Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 25 June 2025 | Viewed by 283
Special Issue Editor
Interests: cigarette smoke; cellular oxidative stress; inflammation; smoking related diseases; antioxidant
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In our daily lives, we encounter many xenobiotic chemicals of environmental or anthropogenic origin. Entering the organism through numerous routes, such as inhalation, ingestion, or dermal absorption, these substances can impact several organs, negatively affecting the organism’s homeostasis and resulting in an increase in morbidity and mortality.
Assessing the toxic effects of xenobiotics on human health is particularly challenging due to the broad diversity and ubiquitous presence of toxic chemicals with possible combined, additive, or cross-reactive toxicities. Furthermore, organisms possess a complex system of xenobiotic-metabolizing enzymes, which can activate or detoxify these substances, further increasing the complexity of this analysis.
Currently, effective -omics methodologies—such as proteomic, transcriptomic, genomic, and metabolomic—along with toxicological approaches and conventional molecular biology techniques, are available to efficiently and accurately study how these substances adversely affect the physiology of the organism at the molecular level.
This Special Issue focuses on xenobiotic-induced molecular effects that could adversely impact human health. Along with elucidating their underlying mechanism of action, these studies will enable us to identify possible biomarkers of exposure and toxic effects and develop targeted preventive or interventional measures to avoid, limit, or manage their noxious effects.
Contributions, original papers, or review articles on this topic are welcome.
Dr. Maria Lisa Garavaglia
Guest Editor
Manuscript Submission Information
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Keywords
- xenobiotic exposure
- human health
- toxic effects
- environmental chemicals
- molecular research
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