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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advanced Research on Immune Cells and Cytokines (3rd Edition)
edited by
submission deadline 31 Jan 2026 | Viewed by 92 | Submission Open
Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system
(This special issue belongs to the Section Molecular Immunology)
New Horizons in Structure and AI-Based Drug Design
edited by
submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design
(This special issue belongs to the Section Molecular Informatics)
Obesity and Obesity-Associated Co-Morbidities: From Mechanisms to Mechanism-Based Therapies
edited by
submission deadline 31 Jan 2026 | Viewed by 91 | Submission Open
Keywords: obesity; adipose tissue inflammation; microbiota; oxidative stress; gene expression regulation; metabolism; obesity-associated co-morbidities; non-communicable disease; cancer; mechanism-based therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Intracellular Host-Bacteria Dynamics: Unraveling the Molecular Basis
edited by
submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open
Keywords: intracellular bacteria; granuloma; immune invasion; Mycobacterium tuberculosis; Burkholderia pseudomallei; Francisella; Brucella; Listeria; Coxiella
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Striated Muscle Physiology
edited by Xuesong Feng
submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open
Keywords: striated muscle; physiology; myopathies; mitochondria; mechanotransduction; epigenetics regulation; muscle aging; muscle regeneration
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Fibrous Proteins: Latest Developments in Molecular Study
edited by Priscila Casado
submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open
Keywords: fibrous proteins; molecular studies; translational applications; inflammatory markers; biomolecular expression; immunological pathways; personalized treatments; diagnostics; clinical practice; etiopathogenies
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacognosy: Bioactive Natural Products and Mechanistic Insights
edited by Luísa Mota Da Silva
submission deadline 31 Jan 2026 | Viewed by 89 | Submission Open
Keywords: pharmacognosy; natural products; bioactive compounds; phytochemistry; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
The Placental Barrier: From Fundamental Mechanisms to Clinical Implications
edited by and María I. De La Calle
submission deadline 31 Jan 2026 | Viewed by 87 | Submission Open
Keywords: placental barrier; maternal– fetal interface; pregnancy pathologies; vertical transmission
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanisms of Action of Environmental Neurotoxicants During Critical Periods of Brain Development submission deadline 31 Jan 2026 | Viewed by 86 | Submission Open
Keywords: environmental neurotoxicants; developmental neurotoxicity; critical windows; animal models; early exposure; long-term programming
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights in Food Science: From Nutritional Value to Safety Evaluation
edited by
submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open
Keywords: nutraceutical; food safety; analytical methods; novel foods; food analysis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Therapeutic Advances in Vaccines
edited by Dorota Kopciuch
submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open
Keywords: therapeutic vaccines; mRNA vaccines; DNA-based vaccines; viral vector vaccines; protein-based vaccines; peptide vaccines; personalized cancer vaccines; antigen persistence; immune activation mechanisms
(This special issue belongs to the Section Molecular Immunology)
New Molecular Insights into Antimicrobial Peptides
edited by
submission deadline 31 Jan 2026 | Viewed by 84 | Submission Open
Keywords: antimicrobial peptides; mode of action; molecular mechanism of biological activity; molecular targets; molecular modeling; structure– activity relationship
(This special issue belongs to the Section Molecular Microbiology)
Autoimmune Diseases: From Molecular Mechanisms to Therapeutic Innovations submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open
Keywords: autoimmunity; biological biomarkers; personalized therapies; biologics and JAK inhibitors; CAR-T cell therapy
(This special issue belongs to the Section Molecular Immunology)
Molecular Research in Renal Endocrinology
edited by Natalija Filipović
submission deadline 31 Jan 2026 | Viewed by 83 | Submission Open
Keywords: renin– angiotensin system; natriuretic peptides; calcitriol; erythropoietin; prostaglandins; endothelins; adrenomedullin
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Unraveling Affective Disorders: From Pathogenesis to Drug Therapy
edited by Lawrence Shih-Hsin Wu
submission deadline 31 Jan 2026 | Viewed by 80 | Submission Open
Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Small Molecules and Antibodies for Targeted Cancer Therapies
edited by Chitra Subramanian
submission deadline 31 Jan 2026 | Viewed by 80 | Submission Open
Keywords: targeted therapy; small molecules; antibodies; drug resistance; metastasis; cancer treatment; mechanism of resistance
(This special issue belongs to the Section Molecular Pharmacology)
Progression of Innate Immunity in Tuberculosis Infections submission deadline 31 Jan 2026 | Viewed by 79 | Submission Open
Keywords: macrophage; neutrophil; innate lymphoid cells; NK cells; mucosal associated invariant T (MAIT) cells; phagocytosis; trained innate immunity; collectins; autophagy; mucociliary clearance; NETosis
(This special issue belongs to the Section Molecular Immunology)
Recent Progress in 3D Cellular Models of the Tumor Microenvironment
edited by
submission deadline 31 Jan 2026 | Viewed by 76 | Submission Open
Keywords: 3D tumor models; immunotherapy; organ-on-a-chip; cell mechanics and mechanotransduction; drug delievery; tumor heterogenity; organoids/spheroids; biomaterials; hydrogels/scaffolds
(This special issue belongs to the Section Molecular Oncology)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition
edited by Fei Guo
submission deadline 31 Jan 2026 | Viewed by 73 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Molecular and Cellular Mechanisms Underlying Kidney Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 68 | Submission Open
Keywords: acute kidney injury; molecular mechanisms; therapeutic agents; experimental model; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Macrophage Dysfunction and Cytokine Storm in Pulmonary Disorders submission deadline 31 Jan 2026 | Viewed by 57 | Submission Open
Keywords: macrophage dysfunction; cytokine storm; lung diseases
(This special issue belongs to the Section Molecular Immunology)
Applications of Molecular Imaging in Nanomedicine
edited by
submission deadline 31 Jan 2026 | Viewed by 49 | Submission Open
Keywords: nanoparticles; biodistribution; magnetic resonance imaging; positron emission tomography; computed tomography; ultrasound imaging; optical imaging; light microscopy; electron microscopy
(This special issue belongs to the Section Molecular Nanoscience)
Focus on Chemoradiation Resistance: The Challenge of Cancer Therapy
edited by and Hendrikx Marc José Henri
submission deadline 31 Jan 2026 | Viewed by 48 | Submission Open
Keywords: genetic; epigenetic; and metabolic determinants of chemoradiation resistance; tumor microenvironmental influences and immune system interactions; DNA damage response pathways and novel radiosensitizers/chemosensitizers; predictive and prognostic biomarkers for treatment response; emerging therapeutic combinations and personalized medicine strategies; concentration-dependent therapy and chemotherapy optimization; intra-arterial infusion and isolated perfusion chemotherapy; quality of life
(This special issue belongs to the Section Molecular Oncology)
Exploring UV-Induced Disease: Insights into Mechanisms and Innovative Strategies for Prevention and Therapy
edited by Hui Xu and
submission deadline 1 Feb 2026 | 1 articles | Viewed by 857 | Submission Open
Keywords: ultraviolet radiation; skin; DNA damage; DNA repair; immunosuppression; inflammatory disease; autoimmune disease; melanoma; non-melanoma skin cancers; genetic susceptibility; chemopre-vention; tumor immunotherapy; skin organoids for UV study; new animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Female and Male Fertility: From Diseases to Current Trends and Research Developments
edited by Fabio Barra
submission deadline 4 Feb 2026 | Viewed by 82 | Submission Open
Keywords: female infertility; male infertility; reproductive health; reproductive outcomes; assisted reproductive technologies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Mechanisms for the Prevention and Treatment of Stroke
edited by
submission deadline 10 Feb 2026 | 1 articles | Viewed by 968 | Submission Open
Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition) submission deadline 10 Feb 2026 | Viewed by 107 | Submission Open
Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models
(This special issue belongs to the Section Molecular Oncology)
Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives
edited by Antonella Bonetti
submission deadline 10 Feb 2026 | Viewed by 100 | Submission Open
Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Driving Liver Disease: From Cellular Stress to Therapeutic Targets submission deadline 18 Feb 2026 | Viewed by 1723 | Submission Open
Keywords: liver disease; molecular mechanisms; hepatocellular stress; fibrosis; non-coding RNAs; metabolism; MASLD; liver fibrosis; hepatocellular carcinoma; therapeutics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetic and Molecular Markers in Prostate Cancer
edited by Thaidy Moreno-Rodriguez
submission deadline 19 Feb 2026 | Viewed by 96 | Submission Open
Keywords: prostate cancer; genetic markers; androgen receptor signaling; molecular biomarkers; therapy resistance mechanisms; liquid biopsy; precision oncology
(This special issue belongs to the Section Molecular Oncology)
The Role of Dysbiosis in Chronic Diseases submission deadline 20 Feb 2026 | 5 articles | Viewed by 28011 | Submission Open
Keywords: microbiota; dysbiosis; microbiota– gut– brain axis; microorganism; metabolites; clinical practices; prebiotics; probiotics
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Cellular Mechanisms of Spinal Cord Injury and Repair
edited by Victoria Moreno-Manzano
submission deadline 20 Feb 2026 | 10 articles | Viewed by 25420 | Submission Open
Keywords: spinal cord injury; molecular changes; neuronal degeneration; circuit regeneration; transcriptomics; cell imaging; single-cell analysis; cell communication; behavior; functional outputs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Probiotics in Health and Disease
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 24953 | Submission Open
Keywords: probiotic; microbiota; quality; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
Plant Metabolomics: Uncovering the Hidden World of Plant Secondary Metabolites
edited by
submission deadline 20 Feb 2026 | 12 articles | Viewed by 23686 | Submission Open
Keywords: metabolomics; secondary metabolites; plant biochemistry; mass spectrometry; NMR spectroscopy; plant signaling pathways; natural products; chemical ecology; metabolic profiling; phytochemicals; medicinal plants; herbal medicines
(This special issue belongs to the Section Molecular Plant Sciences)
Tumor Microenvironments: Molecular Mechanisms and Signaling Pathways Involved in Metastatic Progression
edited by Sonam Mittal
submission deadline 20 Feb 2026 | 7 articles | Viewed by 23087 | Submission Open
Keywords: tumor microenvironment; metastasis; metabolism; cytokines; cancer-derived extracellular vesicles; metabolic reprogramming
(This special issue belongs to the Section Molecular Oncology)
Advanced Research in Prediction of Protein Structure and Function, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 22491 | Submission Open
Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment
(This special issue belongs to the Section Molecular Informatics)
Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 6 articles | Viewed by 21136 | Submission Open
Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights in Steroid Biosynthesis and Metabolism
edited by Amanda C. Swart
submission deadline 20 Feb 2026 | 6 articles | Viewed by 19691 | Submission Open
Keywords: steroid biosynthesis; steroid metabolism; aldo-keto reductase (AKR); cytochrome P450; steroid reductase (SRD5A); 17β -hydroxysteroid dehydrogenases (17β HSD); 11β -hydroxysteroid dehydrogenase (11β HSD); reproduction and sexual differentiation; endogenous cardiac steroids; anabolic steroids; prostate cancer; gut microbiome; immune system; inflammation; cardiovascular disease (CVD); kidney function; hormone replacement therapy (HRT)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Advancements in Cancer Biomarkers submission deadline 20 Feb 2026 | 10 articles | Viewed by 16884 | Submission Open
Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms of Alzheimer’s Disease
edited by Sudip Dhakal
submission deadline 20 Feb 2026 | 10 articles | Viewed by 16345 | Submission Open
Keywords: Alzheimer’ s disease; amyloid beta; tauopathy; autophagy; stress response; mitochondrial dysfunction; cognitive decline; biomarkers; disease models
(This special issue belongs to the Section Molecular Neurobiology)
Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers
edited by Alessandra Bettiol
submission deadline 20 Feb 2026 | 8 articles | Viewed by 15440 | Submission Open
Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Postharvest Biology and Molecular Research of Fruits
edited by
submission deadline 20 Feb 2026 | 6 articles | Viewed by 15272 | Submission Open
Keywords: postharvest biology; fruit; storage technologies; molecular mechanisms; senescence; chilling injury; browning; nutrition; disease; toxin
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Molecular Trends and Prospects in Kidney Diseases submission deadline 20 Feb 2026 | 6 articles | Viewed by 14888 | Submission Open
Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Omics: Sensing, Signaling, Regulation and Homeostasis submission deadline 20 Feb 2026 | 6 articles | Viewed by 14237 | Submission Open
Keywords: plant homeostasis; omics; transcriptomics; metabolomics; proteomics; genomics; ionomics; environmental stress; regulatory mechanisms; metabolic processes; systems biology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Therapeutic Strategies in Allergic Diseases
edited by
submission deadline 20 Feb 2026 | 6 articles | Viewed by 14073 | Submission Open
Keywords: molecular allergy diagnostics; allergen identification; allergen neutralization/elimination strategies; allergen immunotherapy; impact of pollution on allergies; new allergens; cross-reactivity; unexpected allergen sources
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 13404 | Submission Open
Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Function in Health and Diseases
edited by Sally P. Wheatley
submission deadline 20 Feb 2026 | 5 articles | Viewed by 13005 | Submission Open
Keywords: mitochondria; metabolism; lipid; ATP; respiration; calcium; iron; inheritance; apoptosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Organoids and Organs-on-Chip for Medical Research
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 12877 | Submission Open
Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition
edited by
submission deadline 20 Feb 2026 | 12 articles | Viewed by 12535 | Submission Open
Keywords: anti-inflammatory; anti-cancer; antioxidants; antiproliferative; antiviral; antibacterial; antibodies; molecular mechanism; chemoresistance; molecular biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition
edited by and
submission deadline 20 Feb 2026 | 3 articles | Viewed by 12368 | Submission Open
Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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