Molecular Advances in Hereditary Spherocytosis

Dear Colleagues,

Congenital hemolytic anemia caused by erythrocyte membrane defects is a rare and heterogeneous group of disorders, among which Hereditary Spherocytosis (HS) is the most prevalent, affecting 1/2000 to 1/5000 individuals worldwide. Significant progress has been made in understanding the genetic basis of HS and recent molecular advances offer improved insights into the molecular cause, diagnosis, and therapeutic management of HS.

While traditional diagnosis approaches are still used, new techniques offer improved quality and reduced time for diagnosis. Integrating both further optimizes an accurate HS diagnosis, which is important in establishing prognosis and may enable personalized clinical management.

We are pleased to invite you to contribute to this Special Issue, hoping to gather the most recent knowledge on HS.

This Special Issue aims to highlight the most recent advances in clinical, laboratory, and genetic data for accurate HS diagnosis and patient management; evolving from symptom-based therapeutic interventions to molecular targeted therapies in order to mitigate the disease progression and complications seems to be the way forward.

In this Special Issue, original research articles and reviews are welcome, hoping to gather a collection of comprehensive works focusing on state-of-the-art molecular approaches in favor of HS knowledge.

We look forward to receiving your contributions.

Dr. Susana Rocha
Dr. Alice Santos-Silva
Guest Editors

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