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Focus on Gastrointestinal Diseases: Inflammation, 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 July 2025 | Viewed by 1256

Special Issue Editor


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Guest Editor
Emergency Anesthesiological and Reanimation Sciences, Fondazione Policlinico Universitario A. Gemelli, 00168 Roma, Italy
Interests: short stay unit; infection, sepsis; trauma; syncope; pulmonary embolism; inflammatory bowel disease; gastroenteritis; gastrointestinal bleeding; diverticulitis
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Special Issue Information

Dear Colleagues,

Gastrointestinal diseases are common, multifactorial pathologies related to specific genetic, infectious, environmental, and host factors. Understanding the molecular mechanisms underlying the interaction between these factors is critical to understanding the pathophysiology of gastrointestinal diseases and developing new therapies. These are extremely common diseases in the general population that impose high costs on healthcare systems around the world. The emerging role of the intestinal microbiome and local and general immune factors is transforming our understanding of gastrointestinal diseases. The identification of the molecular mechanisms involved in their development has also led to significant advances in the therapeutic field over the past 20 years. The use of biologic drugs that have altered the natural history of inflammatory bowel disease is a clear example. The molecular characterization of the interactions between external pathogens such as Helicobacter pylori and the host may also help to unravel the mechanisms that trigger inflammatory processes in the mucosa, as well as mutations that may predispose an individual to the occurrence of gastrointestinal cancer.

Since the first and second volumes of the Special Issue “Focus on Gastrointestinal Diseases” were successful, we are reopening this Issue in the International Journal of Molecular Sciences (ISSN 1422-0067, IF 6.208, JCR Category Q1). For this third Special Issue, we invite all interested researchers to contribute original research articles or literature reviews on all aspects related to the molecular mechanisms involved in the pathologies of the gastrointestinal system, with a particular focus on, but not limited to, inflammatory intestinal, pancreatic, and gastric diseases. Furthermore, manuscripts with a particular focus on inflammation will be highly welcomed.

https://www.mdpi.com/iournal/iims/Special Issues/FGD

https://www.mdpi.com/iournal/iims/Special Issues/FGD 2022

Dr. Marcello Candelli
Guest Editor

Manuscript Submission Information

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Keywords

  • signal transduction
  • receptor signaling
  • infection and inflammation
  • protein interaction
  • tumor biology
  • growth factors
  • cytokines
  • cell death and differentiation
  • inflammation

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Published Papers (1 paper)

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Review

18 pages, 469 KiB  
Review
Transforming Gastrointestinal Diagnosis with Molecular Endoscopy: Challenges and Opportunities
by Giuseppe Dell’Anna, Francesco Mandarino, Lucia Centanni, Ilaria Lodola, Jacopo Fanizza, Ernesto Fasulo, Sarah Bencardino, Lorenzo Fuccio, Antonio Facciorusso, Gianfranco Donatelli, Tommaso Lorenzo Parigi, Federica Furfaro, Ferdinando D’Amico, Sara Massironi, Alberto Malesci, Federica Ungaro, Silvio Danese and Vito Annese
Int. J. Mol. Sci. 2025, 26(10), 4834; https://doi.org/10.3390/ijms26104834 - 18 May 2025
Viewed by 86
Abstract
Molecular endoscopy represents a transformative advance in the detection, diagnosis, and management of gastrointestinal diseases, addressing the critical limitations of conventional techniques. Current diagnostic standards, such as white light endoscopy (WLE), often fail to detect early-stage lesions, particularly in high-risk populations like Barrett’s [...] Read more.
Molecular endoscopy represents a transformative advance in the detection, diagnosis, and management of gastrointestinal diseases, addressing the critical limitations of conventional techniques. Current diagnostic standards, such as white light endoscopy (WLE), often fail to detect early-stage lesions, particularly in high-risk populations like Barrett’s esophagus or inflammatory bowel disease patients. To overcome these challenges, molecular endoscopy, using fluorescent molecular probes, may offer ultimate precision by targeting disease-specific biomarkers. Technologies like Confocal Laser Endomicroscopy (CLE) and Immunoendoscopy are revolutionizing in vivo diagnostics, enabling the real-time visualization of tissue microarchitecture and physiological mechanisms. Fluorescence molecular endoscopy (FME) enhances the detection of precancerous and cancerous lesions, even those undetectable by conventional methods, by highlighting subtle molecular changes. Clinical applications include early tumor detection, therapy response monitoring, and improved lesion characterization. Despite these advancements, challenges persist, including high costs, a lack of standardization, and the need for specialized training. Recent innovations, such as a multi-parametric rigid standard, aim to ensure the reliable performance assessment and quality control of FME systems, addressing subjective variability and improving reproducibility. In addition, the integration of artificial intelligence (AI) with molecular endoscopy offers the potential to further reduce detection errors and significantly enhance diagnostic accuracy. This advancement underscores the potential of molecular endoscopy for personalized GI disease management, while highlighting the need for ongoing research to refine the technology, validate its clinical utility, and overcome the barriers to routine clinical application. Full article
(This article belongs to the Special Issue Focus on Gastrointestinal Diseases: Inflammation, 3rd Edition)
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