Epigenetic Regulation in Health and Disease: From Molecular Mechanisms to Clinical Applications
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 202
Editor
2. Anthropology Department and Laboratories of Analytical Biology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560, USA
Interests: molecular biology; genetics; epigenetics; forensic biology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epigenetic modifications constitute a dynamic regulatory layer that shapes genome function without altering DNA sequences or orchestrating development, cellular identity, and disease susceptibility. This Special Issue of the International Journal of Molecular Sciences aims to provide a comprehensive and forward-looking forum for cutting-edge research on epigenetic mechanisms and their biological, clinical, and technological implications. We invite original research articles and authoritative reviews addressing DNA methylation, histone modifications, chromatin remodeling, non-coding RNAs, three-dimensional genome organization, and epigenetic crosstalk across scales ranging from single cells to complex tissues. Contributions exploring environmental, developmental, aging-related, and pathological drivers of epigenetic variation—including cancer, metabolic disorders, neurodegeneration, and heritable traits—are particularly encouraged. Studies leveraging innovative experimental approaches, multi-omics integration, computational modeling, and translational applications are welcome. By bringing together diverse perspectives from molecular biology, genetics, biochemistry, and systems biology, this Special Issue seeks to highlight emerging concepts, methodological advances, and unresolved challenges in the field. Ultimately, this collection aims to deepen our understanding of how epigenetic modifications offer new avenues for diagnostics, therapeutics, and precision medicine. We particularly welcome interdisciplinary contributions that bridge fundamental discovery and real-world impact while fostering dialogue between experimentalists, clinicians, and computational scientists worldwide.
Dr. Sara C. Zapico
Guest Editor
Manuscript Submission Information
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Keywords
- epigenetic modifications
- DNA methylation
- histone modifications
- chromatin remodeling
- non-coding RNAs
- environmental epigenetics
- development and aging
- disease epigenetics
- translational epigenetics
- precision medicine
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