Organoids and Organs-on-Chip for Medical Research
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 3691
Special Issue Editor
Interests: kidney pathology; dialysis; vascular pathology; molecular medicine; predictive medicine; personalized medicine; inflammation; ncRNAs; organs-on-chip; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organoids and Organs-on-chip (OoC) represent innovative and challenging ex vivo models, developed as essential tools for basic biology and disease research. Organoids are derived from self-organizing mammalian stem cells, comprising clusters of 3D cells cultured with near-native microanatomy. However, organoids lack some critical elements of the in vivo microenvironment that limit their physiological relevance, such as the presence of vasculature. On the other hand, the OoC allows for precise control over cellular composition, multiple cellular interactions, and the dynamical mechanical forces which cells experience in vivo. When placed within a dynamic environment, OoC is a versatile platform for assessing drug efficacy and toxicity in clinical trials before being administered to patients, thereby contributing to personalized and precision medicine.
These technologies, despite certain simplifications, can be used together, simulating the complexity of tissues and yielding miniaturized organs that replicate complex human biology in vitro. These models are appealing for their flexibility, modularity, and 3D capabilities, allowing researchers to study molecular pathways, identify new biomarkers or therapeutic targets, and explore broad clinical potential. New technologies based in artificial intelligence are being applied for complex analysis and modeling.
Consequently, this Special Issue aims to provide molecular insights into understanding and addressing the disparities in disease susceptibility, progression, and treatment response. Through a comprehensive exploration of these topics, we aim to foster advances in the comprehension of disease pathologies, personalized medicine, therapeutics, and healthcare strategies. We welcome a diverse range of submissions, including both reviews and original research papers. However, pure clinical studies are not suitable for this Issue, although clinical submissions featuring molecular experiments are welcomed. We encourage authors to present protocols, practical insights, novel methodologies, and evidence-based recommendations that can guide biological research and clinical practice. In addition, we expect contributions on new tools based in artificial intelligence for complex modelling. Together, let us propel the field of healthcare towards a personalized medicine.
Dr. Miguel Hueso
Guest Editor
Manuscript Submission Information
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Keywords
- organoids
- organs-on-chip
- tissue engineering
- disease modeling
- biomarkers
- molecular pathways
- nanotechnology
- preclinical models
- artificial organs
- artificial intelligence
- personalized medicine
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