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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Molecular Research on Diabetes Pharmacology

edited by

Ioanna A. Anastasiou

submission deadline 20 Sep 2026 | 1 articles | Viewed by 685 | Submission Open

Keywords: diabetes; pharmacology; antidiabetic drugs; insulin therapy; SGLT2 inhibitors; GLP-1 receptor agonists; combination therapy; personalized medicine; drug development

(This special issue belongs to the Section Molecular Pharmacology)

Exploring Glia: New Insights into Neurobiology and Therapeutic Potential

edited by María de los Ángeles García-Robles

submission deadline 20 Sep 2026 | Viewed by 675 | Submission Open

Keywords: glial metabolism; astrocytes; microglia; oligodendrocytes; tanycytes; obesity; diabetes; metabolic disorders; neurogenesis; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Synthesis and Application of Organic Antibacterial Agents

edited by

Barbara Dmochowska

submission deadline 20 Sep 2026 | Viewed by 661 | Submission Open

Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications

(This special issue belongs to the Section Biochemistry)

Novel Insights into the Molecular Mechanisms of Pancreatitis

edited by

Gi-Sang Bae

submission deadline 20 Sep 2026 | Viewed by 656 | Submission Open

Keywords: acute pancreatitis; chronic pancreatitis; pancreatic fibrosis; mechanisms; digestive enzymes; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Fruit Crops Development

edited by

Xingguo Li

submission deadline 20 Sep 2026 | Viewed by 656 | Submission Open

Keywords: fruit crops; fruit tree; proteomics; genomics; metabolomics; biotic stress; abiotic stress

(This special issue belongs to the Section Molecular Plant Sciences)

Female and Male Fertility: From Diseases to Current Trends and Research Developments

edited by Fabio Barra

submission deadline 20 Sep 2026 | 1 articles | Viewed by 653 | Submission Open

Keywords: female infertility; male infertility; reproductive health; reproductive outcomes; assisted reproductive technologies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress and Perspectives in Natural Products

edited by

Hanae Naceiri Mrabti

and

Naoufal El Hachlafi

submission deadline 20 Sep 2026 | Viewed by 651 | Submission Open

Keywords: natural products; bioactive compounds; pharmacology; nutrition; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective

edited by

Maria Lisa Garavaglia

submission deadline 20 Sep 2026 | Viewed by 644 | Submission Open

Keywords: xenobiotic exposure; human health; toxic effects; environmental chemicals; molecular research

(This special issue belongs to the Section Molecular Toxicology)

Development Biology of Immune Cells

edited by Jacek Z. Kubiak

submission deadline 20 Sep 2026 | Viewed by 630 | Submission Open

Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells

(This special issue belongs to the Section Molecular Immunology)

Oxidative Stress and Mitochondrial Dysfunction in Human Diseases

edited by Patrice X. Petit

submission deadline 20 Sep 2026 | 1 articles | Viewed by 623 | Submission Open

Keywords: aging; DAMPs; inflammation; Fenton reaction; ferroptosis; hydroperoxide; mitochondria; mitophagy; NIX; NLRP3; oxidized mtDNA; RIRR; superoxide anions; stem cells

(This special issue belongs to the Section Molecular Biology)

Latest Advances in Autoimmune and Inflammatory Rheumatic Diseases

edited by

Tanja Grubić-Kezele

submission deadline 20 Sep 2026 | 1 articles | Viewed by 613 | Submission Open

Keywords: autoimmune diseases; inflammatory diseases; rheumatic diseases; molecular mechanisms; pathogenesis; inflammation; central nervous system

(This special issue belongs to the Section Molecular Immunology)

Cellular Plasticity in Health and Diseases

edited by

Giovanni Barillari

submission deadline 20 Sep 2026 | Viewed by 610 | Submission Open

Keywords: stem cells; cytokines; extracellular matrix; cell differentiation; cell locomotion; cell growth; tissue repair; chronic inflammation; dysplasia; hyperplasia; premalignant lesions; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Plant Abiotic Stress Tolerance: 3rd Edition

edited by

Michael Moustakas

submission deadline 20 Sep 2026 | Viewed by 586 | Submission Open

Keywords: acclimation; drought; salinity; pesticides; high–low temperature; high–low light intensity; nutrient deficiencies; heavy metals; UV radiation; photosynthetic efficiency; ROS; antioxidant mechanisms; redox regulation

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Cancer: Targeting Immune Cells and Signalling Pathways

edited by

Tomasz Jędrzejewski

submission deadline 20 Sep 2026 | 1 articles | Viewed by 582 | Submission Open

Keywords: natural compounds; cancer; inflammation; signalling pathways; antineoplastic agents; macrophage; T cells; molecular mechanism of pharmacological action; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Flexible Sensors for Biomedical Application

edited by

Jimin Lee

submission deadline 20 Sep 2026 | Viewed by 572 | Submission Open

Keywords: biomedical applications; molecular diagnostics; molecular recognition mechanisms; biosensors; electrochemical sensing; nanomaterials for sensing; implantable sensors; soft bioelectronics

(This special issue belongs to the Section Biochemistry)

The Role of Polyphenols and Polysaccharides in Human Diseases

edited by

Francisco Les

submission deadline 20 Sep 2026 | Viewed by 552 | Submission Open

Keywords: polyphenols; polysaccharides; bioactive compounds; chronic diseases prevention; functional foods

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Type 2 Diabetes and Its Complications: 2nd Edition

edited by

Anca Pantea Stoian

submission deadline 20 Sep 2026 | Viewed by 547 | Submission Open

Keywords: diabetes type 2; diabetes complications; pathophysiology of type 2 diabetes; new diabetes treatment; cardiovascular disease; stroke; peripheral artery disease; chronic kidney disease; retinopathy; neuropathy; non-alcoholic fatty liver disease in diabetes

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Machine Learning in RNA and Chromatin Dynamics

edited by Haopeng Yu

submission deadline 20 Sep 2026 | Viewed by 547 | Submission Open

Keywords: machine learning; chromatin architecture; RNA dynamics; genomic foundation models; computational biology

(This special issue belongs to the Section Molecular Biology)

Nanocompounds for Drug Delivery

edited by

Angela Staicu

Ana Maria Udrea

and

Andra Dinache

submission deadline 20 Sep 2026 | 1 articles | Viewed by 546 | Submission Open

Keywords: nanocompounds; drug delivery systems; targeted delivery; stimuli-responsive nanocarriers; hybrid nanostructures; controlled release; biocompatibility; photodynamic therapy (PDT); photothermal therapy (PTT)

(This special issue belongs to the Section Molecular Nanoscience)

Environmental Exposures and Emerging Mechanisms in Chronic Obstructive Pulmonary Disease: From Pathogenesis to Precision Therapeutics

edited by

Abderrazzak Bentaher

submission deadline 20 Sep 2026 | Viewed by 528 | Submission Open

Keywords: chronic obstructive pulmonary disease; environmental exposures; disease pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Angiogenin: From Molecular Mechanisms to Clinical Implications

edited by

Iogann Tolbatov

submission deadline 20 Sep 2026 | Viewed by 504 | Submission Open

Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target

(This special issue belongs to the Section Biochemistry)

Molecular Pathways and Mechanisms of Lung Injury: From Environmental Agents to Clinical Implications

edited by

Maria Lisa Garavaglia

and Cristina Porta

submission deadline 20 Sep 2026 | Viewed by 492 | Submission Open

Keywords: lung injury; lung cancer; pulmonary fibrosis; chronic obstructive pulmonary disease; acute respiratory distress syndrome; environmental pollutants and toxins; molecular and cellular mechanisms; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Autophagy and Viral Infections: The Era of New Therapeutical Strategies

edited by

Marisa Granato

submission deadline 20 Sep 2026 | Viewed by 483 | Submission Open

Keywords: autophagy; macroautophagy system; virus; viral infection; influenzae virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in Bee Products: Chemistry, Mechanisms of Action and Nutritional Applications

edited by

Jarosław Widelski

and

Ioanna Chinou

submission deadline 20 Sep 2026 | Viewed by 479 | Submission Open

Keywords: honey; propolis; royal jelly; polyphenols; nutritional properties; bioactivity; analytical and isolation methods; bee pollen

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of the Gut and Oral Microbiota in Neurodevelopment: Molecular Biological Insights

edited by Ioannis Alexandros Charitos

submission deadline 20 Sep 2026 | Viewed by 473 | Submission Open

Keywords: neuroscience; central nervous system; peripheral nervous system; human microbiota; metabolome; gut–oral-microbiota–brain axis; neurodevelopment disorders; cognitive modulation; neurodegenerative diseases; psychobiotics

(This special issue belongs to the Section Molecular Microbiology)

Age-Dependence of Neuroimmune Reactions

edited by

Babak Baban

submission deadline 20 Sep 2026 | Viewed by 468 | Submission Open

Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases

(This special issue belongs to the Section Molecular Immunology)

New Advances in Natural Product Synthesis and Emerging Biotechnology Applications

edited by Katarzyna Kotwica-Mojzych

submission deadline 20 Sep 2026 | Viewed by 464 | Submission Open

Keywords: natural compounds; natural product synthesis; chemical analysis; molecular technologies; biotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Animal Nutrition and Muscle Biology

edited by Usuk Jung

submission deadline 20 Sep 2026 | Viewed by 456 | Submission Open

Keywords: animal nutrition; metabolic regulation; molecular biology; molecular mechanisms; skeletal muscle; intramusculuar fat; skeletal muscle fibrosis

(This special issue belongs to the Section Molecular Biology)

Advances in Nasopharyngeal Carcinoma Immunology, Epigenetics, and Therapy

edited by

Wei Dai

submission deadline 20 Sep 2026 | Viewed by 455 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); epstein–barr virus (EBV); cancer epigenomics; virus–host interaction; tumor microenvironment (TME); immunotherapy; targeted therapy; biomarker; metastasis; radiotherapy resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Theranostic Application of Reactive Oxygen Species-Sensitive Nanocarriers

edited by

Young-Il Jeong

submission deadline 20 Sep 2026 | Viewed by 453 | Submission Open

Keywords: ROS generation; ROS detection; ROS-sensitive nanoparticles; Photodynamic therapy (PDT)

(This special issue belongs to the Section Molecular Nanoscience)

Role of Extracellular Vesicles in Immune Regulation

edited by Rachel Crossland

submission deadline 20 Sep 2026 | Viewed by 451 | Submission Open

Keywords: extracellular vesicle; immune regulation; immunomodulation; antigen presentation; inflammation; autoimmunity

(This special issue belongs to the Section Molecular Immunology)

Advanced Composite Materials: Molecular Design and Applications

edited by Fan Yang

submission deadline 20 Sep 2026 | Viewed by 450 | Submission Open

Keywords: multifunctional applications; mechanical and physical properties; extreme environments; molecular dynamics analysis; composite molecular design, preparation, simulation, and characterization

(This special issue belongs to the Section Materials Science)

Immune Microenvironment and Tissue Remodeling in Oral Diseases and Oral Cancer

edited by

Aiman Ali

submission deadline 20 Sep 2026 | Viewed by 445 | Submission Open

Keywords: immune microenvironment; oral cancer; oral diseases; tissue remodeling; molecular signaling pathways

(This special issue belongs to the Section Molecular Immunology)

Polymer Materials Related to Food Packaging

edited by

Rosie Yagmur Yegin

submission deadline 20 Sep 2026 | Viewed by 431 | Submission Open

Keywords: polymeric materials; food packaging; biodegradable polymers; active packaging; intelligent packaging; nanocomposites; sustainability; circular economy; barrier properties; life cycle assessment

(This special issue belongs to the Section Macromolecules)

Down Syndrome: From Molecular Mechanisms to Therapeutic Strategies

edited by Amy Feldman Lewanda

submission deadline 20 Sep 2026 | Viewed by 427 | Submission Open

Keywords: down syndrome; Trisomy 21; molecular mechanisms; therapeutic strategies; neurodegeneration; comorbidities; animal models

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Strategies for Enhancing Skeletal Muscle Recovery and Regeneration in Health and Disease Conditions

edited by

Elen Miyabara

and

Atsushi Asakura

submission deadline 20 Sep 2026 | Viewed by 424 | Submission Open

Keywords: skeletal muscle; regeneration; muscle wasting; aging; muscle diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Neuroprotective Phytochemicals and Their Multi-Target Mechanisms

edited by

Gerardo Álvarez-Rivera

and

Alejandro Cifuentes

submission deadline 20 Sep 2026 | Viewed by 419 | Submission Open

Keywords: Alzheimer’s disease; neuroprotective phytochemicals; green extraction; technologies; blood–brain barrier permeability; bioavailability; multi-target mechanisms; omics approaches; nanodelivery systems; brain health; neuroprotection

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Perspectives on Female Infertility and Fertility

edited by

Seung-Yup Ku

submission deadline 20 Sep 2026 | Viewed by 410 | Submission Open

Keywords: female infertility; molecular mechanisms of reproduction; oocyte maturation and development; reproductive aging; polycystic ovary syndrome; endometriosis; epigenetic regulation in reproduction; oxidative stress and mitochondrial dysfunction; reproductive biomarkers; precision medicine and regenerative therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Biomarkers in Cardiovascular Disease: Hepatocardiac and Systemic Interactions

edited by

Wioletta Szczurek-Wasilewicz

submission deadline 20 Sep 2026 | Viewed by 409 | Submission Open

Keywords: hepatocardiac interactions; hepatic biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Optical, Raman, and Pathological Imaging Biomarkers for Diagnosis and Therapy

edited by

Yoshinori Harada

submission deadline 20 Sep 2026 | Viewed by 388 | Submission Open

Keywords: optical imaging; Raman spectroscopy; pathological imaging; imaging biomarkers; AI-assisted diagnosis; disease prognosis; therapeutic response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nutrition from Cereal Foods: Molecular Insights into Nutrition, Metabolism and Health Regulation

edited by Genyi Zhang

submission deadline 20 Sep 2026 | Viewed by 384 | Submission Open

Keywords: molecular breeding; cereal crops; bioactive compounds; metabolic syndrome; inflammation; gut health

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Natural Products and Compounds in Anticancer Drug Discovery

edited by

Diana I. Ivanova

submission deadline 20 Sep 2026 | Viewed by 383 | Submission Open

Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions

(This special issue belongs to the Section Molecular Pharmacology)

Skin Diseases: From Molecular Mechanisms to Pathology, 2nd Edition

edited by

Alessandro Terrinoni

submission deadline 20 Sep 2026 | Viewed by 381 | Submission Open

Keywords: skin diseases; immunology; genetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Regulation by Non-Coding RNAs: 2nd Edition

edited by

Won-Ha Lee

submission deadline 20 Sep 2026 | Viewed by 377 | Submission Open

Keywords: lncRNAs; circRNAs; miRNAs

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Serotonin

edited by Joachim Neumann

submission deadline 20 Sep 2026 | Viewed by 373 | Submission Open

Keywords: serotonin; serotonin receptors; migraine; depression; hypertension; heart failure; arrhythmias

(This special issue belongs to the Section Molecular Biology)

Inorganic Chemistry: From Molecules to Materials

edited by

Zoi Lada

submission deadline 20 Sep 2026 | 1 articles | Viewed by 373 | Submission Open

Keywords: inorganic chemistry; molecular design and reactivity; metal–organic frameworks (MOFs); spin crossover compounds; functional materials; structure–property relationships

(This special issue belongs to the Section Materials Science)

Interactions Between Nanoparticles and Biomolecules

edited by