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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Pathogenesis of Pathogenic Fungi: The Era of AI and New Technologies

edited by

Paul Wai Kei Tsang

submission deadline 30 Nov 2026 | Viewed by 286 | Submission Open

Keywords: artificial intelligence; molecular diagnosis and detection; therapeutic targeting; resistance and prediction; host relationships; immunity

(This special issue belongs to the Section Molecular Microbiology)

Plant Natural Products: New Advances in the Discovery, Regulation, and Engineering

edited by

Thiago Barbosa Cahú

and

Bruno Veras

submission deadline 30 Nov 2026 | Viewed by 280 | Submission Open

Keywords: polyphenols; glycoconjugates; plant protein; polysaccharides; crop production; processing wastes; circular economy; techno-economical evaluation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Next-Generation Sequencing Assays in Precision Oncology

edited by Kakoli Das,

Jens Samol

and Chuah Khoon Leong

submission deadline 30 Nov 2026 | Viewed by 278 | Submission Open

Keywords: precision oncology; NGS; genomics; transcriptomics; proteomics; molecular pathology; multi-omics integration

(This special issue belongs to the Section Molecular Oncology)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Nov 2026 | Viewed by 277 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

Latest Research on Mixed Biofilms: Bacterial and Antimicrobial Agents

edited by

Anis Rageh Mohammad Al-Maleki

submission deadline 30 Nov 2026 | Viewed by 273 | Submission Open

Keywords: antimicrobial resistance (AMR); biofilms; mixed-species biofilms; microbial interactions; anti-biofilm strategies; microbial virulence; host–pathogen interactions; microbiome; omics approaches (proteomics, genomics, metabolomics); infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Nov 2026 | Viewed by 270 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Trace Elements in Nutrition and Health Research

edited by

Kyria Jayanne Clímaco Cruz

submission deadline 30 Nov 2026 | Viewed by 269 | Submission Open

Keywords: trace elements; essential elements; toxic trace elements; micronutrient homeostasis; bioavailability; nutrient interactions; deficiency and overload; human health; disease prevention

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Smart and Sustainable Hydrogels for Environmental Applications

edited by Rolando Chamy

submission deadline 30 Nov 2026 | Viewed by 269 | Submission Open

Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine

(This special issue belongs to the Section Materials Science)

Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System

edited by Stefanie Gilles

submission deadline 30 Nov 2026 | Viewed by 263 | Submission Open

Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology

(This special issue belongs to the Section Molecular Immunology)

Translational Pharmacogenomics and Precision Medicine: From Discovery to Application

edited by

Sukru Tuzmen

submission deadline 30 Nov 2026 | Viewed by 261 | Submission Open

Keywords: pharmacogenomics; personalized medicine; drug discovery; cancer genetics; wellness; nutrigenomics; mindfulness; genome; health; dentistry; education; microbiome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Encephalitis: Mechanisms, Models, and Treatment Strategies

edited by

Hasan Tarik Atmaca

and

Gungor Cagdas Dincel

submission deadline 30 Nov 2026 | Viewed by 257 | Submission Open

Keywords: encephalitis; neuroinflammation; host–pathogen interactions; central nervous system; experimental models; comparative medicine; veterinary medicine; human medicine; molecular mechanisms; treatment strategies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights in Cardiovascular Disease

edited by

Sudhir Pandey

submission deadline 30 Nov 2026 | Viewed by 253 | Submission Open

Keywords: heart failure; gut microbiome dysbiosis-cardiotoxicity; diabetic cardiomyopathy; cardiovascular aging; chemotherapy associated cardiotoxicity; autophagy; mitochondrial dysfunction; rhythmic disorders; risk factors; ion channels; energy metabolism; cardiac hypertension; echocardiography; remodelling; transplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Treatments of Diabetes Mellitus: 3rd Edition

edited by

Mihail Virgil Boldeanu

submission deadline 30 Nov 2026 | Viewed by 249 | Submission Open

Keywords: metabolic disorders; diabetes mellitus; inflammation; neurotransmitter; inflammatory biomarkers; molecular target; molecular diagnostics; therapeutics; insulin resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Newest Antibacterial Applications of Metal Nanoparticles

edited by

Serhat Keser

submission deadline 30 Nov 2026 | Viewed by 249 | Submission Open

Keywords: metal oxides; hydroxyapatites; antibacterial; gram positive; gram negative; nanoparticles; antibacterial; antibacterial resistance; bioactivity; biocompatibility; metal-based nanoparticles

(This special issue belongs to the Section Molecular Nanoscience)

Advances in the Integrin System: Relevance of Receptors, Ligands, and Counter-Receptors in Signaling and Pathophysiology

edited by

Carlos Cabañas

and

Carmelo Bernabeu

submission deadline 30 Nov 2026 | Viewed by 240 | Submission Open

Keywords: integrin function; integrin signalling pathways; integrin conformational changes; integrin disease and therapeutic strategies; integrin-ligand interactions; integrin counter-receptors (ICRs); extracellular matrix (ECM) integrin ligands

(This special issue belongs to the Section Molecular Biology)

Natural Bioactives Targeting Molecular Mechanisms in Neurological Disorders: From Pathophysiology to Therapy

edited by Jinatta Jittiwat

submission deadline 30 Nov 2026 | Viewed by 235 | Submission Open

Keywords: natural bioactives; molecular mechanisms; neurological disorders; oxidative stress; neuroinflammation; therapeutic targeting; neuroprotection; mitochondrial dysfunction; apoptosis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Mechanisms in Fibrotic Interstitial Lung Diseases

edited by Eirini Vasarmidi

submission deadline 30 Nov 2026 | Viewed by 229 | Submission Open

Keywords: interstitial lung diseases; rare lung diseases; autoimmune lung diseases; pulmonary fibrosis; molecular pathways; biomarkers; bronchoalveolar lavage; genetics in lung fibrosis; familial fibrosis; pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Leveraging Multiomics for Resilient Crop Development and Food Security

edited by Niharika Sharma

submission deadline 30 Nov 2026 | Viewed by 226 | Submission Open

Keywords: multiomics; crop resilience; climate smart crops; stress tolerance; sustainable crop improvement; genotype‑by‑environment interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Regulatory Networks and Gene Expression Pathways in Bacteria

edited by Miguel A. Ares

submission deadline 30 Nov 2026 | Viewed by 216 | Submission Open

Keywords: bacterial gene expression; regulatory networks; transcription factors; sigma factors; two-component systems; quorum sensing; non-coding RNAs; host–pathogen interactions; bacterial adaptation; RNA-seq

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights Through Bioinformatics and Machine Learning: Precision-Driven Discovery of Drugs, Nutraceuticals, and Insecticides

edited by

Cleydson Breno Rodrigues dos Santos

submission deadline 30 Nov 2026 | Viewed by 215 | Submission Open

Keywords: computational bioactive compound discovery; density functional theory (DFT); antioxidant mechanisms; natural product-based drug discovery; AI-driven molecular modeling

(This special issue belongs to the Section Molecular Informatics)

Molecular Mechanisms Regulating Plant Growth, Development, and Stress Adaptation

edited by

Asma Ayaz

submission deadline 30 Nov 2026 | Viewed by 208 | Submission Open

Keywords: plant growth; plant development; molecular mechanisms; phytohormone signaling; abiotic stress; biotic stress; molecular cloning; plant–microbe interactions; omics approaches; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Diabetes: Molecular Perspectives—from Genetic Risk to Precision Therapy

edited by Suma Elumalai

submission deadline 30 Nov 2026 | Viewed by 207 | Submission Open

Keywords: diabetes mellitus; insulin signaling; β-cell dysfunction; insulin resistance; genomics; epigenetics; multi-omics; inter-organ communication; molecular therapeutics; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioinformatics and Phylogenetics of Molecular Pathways and Human Diseases

edited by

Yang Yang

submission deadline 30 Nov 2026 | Viewed by 205 | Submission Open

Keywords: bioinformatics; phylogenetics; molecular pathways; human disease; multi-omics integration; biomarker discovery; disease knowledge graph

(This special issue belongs to the Section Molecular Informatics)

The Molecular Mechanisms of Lead-Induced Neurotoxicity

edited by

Irena Baranowska-Bosiacka

and

Magdalena Gąssowska-Dobrowolska

submission deadline 30 Nov 2026 | Viewed by 204 | Submission Open

Keywords: lead; neurogenesis and neuronal development; intracellular signaling pathways; synaptic protein function; synaptic transmission and plasticity; neuroinflammation and inflammatory signaling; astrocyte–neuron metabolic cooperation; disturbances in vitamin and micronutrient metabolism; lead-induced alterations of the gut microbiota and gut–brain axis; molecular mechanisms underlying cognitive impairment; pathways contributing to the progression of neurodegenerative disorders following lead exposure

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Nerve Injury and Regeneration

edited by Barbara Hausott

submission deadline 30 Nov 2026 | Viewed by 200 | Submission Open

Keywords: nerve injury; regeneration; sensory neuron; motoneuron; Schwann cell; macrophage; neutrophin; cytokine; transcription factor; microrna

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Addiction and Substance Abuse Disorders

edited by Martin O. Job

submission deadline 30 Nov 2026 | Viewed by 196 | Submission Open

Keywords: psychostimulant use disorders; opioid use disorders; addiction; biomarkers; phenotypes; heterogeneity; genomics; epigenetics; metabolomics; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Engineering of Photo(electro)catalysts: Rational Design and Electron Transfer

edited by Bingqing Zhang

submission deadline 30 Nov 2026 | Viewed by 190 | Submission Open

Keywords: photocatalysis; photoelectrocatalysis; molecular engineering; semiconductor materials; artificial photosynthesis; (photo)electrochemical sensors; energy materials; electron transfer

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Abiotic Stresses in Plants: An Update

edited by Krzysztof Michał Tokarz

submission deadline 30 Nov 2026 | Viewed by 187 | Submission Open

Keywords: extreme temperatures; floods; photosynthetic apparatus; salinity; secondary metabolites; UV radiation; water shortages

(This special issue belongs to the Section Molecular Plant Sciences)

The Effects of Natural Products on Neurological Disorders

edited by Erika Monserrat Estrada-Camarena,

María Eva González Trujano

and Carolina López-Rubalcava

submission deadline 30 Nov 2026 | Viewed by 183 | Submission Open

Keywords: natural products; plants; fungi; vegetables; neurodegeneration; neuroinflammation; mechanism of action; neurodegenerative disorders; mental disorders; animal models; bioactive compounds; behavior

(This special issue belongs to the Section Molecular Neurobiology)

New Insights into Immune Dysregulation Disorders: Second Edition

edited by

Francesco Saettini

submission deadline 30 Nov 2026 | Viewed by 178 | Submission Open

Keywords: immune dysregulation disorders; autoimmune conditions; primary immunodeficiencies; autoinflammatory disorders

(This special issue belongs to the Section Molecular Immunology)

Extraction, Characterization and Application of Bioactive Compounds

edited by

Dorota Gumul

and Marek Kruczek

submission deadline 30 Nov 2026 | Viewed by 178 | Submission Open

Keywords: bioactive compounds; extraction methods; molecular mechanisms; antioxidants; encapsulation; functional foods; bioavailability; food by-products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

A New Perspective on Fruit Quality: From Molecular Regulatory Mechanisms to Nutritional Value

edited by Xuelian Zhang

submission deadline 30 Nov 2026 | Viewed by 176 | Submission Open

Keywords: fruit quality; color regulation; texture; flavor; bioactive compounds; anthocyanins; carotenoids; human nutrition; CRISPR/Cas9; multi omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Tumor Immunology: Molecular Research and Advances

edited by Elizabeth Cristina Perez Hurtado

submission deadline 30 Nov 2026 | Viewed by 175 | Submission Open

Keywords: tumor microenvironment; tumor evasion; immune checkpoint inhibitors; macrophages; biomarkers in cancer; CAR cell therapy; cancer vaccines; lipid metabolism in cancer; metabolic reprogramming of immune response

(This special issue belongs to the Section Molecular Immunology)

Endocrine Disruptors and the Nervous System: From Neurodevelopment to Neurotoxicity

edited by

Eui-Bae Jeung

submission deadline 30 Nov 2026 | Viewed by 174 | Submission Open

Keywords: endocrine disruptors; neurodevelopment; neurotoxicity; neuroendocrine; behavior; cognitive function; molecular mechanisms; alternative testing methods; developmental toxicity; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

ABA Mediated Plant Growth and Development, and Response to Drought and Salt Stress

edited by

Kun Li

and Fengbo Yang

submission deadline 30 Nov 2026 | Viewed by 171 | Submission Open

Keywords: ABA; drought; salt stress; osmotic stress; signal transduction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Advancements in Antimicrobial Agents: Focus on Biofilm Eradication

edited by

Marcus Vinícius Dias-Souza

submission deadline 30 Nov 2026 | Viewed by 170 | Submission Open

Keywords: antibiofilm plant extracts; antibiofilm phytomolecules; antibiofilm nanoparticles; antibiofilm liposomes; biofilm physiology; biofilm biochemistry; molecular biology of biofilms; biofilm eradication; biofilm growth control; structure of biofilms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Studies of Neurocognitive Disorders

edited by

Cristián Sandoval

and Edgar Vásquez Carrasco

submission deadline 30 Nov 2026 | Viewed by 169 | Submission Open

Keywords: neurocognitive disorders; mild cognitive impairment; Alzheimer’s disease; neuroinflammation; biomarkers; oxidative stress; neurodegeneration; multi-omics; precision medicine; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Reproductive Toxicity of Chemicals: 2nd Edition

edited by

Maria Laura Zenclussen

submission deadline 30 Nov 2026 | Viewed by 165 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Biological and Mechanistic Insights in Frontotemporal Dementia and Related Disorders

edited by Barbara Borroni and

Daniela Crescenti

submission deadline 30 Nov 2026 | Viewed by 164 | Submission Open

Keywords: frontotemporal dementia; early-onset dementia; biomarkers; neuroimaging; molecular mechanisms; therapeutic approaches; differential diagnosis; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Role of Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by

Nancy Martínez-Rodríguez

submission deadline 30 Nov 2026 | Viewed by 163 | Submission Open

Keywords: angiotensin II; cardiac fibrosis; heart failure; renin–angiotensin–aldosterone system (RAAS); extracellular matrix remodeling; myofibroblast activation; cardiovascular genomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Carbohydrate-Based Materials: Self-Assemblies and Applications

edited by

Redouane Borsali

and

Hong Li

submission deadline 30 Nov 2026 | Viewed by 159 | Submission Open

Keywords: carbohydrate-based materials; sustainable polymers; self-assembly; structure–property–function relationships; functional materials

(This special issue belongs to the Section Materials Science)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment—2nd Edition

edited by Manuel Morales-Ruiz and

Jordi Ribera

submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Microbiome Research: Multi-Omics Integration for Uncovering Molecular Mechanisms, Functional Pathways, and Microbial Interactions

edited by

Manik Prabhu Narsing Rao

and

Arinthip Thamchaipenet

submission deadline 30 Nov 2026 | Viewed by 155 | Submission Open

Keywords: bioinformatics; metagenomics; comparative genomics; multi-omics integration

(This special issue belongs to the Section Molecular Microbiology)

Secondary Metabolites of Pathogenic Fungi: From Mechanism to Medicine

edited by

Kritsada Pruksaphon

and

Nopawit Khamto

submission deadline 30 Nov 2026 | Viewed by 152 | Submission Open

Keywords: fungal secondary metabolites; mycotoxins; fungal virulence and fungal pathogenesis; biosynthetic gene clusters (BGCs); one strain–many compounds (OSMAC); metabolomics; host–pathogen interaction; ribotoxic stress; one health and climate change; diagnostic biomarkers; antifungal therapeutics; medicinal chemistry; structural biology

(This special issue belongs to the Section Molecular Microbiology)

Probiotics in Metabolism, Inflammation and Nervous System Disorders

edited by Subramanian Thangaleela

submission deadline 30 Nov 2026 | Viewed by 145 | Submission Open

Keywords: probiotics; gut–brain axis; metabolic diseases; neurological disorders; inflammation; secondary metabolites

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research Advances in HIV Infection

edited by

Sıla Akhan

submission deadline 30 Nov 2026 | Viewed by 144 | Submission Open

Keywords: HIV-1; CAR-T therapy; late HIV diagnosis; viral transmission; immune exhaustion; antiretroviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress of Biopolymers in Drug Delivery Systems

edited by

Narendra Kale

submission deadline 30 Nov 2026 | Viewed by 141 | Submission Open

Keywords: biopolymers; biomaterials; drug delivery systems; nanomedicine; targeted delivery; polymer therapeutics; bioengineering; quantitative imaging; stimuli-responsive drug delivery; biomedical polymers

(This special issue belongs to the Section Macromolecules)

Neuropharmacology of Pain: From Molecular Mechanisms to Clinical Translation

edited by

Carlos-Alberto Calderon-Ospina

submission deadline 30 Nov 2026 | Viewed by 134 | Submission Open

Keywords: neuropharmacology; chronic pain; molecular mechanisms; neuroinflammation; neuropathic pain; pharmacological targets; translational research

(This special issue belongs to the Section Molecular Neurobiology)

Unraveling the Mechanistic Pathways of Immune Cell Engagers in Lymphoproliferative Diseases

edited by

Stella Bouziana

submission deadline 30 Nov 2026 | Viewed by 132 | Submission Open

Keywords: lymphoproliferative diseases; immune cell engagers; BiTEs; molecular pathways; next-generation T cell engagers

(This special issue belongs to the Section Molecular Immunology)

Diabetes and Metabolic Dysfunction (Second Edition)

edited by