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Anti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 3rd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 15 August 2025 | Viewed by 573

Special Issue Editor

Special Issue Information

Dear Colleagues,

An increasing amount of anti-cancer and anti-inflammatory active substances are being discovered and applied to cancer and inflammation treatment, and there is also increased focus on basic research into antivirals and antibacterials, playing an important role in the molecular activity and biotechnology innovations of food and cosmetics.

In this Special Issue, we aim to collate papers focused on the role and molecular mechanisms of active substances in anti-inflammation and anti-cancer treatment, food, and cosmetics. We welcome research articles and review papers focused on anti-cancer and anti-inflammatory active substances in cancer, from basic, translational science studies to clinical research.

Volume I of this Special Issue Latest Research on Anti-cancer, Anti-inflammatory, and Antioxidation Active Substances
Volume II of this Special IssueAnti-Cancer, Anti-Inflammatory, and Antioxidation Active Substances: 2nd Edition”

Dr. Ming-Ju Hsieh
Guest Editor

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Keywords

  • anti-inflammatory
  • anti-cancer
  • antioxidants
  • antiproliferative
  • antiviral
  • antibacterial
  • antibodies
  • molecular mechanism
  • chemoresistance
  • molecular biology

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Published Papers (1 paper)

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Research

21 pages, 10277 KiB  
Article
Tephrosia purpurea, with (-)-Pseudosemiglabrin as the Major Constituent, Alleviates Severe Acute Pancreatitis-Mediated Acute Lung Injury by Modulating HMGB1 and IL-22
by Gamal A. Soliman, Mohammed A. Alamri, Rehab F. Abdel-Rahman, Marawan A. Elbaset, Hanan A. Ogaly and Maged S. Abdel-Kader
Int. J. Mol. Sci. 2025, 26(6), 2572; https://doi.org/10.3390/ijms26062572 - 13 Mar 2025
Viewed by 478
Abstract
Ischemia-reperfusion (IR) injury is a major cause of multiple organ failure. The purpose of this study was to look into the role of Tephrosia purpurea (TEP) and its active constituent pseudosemiglabrin (PS) in alleviating severe acute pancreatitis and its associated acute lung injury. [...] Read more.
Ischemia-reperfusion (IR) injury is a major cause of multiple organ failure. The purpose of this study was to look into the role of Tephrosia purpurea (TEP) and its active constituent pseudosemiglabrin (PS) in alleviating severe acute pancreatitis and its associated acute lung injury. We established a rat pancreatic IR model, and the rats were treated with TEP (200 mg/kg and 400 mg/kg) and PS (20 and 40 mg/kg), in addition to the IR control and sham groups. The results showed that the respiratory parameters, including inspiratory time (Ti), expiratory time (Te), duration (Dr), and respiratory rate (RR), were comparable among all groups, while peak inspiratory flow (PIF), forced vital capacity (FVC), and forced expiratory volume at 0.1 s (FEV0.1) were significantly impaired. Notably, PS at 40 mg/kg showed normal PIF, FVC, and FEV0.1/FVC compared to the IR group, indicating an improved lung function. Additionally, TEP and PS showed protective effects on pancreatic and lung tissues compared to the IR control group, with the following effects: alleviating pathological damage; reducing serum levels of trypsinogen activation peptide (TAP), lipase, and amylase; decreasing oxidative stress markers such as MDA and MPO; restoring antioxidant enzyme activity (GPx); suppressing inflammatory markers TNF-α, IL-6, and NF-κB; downregulating HMGB1 gene in pancreatic tissue; and upregulating the IL-22 gene in lung tissues. In conclusion, the obtained findings demonstrate that oral supplementation of TEP and PS to rats with pancreatic IR alleviates pancreatic and lung injuries by reducing oxidative stress and modulating inflammatory processes, which offers an attractive therapeutic option for severe acute pancreatitis and its associated acute lung injury. Full article
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