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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advancements in Antimicrobial Agents: Focus on Biofilm Eradication

edited by

Marcus Vinícius Dias-Souza

submission deadline 30 Nov 2026 | Viewed by 171 | Submission Open

Keywords: antibiofilm plant extracts; antibiofilm phytomolecules; antibiofilm nanoparticles; antibiofilm liposomes; biofilm physiology; biofilm biochemistry; molecular biology of biofilms; biofilm eradication; biofilm growth control; structure of biofilms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies of Neurocognitive Disorders

edited by

Cristián Sandoval

and Edgar Vásquez Carrasco

submission deadline 30 Nov 2026 | Viewed by 170 | Submission Open

Keywords: neurocognitive disorders; mild cognitive impairment; Alzheimer’s disease; neuroinflammation; biomarkers; oxidative stress; neurodegeneration; multi-omics; precision medicine; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Biological and Mechanistic Insights in Frontotemporal Dementia and Related Disorders

edited by Barbara Borroni and

Daniela Crescenti

submission deadline 30 Nov 2026 | Viewed by 167 | Submission Open

Keywords: frontotemporal dementia; early-onset dementia; biomarkers; neuroimaging; molecular mechanisms; therapeutic approaches; differential diagnosis; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Reproductive Toxicity of Chemicals: 2nd Edition

edited by

Maria Laura Zenclussen

submission deadline 30 Nov 2026 | Viewed by 167 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Role of Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by

Nancy Martínez-Rodríguez

submission deadline 30 Nov 2026 | Viewed by 164 | Submission Open

Keywords: angiotensin II; cardiac fibrosis; heart failure; renin–angiotensin–aldosterone system (RAAS); extracellular matrix remodeling; myofibroblast activation; cardiovascular genomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Carbohydrate-Based Materials: Self-Assemblies and Applications

edited by

Redouane Borsali

and

Hong Li

submission deadline 30 Nov 2026 | Viewed by 160 | Submission Open

Keywords: carbohydrate-based materials; sustainable polymers; self-assembly; structure–property–function relationships; functional materials

(This special issue belongs to the Section Materials Science)

Computational Microbiome Research: Multi-Omics Integration for Uncovering Molecular Mechanisms, Functional Pathways, and Microbial Interactions

edited by

Manik Prabhu Narsing Rao

and

Arinthip Thamchaipenet

submission deadline 30 Nov 2026 | Viewed by 157 | Submission Open

Keywords: bioinformatics; metagenomics; comparative genomics; multi-omics integration

(This special issue belongs to the Section Molecular Microbiology)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment—2nd Edition

edited by Manuel Morales-Ruiz and

Jordi Ribera

submission deadline 30 Nov 2026 | Viewed by 156 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Secondary Metabolites of Pathogenic Fungi: From Mechanism to Medicine

edited by

Kritsada Pruksaphon

and

Nopawit Khamto

submission deadline 30 Nov 2026 | Viewed by 153 | Submission Open

Keywords: fungal secondary metabolites; mycotoxins; fungal virulence and fungal pathogenesis; biosynthetic gene clusters (BGCs); one strain–many compounds (OSMAC); metabolomics; host–pathogen interaction; ribotoxic stress; one health and climate change; diagnostic biomarkers; antifungal therapeutics; medicinal chemistry; structural biology

(This special issue belongs to the Section Molecular Microbiology)

Probiotics in Metabolism, Inflammation and Nervous System Disorders

edited by Subramanian Thangaleela

submission deadline 30 Nov 2026 | Viewed by 147 | Submission Open

Keywords: probiotics; gut–brain axis; metabolic diseases; neurological disorders; inflammation; secondary metabolites

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research Advances in HIV Infection

edited by

Sıla Akhan

submission deadline 30 Nov 2026 | Viewed by 145 | Submission Open

Keywords: HIV-1; CAR-T therapy; late HIV diagnosis; viral transmission; immune exhaustion; antiretroviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress of Biopolymers in Drug Delivery Systems

edited by

Narendra Kale

submission deadline 30 Nov 2026 | Viewed by 141 | Submission Open

Keywords: biopolymers; biomaterials; drug delivery systems; nanomedicine; targeted delivery; polymer therapeutics; bioengineering; quantitative imaging; stimuli-responsive drug delivery; biomedical polymers

(This special issue belongs to the Section Macromolecules)

Neuropharmacology of Pain: From Molecular Mechanisms to Clinical Translation

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 30 Nov 2026 | Viewed by 136 | Submission Open

Keywords: neuropharmacology; chronic pain; molecular mechanisms; neuroinflammation; neuropathic pain; pharmacological targets; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Unraveling the Mechanistic Pathways of Immune Cell Engagers in Lymphoproliferative Diseases

edited by

Stella Bouziana

submission deadline 30 Nov 2026 | Viewed by 132 | Submission Open

Keywords: lymphoproliferative diseases; immune cell engagers; BiTEs; molecular pathways; next-generation T cell engagers

(This special issue belongs to the Section Molecular Immunology)

Multi-Omics and Computational Simulation Approaches: Unraveling Novel Antibacterial Mechanisms of Natural Products

edited by Lili Li

submission deadline 30 Nov 2026 | Viewed by 127 | Submission Open

Keywords: natural products; antibacterial mechanism; anti-biofilm; multi-omics; computational simulation; drug-resistant pathogens

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Diabetes and Metabolic Dysfunction (Second Edition)

edited by

Vasilis K. Tsimihodimos

submission deadline 30 Nov 2026 | Viewed by 125 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Leveraging Novel Insights from Basic Science to Improve Hepatocellular Carcinoma Management in the Era of Precision Medicine

edited by

Hikmet Akkız

submission deadline 30 Nov 2026 | Viewed by 124 | Submission Open

Keywords: hepatocellular carcinoma; tumor microenvironment; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Molecular Design, Stabilization, and Controlled Delivery of Probiotics and Bioactive Compounds

edited by Chuang Zhang

submission deadline 30 Nov 2026 | Viewed by 121 | Submission Open

Keywords: probiotics; bioactive compounds; functional foods; microencapsulation; controlled delivery; food biopolymers; molecular interactions; bioavailability; gut microbiota; powder-based delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Viper Envenomation: From Molecular Mechanisms to Treatment

edited by

Svjetlana Karabuva

submission deadline 30 Nov 2026 | Viewed by 119 | Submission Open

Keywords: snake envenomation; viper envenomation; antiviper serum; Europe; guidelines

(This special issue belongs to the Section Molecular Toxicology)

Molecular Biology and Therapeutic Applications of Medicinal Plants

edited by Gothai Sivapragasam and Nanthiney Ragavan

submission deadline 30 Nov 2026 | Viewed by 117 | Submission Open

Keywords: medicinal plants; molecular biology; phytochemicals; wound healing; oxidative stress; inflammation; molecular pharmacology; regenerative medicine; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Mesenchymal Stromal Cells Within the Tissue Microenvironment: Translational Research and Therapeutic Perspectives

edited by Francesco Agostini

submission deadline 30 Nov 2026 | Viewed by 76 | Submission Open

Keywords: mesenchymal stem cells; microenvironment; stem niche; cancer; drug delivery; good manufacturing practice; cell therapy; medium additive substitutes; microfluidic conditions; homing; migration; gene editing by (non-)viral methods

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bladder Cancer

edited by

Hironobu Yamashita

submission deadline 1 Dec 2026 | 1 articles | Viewed by 950 | Submission Open

Keywords: urothelial carcinoma; molecular subtypes; tumor microenvironment (TME); epigenetics; precision medicine; chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Inflammation in Neurodegenerative Diseases

edited by

Selçuk Özdemir

submission deadline 1 Dec 2026 | Viewed by 201 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; molecular pathways; neuronal cell death; mitochondrial dysfunction; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Stem Cells, Biomaterials, and Molecular Therapies in Plastic Surgery

edited by

Stefan D. Momčilović

submission deadline 5 Dec 2026 | 1 articles | Viewed by 590 | Submission Open

Keywords: stem cells; tissue engineering; biomaterials and bioactive scaffolds; hydrogels; 3D bioprinting; regenerative medicine and surgery; molecular therapies; growth factors; scar modulation; skin repair

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biological Applications, Theoretical Studies, Nanomedicine and Molecular Docking Studies in Drug Discovery

edited by

Moragot Chatatikun

submission deadline 10 Dec 2026 | 1 articles | Viewed by 1149 | Submission Open

Keywords: drug discovery; molecular docking; molecular dynamics; QSAR; nanomedicine; nanoparticles; virtual screening; natural products; in vivo validation; ADMET

(This special issue belongs to the Section Molecular Pharmacology)

Bioactivity of Resveratrol and Flavonoids as Antioxidant and Anti-Inflammatory Compounds: Molecular Insights

edited by

José Díaz-Chávez

submission deadline 10 Dec 2026 | 1 articles | Viewed by 1019 | Submission Open

Keywords: resveratrol; flavonoids; polyphenols; antioxidant; anti-inflammatory; molecular mechanism; signal transduction; oxidative stress; gene expression; therapeutic agent

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach—2nd Edition

edited by

María Orosia Lucha López

submission deadline 15 Dec 2026 | 5 articles | Viewed by 5436 | Submission Open

Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Molecular Research on Cancer Treatments: Apoptosis, Autophagy, and Drug Selection

edited by

Md Ataur Rahman

submission deadline 20 Dec 2026 | 12 articles | Viewed by 24035 | Submission Open

Keywords: autophagy; apoptosis; bioactive natural products; nanoparticles and drug delivery; cancer immunotherapy; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Molecular Oncology)

Biocatalysis of Compounds for Pharmaceutical and Biomedical Applications

edited by

Tomasz Siodmiak

submission deadline 20 Dec 2026 | 4 articles | Viewed by 12970 | Submission Open

Keywords: biocatalysis; biomedical application; biotechnology; compounds for pharmacy; compounds for biomedicine; enantiomers; enzyme activity; enzyme engineering; enzyme immobilization; kinetic resolution; pharmaceutical application; supports materials

(This special issue belongs to the Section Molecular Pharmacology)

Cancer Biology and Epigenetic Modifications

edited by

Tamer E. Fandy

submission deadline 20 Dec 2026 | 3 articles | Viewed by 11088 | Submission Open

Keywords: epigenetics; DNA methylation; epigenetic modifiers; histone acetylation; histone methylation; miRNA; ncRNA; chrmoatin remodelling

(This special issue belongs to the Section Molecular Oncology)

Research in Alzheimer’s Disease: Advances and Perspectives

edited by

Silvia Boschi

submission deadline 20 Dec 2026 | 7 articles | Viewed by 11024 | Submission Open

Keywords: neuroinflammation; synaptic dysfunction; oxidative stress; neurofibrillary tangles; mitochondrial dysfunction; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances and Novel Biomarkers in Gastrointestinal Cancers

edited by

Alessandro Mannucci

submission deadline 20 Dec 2026 | 2 articles | Viewed by 10969 | Submission Open

Keywords: gastrointestinal cancers; liquid biopsy; circulating biomarkers; minimal residual disease; early cancer detection; tumor-agnostic assays; molecular diagnostics; precision oncology; predictive biomarkers; translational research

(This special issue belongs to the Section Molecular Oncology)

The Use of Molecular Biology in the Targeted Prevention, Diagnosis and Therapy of Microbial Infections

edited by

Maria D'Accolti

and

Elisabetta Caselli

submission deadline 20 Dec 2026 | 1 articles | Viewed by 6746 | Submission Open

Keywords: microbial infections; AMR; molecular biology; One Health; microbiome

(This special issue belongs to the Section Molecular Microbiology)

From Molecules to Cognition: Biomarkers and Neuropsychological Tools in Neurological Disorders

edited by

Silvia Boschi

submission deadline 20 Dec 2026 | 4 articles | Viewed by 5614 | Submission Open

Keywords: biomarkers; neuropsychological assessment; neurological disorders; neuroimaging; cognitive function; translational neuroscience

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Molecular Research of Animal Genetics and Genomics

edited by Congjiao Sun

submission deadline 20 Dec 2026 | 4 articles | Viewed by 3707 | Submission Open

Keywords: animal genetics; animal genomics; molecular breeding; genetic improvement; molecular evolution; genomic selection; genome-wide association studies (GWAS); CRISPR; multiomics analysis; animal conservation

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Bacteria: 2nd Edition

edited by

Giovanni Stelitano

submission deadline 20 Dec 2026 | 3 articles | Viewed by 3324 | Submission Open

Keywords: bacteria; molecular biology; infections; antimicrobials; bacterial enzymes; bioremediation; enzyme evolution and adaptation

(This special issue belongs to the Section Molecular Microbiology)

Influenza Pathogenesis and Vaccine Development

edited by

Awad Shehata

submission deadline 20 Dec 2026 | 2 articles | Viewed by 2935 | Submission Open

Keywords: avian influenza; influenza virus; influenza surveillance; interspecies transmission; immune response; pandemic preparedness; pathogenesis; One Health; universal vaccines; vaccine development; viral adaptation; viral evolution; zoonotic infections

(This special issue belongs to the Section Molecular Microbiology)

The Role of Fibroblasts in the Regulation of Tissue Inflammation and Repair

edited by Rebeca Illescas Montes

submission deadline 20 Dec 2026 | 1 articles | Viewed by 2647 | Submission Open

Keywords: fibroblast; wound healing; inflammation; tissue repair; immune–stromal crosstalk; extracellular matrix remodeling; myofibroblast; regenerative medicine; exosomes; biomaterials

(This special issue belongs to the Section Molecular Immunology)

Structural Studies of Phosphorus Compounds Today

edited by

Irina Rusakova

submission deadline 20 Dec 2026 | 1 articles | Viewed by 2419 | Submission Open

Keywords: 31P NMR; NMR; organophosphorus compounds; transition-metal complexes with organophosphorus ligands; relativistic effects; solvent effects; quantum chemistry methods for NMR; chemical structure studies; chemistry of organophosphorus compounds

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular and Cellular Neurobiology of Headache and Migraine

edited by

Mamoru Shibata

submission deadline 20 Dec 2026 | 1 articles | Viewed by 2257 | Submission Open

Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache

(This special issue belongs to the Section Molecular Neurobiology)

Autoimmune Diseases: A Swing Dance of Immune Cells, 3rd Edition

edited by

Balik Dzhambazov

submission deadline 20 Dec 2026 | 1 articles | Viewed by 1841 | Submission Open

Keywords: autoimmune diseases; antigens/autoantigens; post-translational modifications; antigen processing and presentation; shared epitopes; molecular mimicry; autoantibodies; immune signaling; animal models; therapeutic agents

(This special issue belongs to the Section Molecular Immunology)

Exosomes and Non-Coding RNA Research in Health and Disease—2nd Edition

edited by

Stergios Boussios

submission deadline 20 Dec 2026 | 1 articles | Viewed by 1785 | Submission Open

Keywords: exosomes; non-coding RNA; health; disease; intercellular communication; cancer; neurodegenerative disorders; cardiovascular diseases; immune regulation; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Trends of Quantum Mechanics, Computational Chemistry, and Spectroscopy in Physical Chemistry

edited by

Dongho Kim

submission deadline 20 Dec 2026 | Viewed by 1086 | Submission Open

Keywords: quantum theory; computational chemistry; spectroscopy

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Neurological and Neurodevelopmental Disorders: Models, Drugs and Technologies

edited by Su-Yun Lyu

submission deadline 20 Dec 2026 | 1 articles | Viewed by 899 | Submission Open

Keywords: neurodevelopmental disorders; disease modeling; molecular mechanisms; neurological; precision medicine; individualized therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Breeding and Comprehensive Utilization of Economic Crops

edited by Xia An

submission deadline 20 Dec 2026 | 1 articles | Viewed by 672 | Submission Open

Keywords: jute; kenaf; flax; okra; mustard; roselle; chloroplast genome; transcriptome; gene cloning; gene function verification; molecular mechanism research; biological stress; abiotic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Intelligent Computational Modeling for Molecular Biomarker Discovery, Prognostic Prediction and Molecular Diagnostics

edited by Chunlong Zhang and Yuming Zhao

submission deadline 20 Dec 2026 | 1 articles | Viewed by 403 | Submission Open

Keywords: molecular biomarkers; prognostic modeling; molecular diagnostics; machine learning; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Informatics)

Unraveling Cell–Cell and Cell–Matrix Interactions: Novel Morphological and Molecular Insights

edited by

José Freni

submission deadline 20 Dec 2026 | Viewed by 357 | Submission Open

Keywords: DGC; sarcoglycans; cell–cell interactions; cell–matrix interactions; morphological analysis; molecular analysis; molecular pathogenesis; translational studies

(This special issue belongs to the Section Molecular Biology)

From Molecular Mechanisms to Patient Related Outcomes: Advances in Spinal Muscular Atrophy Research and Care

edited by

Maria Gavriilaki

submission deadline 20 Dec 2026 | Viewed by 258 | Submission Open

Keywords: spinal muscular atrophy (SMA); neuromuscular disorders; SMN protein; disease modifiers; molecular pathogenesis; gene therapy; biomarkers; translational research; therapeutic advances

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Plant Transcriptomics

edited by

Babar Usman

submission deadline 20 Dec 2026 | Viewed by 155 | Submission Open

Keywords: plant transcriptomics; RNA-sequencing (RNA-seq); Micro-RNA (miRNA); MRNA-miRNA interactions; machine learning in genomics; deep learning for gene expression; gene regulatory networks; convolutional neural networks; transformer models; functional genomics; functional validation; tissue-specific gene expression; stress-responsive transcriptomics; genotype-by-environment transcriptomics; multi-omics integration; AI-assisted breeding; genomic selection; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 25 Dec 2026 | 6 articles | Viewed by 50365 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

Displaying special issue 1501-1550 on page 31 of 62.

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