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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Degradable Polymers: Synthesis, Applications, and Environmental Impact

edited by Ce Sun and

Haiyang Gao

submission deadline 20 Feb 2026 | 1 articles | Viewed by 934 | Submission Open

Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability

(This special issue belongs to the Section Macromolecules)

Molecular and Cellular Neurobiology of Headache and Migraine

edited by

Mamoru Shibata

submission deadline 20 Feb 2026 | 1 articles | Viewed by 926 | Submission Open

Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache

(This special issue belongs to the Section Molecular Neurobiology)

Beyond the Gene: Molecular Circuits Shaping Plant Cells and Tissues

edited by

Tarek Alshaal

submission deadline 20 Feb 2026 | Viewed by 885 | Submission Open

Keywords: cell function; cell polarity; tissue organization; transporter; localization

(This special issue belongs to the Section Molecular Plant Sciences)

Therapeutic Potential: Exploring Membrane Transporters and Channels as Drug Targets

edited by

Jinwei Zhang

submission deadline 20 Feb 2026 | Viewed by 884 | Submission Open

Keywords: membrane transporters; channels; drug targets; therapeutic potential; neurological disorders; metabolic syndromes; methodologies; mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Melatonin in Plants: 3rd Edition

edited by

Małgorzata M. Posmyk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 884 | Submission Open

Keywords: melatonin; phytomelatonin; plants; seed germination; seasonal and circadian rhythms; flowering; fruit ripening; plant immunity; abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular and Histological Approaches in Oral Tissue Regeneration and Diagnostics

edited by

Fabiana Nicita

submission deadline 20 Feb 2026 | 1 articles | Viewed by 877 | Submission Open

Keywords: dentistry; histological analysis; immunofluorescence; molecular pathogenesis; tissue

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense

edited by

Katarzyna Otulak-Kozieł

submission deadline 20 Feb 2026 | 1 articles | Viewed by 801 | Submission Open

Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant– virus interactions; molecular mechanism

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Targeted Therapy of Lymphedema and Lipedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 20 Feb 2026 | Viewed by 790 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Iron and Sulfur in Plants, 4th Edition

edited by

Stefania Astolfi

and

Silvia Celletti

submission deadline 20 Feb 2026 | Viewed by 770 | Submission Open

Keywords: biofortification; Fe– S clusters; iron; iron deficiency; metabolites; methionine; nutrient interaction; root exudates; strategy I; strategy ii; sulfur; sulfur deficiency

(This special issue belongs to the Section Molecular Plant Sciences)

Quantum Chemical Approaches for Investigating Reaction Mechanisms in Organic Chemistry

edited by

Robert O'Reilly

submission deadline 20 Feb 2026 | 1 articles | Viewed by 757 | Submission Open

Keywords: organic chemistry; biochemistry; density functional theory; coupled cluster theory; free radicals; reaction mechanisms; transition states

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Contribution of Astrocytes and Microglia for the Development of Neurological Disorders

edited by

Rommy Von Bernhardi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: aging; astrocytes; glial cells; microglia; neurodegenerative diseases; neuron-glia interaction; neuroimmune response; neuroinflammation

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Molecular Mechanisms and Targeted Therapies for Leukemia

edited by

Moo Kon Song

submission deadline 20 Feb 2026 | Viewed by 744 | Submission Open

Keywords: targeted therapy; acute myeloid leukemia; genetic mutations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Nanomaterial-Mediated Immune Modulation

edited by

Ivan Kempson

submission deadline 20 Feb 2026 | Viewed by 743 | Submission Open

Keywords: nanomaterial; immune modulation; immunological responses

(This special issue belongs to the Section Molecular Nanoscience)

AIEgens in Action: Design, Mechanisms, and Emerging Applications

edited by

Arkadiusz Matwijczuk

submission deadline 20 Feb 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: fluorescence effects; photophysical properties of small molecules; ion detection; molecular spectroscopy; various nanoparticle-based additives; fluorescent and phosphorescent phenomena in solvents; amorphous states; and crystals; quantum-mechanical calculations for molecular systems and compositions (DFT; TD-DFT); molecular aggregation influencing fluorescence and phosphorescence properties of tested systems

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Biosensors: Emerging Technologies and Real-Time Monitoring

edited by

Velmurugan Thavasi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 720 | Submission Open

Keywords: biosensors; real-time monitoring; wearable sensors; electrochemical detection; optical biosensors; point-of-care (POC) diagnostics; biomarker identification and analysis; wireless technologies

(This special issue belongs to the Section Biochemistry)

Cellular Senescence as a Therapeutic Target in Cancer: Mechanisms, Challenges, and Therapeutic Opportunities

edited by

Mi Kyung Park

submission deadline 20 Feb 2026 | 1 articles | Viewed by 711 | Submission Open

Keywords: cellular senescence; cancer therapy; therapeutic targeting; senolytic drugs; senescence-associated secretory phenotype (SASP)

(This special issue belongs to the Section Molecular Oncology)

Vitamin K in Disease Mechanisms and Therapy

edited by Maria Kokozidou

submission deadline 20 Feb 2026 | Viewed by 682 | Submission Open

Keywords: vitamins K; vitamins K-soluble proteins; vitamin K-dependent clotting factors; matrix Gla protein; calcification of blood vessels; vascular stiffness; cardiac output; stroke volume

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Synaptic Structure and Function in the Healthy and Diseased Brain

edited by

Jacopo Meldolesi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: molecular studies; axons; synapses; diseases; glial cells

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Treatment in Skin Cancer

edited by

Jànos Hunyadi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 641 | Submission Open

Keywords: skin cancer; early detection; treatment; prevention; pathophysiology; vitamin-C; cell energetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Biological and Molecular Mechanisms and Targeted Therapies of Leukemia

edited by Anna Sicuranza

submission deadline 20 Feb 2026 | 2 articles | Viewed by 594 | Submission Open

Keywords: leukemia-targeted therapies; AML; CML; venetoclax combination therapy; tyrosine kinase inhibitors (TKIs); hypomethylating agents; ALL; CLL; CAR-T cell therapy; monoclonal antibodies; immune checkpoint inhibitors; resistance mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanisms in Biofilm Formation, Tolerance and Control: 3rd Edition

edited by

Manuel Simões

and Lúcia Chaves Simões

submission deadline 20 Feb 2026 | Viewed by 586 | Submission Open

Keywords: adhesion; antimicrobial action; antimicrobial resistance; biofilm development; biofilm matrix; biofilm structure; quorum sensing; motility; surfaces

(This special issue belongs to the Section Molecular Microbiology)

Molecular Linkages Between Obesity, Diabetes and Cancer

edited by Pilar F. Valerón

submission deadline 20 Feb 2026 | Viewed by 569 | Submission Open

Keywords: obesity; GLUT4; PPARg; lipid transporters (CD36 and AQP7); cancer progression; metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidants: Design, Synthesis, and Mechanism of Actions

edited by Choon Young Lee

submission deadline 20 Feb 2026 | 1 articles | Viewed by 563 | Submission Open

Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator

(This special issue belongs to the Section Macromolecules)

Advancements and Applications of Phyto-Nanotherapy in Targeted Disease Treatment

edited by

Adewale Fadaka

and

Nicole Remaliah Samantha Sibuyi

submission deadline 20 Feb 2026 | Viewed by 543 | Submission Open

Keywords: phyto-nanotherapy; medicinal plants; nanoparticles; targeted drug delivery; phytochemicals; phytotherapy; green nanotechnology; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Role of Quorum Sensing in Plant Microbiome: Advances and Prospects

edited by

Clarisse Brígido

submission deadline 20 Feb 2026 | Viewed by 539 | Submission Open

Keywords: quorum sensing; quorum quenching; rhizosphere signaling; signaling molecules; N-Acyl-L-homoserine lactones; AHLs; microbiome; chemical molecules; sustainable agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

Endometrial Function in Women with Polycystic Ovary Syndrome: Molecular Data

edited by

Stefano Palomba

submission deadline 20 Feb 2026 | Viewed by 536 | Submission Open

Keywords: endometrium; infertility; polycystic ovary syndrome; PCOS; receptivity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Natural Products—3rd Edition

edited by

Bruno Eto

submission deadline 20 Feb 2026 | 1 articles | Viewed by 535 | Submission Open

Keywords: bioactive products; anti-infectives; antioxidants; anti-inflammatory; antiproliferative; clinical phytopharmacology; phytopharmacology; polyphytotherapy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Molecular Research of Facial Adipose Compartments

edited by Marius Valeriu Hînganu

submission deadline 20 Feb 2026 | Viewed by 514 | Submission Open

Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing

(This special issue belongs to the Section Molecular Biology)

Abiotic Stress in Plants, 2nd Edition

edited by

Xiujun Zhang

submission deadline 20 Feb 2026 | 1 articles | Viewed by 508 | Submission Open

Keywords: abiotic stress; ROS; redox; antioxidants; phytohormones; ethylene; plant stress eco-physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Innovative Materials and Procedures for Implant and Prosthodontics

edited by

Margherita Tumedei

and

Massimo Del Fabbro

submission deadline 20 Feb 2026 | Viewed by 502 | Submission Open

Keywords: alloys; biomaterials; dental materials; dental implants; implant dentistry; implant-abutment connection; peri-implant diseases; prosthodontics; surface treatments; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular Diseases: Histopathological and Molecular Diagnostics, 2nd Edition

edited by

Simona Gurzu

submission deadline 20 Feb 2026 | Viewed by 495 | Submission Open

Keywords: cardiovascular disorders; heart failure; aortic diseases; cardiomyocytes; cardiac function; myocarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Fungal Genetics and Functional Genomics Research

edited by

Yuqi Qin

and

Jian Zhao

submission deadline 20 Feb 2026 | 2 articles | Viewed by 491 | Submission Open

Keywords: enzymes; fungal genetics; fungi; gene editing; regulation; secondary metabolites; synthetic biology; transcription

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nerve Growth Factor (NGF): Molecular Functions and Therapeutic Implications

edited by

Elena Fico

and Pamela Rosso

submission deadline 20 Feb 2026 | Viewed by 487 | Submission Open

Keywords: nerve growth factor; neurotrophic therapy; biomolecules; neurotrophic molecular pathways; neuroprotection; preclinical research; clinical research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Regulation and Mechanisms of Nitric Oxide in Endothelial Cells and Beyond

edited by

Roberto Berra-Romani

and

Francesco Moccia

submission deadline 20 Feb 2026 | Viewed by 486 | Submission Open

Keywords: nitric oxide (NO); endothelial cells; endothelial nitric oxide synthase (eNOS); vascular homeostasis; vasodilation; endothelial dysfunction; molecular signaling; vascular diseases; reactive oxygen species (ROS); nitric oxide regulation

(This special issue belongs to the Section Biochemistry)

Reactive Oxygen Species (ROS) and Metal Ions in Biological Systems

edited by

Chryssoula Drouza

and

Debbie C. Crans

submission deadline 20 Feb 2026 | Viewed by 485 | Submission Open

Keywords: reactive oxygen species; reactive oxygen species metabolism; diseases and reactive oxygen species; lipid peroxidation; metal ions and reactive oxygen species; metal based drugs; oxidative stress

(This special issue belongs to the Section Biochemistry)

Stem Cell Therapy for Neurological Disorders

edited by Gabriele Bonaventura

submission deadline 20 Feb 2026 | Viewed by 472 | Submission Open

Keywords: neurodegenerative disease; cell therapy; stem cells; induced pluripotent stem cells; disease modeling; drug target validation

(This special issue belongs to the Section Molecular Neurobiology)

Exploring the Role of Antioxidants in Supplements and Drug Responses

edited by

Maria Greabu

submission deadline 20 Feb 2026 | Viewed by 467 | Submission Open

Keywords: NSAIDs; glucocorticoids; vitamin E; antioxidants; oxidative stress; inflammation

(This special issue belongs to the Section Molecular Immunology)

Molecular Biology of the Thyroid Cancer and Thyroid Dysfunctions: 2nd Edition

edited by Vija Lavinia

submission deadline 20 Feb 2026 | 1 articles | Viewed by 458 | Submission Open

Keywords: animal models; apoptosis; autophagy; cancer biomarker; cancer epidemiology; cancer prevention; cancer screening; cholesterol metabolism; clinical trial; DNA repair; epigenomics; genome instability; genomic database; genomics; invasion; metabolomics; metastasis; methylation; microarray; microRNA; molecular diagnostics; molecular tumor pathology; next-generation sequencing; noncoding RNA; omics; personalized medicine; prognosis; proteomics; radionuclide therapy; signaling pathway; SNP genotyping; targeted therapy; theranostics; thyroid cancer; hyperthyroidism; therapeutic targets; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Monoamine Signalling Pathways as a Target for Pathomechanism of Mental Disorders and Pharmacotherapy

edited by

Agnieszka Zelek-Molik

submission deadline 20 Feb 2026 | Viewed by 442 | Submission Open

Keywords: monoaminergic system; psychiatric disorders; neurotransmission regulation; biomarkers; novel therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Plant Adaptation to Stress

edited by Yuanchun Ma

submission deadline 20 Feb 2026 | Viewed by 435 | Submission Open

Keywords: plant; environmental stresses; signaling pathways; stress-responsive genes; transcription factors; phytohormones; crop resilience; breeding; genetic engineering

(This special issue belongs to the Section Molecular Plant Sciences)

Signaling Pathways in Neuroinflammation or Neurodegenerative Disorders

edited by

Marika Cordaro

submission deadline 20 Feb 2026 | Viewed by 429 | Submission Open

Keywords: inflammation; neuroinflammation; oxidative stress; neurodegenerative disorders; pathology; molecular pathways; dysregulation; mitochondrial dysfunction

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Forensics at Trial

edited by

Guido Viel

submission deadline 20 Feb 2026 | 1 articles | Viewed by 415 | Submission Open

Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology

(This special issue belongs to the Section Molecular Toxicology)

Novel Insights into the Molecular Mechanisms of Pancreatitis

edited by

Gi-Sang Bae

submission deadline 20 Feb 2026 | Viewed by 410 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatic fibrosis; mechanisms; digestive enzymes; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathogenic Mechanisms of Candida auris

edited by

Anastasia Spiliopoulou

submission deadline 20 Feb 2026 | Viewed by 409 | Submission Open

Keywords: C. auris; antifungal resistance; immune evasion

(This special issue belongs to the Section Molecular Microbiology)

Recent Research on Optoelectronic Materials

edited by

Meysam Tayebi

submission deadline 20 Feb 2026 | Viewed by 409 | Submission Open

Keywords: photoelectrochemistry; optoelectronic materials; perovskite materials; semiconductor interfaces; molecular-level catalysis; solar fuel conversion; nanostructured materials; light-harvesting systems

(This special issue belongs to the Section Materials Science)

Molecular Effects of Exercise Training in the Prevention and Treatment of Cardiovascular Diseases

edited by

Maxime Pellegrin

submission deadline 20 Feb 2026 | Viewed by 408 | Submission Open

Keywords: atherosclerosis; cardiovascular disease; exercise training; molecular mechanisms; training modalities

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in the Relationship Between Diabetes and Cancers

edited by

Zsuzsanna Németh

submission deadline 20 Feb 2026 | Viewed by 400 | Submission Open

Keywords: diabetes; insulin resistance; glucose intolerance; glucolipotoxicity; ER stress; oxidative stress; cancer development

(This special issue belongs to the Section Molecular Oncology)

Mitochondrial Disorders: From Molecular Mechanisms to New Therapies

edited by

Yury Ladilov

and

Muhammad Aslam

submission deadline 20 Feb 2026 | Viewed by 399 | Submission Open

Keywords: mitochondrial disorders; mitochondrial dysfunction; molecular mechanisms; targeted therapeutic approaches; mitochondrial biology regulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research Progress of Optoelectronic Materials and Devices

edited by Moon Jong Han

submission deadline 20 Feb 2026 | Viewed by 371 | Submission Open

Keywords: semiconductors; multifunctionalities; optoelectronics; structure-driven properties; thin films; polymers

(This special issue belongs to the Section Materials Science)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 20 Feb 2026 | Viewed by 370 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 951-1000 on page 20 of 67.

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