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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Chemical Tools for Microbial Functionalization: Bridging Organic Chemistry and Biotechnology

edited by Stefania Cicco and

Danilo Vona

submission deadline 20 Jan 2026 | Viewed by 932 | Submission Open

Keywords: organometallic biochemistry; green chemistry; bioorthogonal; living polymers; living functionalization; hybrid materials

(This special issue belongs to the Section Molecular Microbiology)

Microbial Omics: Decoding Microbial Life

edited by

Nicole Hansmeier

submission deadline 20 Jan 2026 | 1 articles | Viewed by 920 | Submission Open

Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics; artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring

(This special issue belongs to the Section Molecular Microbiology)

The Role of Bioactive Natural Products in Human Health

edited by

Eleonora Di Salvo

submission deadline 20 Jan 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: bioactive compound; human health; functional foods; nutraceutical products; food toxicology; antioxidant properties; anti-inflammation; antimicrobial molecules

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Sarcoma Initiation and Metastasis

edited by

Shinji Miwa

submission deadline 20 Jan 2026 | 1 articles | Viewed by 879 | Submission Open

Keywords: sarcoma; molecular target; metastasis; apoptosis; angiogenesis; microenvironment

(This special issue belongs to the Section Molecular Oncology)

Hearing Loss: Molecular Biological Insights, 2nd Edition

edited by María Beatriz Durán-Alonso

submission deadline 20 Jan 2026 | 1 articles | Viewed by 869 | Submission Open

Keywords: genetics; microRNA; epigenetics; CRISPR; multi-omics; presbycusis; ototoxicity; development

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy

edited by

Beatriz Caballero

and

Yaiza Potes

submission deadline 20 Jan 2026 | 1 articles | Viewed by 834 | Submission Open

Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs

(This special issue belongs to the Section Molecular Neurobiology)

Lipid Droplet–Mitochondria Interactions in Health and Disease

edited by Anton Petcherski

submission deadline 20 Jan 2026 | Viewed by 791 | Submission Open

Keywords: mitochondria; lipid droplets; metabolism; lipotoxicity; metabolically active tissue; triacylglycerides; fatty acid oxidation

(This special issue belongs to the Section Biochemistry)

Pathogenesis and Therapy of Oral Carcinogenesis, 3rd Edition

edited by

Marko Tarle

and

Ivica Lukšić

submission deadline 20 Jan 2026 | Viewed by 757 | Submission Open

Keywords: oral cancer; oral premalignant disorders; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis

(This special issue belongs to the Section Molecular Oncology)

Advances in the Physiopathology of Neurodevelopmental Disorders

edited by Antonio Falace

submission deadline 20 Jan 2026 | Viewed by 708 | Submission Open

Keywords: neuronal development; synaptogenesis; developmental and epileptic encephalopathy; epilepsy; biomarkers; neuroimmunology; translational research; cortical malformation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Rational Design and Synthesis of Bioactive Molecules, 2nd Edition

edited by

Irena Kostova

submission deadline 20 Jan 2026 | Viewed by 695 | Submission Open

Keywords: synthesis; structure; bonding; reactivity; chemical properties; physical properties; pharmacological activity; structure– activity relationship; applications

(This special issue belongs to the Section Molecular Biology)

Molecular Issues in Optic Neuropathy

edited by

Nitza Goldenberg-Cohen

submission deadline 20 Jan 2026 | 1 articles | Viewed by 679 | Submission Open

Keywords: optic neuropathy; neuroprotection; glaucoma induced neuropathy; molecular pathways; novel therapeutics strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Green Chemistry Biocatalysis—Advances in the Use of Sustainable Solvents for Biocatalytic Processes

edited by

Rita Craveiro

and

Alexandre Paiva

submission deadline 20 Jan 2026 | Viewed by 675 | Submission Open

Keywords: biocatalysts; enzymes; sustainability; green solvents; biotechnology; biochemical process engineering

(This special issue belongs to the Section Biochemistry)

Chitosan: Structural and Chemical Modification, Properties and Application, 2nd Edition

edited by

Joanna Kluczka

submission deadline 20 Jan 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: chitosan modification; adsorption removal; membrane separation; food preservation; environmental remediation; wastewater treatment; disease treatment; agricultural production; tissue engineering

(This special issue belongs to the Section Macromolecules)

Ion Transporter-Based Biomarkers for Sperm Quality

edited by

Elisabeth Pinart

submission deadline 20 Jan 2026 | Viewed by 657 | Submission Open

Keywords: ion transporters; sperm quality; cryotolerance

(This special issue belongs to the Section Molecular Biology)

Natural Compounds in Neurological Diseases

edited by

Ivan Cruz-Chamorro

submission deadline 20 Jan 2026 | 1 articles | Viewed by 654 | Submission Open

Keywords: natural compounds; neuroprotection; neuroinflammation; oxidative stress; mitochondrial dysfunction; autophagy; bioactive molecules (polyphenols; flavonoids; melatonin; etc.); nutraceuticals (bioactive peptides; hydrolysates; etc.); neurodegenerative diseases

(This special issue belongs to the Section Molecular Neurobiology)

Cell Membrane Electroporation and Electroosmosis Mechanisms

edited by

Paulius Ruzgys

submission deadline 20 Jan 2026 | Viewed by 623 | Submission Open

Keywords: nanosecond electroporation; calcium electroporation; small-molecule electrotransfer; abscopal effect; bacterial electroporation; irreversible electroporation; electrochemotherapy; immune response; apoptosis

(This special issue belongs to the Section Biochemistry)

The Impact of High-Value Compounds from Agri-Food and Waste Sources on Cellular Metabolism

edited by

Anna Spagnoletta

Salvatore Nesci

and

Francesca Oppedisano

submission deadline 20 Jan 2026 | Viewed by 598 | Submission Open

Keywords: phytochemicals; agri-food waste; nutraceutical; cell metabolism; mitochondria; antioxidants; ROS; anti-cancer

(This special issue belongs to the Section Biochemistry)

Reaction Kinetics in Bioinorganic Systems

edited by Łukasz Orzeł and Maria Oszajca

submission deadline 20 Jan 2026 | Viewed by 585 | Submission Open

Keywords: reaction mechanisms; kinetics; biologically active metal complexes; metalloproteins; reactive oxygen; nitrogen and sulfur species; biocatalysis; inorganic chemotherapy and phototherapy

(This special issue belongs to the Section Biochemistry)

Drug Delivery Systems and Treatment of Human Diseases: Prospects and Challenges

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | 1 articles | Viewed by 553 | Submission Open

Keywords: nanodrug delivery; blood– brain barrier; antibodies therapy; molecular mechanism; neuroprotection

(This special issue belongs to the Section Molecular Pharmacology)

Phytochemicals: Mechanisms and Applications in Cancer Prevention and Therapy

edited by

Mateusz Kciuk

and

Damian Kołat

submission deadline 20 Jan 2026 | Viewed by 546 | Submission Open

Keywords: phytochemicals; cancer prevention; cancer therapy; molecular mechanisms; signal transduction pathways; anti-oxidant activity; cell death; gene regulation; therapeutic targets

(This special issue belongs to the Section Biochemistry)

Molecular Research on Skeletal Muscle Metabolism and Diseases

edited by Shen-Liang Chen

submission deadline 20 Jan 2026 | Viewed by 542 | Submission Open

Keywords: muscle; metabolism; mitochondria; peroxisome; stem cell; cahcexia

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Molecular Research on Muscle Atrophy

edited by

Elena Bresciani

submission deadline 20 Jan 2026 | Viewed by 500 | Submission Open

Keywords: muscle atrophy; molecular mechanisms; protein degradation; inflammation; oxidative stress; sarcopenia; cachexia; autophagy; therapeutics; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Protein Structure and Its Interactions

edited by

Dong Hae Shin

submission deadline 20 Jan 2026 | Viewed by 491 | Submission Open

Keywords: protein– protein interactions (PPIs); protein– ligand binding; molecular recognition; binding affinity and specificity; molecular interface analysis

(This special issue belongs to the Section Molecular Biology)

Endocannabinoids, Cannabinoids and Psychiatry: Biological Mechanisms—3rd Edition

edited by

Aron Weller

and Nicholas V. DiPatrizio

submission deadline 20 Jan 2026 | Viewed by 490 | Submission Open

Keywords: endocannabinoids; cannabinoids; psychiatry; neural mechanisms; molecular mechanisms; epigenetics; imaging; psychopathology; stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neurological Disorders: From Molecular Mechanisms to Nanomedicine

edited by

Aruna Sharma

submission deadline 20 Jan 2026 | Viewed by 470 | Submission Open

Keywords: stroke; brain and spinal cord trauma; Alzheimer’ s disease; Parkinson’ s disease; nanodrug formulation; stem cells; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Hormone Receptors in Cancer

edited by Rajeshwar R. Tekmal

submission deadline 20 Jan 2026 | Viewed by 451 | Submission Open

Keywords: hormone recptors; hormone-mediated therapies; agonists and antgonists of hormone ligands; coactivators; corepressors

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Microglia in Neurological Diseases

edited by

Pyung-Hwan Kim

submission deadline 20 Jan 2026 | Viewed by 450 | Submission Open

Keywords: microglia; neuroinflammation; neurodegenerative diseases; molecular signaling; central nervous system (CNS)

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Application of Organic Antibacterial Agents

edited by

Barbara Dmochowska

submission deadline 20 Jan 2026 | Viewed by 420 | Submission Open

Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications

(This special issue belongs to the Section Biochemistry)

Drug Discovery and Development for Renal Disease Treatment

edited by

Keiko Hosohata

submission deadline 20 Jan 2026 | Viewed by 417 | Submission Open

Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies

(This special issue belongs to the Section Molecular Pharmacology)

Targeting Epilepsy: Molecular Mechanisms, Neuroinflammation and Emerging Therapies

edited by

Karoly Orban-Kis

submission deadline 20 Jan 2026 | Viewed by 416 | Submission Open

Keywords: epilepsy; molecular targets; antiepileptic drug discovery; neuroinflammation; epileptogenesis; ion channels; pharmacoresistance; translational neuroscience

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity

edited by Jolanta Kaszuba-Zwoińska

submission deadline 20 Jan 2026 | Viewed by 415 | Submission Open

Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases

(This special issue belongs to the Section Molecular Biology)

Metabolomics Research of Environmental Stress in Plants

edited by

Manish Kumar Patel

and Sonika Pandey

submission deadline 20 Jan 2026 | Viewed by 395 | Submission Open

Keywords: agricultural applications of primary and secondary metabolite; ; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research

(This special issue belongs to the Section Molecular Plant Sciences)

Cognitive Aging: Molecular Perspectives

edited by

Igor Y. Iskusnykh

submission deadline 20 Jan 2026 | Viewed by 391 | Submission Open

Keywords: brain; neuron; aging; neurodegeneration; cognitive neuroscience; inflammation; regeneration; behavioral neuroscience; pharmacology; brain disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Plant Phenotyping and Phenomics for Breeding

edited by

Jaeil Lyu

submission deadline 20 Jan 2026 | Viewed by 375 | Submission Open

Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Animal Reproduction and Development

edited by

Yu-Feng Wang

submission deadline 20 Jan 2026 | Viewed by 375 | Submission Open

Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases, 3rd Edition

edited by

Paramjit S. Tappia

submission deadline 20 Jan 2026 | Viewed by 371 | Submission Open

Keywords: cardiovascular diseases; metabolic diseases; cellular and molecular mechanisms

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Biology and Diagnosis on Biliary and Pancreatic Cancers

edited by Francesco Vasuri and Luca Saragoni

submission deadline 20 Jan 2026 | Viewed by 346 | Submission Open

Keywords: biliary cancer; pancreatic cancer; histological diagnoses; cytological diagnoses; chromosome aneuploidy; specific genetic mutations

(This special issue belongs to the Section Molecular Oncology)

DNA and RNA Nanostructures for the Assembly of Functional Molecules

edited by

Di Liu

and

Kalevi Kairemo

submission deadline 20 Jan 2026 | Viewed by 343 | Submission Open

Keywords: DNA nanotechnology; RNA nanotechnology; biomolecular engineering; biomimetics

(This special issue belongs to the Section Molecular Nanoscience)

Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications

edited by Bhausaheb Dhokale

submission deadline 20 Jan 2026 | Viewed by 342 | Submission Open

Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy

(This special issue belongs to the Section Materials Science)

Advances in Plant Cell Dynamics

edited by

Andrei Smertenko

submission deadline 20 Jan 2026 | Viewed by 328 | Submission Open

Keywords: organelles; cellular polarity; cytoskeleton; vesicle trafficking; cell wall synthesis; signalling; differentiation

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Jan 2026 | Viewed by 320 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

DNA Damage and Repair: Current Research

edited by

Mahara A. Valverde Ramírez

and Emilio Rojas

submission deadline 20 Jan 2026 | 1 articles | Viewed by 319 | Submission Open

Keywords: DNA damage; DNA repair; endogenous compounds; exogenous compounds; therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Insight into Bacteriophage and Their Potential Applications

edited by Wilfried Moreira

submission deadline 20 Jan 2026 | Viewed by 314 | Submission Open

Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Advancements and Trends in Plant Genomics

edited by Rongbin Hu

submission deadline 20 Jan 2026 | Viewed by 314 | Submission Open

Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas

(This special issue belongs to the Section Molecular Plant Sciences)

New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges

edited by Luyi Zou

submission deadline 20 Jan 2026 | Viewed by 308 | Submission Open

Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance

(This special issue belongs to the Section Materials Science)

Molecular Research on Autophagy, 2nd Edition

edited by

Maria Ines Vaccaro

submission deadline 20 Jan 2026 | Viewed by 308 | Submission Open

Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges

edited by

Francesco Tandoi

submission deadline 20 Jan 2026 | Viewed by 294 | Submission Open

Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy

edited by Wensheng Xie

submission deadline 20 Jan 2026 | Viewed by 293 | Submission Open

Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials

(This special issue belongs to the Section Molecular Biophysics)

The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue”

edited by

Takehiko Fujino

and

Masanori Honsho

submission deadline 20 Jan 2026 | Viewed by 285 | Submission Open

Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state

(This special issue belongs to the Section Molecular Neurobiology)

Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics

edited by

Vincenza Barresi

submission deadline 20 Jan 2026 | Viewed by 281 | Submission Open

Keywords: antisense oligonucleotides (ASOs); siRNAs; peptide nucleic acids (PNAs); aptamers; transcriptional therapy; nanocarriers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 1251-1300 on page 26 of 69.

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