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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms and Reparative Therapeutic Strategies in Neurodegenerative Diseases
edited by and Amir Hadanny
submission deadline 31 Oct 2026 | Viewed by 225 | Submission Open
Keywords: neurodegeneration; cell death signaling; oxidative stress; mitochondrial dysfunction; brain repair
(This special issue belongs to the Section Molecular Neurobiology)
Multi-Omics and AI-Driven Discovery of Abiotic Stress Resilience in Crops
edited by
submission deadline 31 Oct 2026 | Viewed by 225 | Submission Open
Keywords: genomics; pangenome; abiotic stress; multi-omics; artificial intelligence; climate extremes; predictive breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Biochemical Functions and Therapeutic Potential of Dietary Bioactive Peptides
edited by
submission deadline 31 Oct 2026 | Viewed by 225 | Submission Open
Keywords: bioactive peptides; molecular mechanisms; structure–activity relationship; peptidomics; functional foods; by-product valorization; antioxidant activity; bioavailability; cellular signaling; multidisciplinary approaches
(This special issue belongs to the Section Biochemistry)
Epigenetic Regulation in Health and Disease: From Molecular Mechanisms to Clinical Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 223 | Submission Open
Keywords: epigenetic modifications; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; environmental epigenetics; development and aging; disease epigenetics; translational epigenetics; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Bioactive Foods in Metabolic Disease: Mechanisms and Therapeutic Opportunities
edited by Salima Akter and
submission deadline 31 Oct 2026 | Viewed by 222 | Submission Open
Keywords: metabolic diseases; medicinal foods; nutrient signaling; functional nutrition; insulin resistance; metabolomics; phytochemicals; precision nutrition; gut microbiome
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Modifications Driven by Parasite–Host Interplay submission deadline 31 Oct 2026 | Viewed by 221 | Submission Open
Keywords: pathogens; molecular pathogenesis; immunomodulation; evasion; host defense mechanisms; parasitic signaling
(This special issue belongs to the Section Molecular Biology)
Research on the Immunomodulatory Role of Macrophages
edited by
submission deadline 31 Oct 2026 | Viewed by 219 | Submission Open
Keywords: disease models; immunometabolism; extracellular vesicles; biomarkers; inflammation; therapeutic targets; pregnancy
(This special issue belongs to the Section Molecular Immunology)
Computing Methods to Improve the Polymerization/Performance of Biopolymers and Their Composites
edited by
submission deadline 31 Oct 2026 | Viewed by 216 | Submission Open
Keywords: biopolymers; PLA; PHA; PHB; molecular dynamic; DFT; catalyst; simulation; calculation; artificial intelligence
(This special issue belongs to the Section Materials Science)
Progress in Functional Genomics and Regulation of Gene Expression
edited by Alejandro Bravo-Patino
submission deadline 31 Oct 2026 | Viewed by 215 | Submission Open
Keywords: functional genomic; gene regulation; gene interactions; biomarkers; differential gene expression; epigenetics and gene regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Congenital Heart Disease: From Molecular Mechanisms to Therapeutic Strategies submission deadline 31 Oct 2026 | Viewed by 211 | Submission Open
Keywords: genetics; gene expression; epigenetics; non-coding RNAs; omics data analysis; cardiogenesis; environmental risk factors; disease marker
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autophagy in Aging: Molecular Mechanisms and Therapeutic Implications submission deadline 31 Oct 2026 | Viewed by 210 | Submission Open
Keywords: autophagy; aging; mitophagy; molecular mechanisms
(This special issue belongs to the Section Molecular Biology)
Insights on the Efficacy and Safety of Cytotoxic Agents in Lung Cancer submission deadline 31 Oct 2026 | Viewed by 207 | Submission Open
Keywords: lung cancer; cytotoxic agents; chemotherapy; antibody–drug conjugates; non-small-cell lung cancer; small-cell lung cancer; drug safety; platinum-based chemotherapy; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Molecular Immunology and Defenses: Oral and Periodontal Health
edited by Evangelos Papathanasiou
submission deadline 31 Oct 2026 | Viewed by 206 | Submission Open
Keywords: periodontal disease; immune response; host defense; inflammation; immune regulation
(This special issue belongs to the Section Molecular Immunology)
Adrenal Endocrinology: Molecular Insights and Emerging Trends
edited by , and Francesco Circosta
submission deadline 31 Oct 2026 | Viewed by 205 | Submission Open
Keywords: adrenal disorders; steroid profiling; multi-omics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Multiple Roles of RNA and RNases
edited by
submission deadline 31 Oct 2026 | Viewed by 204 | Submission Open
Keywords: RNA; RNase; diagnosis markers; drug design; cell signalling; immunology; infection; cancer; structural biology; RNA-binding proteins; RNA recognition patterns; RNA catalysis
(This special issue belongs to the Section Molecular Biology)
High Fat Diet Metabolism and Diseases: 2nd Edition submission deadline 31 Oct 2026 | Viewed by 202 | Submission Open
Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Recent Advances in Therapeutic Targets for Musculoskeletal Tumors
edited by Japneet Kaur
submission deadline 31 Oct 2026 | Viewed by 200 | Submission Open
Keywords: musculoskeletal tumors; sarcoma; bone metastasis; tumor microenvironment; targeted therapy; immunotherapy; biomarkers; drug resistance; signaling pathways; cancer biology
(This special issue belongs to the Section Molecular Oncology)
Nutrient Sensing in Human Metabolic Disorders
edited by
submission deadline 31 Oct 2026 | Viewed by 199 | Submission Open
Keywords: nutrient sensing; obesity; insulin resistance; type 2 diabetes; metabolic disease; adipokines; AMPK; mTOR; inflammation; oxidative stress
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Functional Emulsion Systems in Pharmaceutical Science: Stability, Drug Delivery, and Biocatalytic Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open
Keywords: emulsion systems; emulsion stability; drug delivery; pharmaceutical formulations; surfactants; supports; enzyme immobilization; biocatalysis; chiral drugs; kinetic resolution; enantioselective synthesis; lipolytic activity
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Gene and Nucleic Acid-Based Therapeutics: From Molecular Innovations to Potential Misuse
edited by
submission deadline 31 Oct 2026 | Viewed by 198 | Submission Open
Keywords: gene therapy; nucleic acid therapeutics; mRNA therapeutics; lipid nanoparticles (LNPs); genome editing (CRISPR/Cas); gene delivery systems; cell therapy; pharmacokinetics and safety; gene doping; detection methods
(This special issue belongs to the Section Molecular Genetics and Genomics)
Application of Genome Editing in Crop Improvement for Abiotic Stress Resistance
edited by
submission deadline 31 Oct 2026 | Viewed by 197 | Submission Open
Keywords: genome editing; crop improvement; abiotic stress resistance; CRISPR-Cas9; crop breeding; food security; agricultural sustainability
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Biology of Histone Demethylases
edited by
submission deadline 31 Oct 2026 | Viewed by 196 | Submission Open
Keywords: histone demethylase and transcriptional regulation; histone demethylase function; histone demethylase and cancer; histone methylation and genotoxic damage; histone demethylase expression
(This special issue belongs to the Section Molecular Biology)
Environmental Genomics and Epigenomics: Response, Development and Disease
edited by
submission deadline 31 Oct 2026 | Viewed by 196 | Submission Open
Keywords: developmental toxicology; environmental genomics; environmental pollutants; gene–environment interaction; integrated omics; transgenerational effects; environmental health; risk assessment
(This special issue belongs to the Section Molecular Genetics and Genomics)
Protein S in Coagulation, Inflammation, and Cancer
edited by
submission deadline 31 Oct 2026 | Viewed by 196 | Submission Open
Keywords: Protein S; hemostasis; anticoagulation; inflammation; cancer biology; thrombotic disorders; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Oncology)
Advances in Molecular Biomaterials for Pollutants Removal
edited by Jarosław Chwastowski and
submission deadline 31 Oct 2026 | Viewed by 195 | Submission Open
Keywords: biomaterials; biosorption; biodegradation; microorganisms; isotherm and kinetic modeling; organic sorbents
(This special issue belongs to the Section Materials Science)
Nano–Plant Interactions: Molecular Mechanisms and Applications in In Vitro Systems
edited by
submission deadline 31 Oct 2026 | Viewed by 191 | Submission Open
Keywords: nano–plant interactions; nanomaterials; nanoparticle uptake; plant tissue cultures; nanoparticle-induced molecular responses
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products and Functional Biomaterials in Wound Healing and Cancer Treatment
edited by Shaik Nyamathulla
submission deadline 31 Oct 2026 | Viewed by 190 | Submission Open
Keywords: cancer; wound healing; biomaterials; diabetes; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Protein Kinase in Health and Diseases, 2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 190 | Submission Open
Keywords: protein kinases; phosphorylation; cancer; neurological disorder; targeted therapies; meta-bolic diseases
(This special issue belongs to the Section Molecular Biology)
Molecular Research and Insight in Plant Genetic Breeding
edited by
submission deadline 31 Oct 2026 | Viewed by 188 | Submission Open
Keywords: plant genetic breeding; crop genomics; gene editing; molecular markers; functional genomics; germplasm enhancement; omics breeding; crop improvement
(This special issue belongs to the Section Molecular Plant Sciences)
Overcoming Membrane Protein Challenges with Computational Methods
edited by
submission deadline 31 Oct 2026 | Viewed by 184 | Submission Open
Keywords: membrane protein; structural and functional properties; computational approaches; molecular dynamics; free energy calculations; computational docking and drug design approaches
(This special issue belongs to the Section Macromolecules)
Discovery, Synthesis, and Therapeutic Applications of Enzyme Inhibitors submission deadline 31 Oct 2026 | Viewed by 183 | Submission Open
Keywords: cardiovascular diseases; neuroinflammation; neurodegeneration; cancer; clinical trial
(This special issue belongs to the Section Biochemistry)
Ion Channel in Physiology
edited by Isaac E. García
submission deadline 31 Oct 2026 | Viewed by 182 | Submission Open
Keywords: ion channels; channel gating mechanisms; structure–function relationships; electrophysiology; cryo-electron microscopy (cryo-EM); connexin hemichannels and gap junctions; pannexin channels; ion transporters; cell signaling and homeostasis; channelopathies
(This special issue belongs to the Section Molecular Biophysics)
Nanobodies and Monoclonal Antibodies: Epitope, Structure and Neutralization
edited by David Vance
submission deadline 31 Oct 2026 | Viewed by 181 | Submission Open
Keywords: monoclonal antibody; nanobody; antibody-antigen interactions; epitope mapping; neutralizing mechanisms; structural biology; vaccine design
(This special issue belongs to the Section Molecular Nanoscience)
Beyond the Single Gene: The Polygenic Architecture of Drug Response submission deadline 31 Oct 2026 | Viewed by 179 | Submission Open
Keywords: pharmacogenomics; pharmacogenetics; polygenic architecture; polygenic risk scores; precision medicine; adverse drug reactions; epistasis/gene–gene interactions; genomic biomarkers
(This special issue belongs to the Section Molecular Pharmacology)
Bioactive Lipid Signaling in Cardiovascular and Metabolism-Associated Diseases
edited by
submission deadline 31 Oct 2026 | Viewed by 178 | Submission Open
Keywords: bioactive lipids; inflammation; lipid metabolism; lipid signaling pathways; cardiovascular and metabolism-associated diseases; cellular phenotype; lipid receptors; cardiovascular treatments; lipidomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Respiratory Tract Infections: Molecular Pathogenesis, Advanced Diagnostics, and Translational Strategies
edited by Roy Rillera Marzo
submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open
Keywords: respiratory tract infections; host–pathogen interactions; molecular diagnostics; genomics and proteomics; antimicrobial resistance; biomarkers; immune response; precision medicine; translational research; infectious disease epidemiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Functional Materials for Environmental Remediation and Ecosystem Sustainability
edited by Chenyu Wang
submission deadline 31 Oct 2026 | Viewed by 167 | Submission Open
Keywords: functional nanomaterials; environmental remediation; water pollution control; self-assembled systems; ecosystem sustainability; advanced adsorbents; catalysis and oxidation; polyphosphate-based materials; green chemistry; environmental sensors
(This special issue belongs to the Section Molecular Nanoscience)
New Predictive Biomarkers for Ovarian Cancers submission deadline 31 Oct 2026 | Viewed by 159 | Submission Open
Keywords: ovarian cancer; biomarkers; chemorresistance; nanotechnology; ovarian cancer signaling; metabolic plasticity in ovarian cancer; omics in ovarian cancer
(This special issue belongs to the Section Molecular Oncology)
Aging, Regeneration and Stem Cell Biology of Fascial Tissue
edited by and
submission deadline 31 Oct 2026 | Viewed by 125 | Submission Open
Keywords: fascia; aging; regeneration; stem cells; extracellular matrix; fibrosis; mechanobiology; mesenchymal stem cells; tissue repair; myofascial pain
(This special issue belongs to the Section Molecular Biology)
Spike Protein Receptor submission deadline 15 Nov 2026 | Viewed by 315 | Submission Open
Keywords: spike protein; receptor binding; ACE2 interaction; viral entry; structural virology; immune recognition; antibody and IgA epitopes; variant transmissibility; receptor-blocking therapeutics
(This special issue belongs to the Section Molecular Biophysics)
Medicinal Plants and Natural Compounds in Health and Disease: Progresses, Challenges, Opportunities, 2nd Edition submission deadline 20 Nov 2026 | 7 articles | Viewed by 32121 | Submission Open
Keywords: medicinal plants; phytochemicals; vitamins; oxidative stress; gene expression; protein expression; cellular signaling; ethnopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Unraveling the Molecular Mechanisms of Neurodegeneration
edited by
submission deadline 20 Nov 2026 | 6 articles | Viewed by 21639 | Submission Open
Keywords: protein accumulation; mitochondria; genetic and epigenetic alterations; oxidative stress; apoptosis; autophagy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Emerging Therapies in Neurovascular Disease
edited by Leonidas D. Panos
submission deadline 20 Nov 2026 | 3 articles | Viewed by 19478 | Submission Open
Keywords: neurovascular diseases; blood–brain barrier; endothelial dysfunction; cellular signaling; gene therapy
(This special issue belongs to the Section Molecular Neurobiology)
Dermatology: Advances in Pathophysiology and Therapies (3rd Edition) submission deadline 20 Nov 2026 | 9 articles | Viewed by 18793 | Submission Open
Keywords: immunodermatology; cutaneous lymphoma; cutaneous drug reaction; erythroderma; psoriasis; atopic dermatitis; eczematous reactions; cutaneous manifestation of systemic diseases; cutaneous vasculitis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnostics and Genomics of Tumors, 2nd Edition
edited by
submission deadline 20 Nov 2026 | 12 articles | Viewed by 14529 | Submission Open
Keywords: tumor biology; cancer genomics; molecular diagnostics; biomarkers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Advancing Regenerative Medicine: Basic Research and Translation in Clinics
edited by
submission deadline 20 Nov 2026 | 4 articles | Viewed by 11819 | Submission Open
Keywords: regenerative medicine; stem cells; tissue engineering; exosomes; orthobiologics
(This special issue belongs to the Section Molecular Biology)
Peripheral Neuropathies: Molecular Research and Novel Therapy—2nd Edition
edited by
submission deadline 20 Nov 2026 | 3 articles | Viewed by 10132 | Submission Open
Keywords: axonal degeneration; demyelination; schwann cells; dorsal root ganglia; diabetic neuropathy; chemotherapy-induced peripheral neuropathies; immune-mediated neuropathies; immune checkpoint inhibitors; charcot-marie-tooth disease; autonomic neuropathies
(This special issue belongs to the Section Molecular Neurobiology)
Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition submission deadline 20 Nov 2026 | 4 articles | Viewed by 10124 | Submission Open
Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies
(This special issue belongs to the Section Molecular Oncology)
Glioblastoma: Molecular Pathogenesis and Treatment submission deadline 20 Nov 2026 | 4 articles | Viewed by 9325 | Submission Open
Keywords: glioblastoma; molecular therapy; pathogenesis; immunotherapy; brain tumor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Bioactive Natural Compounds in Neuroscience
edited by
submission deadline 20 Nov 2026 | 3 articles | Viewed by 7877 | Submission Open
Keywords: natural products; bioactive metabolites; secondary metabolites; neuronal development; neurotrophins; neuromedicine; neurodegeneration; memory disorders
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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