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Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of Natural Products—3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 February 2026 | Viewed by 388

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Laboratoires TBC, Laboratory of Pharmacology, Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Lille, 3, Rue du Professeur Laguesse, B.P. 83, F-59000 Lille, France
Interests: clinical pharmacology and phyto-pharmacology; drug development; transport of drugs and xenobiotics across biological barriers; therapeutic food supplements; diabetes and hypertension
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Special Issue Information

Dear Colleagues,

Bioactive molecules from plants and fungi have been used for centuries as the main source of natural bioactive molecules. Today, these molecules are derived from humans and animals. For example, cruor, the main component responsible for the red color of mammals’ blood, contains 90% hemoglobin, a protein that is considered a rich source of bioactive peptides. The hydrolysates of human and bovine hemoglobin have made it possible to isolate peptides with antioxidant, antibacterial, anti-inflammatory, and antiproliferative properties. Molecules and peptides derived from human and bovine hemoglobin could be the source of natural bioactive products for the development of biological drugs and biosimilars. Comparisons of the activities of bioactive products derived from animals and plants are increasingly being performed by the pharmaceutical industry to develop effective drugs at low costs.

Prof. Dr. Bruno Eto
Guest Editor

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Keywords

  • bioactive products
  • anti-infectives
  • antioxidants
  • anti-inflammatory
  • antiproliferative
  • clinical phytopharmacology
  • phytopharmacology
  • polyphytotherapy

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Published Papers (1 paper)

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Research

22 pages, 1165 KB  
Article
Synergistic Effects of High-Intensity Interval Training and Asparagus officinalis L. Root Extract Supplementation on Metabolic Regulation, Oxidative Stress, and Inflammation in Overweight and Obese Adults
by Piyapong Prasertsri, Tadsawiya Padkao, Orachorn Boonla, Surachat Buddhisa, Nattaphol Prakobkaew, Siriporn Sripinyowanich and Jatuporn Phoemsapthawee
Int. J. Mol. Sci. 2025, 26(24), 12054; https://doi.org/10.3390/ijms262412054 - 15 Dec 2025
Viewed by 19
Abstract
Excess adiposity is associated with increased oxidative stress and inflammation, which contribute to metabolic dysregulation. Both exercise training and bioactive plant-derived compounds have been explored as therapeutic strategies to mitigate these effects. Asparagus (Asparagus officinalis L.) root extract, rich in ecdysteroids such [...] Read more.
Excess adiposity is associated with increased oxidative stress and inflammation, which contribute to metabolic dysregulation. Both exercise training and bioactive plant-derived compounds have been explored as therapeutic strategies to mitigate these effects. Asparagus (Asparagus officinalis L.) root extract, rich in ecdysteroids such as 20-hydroxyecdysone (20E), exhibits potent antioxidant and anti-inflammatory activities. This randomized controlled trial investigated the combined effects of high-intensity interval training (HIIT) and asparagus root extract (ARE) supplementation on metabolic parameters, oxidative stress, inflammatory biomarkers, and white blood cell counts in overweight and obese adults. Seventy-two participants aged 18–30 years with a body mass index ≥ 23 kg/m2 were randomly assigned to one of four groups: control (CON), ARE supplementation only (ARE), HIIT only (HIIT), and combined intervention (COM). The HIIT protocol comprised a modified Tabata regimen of progressive bodyweight intervals at 80–90% and 40–50% of maximal perceived exertion, performed three times per week for 12 weeks. Participants in the ARE and COM groups received a daily oral dose of ARE providing 1.71 ± 0.24 mg/kg/day of 20E. Compared with the CON group, the HIIT group showed significant reductions in total cholesterol (TC), the TC/high-density lipoprotein cholesterol (HDLC) ratio, and blood glucose levels, alongside significant increases in HDLC and superoxide dismutase (SOD) activity (all p < 0.05). The COM group demonstrated significant decreases in protein carbonyls and interleukin-6 levels and in the TC/HDLC ratio (all p < 0.05) as well as a significant increase in SOD activity (p = 0.002). The ARE group, meanwhile, exhibited significant increases in both SOD activity (p < 0.001) and malondialdehyde levels (p = 0.017). These findings suggest that combining HIIT with ARE supplementation produces synergistic improvements in oxidative and inflammatory status, whereas HIIT alone primarily enhances metabolic regulation in overweight and obese individuals. Full article
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