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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetic Advances in Neurobiology of Health and Disease

edited by

Efthimios M. C. Skoulakis

and Katerina Papanikolopoulou

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2294 | Submission Open

Keywords: genomics; proteins; proteomics; signaling

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Diagnosis and Prevention of Infectious Diseases

edited by

Marília Andreza Da Silva Ferreira

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2292 | Submission Open

Keywords: host–pathogen interactions; molecular diagnostics; infectious diseases; emerging and reemerging pathogens; prevention; diagnosis; molecular epidemiology; omics; molecular surveillance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Application of Nanomedicine in Cancer Targeting and Treatment

edited by

Kee Siang Lim

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2265 | Submission Open

Keywords: nanomedicine; nanoimaging/bioimaging; cancer biology; theranostics; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

New Insights into Intercellular Communication and Signal Transduction

edited by

Dongki Yang

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2201 | Submission Open

Keywords: intercellular communication; signal transduction; extracellular vesicles (EVs); exosomes; tunneling nanotubes (TNTs); cytokines; hormonal signaling; neurotransmitters; mechanotransduction; immune signaling

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Retinal Diseases: 2nd Edition

edited by Hsiaoming Chao, Robert Casson and Hsi-Kung Kuo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 2123 | Submission Open

Keywords: faricimab; modified cerebrolysin; stem cells; gene therapy; retinal chip; femtosecond; artisan aphakia; artiflex; exozyme; silicon oil; amniotic membrane; EOG; multifocal ERG; flash ERG; VEP; microperimetry; OCT-A

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Stroke

edited by

Hee-Jung Song

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2098 | Submission Open

Keywords: stroke; microglia; neuroinflammation; molecular mechanisms; ischemic injury

(This special issue belongs to the Section Molecular Neurobiology)

Circulating Tumor Cells in Oncology: From Liquid Biopsy to Clinical Decision-Making

edited by

Maria Beatrice Morelli

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2083 | Submission Open

Keywords: circulating tumor cells (CTCs); liquid biopsy; cancer biomarkers; precision oncology; metastasis; cancer diagnostics; cancer prognosis; CTC enrichment; CTC isolation techniques; single-cell analysis; tumor microenvironment; CTC culture; immune surveillance; blood-based biomarkers; molecular profiling; CTC-derived cell lines; treatment resistance; personalized cancer therapy; cell reprogramming; anti-tumor immunity

(This special issue belongs to the Section Molecular Oncology)

Brain Ischemia: From Molecular Mechanisms to Innovative Therapies

edited by

Ryszard Pluta

submission deadline 31 Mar 2027 | 1 articles | Viewed by 2075 | Submission Open

Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Biology)

New Pharmacological Insights on Natural Macromolecules and Natural Small Molecules: 2nd Edition

edited by

Dong-Sung Lee

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1840 | Submission Open

Keywords: bioactive natural molecules; natural macromolecules; natural small molecules; drug delivery; inflammatoty diseases; neurodegenerative diseases; skin diseases; cancer; metabolic diseases

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Anti-Inflammatory Drugs: New and Old Compounds with Novel Delivery Systems Contributing to Improve the Treatment of Inflammatory Diseases

edited by S. Gorzalczany

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1828 | Submission Open

Keywords: inflammation; new compounds; novel formulation; mechanism of action; biological drug; arthritis; inflammatory bowel disease

(This special issue belongs to the Section Molecular Biology)

Ion Channels in Health and Disease: From Physiology to Therapeutics

edited by

Yohan Seo

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1705 | Submission Open

Keywords: ion channels; cellular homeostasis; chronic diseases; cancer; inflammation; therapeutic targets; drug resistance; channel modulators; translational medicine

(This special issue belongs to the Section Molecular Biology)

New Advances in Infectious and Immunoinflammatory Mechanisms of Alzheimer's Disease

edited by Hiroshi Nakanishi

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1683 | Submission Open

Keywords: Alzheimer's Disease; amyloid; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Fluorescent Nanoparticles: Composition, Properties, and Biomedical Applications

edited by Bonghwan Chon

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1659 | Submission Open

Keywords: fluorescent nanoparticles; bioimaging; targeted drug delivery; cancer nanotherapy; quantum dots; surface functionalization; biomedical nanotechnology; theragnostic; fluorescence imaging; deep tissue imaging

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Neuroprotective Drug Development and Therapeutic Applications

edited by Jolanta Helena Kotlińska

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1519 | Submission Open

Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders

(This special issue belongs to the Section Molecular Neurobiology)

Pancreatic Ductal Adenocarcinoma: Unveiling Pathogenic Mechanisms and Pioneering Novel Therapeutic Strategies

edited by

Elena Astanina

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1496 | Submission Open

Keywords: pancreatic ductal adenocarcinoma; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Eukaryotic Mitogenomes: Key Insights

edited by

Yuri Kartavtsev

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1467 | Submission Open

Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations

(This special issue belongs to the Section Molecular Biology)

Non-Coding RNAs as Key Regulators in Human Disease Processes

edited by

Beatrice Polini

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1449 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs; circular RNAs; biomarkers; therapeutic targets; molecular mechanisms; RNA-based therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Systemic Sclerosis

edited by

Filomena Napolitano

and

Nunzia Montuori

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1448 | Submission Open

Keywords: systemic sclerosis; autoimmune disease; fibrosis; vasculopathy; immune dysregulation; fibroblasts; endothelial dysfunction; epigenetics; transcriptomics; biomarkers

(This special issue belongs to the Section Molecular Biology)

Molecular Insight into Oral Health: Disease and Medicine

edited by Norio Sogawa

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1425 | Submission Open

Keywords: oral health; disease; molecular medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fractalkine (CX3CL1) and Its Chemoattractant and Adhesion Molecule Properties in Health and Disease, 2nd Edition

edited by Dariusz Szukiewicz

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1409 | Submission Open

Keywords: fractalkine; transmembrane fractalkine; soluble fractalkine; fractalkine receptor; CX3CL1-CX3CR1 signaling; inflammation; chemokine; cell adhesion; chemotaxis; immune response; angiogenesis; implantation; atherosclerosis; carcinogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pregnancy-Related Complications: Molecular Pathogenesis and Therapeutic Strategies

edited by

Alicia E. Damiano

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1404 | Submission Open

Keywords: pregnancy-related complications; placental dysfunction; maternal-fetal communication; extracellular vesicles; translational research; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Research of Estrogen Receptors in Health and Diseases

edited by

Maciej Iek Skrzypczak

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1371 | Submission Open

Keywords: estrogen receptors; physiology; pathobiology; cancer; benign diseases and disorders

(This special issue belongs to the Section Biochemistry)

Autophagy: A Double-Edged Sword in Disease Pathogenesis and Cancer Progression

edited by

Antonio Ieni

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1363 | Submission Open

Keywords: autophagy; cancer therapy resistance; tumor microenvironment; immunometabolism

(This special issue belongs to the Section Molecular Biology)

Recent Research in Cerebellar Development and Disease

edited by Maryam Rahimi-Balaei

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1320 | Submission Open

Keywords: cerebellar development; cerebellum; neural development; neurogenesis; neuronal migration; cerebellar malformations

(This special issue belongs to the Section Molecular Neurobiology)

Plant Epigenetic Memory Under Abiotic Stress

edited by

Md Mezanur Rahman

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1299 | Submission Open

Keywords: plant epigenetics; epigenetic memory; abiotic stress; DNA methylation; histone modification; chromatin remodeling; transgenerational inheritance; stress-responsive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Structure, Properties, and Applications of Carbon Materials

edited by

Javier Arcibar-Orozco

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1298 | Submission Open

Keywords: carbon-based structures; diamonds; carbon quantum dots; carbon composites; graphene; nanotubes

(This special issue belongs to the Section Materials Science)

The Placental Barrier: From Fundamental Mechanisms to Clinical Implications

edited by

Ricardo Emilio Fretes

and María I. De La Calle

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1245 | Submission Open

Keywords: placental barrier; maternal–fetal interface; pregnancy pathologies; vertical transmission

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Functional and Regulatory Cancer Genomics

edited by

Apostolos Zaravinos

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1244 | Submission Open

Keywords: cancer genomics; functional genomics; regulatory genomics; epigenetics; transcriptomics; non‑coding RNAs; single‑cell genomics; multi‑omics; tumor heterogeneity; precision oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Understanding Cardiotoxicity: From Mechanisms to Therapeutic Implications

edited by

Anna A. Borowiec

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1242 | Submission Open

Keywords: cardiotoxicity; mechanisms of cardiotoxicity; cancer-therapy-related cardiac dysfunction; chemotherapy-related cardiotoxicity; radiotherapy-related cardiotoxicity; immunotherapy-related cardiotoxicity; cardioprotection; molecular pathways; oxidative stress; apoptosis; cardiac biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Precision Medicine for Cancer-Associated Thrombosis: The Role of Biomarkers

edited by Darko Antic

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1178 | Submission Open

Keywords: biomarkers; precision medicine; cancer-associated thrombosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Mar 2027 | 2 articles | Viewed by 1119 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Photophysics and Photochemistry in Biological Molecules

edited by

María Alicia Biasutti

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1089 | Submission Open

Keywords: photochemistry; photodegradation; Reactive Oxygen Species (ROS); emerging contaminants; bioremediation; biomolecules; carotenoids; enzymes; fatty acids; DNA; RNA; photodynamic therapy; fluorescence; photosynthesis; phototoxicity; photosensitizers

(This special issue belongs to the Section Biochemistry)

Advanced Functional Materials and Their Applications in Energy, Environment and Biomedical Fields

edited by

Vishwajit Chavda

and Woong Kim

submission deadline 31 Mar 2027 | Viewed by 1081 | Submission Open

Keywords: nanomaterials; synthesis; characterization; nanocomposites; nanoparticles; catalysis; adsorption; energy storage; environmental remediation; biomedical applications

(This special issue belongs to the Section Materials Science)

Recent Advances in Plant–Microbe Interactions

edited by

Daowan Lai

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1064 | Submission Open

Keywords: plant–microbe interactions; plant defense; pathogenicity; genetics; biochemistry; artificial intelligence; synthetic biology; symbiosis; plant protection

(This special issue belongs to the Section Molecular Plant Sciences)

Nanobiomaterials for Medical Research: From Molecular Mechanisms to Clinical Translation

edited by

Carmen Curutiu

Alina Maria Holban

and

Florin Iordache

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1050 | Submission Open

Keywords: nanomaterials; biopolymers; medical research; chronic diseases; molecular mechanisms

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Antimicrobial Resistance: Molecular and Biochemical Perspectives

edited by

Emanuela Santoro

submission deadline 31 Mar 2027 | 1 articles | Viewed by 1027 | Submission Open

Keywords: antimicrobial resistance mechanisms; molecular basis of resistance; metabolic reprogramming in bacteria; biofilm formation and regulation; resistance gene expression and regulation

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Advances in Coagulation and Bleeding

edited by

Muriel Meiring

submission deadline 31 Mar 2027 | 1 articles | Viewed by 967 | Submission Open

Keywords: thrombosis; haemostasis; inflammation-coagulation cross ralk; proteomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Advances in Biophysical Studies on Lipid Membranes

edited by Wallance Moreira Pazin

submission deadline 31 Mar 2027 | 1 articles | Viewed by 961 | Submission Open

Keywords: membrane biophysics; lipid organization; lipid–protein interactions; molecular dynamics simulations; membrane mechanics; nanoscale transport; model membrane systems; biomolecular interactions; membrane structure and dynamics; molecular-level characterization

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanism and Pathogenesis of Neuroinflammation in Neurological Disorders

edited by

Masashi Tanaka

submission deadline 31 Mar 2027 | Viewed by 944 | Submission Open

Keywords: age-related disorders; Alzheimer’s disease; amyloid-β; bioactive molecules; cognitive impairment; dementia; glial activation; microglia; neuroinflammation; neurological disorders; neurotherapeutics; tau hyperphosphorylation

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research on Noble Metal Nanoparticles

edited by

Shinmori Hideyuki

submission deadline 31 Mar 2027 | 2 articles | Viewed by 922 | Submission Open

Keywords: nanostructure; gold nanoparticles; silver nanoparticles; heterometallic nanoparticles; core–shell structure; surface chemistry; colloid chemistry; localized surface plasmon resonance

(This special issue belongs to the Section Molecular Nanoscience)

Animal Reproduction and Development: Current Issues and Future Perspectives

edited by

Kamil Janelt

submission deadline 31 Mar 2027 | 2 articles | Viewed by 891 | Submission Open

Keywords: reproductive and developmental biology; molecular and cellular mechanisms; gene regulation and epigenetics; physiology and metabolic regulation; biotechnology and translational research

(This special issue belongs to the Section Molecular Biology)

Medicinal Plants: Molecular Dissection of Active Compounds

edited by

Moxian Chen

and

Abazar Ghorbani

submission deadline 31 Mar 2027 | 1 articles | Viewed by 828 | Submission Open

Keywords: medicinal plants; active compounds; secondary metabolites; biosynthetic pathways; metabolic regulation; terpenoids; flavonoids; multi-omics; metabolic engineering; bioactivity

(This special issue belongs to the Section Molecular Plant Sciences)

Artificial Intelligence in Drug Design: Molecular Aspects

edited by

Dorota Latek

submission deadline 31 Mar 2027 | 1 articles | Viewed by 785 | Submission Open

Keywords: artificial intelligence; machine learning; drug design; medical imaging; apoptosis; metastasis; anticancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Novel Metallic Biomaterials: From Research to Clinical Translation

edited by Ke Yang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 770 | Submission Open

Keywords: metallic biomaterials; bio-functionality; biocompatibility; mechanical properties; clinical application

(This special issue belongs to the Section Materials Science)

Mathematical Calculation and Modeling in Biology

edited by Nan Sheng

submission deadline 31 Mar 2027 | 1 articles | Viewed by 762 | Submission Open

Keywords: mathematical modeling; computational biology; machine/deep learning; molecular biology; molecular interactions; gene; protein; small molecule; computational drug design; multi-omics

(This special issue belongs to the Section Molecular Informatics)

Molecular Targets in Reproductive Diseases

edited by

Changwon Yang

submission deadline 31 Mar 2027 | 1 articles | Viewed by 744 | Submission Open

Keywords: reproductive diseases; endometriosis; polycystic ovary syndrome; infertility-related disorders; pregnancy complications; reproductive system cancers; reproductive medicine; precise diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Peptides: Function, Metabolism and Synthesis

edited by

Leandro Mantovani de Castro

submission deadline 31 Mar 2027 | Viewed by 699 | Submission Open

Keywords: bioactive peptides; antimicrobial peptides; antitumoral peptides; neurodegenerative diseases; metabolic diseases; chemical synthesis; cellular proteolysis; mass spectrometry; peptidomics; intracellular peptides; micropeptides

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring Glia: New Insights into Neurobiology and Therapeutic Potential

edited by María de los Ángeles García-Robles

submission deadline 31 Mar 2027 | Viewed by 683 | Submission Open

Keywords: glial metabolism; astrocytes; microglia; oligodendrocytes; tanycytes; obesity; diabetes; metabolic disorders; neurogenesis; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Pathophysiology of Lung Diseases—2nd Edition

edited by

Theodoros Karampitsakos

and Vassilios Tzilas

submission deadline 31 Mar 2027 | Viewed by 662 | Submission Open

Keywords: biomarkers; asthma; COPD; pulmonary fibrosis; post-COVID-19; interstitial lung disease; pathogenesis; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Podocyte Research: Molecular Insights and Clinical Applications

edited by

Hans Lorenzo

submission deadline 31 Mar 2027 | Viewed by 605 | Submission Open

Keywords: podocytes; glomerular filtration barrier; slit diaphragm; podocyte injury; proteinuria; focal segmental glomerulosclerosis; nephrotic syndrome; cell death; non-coding RNAs; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2851-2900 on page 58 of 62.

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