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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Omics Approaches to Decipher Inborn Errors of Immunity and Secondary Immunodeficiencies

edited by

Francesco Saettini

submission deadline 31 Oct 2026 | 1 articles | Viewed by 842 | Submission Open

Keywords: inborn errors of immunity; primary immunodeficiency; secondary immunodeficiency; omics; genomics; proteomics; metabolomics; transcriptomics; lipidomics; single-cell; spatial transcriptomics; immune dysregulation

(This special issue belongs to the Section Molecular Immunology)

The Role of Functional Foods in Human Disease and Health

edited by

Ochuko Lucky Erukainure

and Chika Ifeanyi Chukwuma

submission deadline 31 Oct 2026 | 2 articles | Viewed by 824 | Submission Open

Keywords: functional foods; oxidative stress; immune responses; metabolic balance

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Protein Biomarkers in Cancer and Neurodegeneration

edited by

Barbara Mroczko

submission deadline 31 Oct 2026 | 2 articles | Viewed by 811 | Submission Open

Keywords: neurological diseases; potential biomarkers; tumour markers

(This special issue belongs to the Section Biochemistry)

Deciphering the Molecular Landscape of Thyroid Biology and Pathogenesis

edited by Cesar Seigi Fuziwara

submission deadline 31 Oct 2026 | 2 articles | Viewed by 807 | Submission Open

Keywords: thyroid cancer; thyroid diseases; gene regulation; signalling pathways; miRNA; lncRNAs; epigenetics; endocrine disruptors; thyroid development; animal models

(This special issue belongs to the Section Molecular Biology)

Molecular Docking and Structure-Based Modeling

edited by Serap Yalçın Azarkan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: molecular docking; structure-based drug design; challenging diseases; cancer; neurological disorders; infectious diseases; computational technique; binding affinity estimation; computer-based methods; personalized treatments

(This special issue belongs to the Section Molecular Biology)

Pathophysiology and Treatments of Spinal Cord Injury

edited by Roxana Rodríguez-Barrera and Elisa García-Vences

submission deadline 31 Oct 2026 | 1 articles | Viewed by 801 | Submission Open

Keywords: spinal cord injury; treatments; therapy cell; neuromodulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biomarkers and Mechanisms of Environmental Exposure

edited by

Supakit Khacha-Ananda

submission deadline 31 Oct 2026 | 1 articles | Viewed by 771 | Submission Open

Keywords: multi-omics technologies; molecular toxicology; environmental toxicants; toxicants; mechanism of toxicity; biomarkers; in vitro; in vivo; human model; health

(This special issue belongs to the Section Molecular Toxicology)

Recent Research on Natural Compounds: Biosynthesis, Analysis, and Application

edited by

Aleksandar Shkondrov

submission deadline 31 Oct 2026 | 1 articles | Viewed by 770 | Submission Open

Keywords: phytochemicals; natural compounds; chromatography; MS; NMR; analysis; identification; extraction; standardisation; quantitation; activity; moleabular mechanism; biosynthesis

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms Underlying Natural Products for Metabolic Disease Treatment

edited by

Saioa Gómez-Zorita

submission deadline 31 Oct 2026 | Viewed by 767 | Submission Open

Keywords: metabolic diseases; natural products; MAFLD

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Molecular Targets and Prognostic Markers Focused on Improving Quality in Healthcare, 2nd Edition

edited by

Ion Cristóbal

submission deadline 31 Oct 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: prognostic markers; molecular targets; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Studies of Neuroplasticity

edited by Jorge Bergado

submission deadline 31 Oct 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: neural plasticity; influence of trophic factors on plasticity; molecular cascades of plasticity; restorative neurology

(This special issue belongs to the Section Molecular Neurobiology)

Drug Toxicity and Its Impact on Disease Therapies

edited by Metoda Lipnik-Štangelj

submission deadline 31 Oct 2026 | 2 articles | Viewed by 706 | Submission Open

Keywords: computational methods; toxicity prediction; pharmacogenomics; molecular mechanisms; drug-induced toxicity; adverse drug effects; organ toxicity; polypharmacy

(This special issue belongs to the Section Molecular Pharmacology)

Aptamers: Insights into Functional and Structural Research

edited by

Serap Evran

submission deadline 31 Oct 2026 | Viewed by 677 | Submission Open

Keywords: nucleic acid aptamers; aptamer selection; SELEX; post-SELEX; aptamer engineering; aptasensors, diagnostic aptamers; therapeutic aptamers; aptamer–target interaction; aptamer structure

(This special issue belongs to the Section Molecular Biology)

Advances in Legume Crop Breeding, Genetics, and Genomic Approaches

edited by

Duygu Sari

submission deadline 31 Oct 2026 | 1 articles | Viewed by 673 | Submission Open

Keywords: legume breeding; plant genetics; crop improvement; molecular breeding; genomic approaches; genetic diversity; abiotic stress tolerance; root system architecture; interspecific hybridization; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Antioxidant, Anti-Inflammatory and Anticancer Activities of Natural Products

edited by

Daeho Kwon

submission deadline 31 Oct 2026 | 1 articles | Viewed by 671 | Submission Open

Keywords: antioxidant; immunology; cancer; natural products; molecular biology; cell biology; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Deciphering the Molecular Symphony of Microbiome-Driven Immune Modulation

edited by Edda Russo and

Sara Salvetti

submission deadline 31 Oct 2026 | Viewed by 648 | Submission Open

Keywords: microbiome; immune; microbial-host interactions

(This special issue belongs to the Section Molecular Immunology)

The Microbiome: Bridging Human Health and Natural Ecosystems

edited by

Nitin Saksena

submission deadline 31 Oct 2026 | 1 articles | Viewed by 646 | Submission Open

Keywords: microbiome; human health; natural ecosystems; gut microbiome; environmental microbiomes; gut–brain axis; soil microbiome; 16S sequencing; aquatic microbiome; climate change; One Health; probiotics; metagenomics; microbial diversity; therapeutic interventions

(This special issue belongs to the Section Molecular Microbiology)

Environmental Stressors and Aquatic Life: A Molecular Perspective

edited by Xin Zhang

submission deadline 31 Oct 2026 | 1 articles | Viewed by 640 | Submission Open

Keywords: aquaculture; aquatic organisms; environmental stress; aquaculture ecology; pathology; physiology and toxicology; molecular biology and multi-omics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Plant–Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 31 Oct 2026 | Viewed by 607 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targets for HPV-Related Head and Neck Cancer

edited by

Joshua D. Smith

submission deadline 31 Oct 2026 | Viewed by 607 | Submission Open

Keywords: human papillomavirus; HPV; head and neck; squamous cell carcinoma; recurrent; p16; immune; targeted; vaccine; antibody

(This special issue belongs to the Section Molecular Oncology)

Skin Immune-Related Diseases: New Molecular Insights in Pathogenesis and Treatment

edited by

Bogusław Nedoszytko

Radoslaw Spiewak

Agnieszka Owczarczyk-Saczonek

and

Dorota Purzycka-Bohdan

submission deadline 31 Oct 2026 | 1 articles | Viewed by 603 | Submission Open

Keywords: skin immune system (SIS); immune-mediated skin diseases; allergens; haptens; allergy to nickiel; inflammatory; allergic and autoimmunologic skin diseases; immunological retuning of the skin in systemic reactions to xenobiotics and foreign bodies; atopic dermatitis; psoriasis; allergic contact dermatitis; skin cancer: BCC, SCC, melanoma; T-cells lymphomas; mastocytosis; genomic studies: GWAS, NGS, SNPs; transcriptomic, proteomic studies in skin disorders; regulations of genes expression by epigenetic mechanisms: noncoding RNAs (ln, pi mi RNAs); promoter methylations; histone modifications; transcriptions factors: NFkB; oncogenes; cytokine and chemokine networks; growth factors; molecular markers of skin diseases; artificial intelligence (AI) in patients’ data analysis; AI applications in molecular biology and medicine; biological therapy of skin diseases; JAK/STAT inhibitors in skin diseases; BRAF inhibitors in skin diseases; gene therapies

(This special issue belongs to the Section Molecular Immunology)

T Cells in Cancer: From Effectors to Regulators and Therapeutic Targeting

edited by

Sabrina Bossio

submission deadline 31 Oct 2026 | 1 articles | Viewed by 577 | Submission Open

Keywords: T-cell in cancer; tumor microenvironment (TME); T cell exhaustion; oncogenic signaling pathways; cancer immunotherapy; immunometabolism

(This special issue belongs to the Section Molecular Immunology)

Agro-Food Waste: From Bioactive Molecules to Materials

edited by

Natale Badalamenti

and

Antonella Maria Maggio

submission deadline 31 Oct 2026 | Viewed by 563 | Submission Open

Keywords: agro-food waste; phytochemistry; novel bio-products; physical–chemical characterization; innovative and sustainable extraction methodologies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Microenviromental Signalling in Tumorigenesis and Anti-Cancer Drugs Resistance

edited by

Pierluigi Scalia

submission deadline 31 Oct 2026 | Viewed by 524 | Submission Open

Keywords: tumor microenvironment; cancer cell signaling; paracrine and autocrine mechanisms; cancer drug resistance; oncogenic pathways; immune checkpoints; cancer immune evasion; cancer-associated fibroblasts; tumor-infiltrating lymphocytes; onco-immunology; CAR-T

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanism and Therapeutic Strategy in Viral Infection

edited by Luisa Fernanda Duarte, Aracelly Gaete-Argel and Aldo Barrera

submission deadline 31 Oct 2026 | 1 articles | Viewed by 516 | Submission Open

Keywords: viral infections; immune evasion; inflammation; antiviral responses; vaccine; drug delivery systems; single-cell analysis; multi-omics approaches

(This special issue belongs to the Section Molecular Microbiology)

Structure-Based Design of Drugs and Other Bioactive Molecules

edited by

Antonio Carrieri

submission deadline 31 Oct 2026 | Viewed by 513 | Submission Open

Keywords: three-dimensional structure; molecular descriptor; molecular similarity; database searching; drug repositioning; target fishing; novel algorithm; data prediction

(This special issue belongs to the Section Molecular Informatics)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 31 Oct 2026 | Viewed by 511 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

Microbial Fermentation Optimization and Product Bioactivity

edited by

Wai Prathumpai

submission deadline 31 Oct 2026 | 1 articles | Viewed by 498 | Submission Open

Keywords: microbial processes; bioprocess engineering; bioreactor process optimization; engineering design; synthetic biology; metabolic engineering; metabolic regulation

(This special issue belongs to the Section Molecular Microbiology)

RNA Processing in Diseases

edited by

Naoyuki Kataoka

submission deadline 31 Oct 2026 | Viewed by 488 | Submission Open

Keywords: RNA splicing; alternative splicing; aberrant splicing; mis-splicing; RNA modification; RNA export; RNA processing; translation; mRNA stability

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Mineral Nutrition and Tolerance to Salt and Drought in Plants

edited by

Bruno Filipe Pereira de Sousa

submission deadline 31 Oct 2026 | Viewed by 486 | Submission Open

Keywords: ionic stress; water stress; salinity; mineral nutrition; uptake and transport; signalling and metabolism; plant-microbe interactions; tolerance mechanisms; plant physiology; climate change

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Targeted Therapy and Epigenetic Advances in Cancer

edited by Qing Sheng Mi and

Li Zhou

submission deadline 31 Oct 2026 | Viewed by 477 | Submission Open

Keywords: cancer; epigenetic; therapeutic targets; chromatin; DNA methylation; histone modification; noncoding RNA; histone variants

(This special issue belongs to the Section Molecular Oncology)

Aquaculture: Genomics, Genetics and Breeding

edited by Chunde Wang and Shaoxuan Wu

submission deadline 31 Oct 2026 | 2 articles | Viewed by 458 | Submission Open

Keywords: aquaculture; genetics; molecular breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

Intercellular Adhesion and Inflammatory Response in Cancer

edited by Anna Pryczynicz

submission deadline 31 Oct 2026 | Viewed by 456 | Submission Open

Keywords: adhesion; cancer; cancer therapy; inflammation; microenvironment

(This special issue belongs to the Section Molecular Biology)

New Advances in Synaptic Transmission

edited by

Frank Schmitz

submission deadline 31 Oct 2026 | Viewed by 450 | Submission Open

Keywords: synapses; synaptic transmission; synaptic activity; neurological disease

(This special issue belongs to the Section Molecular Neurobiology)

Allergy, Allergens and Therapeutics: Towards New Horizons

edited by

Luis Manuel Teran

and Gandhi Pavón-Romero

submission deadline 31 Oct 2026 | Viewed by 443 | Submission Open

Keywords: allergy; allergens; asthma; atopic dermatitis; urticaria; diagnostics; therapeutics; depemokimab; rimibrutinib; bazolvolimab

(This special issue belongs to the Section Molecular Immunology)

Functional and Hybrid Imaging in Molecular Neuroscience

edited by Marija-Magdalena Petrinovic

submission deadline 31 Oct 2026 | Viewed by 443 | Submission Open

Keywords: molecular imaging; functional MRI; PET; multimodal brain imaging; neuroreceptor mapping; neuroinflammation; neurodegeneration; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Phage Therapy: Breakthroughs and Challenges

edited by

Spyridon Megremis

and

Anisha Mahendra Thanki

submission deadline 31 Oct 2026 | Viewed by 433 | Submission Open

Keywords: phage therapy; phage production; phage engineering; phage genomics; phage evolution; phage structural biology

(This special issue belongs to the Section Molecular Microbiology)

From Molecular Mechanisms to Precision Medicine in Gastrointestinal Cancers: (Epi)genetics, Pharmacogenomics, and Emerging Biomarkers

edited by

Kostas A. Triantaphyllopoulos

submission deadline 31 Oct 2026 | Viewed by 430 | Submission Open

Keywords: gastrointestinal and colorectal cancer; genetic and epigenetic regulation; multi-omics and computational biology; molecular pathology and biomarker discovery; translational and precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Lipid Metabolites in Age-Related Comorbidities: From Mechanisms to Therapeutics

edited by

Sadanand Fulzele

submission deadline 31 Oct 2026 | Viewed by 411 | Submission Open

Keywords: lipid metabolites; aging; sarcopenia; osteoporosis; osteoarthritis

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms of Melanoma Resistance to Targeted Therapy

edited by

Ignacija Vlasic

and

Anđela Horvat

submission deadline 31 Oct 2026 | Viewed by 408 | Submission Open

Keywords: melanoma; targeted therapy; mechanisms of therapy resistance; predictive biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Disease-Modifying Strategies in Type 1 Diabetes

edited by

Tarun Pant

submission deadline 31 Oct 2026 | Viewed by 405 | Submission Open

Keywords: type 1 diabetes; molecular mechanisms; disease-modifying strategies; immunometabolism; cytokine signaling; precision immunotherapy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Research Progress on Food Packaging Materials

edited by Ayca Aydogdu Emir

submission deadline 31 Oct 2026 | Viewed by 394 | Submission Open

Keywords: bio-based polymers; biodegradable packaging; active packaging; intelligent systems; antimicrobial films; nanotechnology; agri-food by-products; shelf-life extension; molecular interactions; sustainable materials

(This special issue belongs to the Section Materials Science)

Advances in Estrogen Therapy for CNS Diseases

edited by

Istvan Merchenthaler

submission deadline 31 Oct 2026 | Viewed by 392 | Submission Open

Keywords: estrogen; central nervous system (CNS) diseases; neurodegenerative disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Repurposed Anti-Cancer Drugs

edited by Jacek Kubiak and Malgorzata Kloc

submission deadline 31 Oct 2026 | 1 articles | Viewed by 390 | Submission Open

Keywords: repurposed drugs; cancer; cell cycle; computational approaches; apoptosis; molecular pathways; metformin; sertraline; thalidomide; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Ophthalmology: New Molecular Insights and Therapeutic Strategies

edited by

Meritxell López-Gallardo

and

José A. Fernández-Albarral

submission deadline 31 Oct 2026 | Viewed by 383 | Submission Open

Keywords: ophthalmology; molecular mechanisms; neuroinflammation; oxidative stress; retinal degeneration; neuroprotection; gene therapy; regenerative medicine; ocular biomarkers; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular-Scale Design, Synthesis, and Applications of (Photo)Electrochemical Materials for Sustainable Energy and Environmental Solutions

edited by

Shiwei Lin

and

Zhaohui Xiao

submission deadline 31 Oct 2026 | Viewed by 380 | Submission Open

Keywords: molecular-scale material engineering; photoelectrocatalysis/electrocatalysis; sustainable energy conversion; atomic-precision synthesis; environmental remediation technologies

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Polysaccharides: Properties, Structure and Biological Activity

edited by

Thanapon Charoenwongpaiboon

submission deadline 31 Oct 2026 | Viewed by 380 | Submission Open

Keywords: polysaccharides; oligosaccharides; carbohydrate engineering; glycosidic linkage; polysaccharide modification; bioactive carbohydrates; prebiotic activity; immunomodulatory effects; antioxidant activity; functional biomaterials

(This special issue belongs to the Section Macromolecules)

Mesenchymal Stromal/Stem Cells (MSCs) in Regenerative Medicine

edited by

Miomir Knezevic

submission deadline 31 Oct 2026 | Viewed by 378 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; regenerative medicine; cell therapy; immunomodulation; molecular mechanisms; extracellular vesicles; translational research; clinical applications; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroendocrine Tumors (NETs): New Molecular Insights

edited by Juan Pablo Petiti

submission deadline 31 Oct 2026 | Viewed by 376 | Submission Open

Keywords: neuroendocrine neoplasms; cell signaling; biomarkers; molecular targets; tumor progression; invasion

(This special issue belongs to the Section Molecular Oncology)

Advances in Computational Research in Molecular Oncology: Tumor Initiation, Progression, and Treatment

edited by

Lip Yee Por

submission deadline 31 Oct 2026 | Viewed by 373 | Submission Open

Keywords: artificial intelligence; molecular oncology; multi-omics; digital twin; systems biology

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 1251-1300 on page 26 of 63.

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