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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fibrotic Disease: From Pathophysiology to Treatment
edited by Galina S. Bogatkevich
submission deadline 20 Jul 2025 | Viewed by 959 | Submission Open
Keywords: lung; liver; heart; kidney; fibrosis; systemic sclerosis; mechanisms; pathophysiology; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Pharmacogenetics
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 949 | Submission Open
Keywords: pharmacogenetics; pharmacokinetics; pharmacodynamics; genotype; haplotype; biomarker; single-nucleotide polymorphism; genomic variant; genetic testing; adverse drug reactions; clinical implementation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights in Bacterial Infection Research: From Mechanisms to Therapies
edited by Marcin Równicki and
submission deadline 20 Jul 2025 | Viewed by 940 | Submission Open
Keywords: bacteria; infection; antibiotic resistant; bacterial persisters; antimicrobial therapies; host-pathogen interactions
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Nanomedicines Against Bacterial Infections
edited by , Nuno Guimarães, and
submission deadline 20 Jul 2025 | Viewed by 921 | Submission Open
Keywords: nanotechnology; nanoparticle; nanocarriers; nanoantibiotic; drug delivery system; targeted delivery; theranostic; infectious diseases; antibacterial agent; antimicrobial resistance; biomedical application
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Genetic Variants of Parkinson’s Disease
edited by Michael Schlossmacher and
submission deadline 20 Jul 2025 | 1 articles | Viewed by 910 | Submission Open
Keywords: DNA; PD prevention; genetic variants of Parkinson's disease
(This special issue belongs to the Section Molecular Neurobiology)
Interplay of Metabolism and Inflammation in Gastrointestinal Disease
edited by Marios Papadakis and
submission deadline 20 Jul 2025 | Viewed by 881 | Submission Open
Keywords: gastrointestinal diseases; inflammation; metabolic dysregulation; metabolic processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research on Tumor Suppressor Proteins
edited by Jie Liu
submission deadline 20 Jul 2025 | 1 articles | Viewed by 835 | Submission Open
Keywords: DNA repair; genome stability; tumor suppressor; BRCA1; BRCA2; PALB2; RAD51C
(This special issue belongs to the Section Molecular Oncology)
Molecular Research in Redox Balance in Pathological and Physiological Conditions
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 834 | Submission Open
Keywords: oxidative stress; nitrosative stress; antioxidative stress; redox signaling; inflammation; antioxidants; reactive oxygen species; reactive nitrogen species; pathological states; physiological condition
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Neurologic and Neurodegenerative Disorders submission deadline 20 Jul 2025 | 1 articles | Viewed by 788 | Submission Open
Keywords: traumatic brain injury; chronic traumatic encephalopathy; Alzheimer’ s disease; motor neuron disease; amyotrophic lateral sclerosis; neurosignalling; neurodegeneration; brain– gut axis impairment; oxidative stress; chronic inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurodegeneration and Neuroinflammatory Processes in Age-Related Diseases
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 759 | Submission Open
Keywords: age-related diseases; neurodegenerative diseases; neurodegeneration; neuroinflammation; aging
(This special issue belongs to the Section Molecular Neurobiology)
The 50th Anniversary of the Discovery of Reciprocal Translocation between Chromosome 9 and 22: The Impact on Molecular and Genomic Knowledge on Cancer submission deadline 20 Jul 2025 | Viewed by 749 | Submission Open
Keywords: cancer genomics; cancer biomarkers; cancer pathogenesis; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Molecular Research of Gut Microbiota in Human Health and Diseases submission deadline 20 Jul 2025 | Viewed by 741 | Submission Open
Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights into the Obstetrics and Gynecology
edited by
submission deadline 20 Jul 2025 | Viewed by 736 | Submission Open
Keywords: ginecology; pelvic disorders; endometrial; cervical and ovarian cancers; covid and pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Latest Review Papers in Molecular Genetics and Genomics 2024 submission deadline 20 Jul 2025 | Viewed by 680 | Submission Open
Keywords: gene regulation; chromatin; epigenetics; genomes; cancer genetics and epigenetics; functional genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Synthesis and Characterization of Nanocarriers and Hydrogels for Multiple Biomedical Applications submission deadline 20 Jul 2025 | Viewed by 663 | Submission Open
Keywords: nanocarrier synthesis; nanocarrier characterization; stimulus-sensitive nanocarriers; hydrogels; drug delivery systems; biomedical applications; nanotechnology in medicine; targeted drug delivery; controlled release; theranostic; nanomedicine; pH-sensitive nanocarriers; temperature-sensitive hydrogels; polymer-based nanocarriers; nanoparticle-hydrogel composites
(This special issue belongs to the Section Molecular Nanoscience)
Cell Envelope Biogenesis and, Molecular Strategies to Maintain Cellular Homeostasis in Bacteria submission deadline 20 Jul 2025 | 1 articles | Viewed by 652 | Submission Open
Keywords: LpxC and the regulation of LPS; periplasmic protein folding; disulfide bond formation; BAM proteins and assembly of outer membrane proteins; periplasmic protease DegP (HtrA); lipopolysaccharide assembly; LPS modifications and diversity; LPS and phospholipid trafficking; bacterial virulence factors; antibiotic resistance; extracytoplasmic function sigma factors; regulatory RNAs; two-component systems; lipid A and its modification
(This special issue belongs to the Section Molecular Microbiology)
Modulating the Function of the Immune System by Thyrotropin and Thyroid Hormones
edited by Graciela Alicia Cremaschi and Claudia Gabriela Pellizas
submission deadline 20 Jul 2025 | Viewed by 633 | Submission Open
Keywords: thyrotropin (TSH); thyroid hormones (THs); immune modulation; immunology; immune; autoimmune; immunoendocrinology; hypothalamic-pituitary-thyroid axis; antitumor immune response
(This special issue belongs to the Section Molecular Immunology)
KRAS-Mutant Cancers: From Basic Biology to Clinical Translation
edited by , and Luka Bočkor
submission deadline 20 Jul 2025 | Viewed by 623 | Submission Open
Keywords: KRAS mutations; KRAS signalling; cancer; KRAS inhibitors; drug resistance; tumour microenvironment; cellular metabolism
(This special issue belongs to the Section Molecular Oncology)
Stroke: Novel Molecular Mechanisms and Therapeutic Approaches
edited by Kang-Ho Choi
submission deadline 20 Jul 2025 | Viewed by 606 | Submission Open
Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds: Structural Diversity, Modifications, and Biological Activities
edited by Tomasz Pospieszny
submission deadline 20 Jul 2025 | 1 articles | Viewed by 600 | Submission Open
Keywords: bile acids; molecular research; biological activity; natural products; steroids
(This special issue belongs to the Section Bioactives and Nutraceuticals)
GABA Signaling in Health and Disease in the Nervous System, 2nd Edition submission deadline 20 Jul 2025 | Viewed by 566 | Submission Open
Keywords: gamma-aminobutyric acid; neurodevelopment; neuronal differentiation; neuronal disorders; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Iron and Sulfur in Plants, 4th Edition submission deadline 20 Jul 2025 | Viewed by 564 | Submission Open
Keywords: biofortification; Fe– S clusters; iron; iron deficiency; metabolites; methionine; nutrient interaction; root exudates; strategy I; strategy ii; sulfur; sulfur deficiency
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in the Genetic Research on Psychiatric Disorders
edited by Lawrence Shih-Hsin Wu
submission deadline 20 Jul 2025 | Viewed by 558 | Submission Open
Keywords: genetics; bipolar disorder; schizophrenia; major depressive disorder; autism; substance abuse; genomics
(This special issue belongs to the Section Molecular Neurobiology)
New Insights and Research on Nutrition and Obesity
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 540 | Submission Open
Keywords: nutrition; obesity; malnutrition; overnutrition; molecular and cellular mechanisms; nutrient– gene interactions; metabolic disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Colorectal Cancer: Molecular Mechanism and Treatment Strategies
edited by
submission deadline 20 Jul 2025 | Viewed by 520 | Submission Open
Keywords: colorectal cancer; personalized treatment; treatment strategies; cancer biology
(This special issue belongs to the Section Molecular Oncology)
Molecular and Cellular Mechanisms of Genotoxicity
edited by
submission deadline 20 Jul 2025 | Viewed by 512 | Submission Open
Keywords: DNA damage; gene instab; genetic instab; DNA methyl; genotoxic; gene mutation; DNA repair; genotoxicity; toxicogenetic; toxicogenomic
(This special issue belongs to the Section Molecular Toxicology)
Rational Design and Synthesis of Bioactive Molecules, 2nd Edition
edited by
submission deadline 20 Jul 2025 | Viewed by 506 | Submission Open
Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure– activity relationship; applications
(This special issue belongs to the Section Molecular Biology)
Vitamin D Signaling in Human Health and Diseases
edited by
submission deadline 20 Jul 2025 | Viewed by 493 | Submission Open
Keywords: vitamin D receptor; vitamin D; prevention; therapeutic potential; mineral homeostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Skin Diseases (Second Edition)
edited by
submission deadline 20 Jul 2025 | 1 articles | Viewed by 489 | Submission Open
Keywords: hyperproliferative skin diseases; psoriasis; keratinocyte carcinoma; actinic keratosis; atopic dermatitis; skin inflammation; inflammation-associated skin diseases; epidermal differentiation; epidermal cell metabolism; 3D models; in vivo models
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Hereditary Spherocytosis submission deadline 20 Jul 2025 | Viewed by 489 | Submission Open
Keywords: hereditary spherocytosis; erythrocyte membrane molecular defects; next-generation sequencing; molecular diagnosis; molecular mechanisms of disease
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer
edited by
submission deadline 20 Jul 2025 | Viewed by 478 | Submission Open
Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Advancements in Genomic Technologies for Molecular Safety Assessment
edited by
submission deadline 20 Jul 2025 | Viewed by 477 | Submission Open
Keywords: gene expression; safety assessment; genomic technologies; genomic tools; molecular toxicology; toxicity; predictive safety assessments; proteomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Superoxide submission deadline 20 Jul 2025 | Viewed by 470 | Submission Open
Keywords: superoxide; SOD; antioxidants; superoxide radical; natural product
(This special issue belongs to the Section Biochemistry)
Mechanistic Studies of Mitosis
edited by Eleni Petsalaki
submission deadline 20 Jul 2025 | Viewed by 465 | Submission Open
Keywords: mitosis; cancer; cell biology; spindle checkpoint; abscission; abscission checkpoint; cytokinesis
(This special issue belongs to the Section Biochemistry)
Omics-Driven Unveiling of the Structure and Function of Nanoparticles
edited by
submission deadline 20 Jul 2025 | Viewed by 461 | Submission Open
Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics
(This special issue belongs to the Section Molecular Biophysics)
Molecular Insight into Skin Infection and Inflammation
edited by
submission deadline 20 Jul 2025 | Viewed by 460 | Submission Open
Keywords: skin infection; skin inflammation; inflammatory skin diseases; atopic dermatitis; skin microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Molecular Pathology, Drug Resistance and Diagnostics of Human Fungal Diseases
edited by
submission deadline 20 Jul 2025 | Viewed by 459 | Submission Open
Keywords: host-fungal interaction; pathogenesis; virulence; antifungal immunity; antifungal resistance; molecular diagnosis
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research in Myocarditis
edited by Cristina Vicenzetto
submission deadline 20 Jul 2025 | 1 articles | Viewed by 448 | Submission Open
Keywords: myocarditis; autoimmunity; viral myocarditis; molecular mechanisms; genetic background; therapeutic targets
(This special issue belongs to the Section Molecular Immunology)
Molecular Applications of Spectroscopy in Drug Structure and Activity Analysis
edited by
submission deadline 20 Jul 2025 | Viewed by 445 | Submission Open
Keywords: spectroscopic techniques; Raman microscopy and imaging; IR/FT-IR/ATR; UV/Vis; XRD; polymorphic forms; material purity; pharmaceutical finished products; biosimilars; stability of APIs and excipients; interaction between APIs and excipients; counterfeit identification; reverse engineering in pharmacy; at-line; in-line
(This special issue belongs to the Section Molecular Biophysics)
Optical Molecular Systems: From Design to Applications submission deadline 20 Jul 2025 | Viewed by 444 | Submission Open
Keywords: luminescent materials; spectral conversion; smart optical materials; human-centric lighting; healthcare diagnostics; imaging; and therapeutics; advanced optical sensors
(This special issue belongs to the Section Materials Science)
Molecular Metabolism in Plant Chemistry
edited by
submission deadline 20 Jul 2025 | Viewed by 442 | Submission Open
Keywords: phytochemistry; plant secondary metabolism; biosynthesis of secondary metabolites; plant and pathogens; stress tolerance and resistance; plant cell cultures; plant biotechnology; bioactive natural products
(This special issue belongs to the Section Biochemistry)
Neurogenetics: Applications of Precision Medicine and Gene Therapy for Rare Neurogenetic Disorders submission deadline 20 Jul 2025 | Viewed by 436 | Submission Open
Keywords: precision medicine; gene therapy; neurogenetics; rare monogenic diseases; inherited nervous system disorders; mitochondrial diseases (e.g.; LHON; MELAS); lysosomal storage disorders (e.g.; Tay– Sachs; Gaucher); hereditary neuropathies (e.g.; CMT; hATTR); motor neuron diseases (e.g.; SMA; ALS); spinocerebellar ataxias (e.g.; SCA); biomarkers in neurology
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Mechanisms in Learning and Memory
edited by
submission deadline 20 Jul 2025 | Viewed by 435 | Submission Open
Keywords: learning; memory; animal models; conditioning; molecular mechanisms; genetic mechanisms; epigenetic mechanisms
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging
edited by
submission deadline 20 Jul 2025 | Viewed by 434 | Submission Open
Keywords: aging; age-related; immunosenescence; immune system; inflammaging
(This special issue belongs to the Section Molecular Immunology)
Myelination in the Nervous Systems: From Molecular Pathways to Therapeutic Strategies
edited by Yanming Wang
submission deadline 20 Jul 2025 | Viewed by 403 | Submission Open
Keywords: myelination; the central nervsou system; neurodegenerative discorders; multiple sclerosis; leukodystrophies; myelin repair and regeneration
(This special issue belongs to the Section Molecular Biology)
Role of the Epithelial Mesenchymal Transition in Cancer Development and Invasiveness
edited by
submission deadline 20 Jul 2025 | Viewed by 402 | Submission Open
Keywords: epithelial mesenchymal transition; EMT; cancer; epithelial protein; mesenchymal phenotype; therapeutic approach
(This special issue belongs to the Section Molecular Oncology)
Molecular Linkages Between Obesity, Diabetes and Cancer
edited by Pilar F. Valerón
submission deadline 20 Jul 2025 | Viewed by 397 | Submission Open
Keywords: obesity; GLUT4; PPARg; lipid transporters (CD36 and AQP7); cancer progression; metastasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chemoinformatics and Bioinformatics Tools in Structure-Activity Modelling in Molecular Sciences: 3rd Edition
edited by
submission deadline 20 Jul 2025 | Viewed by 382 | Submission Open
Keywords: chemoinformatics tools and models; bioinformatics tools and models; structure– activity modeling; structure– property modeling; QSAR; QSPR; drug/structure identification in bioprospecting research; molecular docking; molecular interactions; protein– protein interactions; development of algorithms; databases and web servers; data mining in chemoinformatics and bioinformatics; structure representation and optimization; molecular descriptors; modeling of health and environmentally relevant endpoints (activities; properties); toxicity modeling and prediction; carcinogenicity modeling and prediction; computational methods in molecular sciences; model validation approaches; multivariate modeling; predictive modeling; descriptive modeling; continuous data modeling; classification data modeling; machine learning in molecular sciences; deep learning in molecular sciences; structure visualization tools
(This special issue belongs to the Section Molecular Informatics)
The Molecular Mechanisms and Pathogenesis of Food Allergy and New Technologies
edited by
submission deadline 20 Jul 2025 | Viewed by 381 | Submission Open
Keywords: food allergy; omics; genomics; proteomics; transcriptomics; metabolomics; systems biology; micro/nanoabrication
(This special issue belongs to the Section Molecular Immunology)
From Bench to Bedside: A Triad of Innovation in Gastric Cancer Treatment—Immunotherapies, Gene Therapy and Surgery Unite submission deadline 20 Jul 2025 | Viewed by 380 | Submission Open
Keywords: immunotherapy; gene therapy; advanced surgery
(This special issue belongs to the Section Molecular Oncology)
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