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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Genetics of Human Reproduction submission deadline 20 Sep 2025 | 7 articles | Viewed by 8778 | Submission Open
Keywords: genetic; human reproduction; infertility; medically assisted reproduction; pregnancy complications; recurrent miscarriage
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Insight into the Processing and Characterization of Animal Fats and Vegetable Oils
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 8438 | Submission Open
Keywords: lipid molecules; oils; fats; lipase; interesterification; hydrolysis; phospholipids; fatty acids; molecular research; nutrition; cosmetics matrices; medical applications; food; pharmacy; bioengineering; novel applications; biofuels
(This special issue belongs to the Section Molecular Biology)
State-of-the-Art Molecular Oncology in Brazil, 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 8255 | Submission Open
Keywords: apoptosis; autophagy; calcium; cancer; cell death; chemotherapy; metabolism; mitochondria; drug resistance; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Plant Abiotic Stress Tolerance: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 6 articles | Viewed by 8155 | Submission Open
Keywords: acclimation; drought; salinity; pesticides; high– low temperature; high– low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation
(This special issue belongs to the Section Molecular Plant Sciences)
Current Advances and Perspectives in Microbial Genetics and Genomics
edited by and Lucila Saavedra
submission deadline 20 Sep 2025 | 5 articles | Viewed by 8009 | Submission Open
Keywords: microbial genetics; genomics and metagenomics; gene regulation; microbe– host interactions; adaption and resistance mechanisms; microbial metabolism
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms and Pathophysiology of Sepsis
edited by
submission deadline 20 Sep 2025 | 7 articles | Viewed by 7825 | Submission Open
Keywords: animal models; therapeutic concepts; biomarkers; sepsis; immune suppression; epigenetics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Pain submission deadline 20 Sep 2025 | 3 articles | Viewed by 7770 | Submission Open
Keywords: cancer; inflammation; neuropathy; primary sensory neurons; spinal cord; brain
(This special issue belongs to the Section Molecular Pharmacology)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 20 Sep 2025 | 3 articles | Viewed by 7641 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Zebrafish as a Model in Human Disease: 3rd Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 7610 | Submission Open
Keywords: zebrafish; CRISPR/Cas9; transgenic lines; biosensors; endothelial cells; extracellular matrix; genetic mutant for human disease modeling; xenografts
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Spinal Cord Injury
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 7574 | Submission Open
Keywords: spinal cord injury; molecular mechanisms; stem cell therapy; tissue engineering; neuroinflammation; neuroprotection; genetic regulation; epigenetics; therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Mycotoxins, Immunity, and Inflammation
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 7537 | Submission Open
Keywords: mycotoxin; immunity; inflammation; immunotoxicity; immunology
(This special issue belongs to the Section Molecular Toxicology)
Arrhythmias: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7506 | Submission Open
Keywords: cardiac arrhythmias; atrial fibrillation; ventricular arrhythmia; electrophysiologic alternation; ion channel; connexin; autonomic nerve system dysfunction; sleep-disordered breathing; obstructive sleep apnea
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Boosting the Production of Bioactive Compounds: Biotechnology and Metabolic Engineering of Medicinal Plants submission deadline 20 Sep 2025 | 5 articles | Viewed by 7498 | Submission Open
Keywords: bioactive compounds; plant tissue culture; elicitors; metabolic engineering; gene expression; medicinal plants; metabolic pathway; plant biotechnology
(This special issue belongs to the Section Molecular Plant Sciences)
Advanced Research of Metallic Nanoparticles
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7447 | Submission Open
Keywords: metallic nanoparticles (MNPs); biosensors; synthesis methods; molecular spectroscopy characteristic; molecular medicine; molecular biology
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research of Epithelial Function and Barrier Dysfunction
edited by Fariba Rezaee
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7318 | Submission Open
Keywords: epithelial cells; actin cytoskeleton; viral infection; apical junctional complex; tight junction; adherens junction; barrier dysfunction; trans-epithelial electrical resistance; permeability; epithelial barrier
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances and Insights into Liver Diseases
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 7299 | Submission Open
Keywords: liver; hepatocellular carcinoma; cancer; hepatitis; cirrhosis; encephalopathy; non-alcoholic fatty liver disease; autoimmune diseases; Wilson’ s disease; fatty liver disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Natural Compounds in Human Health and Disease
edited by Jaewon Shim and
submission deadline 20 Sep 2025 | 5 articles | Viewed by 7279 | Submission Open
Keywords: natural compound; therapeutic applications; action mechanisms of natural compounds; traditional medicine
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Biology of Protein Kinases: Regulatory Mechanisms, Therapeutic Targets and Cancer Treatments
edited by Jaw Ji Yang
submission deadline 20 Sep 2025 | 2 articles | Viewed by 7183 | Submission Open
Keywords: protein kinases; signal transduction; cancer therapy; regulatory mechanisms; kinase inhibitors; therapeutic targets; molecular biology; structural biology; translational research; clinical applications
(This special issue belongs to the Section Molecular Biology)
The Role and Mechanism of P2X7 Receptor in Cancer and Inflammatory Diseases
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6997 | Submission Open
Keywords: P2X7 receptor; inflammation; cancer; purinergic signalling
(This special issue belongs to the Section Molecular Immunology)
Viral Infections and Immune Responses submission deadline 20 Sep 2025 | 4 articles | Viewed by 6919 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity
(This special issue belongs to the Section Molecular Immunology)
The Biochemistry, Molecular and Cell Biology Beyond Flowers
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6654 | Submission Open
Keywords: flowers; homeotic genes; MADSBox; molecular expression; pollination; stress; transcription factors
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Anti-cancer Drug Discovery and Development
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6551 | Submission Open
Keywords: anti-cancer drug resistant; cancer recurrence; cancer metastasis; cancer stem cells; target validation; target identification; metabolic reprogramming of cancer stem cells; unmet medical needs
(This special issue belongs to the Section Molecular Pharmacology)
State-of-the-Art Molecular Immunology in Chile, 2nd Edition submission deadline 20 Sep 2025 | 3 articles | Viewed by 6544 | Submission Open
Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile
(This special issue belongs to the Section Molecular Immunology)
Drug Discovery: Design, Synthesis and Activity Evaluation submission deadline 20 Sep 2025 | 4 articles | Viewed by 6481 | Submission Open
Keywords: drug design; organic synthesis; biological activity evaluation; biologically active compounds; diagnostic/therapeutic agents; labeled ligands; structure– activity relationships (SARs); structural biological studies; computational studies; pharmacokinetics/pharmacodynamics; drug delivery
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms of Microbe–Skin Interactions
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 6258 | Submission Open
Keywords: colonization; cosmetics; diseases (e.g.; acne; diabetic foot syndrome (DFS); psoriasis; etc.); health; immunity; lipidomics; metabolomics; metagenomics; neurotransmitter; physiology; skin habitat; skin microbiota; prebiotics; probiotics; wound healing
(This special issue belongs to the Section Molecular Microbiology)
Molecular Basis of Pancreatic Secretion and Metabolism
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 6122 | Submission Open
Keywords: exocrine of the pancreas; endocrine of the pancreas; acute pancreatitis; chronic pancreatitis; cystic fibrosis; pancreatic metabolic hormones; pancreatic metabolic disease; mechanism of pancreatic bicarbonate secretion; the sodium bicarbonate cotransporter (NBC); cystic fibrosis transmembrane conductance regulator (CFTR); regulators of the ion channels and ion transporters involved in secretion
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Application of Natural Products in Biomedicine and Pharmacotherapy: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 6 articles | Viewed by 6068 | Submission Open
Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Research for Legume Genomics, Genetics, and Breeding, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 6045 | Submission Open
Keywords: legumes; genomics; plant breeding; seed composition; gene function; biotic and abiotic stress; legume pathogen resistance/mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
CNS Injuries: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 5968 | Submission Open
Keywords: stroke; TBI; brain edema; SCI; spinal cord edema; neuroinflammation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Apoptosis and Autophagy as Strategies in Cancer Treatment
edited by Dorota Ciołczyk-Wierzbicka
submission deadline 20 Sep 2025 | 3 articles | Viewed by 5956 | Submission Open
Keywords: apoptosis; autophagy; cancer therapy/treatment; drug resistance; signaling pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Melanoma and Skin Cancers: 2nd Edition
edited by , and Maria Grazia Vitale
submission deadline 20 Sep 2025 | 5 articles | Viewed by 5951 | Submission Open
Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Oxidative Stress and Cell Damage
edited by Haruhiko Inufusa, Koji Abe and Shigeru Hirano
submission deadline 20 Sep 2025 | 2 articles | Viewed by 5725 | Submission Open
Keywords: oxidative stress; damages on cells; organs; body; prevention damages; parameter of oxidative stress; antioxidants
(This special issue belongs to the Section Molecular Biology)
Exploring the Pathogenetic Mechanisms in Respiratory Virus Infections: Recent Advances and Future Directions
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 5591 | Submission Open
Keywords: respiratory viruses; virus-host interactions; inflammation; metabolic pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Therapies for Metabolic-Associated Fatty Liver Diseases
edited by Yi-Ming Arthur Chen
submission deadline 20 Sep 2025 | 2 articles | Viewed by 5570 | Submission Open
Keywords: metabolic-associated fatty liver disease; MAFLD; metabolic dysfunction-associated steatohepatitis; MASH; molecular mechanism; genetic polymorphism; individualized medicine; prevention; new drug development; health supplements; diagnosis; epidemiology; lifestyle
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Compounds for Counteracting GI and Liver Diseases submission deadline 20 Sep 2025 | 4 articles | Viewed by 5542 | Submission Open
Keywords: natural compounds; gastrointestinal diseases; liver diseases; pharmacological potential
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Flow Cytometry: Applications and Challenges
edited by
submission deadline 20 Sep 2025 | 5 articles | Viewed by 5440 | Submission Open
Keywords: flow cytometry; non-conventional flow cytometry; hematology; morphology; molecular tests; cell biology; immunology; target therapy; microbiology; antigens; functional mechanisms; new technologies
(This special issue belongs to the Section Molecular Biology)
Noncovalent Interactions and Applications in Materials and Catalysis
edited by Snežana D. Zarić
submission deadline 20 Sep 2025 | 4 articles | Viewed by 5427 | Submission Open
Keywords: noncovalent interactions; materials; catalysis; crystal structures; quantum chemistry calculations; hydrogen bonds; stacking interactions; spectroscopy
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Molecular Advances in Cell Proliferation, Senescence and Apoptosis
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 5313 | Submission Open
Keywords: biological molecules; cell proliferation; senescence; apoptosis; human diseases
(This special issue belongs to the Section Molecular Biology)
Bioactive Compounds and Their Anticancer Effects
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 5212 | Submission Open
Keywords: ferroptosis; natural compounds; bioactive compounds; p53; anti-cancer drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights in Prion Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 5200 | Submission Open
Keywords: prion diseases; prion mutation; genetic modifier; neurodegenerative diseases; therapy; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Stem Cells in Human Health and Diseases submission deadline 20 Sep 2025 | 3 articles | Viewed by 4970 | Submission Open
Keywords: stem cells biology; iPSCs; hESC
(This special issue belongs to the Section Molecular Biology)
The Role of Oxidative Stress and Antioxidants in Human Disease
edited by
submission deadline 20 Sep 2025 | 4 articles | Viewed by 4953 | Submission Open
Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bacterial Adaptation Strategies to the Host: From Acute, Aggressive to Chronic, Dormant Infections, 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4942 | Submission Open
Keywords: dormancy; phenotype switching; bacterial stress; survival strategies; persisters; resuscitation; starvation; cell cycle arrest; ATP homeostasis
(This special issue belongs to the Section Molecular Microbiology)
Biofunctional Coatings for Medical Applications submission deadline 20 Sep 2025 | 4 articles | Viewed by 4934 | Submission Open
Keywords: biofunctional coatings; thin film deposition techniques; surface engineering; tissue engineering; materials’ doping and co-doping; medical applications
(This special issue belongs to the Section Materials Science)
Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease:2nd Edition submission deadline 20 Sep 2025 | 6 articles | Viewed by 4925 | Submission Open
Keywords: antioxidants; biomarkers; cellular functions; disease etiology; disease progression; metabolic disorders; metabolic signaling; oxidative stress; pathophysiological states; reactive oxygen species; redox homeostasis; redox signaling
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Cellular and Molecular Biology in the Compromised Neonate
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4905 | Submission Open
Keywords: compromised neonate; infections; placental dysfunction; disrupted oxygen supply; molecular and cellular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Synthetic Methodologies in Drug Development
edited by
submission deadline 20 Sep 2025 | 3 articles | Viewed by 4832 | Submission Open
Keywords: organic chemistry; medicinal chemistry; catalysis; photo-catalysis; green chemistry; drug design; drug analysis; flow chemistry
(This special issue belongs to the Section Molecular Pharmacology)
Emerging Advances in Cancer Biomarkers: Machine Learning, Radiomics, Genomics, and More
edited by and
submission deadline 20 Sep 2025 | 2 articles | Viewed by 4826 | Submission Open
Keywords: cancers; biomarkers; precision medicine; artificial intelligence; machine learning; radiomics; genomics; radiogenomics; multi-omics; pharmacogenetics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Neurodegenerative Diseases and Inflammation: Pathogenesis, Biomarkers and Treatments
edited by and Anna Maria Ciaccio
submission deadline 20 Sep 2025 | 1 articles | Viewed by 4804 | Submission Open
Keywords: neurodegeneration; inflammation; biomarkers; Alzheimer’ s disease; molecular mechanism; pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fish Immunology, 5th Edition submission deadline 20 Sep 2025 | 4 articles | Viewed by 4765 | Submission Open
Keywords: fish immunology; innate immunity; acquired immunity; leucocytes; disease; immunostimulants; immunodepression; inflammation
(This special issue belongs to the Section Molecular Immunology)
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