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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Genetic Insights into Neuropsychiatric Disorders: From Mechanisms to Management submission deadline 30 Jan 2026 | 1 articles | Viewed by 366 | Submission Open
Keywords: psychiatry; neurology; psychotic disorders; depressive disorders; neurocognitive disorders; neuropsychiatry; genetics; psychopharmacology; neuromodulation; genome-wide association studies (GWAS); transcriptomics; epigenetics; gene-environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Nutritional Modulators of Healthy Longevity: Mechanisms and Interventions
edited by
submission deadline 30 Jan 2026 | Viewed by 335 | Submission Open
Keywords: aging; healthspan; nutrient signaling; oxidative stress; inflammation; autophagy; sarcopenia; bioactive compounds; molecular nutrition; protein metabolism
(This special issue belongs to the Section Molecular Biology)
Developing Methods and Molecular Basis in Plant Biotechnology: 2nd Edition
edited by
submission deadline 30 Jan 2026 | Viewed by 285 | Submission Open
Keywords: plant biotechnology; plant genetics; plant proteomics; plant metabolomics; stress
(This special issue belongs to the Section Molecular Plant Sciences)
Photosensitizers for Photodynamic Therapy: From Molecular Design to Application submission deadline 30 Jan 2026 | Viewed by 246 | Submission Open
Keywords: photodynamic therapy (PDT); photosensitizers (PS); reactive oxygen species (ROS); molecular design; nanocarriers; porphyrins and analogs; targeted drug delivery; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Peripheral Neuropathy: Exploring Pathogenic Pathways and Therapeutic Approaches
edited by Yuehling Hsieh
submission deadline 30 Jan 2026 | Viewed by 230 | Submission Open
Keywords: peripheral neuropathy; biochemical mechanisms; biomarkers; nerve regeneration; therapeutic approaches; pain management; denervated muscle atrophy; translational medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Oral Health: Disease and Medicine
edited by Norio Sogawa
submission deadline 30 Jan 2026 | Viewed by 185 | Submission Open
Keywords: oral health; disease; molecular medicine  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis and Molecular Applications of Nanomaterials submission deadline 30 Jan 2026 | Viewed by 173 | Submission Open
Keywords: nanomaterials; synthesis; molecular applications
(This special issue belongs to the Section Molecular Nanoscience)
Interaction of Gut Microbiota and Food Bioactive Compounds
edited by and
submission deadline 30 Jan 2026 | Viewed by 169 | Submission Open
Keywords: gut microbiome; molecular mechanisms; metabolomics; transcriptomics; bioactive compounds; microbial enzymes; host– microbe signaling; personalized nutrition; systems biology; functional genomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research on Immune Mechanisms in Kidney Disease
edited by Niels Olsen Saraiva Câmara
submission deadline 30 Jan 2026 | Viewed by 168 | Submission Open
Keywords: kidney disease; molecular sensors; kidney metabolism; immunity; AKI to CKD transition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research on Gut Microbiota in Health and Disease
edited by Li Cui
submission deadline 30 Jan 2026 | Viewed by 165 | Submission Open
Keywords: microbiota-host crosstalk; HMA models; microbial metabolites; gut– brain axis; translational microbiome
(This special issue belongs to the Section Molecular Microbiology)
Recent Advances in Endometriosis Pathophysiology and Pharmacological Treatment (2nd Edition)
edited by
submission deadline 30 Jan 2026 | Viewed by 163 | Submission Open
Keywords: endometriosis; pathophysiology; pharmacological treatment; estrogen
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant–Rhizobium Interaction
edited by Rujin Chen
submission deadline 30 Jan 2026 | Viewed by 157 | Submission Open
Keywords: legume; rhizobia; symbiotic nitrogen fixation
(This special issue belongs to the Section Molecular Plant Sciences)
Cellular and Molecular Pathogenesis of Gynecologic Diseases: Focus on Uterine and Ovarian Dysfunction
edited by
submission deadline 30 Jan 2026 | Viewed by 152 | Submission Open
Keywords: molecular pathogenesis; uterine diseases; ovarian dysfunction; cellular mechanisms; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Therapy for Human Haemoglobinopathy
edited by Alex Felice and
submission deadline 30 Jan 2026 | Viewed by 148 | Submission Open
Keywords: haemoglobin (Hb); hemoglobinopathy (Hbpy); globin; thalassaemia; sickle cell; stem cell; gene therapy/editing; therapeutics; HbF inducing agents
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Application of Platelet-Rich Plasma
edited by
submission deadline 30 Jan 2026 | Viewed by 145 | Submission Open
Keywords: platelet-rich plasma; fibrin scaffold; regenerative medicine; molecular biology; translational medicine
(This special issue belongs to the Section Molecular Biology)
Rewriting Medicine: Stem Cells and Regeneration
edited by
submission deadline 30 Jan 2026 | Viewed by 143 | Submission Open
Keywords: regenerative medicine; stem cell biology; stem cell therapy; induced pluripotent stem cell; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Molecular Advances of Osteomuscolar Conditions
edited by
submission deadline 30 Jan 2026 | Viewed by 142 | Submission Open
Keywords: osteomuscular conditions; musculoskeletal disorders; bone; cartilage; and muscle degeneration
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tumor Viruses: Infection, Carcinogenesis, and Treatment
edited by
submission deadline 30 Jan 2026 | Viewed by 130 | Submission Open
Keywords: tumor viruses; viral oncogenesis; EBV; HPV; KSHV; HBV; HCV; HTLV-1; and MCPyV; virus-associated cancers; merging oncoviruses; viral latency; immune evasion; antiviral therapy; immunotherapy; cancer vaccines; gene-editing technologies
(This special issue belongs to the Section Molecular Microbiology)
Targeting Hallmarks of Acute Myelocytic Leukemia (AML): Differentiation Induction in Non-Acute Promyelocytic Leukemia (Non-APL) AML
edited by
submission deadline 30 Jan 2026 | Viewed by 126 | Submission Open
Keywords: differentiation induction in non-APL AML; phenotypic unlocking of AML hallmarks; targeting non-oncogene addictions in AML; small molecules with differentiation-inducing capacity; epigenetic modelling in AML (azacitidine; decitabine); receptor-triggered transcription factors in AML; combined targeting of receptor-triggered transcription factors in AML; metronomic application of AML therapy; reduction in treatment toxicity by phenotypic unlocking of AML hallmarks; combination therapies for phenotypic unlocking of AML hallmarks; acquired genetic/molecular-genetic aberrations and adaptation of differentiation promoting therapy in AML
(This special issue belongs to the Section Molecular Oncology)
DNA Damage, Genome Stability and the Human Disease
edited by
submission deadline 30 Jan 2026 | Viewed by 124 | Submission Open
Keywords: DNA damage; human diseases; DNA repair; genomic instability; therapeutic strategies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Cardiovascular Diseases: From Molecular Diagnosis to Treatment
edited by
submission deadline 30 Jan 2026 | Viewed by 109 | Submission Open
Keywords: cardiovascular diseases; molecular diagnosis; multi-omics approaches; liquid biopsies; molecular imaging; gene and cell therapies; nanomedicine; pharmacogenomics; targeted molecular therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Environmental Carcinogenesis
edited by Grażyna Gromadzka
submission deadline 30 Jan 2026 | Viewed by 90 | Submission Open
Keywords: environmental carcinogenesis; molecular mechanisms; gene– environment interaction; endocrine disruptors; oxidative stress; epigenetics; cancer biomarkers; environmental pollutants; molecular epidemiology; cancer prevention; cancer treatment
(This special issue belongs to the Section Molecular Toxicology)
Neural Signaling: The Perspective of Molecular Genetics
edited by
submission deadline 30 Jan 2026 | Viewed by 86 | Submission Open
Keywords: molecular neurogenetics; neural signaling; gene editing; neural circuits; neural plasticity; neurodegenerative disorders; single-cell technologies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Sarcomeric Proteins in Health and Disease: Progress and Prospects
edited by
submission deadline 30 Jan 2026 | Viewed by 84 | Submission Open
Keywords: sarcomeric proteins; muscle contraction; sarcomere
(This special issue belongs to the Section Molecular Biophysics)
The Regulation of Metabolism by Sugars During Plant Responses to Environmental Factors and Their Function During Development
edited by
submission deadline 30 Jan 2026 | Viewed by 77 | Submission Open
Keywords: plant metabolism; sugar signalling; enzymes of sucrose metabolism; environmental factors; plant defense responses; developmental regulation; phytohormones; secondary metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Functional Roles of Epithelial and Endothelial Cells submission deadline 31 Jan 2026 | 9 articles | Viewed by 18935 | Submission Open
Keywords: epithelial cells; wound healing; endothelial cells; skin; cornea; functionality; barrier
(This special issue belongs to the Section Biochemistry)
Common Mechanisms in Gestational Diabetes, Preeclampsia, and Coronavirus Disease 2019
edited by
submission deadline 31 Jan 2026 | 6 articles | Viewed by 8726 | Submission Open
Keywords: gestational diabetes; preeclampsia; inflammation; immunoglobulins; glycolisation; platelet aggregation; microvascular thrombosis; coronavirus disease 2019
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pituitary Tumors: An Update in the Pathogenetic Mechanisms, the Diagnostic Methods and the Therapeutic Approaches
edited by
submission deadline 31 Jan 2026 | 3 articles | Viewed by 7823 | Submission Open
Keywords: pituitary neuroendocrine tumors (PitNETs); pituitary transcription factors; PIT1; TPIT; SF1; GATA3; ERα ; pituicytoma; hypothalamic neurocytoma; hypothalamic gangliocytoma
(This special issue belongs to the Section Molecular Oncology)
Cytokines and Other Biomarkers of Health Status
edited by Anna Cywińska and
submission deadline 31 Jan 2026 | 5 articles | Viewed by 4918 | Submission Open
Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research into Chronic Heart Failure
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 4868 | Submission Open
Keywords: heart failure; oxidative stress; cardiac remodeling; cardiomyopathy; proteomic; molecular science
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Studies on Lactic Acid Bacteria and Their Products in Health and Diseases: 3rd Edition submission deadline 31 Jan 2026 | 5 articles | Viewed by 4867 | Submission Open
Keywords: lactic acid bacteria; probiotics health benefits; gut microbiota modulation; functional foods with biological applications; immunomodulatory mechanisms; antimicrobial peptide production and its mechanisms; host-microbe interactions; functional dairy and meat products; inflammatory bowel diseases; metabolic health improvement; bioactive microbial metabolites; food safety and management; metabolic diseases and disorders; antibiotic-associated complications
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Circulating Biomarkers for the Diagnosis of Neurobiological Diseases—3rd Edition
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 4125 | Submission Open
Keywords: circulating miRNAs; differently expressed genes; long COVID-19; neurobiological diseases; mesenchymal stem cells; circulating pasma exosomes; neuropathogenesis; proteomic analysis
(This special issue belongs to the Section Molecular Neurobiology)
Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition
edited by Xiaogang Li
submission deadline 31 Jan 2026 | 3 articles | Viewed by 3912 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Fish Nutrition, Biochemical Pathways, and Physiological Adaptations
edited by Paula Simó-Mirabet and Fernando Naya-Català
submission deadline 31 Jan 2026 | 2 articles | Viewed by 3714 | Submission Open
Keywords: fish; nutrition; metabolism; physiology; growth performance; fish stress; transcriptomics; metataxonomics; metagenomics; epigenomics; aquaculture
(This special issue belongs to the Section Molecular Biology)
Antibody Engineering and Therapeutic Applications
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 3296 | Submission Open
Keywords: monoclonal antibody (mAb) therapies; antibody engineering; antibody-drug conjugate (ADC); chimeric antigen receptor T cell (CAR-T); bispecific antibody; T-cell engager (TCE); cancer immunotherapy; immunocytokine; AI-driven antibody design; antibody structure and mechanism of action
(This special issue belongs to the Section Molecular Pharmacology)
Challenges and Future Perspectives in Treatment for Lung Cancer: 2nd Edition
edited by Ilaria Marrocco and
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2938 | Submission Open
Keywords: lung cancer; non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immunotherapy; drug resistance; drug delivery
(This special issue belongs to the Section Molecular Oncology)
Oxidative and Redox Signalling in Neurological Diseases
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2667 | Submission Open
Keywords: gasotransmitters; neurological diseases; oxidative stress; redox signalling; reactive oxygen species (ROS); neuroinflammation; mitochondrial dysfunction; cell death/apoptosis; nitrosative stress; endogenous gas signalling; neuromodulation; neurovascular coupling; therapeutic strategies; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Plant–Microbe Interaction submission deadline 31 Jan 2026 | 1 articles | Viewed by 2453 | Submission Open
Keywords: biomarkers; molecular biotechnology; cell signalling; microbiota signaling; genetic editing of microbes; plant-microbe stress response; plant-microbe stress mitigation; plant-microbe underlying mechanisms
(This special issue belongs to the Section Molecular Plant Sciences)
Nutraceuticals and Healthy Aging: Molecular Mechanisms and Therapeutic Perspectives
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2448 | Submission Open
Keywords: molecular mechanisms of the action of nutraceuticals on cellular aging; nutraceuticals and neuroprotection; effects of nutraceuticals on skin aging; nutraceuticals in the prevention or management of age-related metabolic diseases; interaction between nutraceuticals and gut microbiota in aging; nutraceuticals in bone and joint health; role of nutraceuticals in menopausal management; impact of nutraceuticals on BPH and prostate health; multi-target approaches of nutraceuticals in healthy aging; innovative nutraceutical delivery and formulation strategies to increase bioavailability; clinical and preclinical studies of nutraceuticals in the elderly population
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Th2-Mediated Inflammation in Dermatology: Mechanistic and Therapeutic Perspectives
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 2100 | Submission Open
Keywords: Th2 inflammation; inflammatory skin disease; immunology of the skin; type 2 inflammatory diseases; immunophenotype
(This special issue belongs to the Section Molecular Immunology)
Innovative Strategies and Molecular Insights Into Wound Healing
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 2045 | Submission Open
Keywords: wound healing; tissue regeneration; hypertrophic scar; biomaterials; stem cell therapy; gene therapy; exosomes; burn rehabilitation; inflammation; regenerative medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into the Mechanisms of Neurodegeneration and Regeneration: From Bench to Bedside
edited by Irina Ivanova Stoyanova
submission deadline 31 Jan 2026 | 3 articles | Viewed by 1971 | Submission Open
Keywords: neurodegeneration; neuroregeneration; molecular neurobiology; brain development; developmental brain disorders; synaptogenesis; synaptic plasticity; cognitive neuroscience; neurotrauma
(This special issue belongs to the Section Molecular Neurobiology)
HIV Infection, Pathogenesis and Treatment
edited by
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1841 | Submission Open
Keywords: HIV Infection; HIV; host immune responses; pathogenesis
(This special issue belongs to the Section Molecular Microbiology)
Neuropharmacological Innovations in Treating Neurodegenerative Diseases
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1812 | Submission Open
Keywords: neuropharmacology; neurodegenerative disorders; targeted drug delivery; blood– brain barrier permeability; synaptic modulation; neuroprotective agents; disease-modifying therapies; molecular mechanisms of neurodegeneration; innovative drug targets; translational neuroscience
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Pancreatic Diseases
edited by
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1748 | Submission Open
Keywords: pancreatic cancer; pancreatic neuroendocrine tumors; KRAS; KRAS inhibitors; KRASG12D inhibitor in pancreatic ductal adenocarcinoma; XPO1 inhibitor; PNET
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA-Based Regulation in Human Health and Disease submission deadline 31 Jan 2026 | 1 articles | Viewed by 1717 | Submission Open
Keywords: non-coding RNAs (ncRNAs); small nucleolar RNAs (snoRNAs); long non-coding RNAs (lncRNAs); microRNAs (miRNAs); piwi-interacting RNAs (piRNAs); circular RNAs (circRNAs); RNA modifications (m6A; pseudouridylation); RNA-protein interactions; post-transcriptional gene regulation; RNA interference (RNAi); antisense oligonucleotides (ASOs); RNA-binding proteins (RBPs); epitranscriptomics; RNA-based therapeutics; cancer-associated ncRNAs; neurodegenerative diseases and RNA regulation; cardiovascular RNA biology; metabolic disorders and RNA; ribosomal RNA modifications; RNA-targeted drug discovery
(This special issue belongs to the Section Molecular Genetics and Genomics)
25th Anniversary of IJMS: Updates and Advances in Molecular Biology submission deadline 31 Jan 2026 | 2 articles | Viewed by 1667 | Submission Open
Keywords: next-generation sequencing (NGS); CRISPR-Cas9; liquid biopsy; molecular diagnostics; personalized medicine; genome-wide association studies (GWAS)
(This special issue belongs to the Section Molecular Biology)
Abiotic Stress in Plants: Physiological and Molecular Responses
edited by Edyta Zdunek-Zastocka
submission deadline 31 Jan 2026 | 2 articles | Viewed by 1388 | Submission Open
Keywords: cold; drought; gene expression; heat; heavy metals; oxidative stress; salinity; stress tolerance; stress perception; stress signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Voltage-Gating and Modulation in Ion Channels
edited by Joao Carvalho de Souza
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1375 | Submission Open
Keywords: voltage-gated ion channels; voltage sensing; voltage sensor coupling; new modulators; ion channel modulation; cell excitability
(This special issue belongs to the Section Molecular Biophysics)
Molecular Advances in Radiation Oncology: Mechanisms, Immunotherapy and Innovation
edited by Jasna But-Hadžić
submission deadline 31 Jan 2026 | 1 articles | Viewed by 1371 | Submission Open
Keywords: molecular radiation oncology; DNA damage response; immunoradiotherapy; radiosensitization; tumor– immune interactions; radiogenomics; predictive biomarkers; combination therapies; translational radiobiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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