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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into the Molecular Mechanisms of the UPR and Cell Stress
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2847 | Submission Open
Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection
(This special issue belongs to the Section Molecular Biology)
Benchmarking of Modeling and Informatic Methods in Molecular Sciences
edited by Abby Parrill
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2831 | Submission Open
Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation
(This special issue belongs to the Section Molecular Informatics)
Integrating Molecular Insights on Plant Microbes and Insect Pests
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2829 | Submission Open
Keywords: pathogenic microbes; resistance mechanisms; signaling pathways; omics technologies; plant and insect interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Depression—2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 2753 | Submission Open
Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors
(This special issue belongs to the Section Molecular Neurobiology)
New Advances in Radiopharmaceuticals and Radiotherapy
edited by Feifei An
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2723 | Submission Open
Keywords: positron emission tomography; single photon emission computed tomography; boron neutron capture therapy; alfa-particle; radiopharmaceutical; radiotherapy; radiosensitizer; Cu-67; Lu-177; I-131; Ac-225; Pb-212; At-211  
(This special issue belongs to the Section Molecular Pharmacology)
Cell Cycle-Related Proteins: Biochemical Regulative/Deregulative Mechanisms
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2709 | Submission Open
Keywords: cell cycle; cell division; cyclins; cyclin-dependent kinases (CDKs); biochemical regulative mechanisms
(This special issue belongs to the Section Biochemistry)
DNA Virus Infection: HPV-Related Cancers, Pathology, Biomarkers and Immunotherapy submission deadline 20 Dec 2025 | 1 articles | Viewed by 2695 | Submission Open
Keywords: HPV; molecular diagnostics; HPV ctDNA; cancer; mutations; viral oncogenicity; immunotherapy; biomarkers; oncology; cancer treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Host-Virus Interaction
edited by and
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2693 | Submission Open
Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies
(This special issue belongs to the Section Molecular Immunology)
Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics
edited by Clinton B. Mathias and Michiko K. Oyoshi
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2635 | Submission Open
Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13
(This special issue belongs to the Section Molecular Immunology)
The Role of Thyroid Hormone in Health and Disease
edited by Sandra Incerpi and Jens Z. Pedersen
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2623 | Submission Open
Keywords: nongenomic effects; integrin α vβ 3; crosstalk; signal transduction; metabolites; 3; 5-diiodothyronine; tetraiodothyrocetic acid (tetrac); antioxidant; oxidative stress; stilbene derivatives
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Osteoarthritis: From Pathophysiology to Novel Therapy submission deadline 20 Dec 2025 | 2 articles | Viewed by 2545 | Submission Open
Keywords: osteoarthritis; therapeutic targets; molecular mechanisms; biomarkers; bone degenerative disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pregnancy-Related Complications: From Pathogenesis to Treatment submission deadline 20 Dec 2025 | 1 articles | Viewed by 2480 | Submission Open
Keywords: adverse pregnancy outcomes; spontaneous preterm birth; idiopathic preterm birth; preeclampsia; fetal growth restriction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2474 | Submission Open
Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory
(This special issue belongs to the Section Molecular Toxicology)
Challenges in Molecularly Imprinted Materials
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2410 | Submission Open
Keywords: molecularly imprinted polymer; ion imprinting; molecular recognition; artificial receptor; binding polymer; biomimetic sensor; computer simulation; hybrid materials; nanocomposites; modeling and optimization
(This special issue belongs to the Section Materials Science)
Imaging Molecules in Biomedical Research
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2404 | Submission Open
Keywords: biomedicine; histochemistry; immunohistochemistry; in situ hybridization; magnetic resonance imaging; optical imaging; photoacoustic imaging; ultrasound imaging; Raman microscopy
(This special issue belongs to the Section Biochemistry)
Genetics and Breeding for Sugar Crops
edited by Muqing Zhang
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2376 | Submission Open
Keywords: sugarcane; molecular genetics and breeding; plant pathology; stress biology; GWAS; QTL; precision breeding; molecular marker; gene editing; transgene
(This special issue belongs to the Section Molecular Plant Sciences)
Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2372 | Submission Open
Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase
(This special issue belongs to the Section Molecular Biology)
Mechanistic Insights, Therapeutic Potential, and Applications of Natural Bioactive Compounds
edited by and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2311 | Submission Open
Keywords: oxidative stress; inflammation; chronic diseases; natural bioactive compounds; plant-derived molecules; redox homeostasis; anti-inflammatory mechanisms; antioxidant activity; drug discovery; synergistic effects; combination therapies
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Development of Dopaminergic Neurons, 4th Edition
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2305 | Submission Open
Keywords: neuron; dopamine; mDA; signalling pathways; human stem cell
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Rhizobia
edited by , María J. Delgado and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2216 | Submission Open
Keywords: biodiversity; environmental factors; plant– rhizobia interaction; nitrogen fixation; regulation; signaling; symbiosis
(This special issue belongs to the Section Molecular Microbiology)
Oxidative Stress and Mitochondria in Human Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2096 | Submission Open
Keywords: mitochondrial dynamics; ROS; antioxidants; mitophagy; oxidative damage; lipid peroxidation; neurodegenerative diseases; cancer; obesity
(This special issue belongs to the Section Biochemistry)
Autophagic Related Proteins in Cancer
edited by Pietri Puustinen
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1984 | Submission Open
Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth
(This special issue belongs to the Section Molecular Oncology)
Molecular Research of Abiotic Stress in Plants
edited by Deguo Han
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1977 | Submission Open
Keywords: abiotic stress; salt stress; drought stress; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1923 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1919 | Submission Open
Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations
(This special issue belongs to the Section Molecular Neurobiology)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Dec 2025 | 3 articles | Viewed by 1885 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Antimicrobial Peptides in Reproductive Health and Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1863 | Submission Open
Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair
edited by Anisa Shaker
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1826 | Submission Open
Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Treatment of Neurodegenerative Diseases with Natural Products
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1751 | Submission Open
Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1731 | Submission Open
Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1711 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
New Insights into Photosystem I (Second Edition) submission deadline 20 Dec 2025 | 1 articles | Viewed by 1661 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Research in Probiotic Yeasts: Molecular Aspects submission deadline 20 Dec 2025 | 1 articles | Viewed by 1595 | Submission Open
Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds
(This special issue belongs to the Section Molecular Microbiology)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1589 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
New Insights into Anticancer Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 1562 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1545 | Submission Open
Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1518 | Submission Open
Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Biocomposite Hydrogels for Biomedical Applications submission deadline 20 Dec 2025 | 1 articles | Viewed by 1477 | Submission Open
Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing
(This special issue belongs to the Section Materials Science)
Epilepsy: From Molecular Basis to Therapy, 2nd Edition submission deadline 20 Dec 2025 | 1 articles | Viewed by 1467 | Submission Open
Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Structural Characterization and Pharmacological Activity of Natural Compounds
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1464 | Submission Open
Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1436 | Submission Open
Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
Role of Ion Channels in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1427 | Submission Open
Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology
(This special issue belongs to the Section Molecular Biology)
Insights into Functional Nanomaterials: Application-Related Structural Analysis
edited by Zoltán Dudás
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1416 | Submission Open
Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Insights into Virus-Host Immune Interactions
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1339 | Submission Open
Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances in Plant Reproductive Development
edited by Zsolt Pónya and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1315 | Submission Open
Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls
(This special issue belongs to the Section Molecular Plant Sciences)
Ongoing Anticancer Agents
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1303 | Submission Open
Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies
(This special issue belongs to the Section Molecular Oncology)
The Role of Non-Coding RNAs in Female Reproduction
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1232 | Submission Open
Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neural Stem Cells: Latest Applications and Future Perspectives submission deadline 20 Dec 2025 | 1 articles | Viewed by 1225 | Submission Open
Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease
(This special issue belongs to the Section Molecular Biology)
Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target submission deadline 20 Dec 2025 | 1 articles | Viewed by 1220 | Submission Open
Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer
(This special issue belongs to the Section Molecular Immunology)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1175 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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