Effects of Xenobiotic Exposure on Lung Health: A Molecular Perspective
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: 25 June 2025 | Viewed by 262
Special Issue Editor
Interests: cigarette smoke; cellular oxidative stress; inflammation; smoking related diseases; antioxidant
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In our daily lives, we are faced with many xenobiotic chemicals of environmental or anthropogenic origin. These molecules can negatively impact the organism’s homeostasis, resulting in an increase in morbidity and mortality. Due to their morphology and function, lungs are particularly affected by the harmful effects of a vast array of inhaled carcinogens and toxicants.
Assessing the toxic effects of xenobiotics on lung health is extremely challenging due to the wide range of chemicals that this organ is exposed to, potentially cross-affecting one another. Furthermore, the lung possesses a variety of xenobiotic-metabolizing enzymes, which can induce the bioactivation of procarcinogens or other toxic substances. The complexity of this analysis is increased considering the harmful role of these derived bioactive compounds.
Currently, effective proteomic, transcriptomic, genomic, and metabolomic methodologies are available to efficiently and accurately study how these substances adversely affect lung physiology.
This Special Issue focuses on xenobiotic-induced molecular modifications affecting lung health. The results of these analyses will enable us to define targeted preventive or interventional measures to avoid, limit, or manage their noxious effects.
Contributions, original papers, or review articles on this topic are welcome.
Dr. Maria Lisa Garavaglia
Guest Editor
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Keywords
- xenobiotic exposure
- lung health
- toxic effects
- chemicals
- molecular research
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