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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Pharmacology of Medicinal Plants
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4931 | Submission Open
Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Biosynthesis of Phytochemicals and Their Applications in Novel Drug Lead Development
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4911 | Submission Open
Keywords: biosynthesis of phytochemicals in plants; phytochemical isolation; phytochemical structure; animal and human protein targets of phytochemicals; chemical derivatives of phytochemicals
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition submission deadline 20 Feb 2026 | 5 articles | Viewed by 4830 | Submission Open
Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnosis in Cardiovascular Diseases
edited by Calogera Pisano, and Giuseppe Raffa
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4772 | Submission Open
Keywords: cardiac diseases; molecular diagnosis; aortopathy; aneurysm; dissection; heart failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder
edited by Yang Mao-Draayer
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4738 | Submission Open
Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanism of Extracellular Vesicles in Human Diseases
edited by Eszter Ágnes Tóth
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4720 | Submission Open
Keywords: extracellular vesicles; intercellular communication; disease pathophysiology; biomarkers; nanoscience; biomolecular interactions
(This special issue belongs to the Section Molecular Biology)
Research on Gene Mutations in Cancer and Chronic Diseases
edited by Adam Szpechciński
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4689 | Submission Open
Keywords: germline and somatic mutation; pathogenesis of cancer and chronic diseases; molecular techniques for gene mutation detection; biomarkers; molecular diagnostics; bioinformatics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4645 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 4600 | Submission Open
Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab
(This special issue belongs to the Section Molecular Immunology)
Advanced Research on Enzymes in Biocatalysis submission deadline 20 Feb 2026 | 6 articles | Viewed by 4570 | Submission Open
Keywords: biocatalysis; bioprocess; enzyme immobilization; enzyme production; response surface methodology (RSM); enzymatic-assisted extraction; enzymatic-catalyzed synthesis; enzyme modelling; bioreactor; bioconversion; cascade biocatalysis; enzymatic kinetic; enzyme engineering; ultrasound-assisted enzymatic reaction; directed evolution; machine learning-assisted enzyme engineering; waste-to-value bioprocesses
(This special issue belongs to the Section Biochemistry)
Advancements in Hematology: Molecular Biology and Targeted Therapies
edited by Fabio Stagno and
submission deadline 20 Feb 2026 | 5 articles | Viewed by 4567 | Submission Open
Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Non-Coding RNA in Physiology and Pathophysiology: Second Edition
edited by Maria Rosaria Tumolo
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4563 | Submission Open
Keywords: microRNA; long non-coding RNA; circular RNA; epigenetics; musculoskeletal pain; cardiovascular disease; metabolic disease; nervous system disorders; cancer; aging
(This special issue belongs to the Section Molecular Biology)
Roles of Lipid Rafts in the Regulation of Cellular Processes and Diseases
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4423 | Submission Open
Keywords: lipid rafts; glycosphingolipid; ganglioside; sphingomyelin; cholesterol; GPI-anchored proteins; caveolae; detergent-resistant membrane; signal transduction; disease
(This special issue belongs to the Section Biochemistry)
Artificial Intelligence and Computer-Aided Design: Molecular Simulation Technology in Exploring Bioactive Compounds for Health Promotion
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4363 | Submission Open
Keywords: molecular simulation; bioactive compounds; molecular docking; molecular dynamics; quantum mechanics; functional mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Recent Research of Nanomaterials in Molecular Science: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 4331 | Submission Open
Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy
(This special issue belongs to the Section Molecular Nanoscience)
Marine Natural Compounds: Biotechnological Potential and Pharmacological Targets
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4206 | Submission Open
Keywords: marine natural compounds; structure elucidation; biologic activity; structure-activity relationships; biosynthesis; biotechnology; pharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Asthma and Allergy
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4171 | Submission Open
Keywords: asthma; allergy; molecular mechanisms; exposome; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoimmunology: Interactions of the Bone and Immune System submission deadline 20 Feb 2026 | 1 articles | Viewed by 4121 | Submission Open
Keywords: osteoimmunology markers; bone infection; inflammation and bone; immune response and bone; diagnostic and prognostic markers; bone remodeling; osteoclasts; immune-mediated bone diseases; bone– immune interface
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Neutrophil Extracellular Traps (Nets) in Human Diseases
edited by Eisuke F. Sato
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4063 | Submission Open
Keywords: neutrophil extracellular traps (NETs); neutrophils; inflammation; autoimmune diseases; cardiovascular diseases; tumor metastasis; thrombosis; molecular mechanisms; disease progression; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Metabolic Engineering and Synthetic Biology of Yeasts
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 4013 | Submission Open
Keywords: yeast metabolic engineering; synthetic biology; CRISPR-Cas9; metabolic pathways; bio-based chemicals; bioprocess engineering; yeast strain optimization; industrial biotechnology
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research of Gut Microbiota in Human Health and Diseases submission deadline 20 Feb 2026 | 2 articles | Viewed by 3981 | Submission Open
Keywords: gut microbiota; gut metabolites; gastroenterology; microbiology; inflammation; human diseases
(This special issue belongs to the Section Molecular Microbiology)
Omics-Driven Unveiling of the Structure and Function of Nanoparticles
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3978 | Submission Open
Keywords: nanoparticles; nanotechnology; drug delivery; protein corona; proteomics; nano-proteomics; matabolomics; lipidomics
(This special issue belongs to the Section Molecular Biophysics)
Gut Microbiome Stability in Health and Disease
edited by and Yoshitohi Ogura
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3967 | Submission Open
Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus—Second Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3810 | Submission Open
Keywords: systemic lupus erythematosus; lupus nephritis; neuropsychiatric lupus; autoimmunity; biomarkers; B lymphocyte; interferons
(This special issue belongs to the Section Molecular Immunology)
Advances in Stem Cell-Based Regenerative Medicine for Renal Disorders
edited by In-Yong Kim
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3784 | Submission Open
Keywords: chronic kidney disease; acute kidney injury; stem cells; regenerative medicine; stem cell therapy; cellular reprogramming; cell transplantation
(This special issue belongs to the Section Molecular Biology)
Brain-Body Interactions in Mental Disorders: Molecular Mechanisms and Therapeutics
edited by Yan-Xue Xue
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3755 | Submission Open
Keywords: mental disorders; brain– body interactions; neural mechanisms; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3725 | Submission Open
Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health
(This special issue belongs to the Section Molecular Pharmacology)
The Extracellular Matrix in Physiopathology
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3627 | Submission Open
Keywords: extracellular matrix; glycosaminoglycans; matrix metalloproteinases; tissue remodeling; cell interactions; physiopathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Diagnosis and Treatment of Colorectal Cancer
edited by Steven T. Brower and Robert Pergolizzi
submission deadline 20 Feb 2026 | 3 articles | Viewed by 3545 | Submission Open
Keywords: colorectal cancer; biomarkers; epigenetics; targeted therapy; chemoresistance; personalized cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Cutting-Edge Innovations in Molecular and Nanoscale Engineering for Energy Applications submission deadline 20 Feb 2026 | 2 articles | Viewed by 3543 | Submission Open
Keywords: nanostructured electrode materials; energy storage; energy conversion; energy materials
(This special issue belongs to the Section Materials Science)
Drug Therapy of Systemic Lupus Erythematosus
edited by Dionysis Nikolopoulos
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3508 | Submission Open
Keywords: systemic lupus erythematosus; treatment; drugs; tailored strategies; precision medicine; biologics; cell therapy; randomized clinical trials
(This special issue belongs to the Section Molecular Pharmacology)
Progress in the Use of Graphene and Graphene-Like Materials in Various Applications
edited by Piotr Kamedulski
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3448 | Submission Open
Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications
(This special issue belongs to the Section Materials Science)
Advances in Structural and Functional Properties of G-Quadruplexes and Aptamers submission deadline 20 Feb 2026 | 5 articles | Viewed by 3448 | Submission Open
Keywords: G-quadruplex structure; aptamer; DNAzyme; catalytic G-quadruplexes
(This special issue belongs to the Section Molecular Biology)
Functional Genomics of Insects: Unraveling Genetic Mechanisms and Applications
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 3434 | Submission Open
Keywords: genomics; comparative genomics; gene regulation networks; developmental biology; metamorphosis; vector biology; insecticide resistance mechanisms; insect– plant interactions; environmental adaptation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Erythrocyte Cell Death: Molecular Insights
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3369 | Submission Open
Keywords: cell death signaling; eryptosis; erythrocyte senescence; erythrocytes; necroptosis; regulated cell death
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Osteoarthritis Pathways and Biomarker Research
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 3349 | Submission Open
Keywords: osteoarthritis; low-grade inflammation; cartilage chondrocyte; synovial membrane; synovial fluid; subchondral bone; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Neuroscience: Molecular Biological Insights
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3307 | Submission Open
Keywords: neurodegenerative diseases; neurodevelopmental disorders; neurohiv; drug abuse; neuropharmacology; epigenetics; exosomes; inflammasomes; biomarkers; gene therapy; stem cell therapy; deep brain stimulation; Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; autism spectrum disorder; ADHD; dyslexia; neuroinflammation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Forensics and the Genetic Foundations of Forensic Biology
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3213 | Submission Open
Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault
(This special issue belongs to the Section Molecular Biology)
Skin Microbiome and Skin Health: Molecular Interactions
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3199 | Submission Open
Keywords: skin microbiota; human disease; human health; omics; microbiota– host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Targeted Regulation of Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3198 | Submission Open
Keywords: autoimmunity; autoimmune diseases; multiple sclerosis; rheumatoid arthritis; lupus; type 1 diabetes; inflammatory bowel disease; biomarkers; immune cells; signaling molecules
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Cervical Cancer and Its Therapy
edited by Ilaria Cuccu and
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3124 | Submission Open
Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes
(This special issue belongs to the Section Molecular Oncology)
Inflammation in Pregnancy and Childbirth
edited by and Maciej Ziętek
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3109 | Submission Open
Keywords: pregnancy; labor; eicosanoid; chronic inflammation; cytokines; intestinal dysbiosis; mitogen-activated protein kinase; nuclear factor kappa-light-enhancer-activated B cell; maresins; resolvins and protectins
(This special issue belongs to the Section Molecular Immunology)
Molecular and Cellular Aspects of Breast Cancer Metastasis
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3098 | Submission Open
Keywords: precision medicine; omics-based discovery research (genomics; proteomics; transcriptomics; and radiomics); non-invasive test; liquid biopsy; first-in-class medications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Crop Stress Biology and Molecular Breeding: 5th Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2995 | Submission Open
Keywords: biotic and abiotic stress; variety improvement; crop stress biology; molecular breeding; biological basis; signal transduction pathway; agronomic traits; excellent germplasm
(This special issue belongs to the Section Molecular Plant Sciences)
Melanoma: Molecular Mechanism and New Agents for Prevention and Therapy
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2938 | Submission Open
Keywords: melanoma; therapy resistance; melanoma microenvironment (MME); melanoma plasticity; epigenetic mechanism; predictive markers; prognostic markers; extracellular vesicles; molecular therapy; natural molecules
(This special issue belongs to the Section Molecular Oncology)
Current Developments in Glioblastoma Research and Therapy: 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 2929 | Submission Open
Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors
(This special issue belongs to the Section Molecular Neurobiology)
Modulating the Niche: Targeting the Tumor Microenvironment for Enhanced Therapy
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2894 | Submission Open
Keywords: microenvironment dynamics; immune modulation; biomarker discovery; tumor microenvironment; extracellular matrix; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
CRISPR/Cas Systems and Genome Editing—3rd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2839 | Submission Open
Keywords: CRISPR/Cas; bacterial argonauts; transcription regulation; genome editing; genome editing tools
(This special issue belongs to the Section Molecular Genetics and Genomics)
Micro(nano) Plastics and Estrogens as Endocrine Disruptors Meet the Female Reproductive System, Breast and Colon: What Is Going On? submission deadline 20 Feb 2026 | 1 articles | Viewed by 2821 | Submission Open
Keywords: micro(nano) plastics; estrogens; endocrine disruptors; female reproductive system; breast; colon
(This special issue belongs to the Section Molecular Biology)
The Molecular Network, Key Biomarkers, and Therapeutic Targets in Colorectal Cancer submission deadline 20 Feb 2026 | 1 articles | Viewed by 2804 | Submission Open
Keywords: inflammation; metabolism; tumor-associated macrophages; tumor microenvironment; early-onset colorectal cancer; colorectal neoplasms; obesity; immunotherapy; epigenetics; cytokines; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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