and gravity on cell biology opening new therapeutic perspectives.

Dr. Gianluigi Pasta
Dr. Virginie Sottile
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone regeneration
  • bone extracellular matrix
  • regenerative medicine
  • biomaterials

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Published Papers (1 paper)

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Research

14 pages, 4281 KiB  
Article
A Biodegradable Tissue Adhesive for Post-Extraction Alveolar Bone Regeneration under Ongoing Anticoagulation—A Microstructural Volumetric Analysis in a Rodent Model
by Marius Heitzer, Philipp Winnand, Mark Ooms, Zuzanna Magnuska, Fabian Kiessling, Eva Miriam Buhl, Frank Hölzle and Ali Modabber
Int. J. Mol. Sci. 2024, 25(8), 4210; https://doi.org/10.3390/ijms25084210 - 10 Apr 2024
Cited by 1 | Viewed by 1525
Abstract
In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential [...] Read more.
In addition to post-extraction bleeding, pronounced alveolar bone resorption is a very common complication after tooth extraction in patients undergoing anticoagulation therapy. The novel, biodegenerative, polyurethane adhesive VIVO has shown a positive effect on soft tissue regeneration and hemostasis. However, the regenerative potential of VIVO in terms of bone regeneration has not yet been explored. The present rodent study compared the post-extraction bone healing of a collagen sponge (COSP) and VIVO in the context of ongoing anticoagulation therapy. According to a split-mouth design, a total of 178 extraction sockets were generated under rivaroxaban treatment, of which 89 extraction sockets were treated with VIVO and 89 with COSP. Post-extraction bone analysis was conducted via in vivo micro-computed tomography (µCT), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) after 5, 10, and 90 days. During the observation time of 90 days, µCT analysis revealed that VIVO and COSP led to significant increases in both bone volume and bone density (p ≤ 0.001). SEM images of the extraction sockets treated with either VIVO or COSP showed bone regeneration in the form of lamellar bone mass. Ratios of Ca/C and Ca/P observed via EDX indicated newly formed bone matrixes in both treatments after 90 days. There were no statistical differences between treatment with VIVO or COSP. The hemostatic agents VIVO and COSP were both able to prevent pronounced bone loss, and both demonstrated a strong positive influence on the bone regeneration of the alveolar ridge post-extraction. Full article
(This article belongs to the Special Issue Molecular Advances Related to Bone Regeneration)
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