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The Molecular Mechanisms and Pathogenesis of Food Allergy and New Technologies

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: closed (20 July 2025) | Viewed by 958

Special Issue Editor


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Guest Editor
Department of Food Technology, Spanish National Research Council (CSIC), Marine Research Institute (IIM), 36208 Vigo, Spain
Interests: proteomics; mass spectrometry; tandem mass spectrometry; proteins; food science and technology; molecular biology; food safety; confocal microscopy; food quality; food and nutrition
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Special Issue Information

Dear Colleagues,

Food allergy is considered one of the major concerns in food safety. It is estimated to affect 6-8% of young children and about 2-4% of adults. The prevalence of this emerging worldwide problem has been increasing during the last two decades, especially in industrialized countries, although the reason for this rise remains an open question. Currently, there is no cure for food allergy, and individuals with it must practice strict avoidance of food allergen.

A major limitation that frustrates the development of current treatments is the lack of the mechanistic understanding of what makes a food protein an allergen, and the immunological and gastrointestinal mechanisms that control the induction of tolerance vs sensitization to food allergy.

Advanced new technologies based on Genomics, Proteomics, Transcriptomics, Metabolomics, Microbiology, Systems Biology, Micro/Nanofabrication of devices and Food Technology make them favorable strategies for food allergy control, therapy and study, where research institutions, industries, regulatory and health laboratories collaborate to acquire knowledge and guarantee food quality and safety for consumers.

In this Special Issue, we invite experts as well as beginners in the field of food allergy and advanced technologies to contribute their ideas for accelerating the implementation of new technologies procedures in food allergy.

Dr. Mónica Carrera
Guest Editor

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Keywords

  • food allergy
  • omics
  • genomics
  • proteomics
  • transcriptomics
  • metabolomics
  • systems biology
  • micro/nanoabrication

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Published Papers (1 paper)

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Review

22 pages, 1066 KB  
Review
Mass Spectrometry-Based Proteomics for Seafood Allergen Detection and Quantification: Current Trends and Technological Frontiers
by Manuel G. Amado, Manuel Pazos and Mónica Carrera
Int. J. Mol. Sci. 2025, 26(18), 8962; https://doi.org/10.3390/ijms26188962 - 15 Sep 2025
Viewed by 399
Abstract
Food allergy is a growing global health concern, with seafood representing one of the most significant sources of allergic reactions. The primary allergens responsible for fish and shellfish allergies are β-parvalbumins and tropomyosin, respectively. Therefore, ensuring food safety requires precise and reliable methods [...] Read more.
Food allergy is a growing global health concern, with seafood representing one of the most significant sources of allergic reactions. The primary allergens responsible for fish and shellfish allergies are β-parvalbumins and tropomyosin, respectively. Therefore, ensuring food safety requires precise and reliable methods for the detection and quantification of these molecules. Traditional approaches, such as ELISA and PCR, have notable limitations in terms of specificity, sensitivity, and multiplexing capabilities. In contrast, liquid chromatography coupled with mass spectrometry (LC-MS) has emerged over the past decade as a powerful alternative, offering enhanced accuracy and analytical depth. Various LC-MS-based strategies have been developed for the identification and quantification of seafood allergens, contributing to improved allergen monitoring and risk assessment. Nevertheless, the routine implementation of these methods in analytical laboratories still faces several challenges, including high equipment costs, complex workflows, and the need for standardized reference materials and protocols. Continued technological advances and validation efforts are necessary to overcome these barriers and to integrate LC-MS-based techniques into routine food allergen testing. Full article
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