Emerging Roles for Serotonin in Regulating Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 July 2025 | Viewed by 2535
Special Issue Editors
Interests: determination and role of serotonin in integrating nervous, behavioral and neuroendocrine stress responses in mammals and fish; metabolism study of animal plasma and serum proteoglycans (PGs) and acid glycosaminoglycans (GAGs) and their antioxidant activity; characterization of plasma and erythrocyte membranes phospholipid composition in animal species and their relationship with GAGs; stress response of Sparus aurata by investigating the functional properties of the hemoglobin system and globin gene expression
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Interests: circulation serotonin concentration as a pivotal biomarker of animal stress; studies of ecotoxicology and risk from xenobiotics; investigation on the effects of xenobiotics with potential endocrine or carcinogenic activity on fish models; studies on the in vivo and in vitro effects of anti-inflammatory substances; research for contaminants in fresh and processed foods for humans
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Special Issue Information
Dear Colleagues,
Physical and psychological stress in humans is most frequently monitoring by means of the adrenocortical response and blood parameters. Serotonin (5-Hydroxytryptamine, 5-HT) is a biogenic amine that functions as a neurotransmitter and as a stress response mediator. The serotoninergic system is anatomically and functionally largely conserved across vertebrate species where the neurotransmitter serotonin is known to modulate different biological functions, either centrally or peripherally: it can regulate a wide range of immunomodulatory effects, and there is evidence that high 5-HT concentrations appear to stabilize HPA axis activity. In addition, monoamines and their associated enzymes as well as receptors are also present in peripheral tissues, including the gastrointestinal tract, where they are thought to be involved in the regulation of nutrient absorption, blood flow, and gut motility. There are two sites for the production of 5-HT in the gut by specific epithelial cells called enterochromaffin (EC) cells and enteric serotoninergic neurons. Tryptophan is the essential amino acid precursor of 5-HT, in a two-step process, strongly conserved in the animal kingdom, by the action of the enzymes tryptophan hydroxylase (TPH) and 5-hydroxy tryptophan decarboxylase. TPH expression is limited to a few specific cells. Two TPH enzymes exist, including peripheral (TPH-1), which are found in EC cells, and central (TPH-2) isoforms, uniquely found in both the brain and intestine. The serotoninergic system in mammals is modulated by a variety of environmental factors, and it is a target for several environmental stressors that may interfere with the physiological and pathological modulation of 5-HT by seasonal influences, including photoperiods, diurnal variations, temperature, diet, influences of sex steroid hormones, and so on.
Dr. Giuseppe Bruschetta
Prof. Dr. Patrizia Licata
Guest Editors
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Keywords
- serotonin
- cortisol
- phospholipids
- glycosaminoglycans
- oxidative stress
- veterinary anesthesia and analgesia
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