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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules

edited by

Mauricio Alcolea Palafox

submission deadline 20 Dec 2025 | Viewed by 398 | Submission Open

Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties

(This special issue belongs to the Section Molecular Biophysics)

Molecular Advances in Chronic Pain: Mechanisms and Therapeutic Innovations

edited by

Roberto Tedeschi

submission deadline 20 Dec 2025 | Viewed by 390 | Submission Open

Keywords: chronic pain; pain mechanisms; pain management; therapeutic innovation; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Tumor Angiogenesis and Metastasis: From Molecular Signalling to Therapeutic Approaches

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 Dec 2025 | Viewed by 374 | Submission Open

Keywords: tumour angiogenesis; tumour invasion; tumour metastasis; molecular mechanisms; metabolic patterns; signalling pathways

(This special issue belongs to the Section Molecular Oncology)

Anticancer Antibiotics: Progresses, Opportunities and Challenges

edited by Jose Kaneti

submission deadline 20 Dec 2025 | Viewed by 371 | Submission Open

Keywords: tetracycline antibiotics; antitumor activity; molecular mechanism; G-quadruplex complexes; computational modeling; pharmacological evaluation

(This special issue belongs to the Section Molecular Pharmacology)

Thrombo-Inflammatory Signaling and Complications in Autoimmune Disorders

edited by

Alexandros Tsoupras

submission deadline 20 Dec 2025 | Viewed by 368 | Submission Open

Keywords: inflammation; thrombosis; platelets; coagulation; autoimmune disorders; rheumatoid arthritis; systematic erythematosus lupus; antiphospholipid syndrome; thrombo-inflammation; antithrombotic; antiplatelet

(This special issue belongs to the Section Molecular Immunology)

Growth Factor Signaling in Cancer Progression

edited by

Hyeong-Reh Choi Kim

and Abdo J. Najy

submission deadline 20 Dec 2025 | Viewed by 368 | Submission Open

Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

The Roles of AI in Disease Diagnosis and Treatment

edited by

Miguel Souto-Bayarri

submission deadline 20 Dec 2025 | Viewed by 347 | Submission Open

Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pharmacology of Cation-Permeable Ion Channels

edited by

Jian Shi

submission deadline 20 Dec 2025 | Viewed by 333 | Submission Open

Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Aging: How Can We Live Beyond 100 Years?

edited by

Shin Murakami

submission deadline 20 Dec 2025 | Viewed by 333 | Submission Open

Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases

(This special issue belongs to the Section Molecular Biology)

Antiviral Mechanisms of Natural/Synthetic Compounds

edited by Cybele Carina García

submission deadline 20 Dec 2025 | Viewed by 331 | Submission Open

Keywords: antiviral mechanisms; natural compound; synthetic compound; druggable viral/host target; emerging virus; host– virus interaction; innate antiviral response; cell-intrinsic restriction factor

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Targets and Mechanisms of Innovative Therapies and Natural Adjuvants in Glioblastoma Management

edited by

Maria Grazia Bottone

and Fabrizio De Luca

submission deadline 20 Dec 2025 | Viewed by 330 | Submission Open

Keywords: glioblastoma; targeted therapy; traditional and emerging therapies; signaling pathways; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases

edited by

Tianhai Tian

submission deadline 20 Dec 2025 | Viewed by 327 | Submission Open

Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention

(This special issue belongs to the Section Molecular Informatics)

Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice

edited by

Iain P. Hargreaves

submission deadline 20 Dec 2025 | Viewed by 322 | Submission Open

Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense

(This special issue belongs to the Section Molecular Biology)

Stem Cell or Exosome-Based Therapy for Kidney and Urinary Tract Diseases: Mechanisms, Applications, and Future Perspectives

edited by

Yuanyuan Zhang

submission deadline 20 Dec 2025 | Viewed by 317 | Submission Open

Keywords: stem cell therapy; exosome therapy; kidney disease; regenerative medicine; cell differentiation; tissue engineering; drug discovery; in vitro 3D models; anti-inflammation; antioxidant stress; antifibrosis; extracellular vesicles; precision medicine; bioengineering; artificial intelligence; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Abscisic Acid, a New Old Friend to Regulate Abiotic Stress Tolerance in Plants

edited by Marta Marina Pérez-Alonso and

Miguel González-Guzmán

submission deadline 20 Dec 2025 | Viewed by 317 | Submission Open

Keywords: abscisic acid (ABA); ABA perception; ABA signaling network; abiotic stress; hormonal crosstalk; crop species; stress tolerance; plant productivity; agriculture

(This special issue belongs to the Section Molecular Plant Sciences)

DNA Methylation in Cancer: Progress and Challenges

edited by

Michael Eccles

submission deadline 20 Dec 2025 | Viewed by 312 | Submission Open

Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights into Chronic Liver Disease and Liver Failure

edited by Paolo Gallo

submission deadline 20 Dec 2025 | Viewed by 306 | Submission Open

Keywords: cirrhosis; portal hypertension; liver failure; advanced chronic liver disease; sarcopenia and malnutrition; ascites; medical treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics

edited by

Shihping Hsu

submission deadline 20 Dec 2025 | Viewed by 300 | Submission Open

Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level

edited by

Alessandro Romano

and

Amilcare Barca

submission deadline 20 Dec 2025 | Viewed by 297 | Submission Open

Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)

(This special issue belongs to the Section Molecular Neurobiology)

Cell–Cell Communication Through Extracellular Vesicles

edited by Federica Fratini

submission deadline 20 Dec 2025 | Viewed by 284 | Submission Open

Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape

(This special issue belongs to the Section Molecular Biology)

Molecular Immunology of Infectious Diseases

edited by

Salvatore Giovanni De Simone

submission deadline 20 Dec 2025 | Viewed by 277 | Submission Open

Keywords: molecular immunology; infectious diseases; innate immunity; adaptive immunity; immunomodulation-based therapies

(This special issue belongs to the Section Molecular Immunology)

Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives

edited by

Moon Nyeo Park

submission deadline 20 Dec 2025 | Viewed by 265 | Submission Open

Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering

edited by

Isabel Calejo

submission deadline 20 Dec 2025 | Viewed by 265 | Submission Open

Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues

(This special issue belongs to the Section Materials Science)

Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 20 Dec 2025 | Viewed by 249 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Molecular Applications of Nanoparticles in Cancer Therapy

edited by Carlos Caro and Iñigo Martínez-Zubiaurre

submission deadline 20 Dec 2025 | Viewed by 249 | Submission Open

Keywords: nanomedicine; molecular biology of cancer; advanced therapies; tumor microenvironment; cellular crosstalk

(This special issue belongs to the Section Materials Science)

Advances in Targeted Cancer Therapy and Side-Effect Management

edited by Wei-Min Chang

submission deadline 20 Dec 2025 | Viewed by 231 | Submission Open

Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Immunology and Immunotherapy for Head and Neck Cancer

edited by

Aurora Mirabile

submission deadline 20 Dec 2025 | Viewed by 228 | Submission Open

Keywords: immunotherapy; head and neck cancer; toxicity management; immune system; nutrition; immune therapy and organ failure; mechanisms of immunotherapy resistance

(This special issue belongs to the Section Molecular Immunology)

Acute Leukemia: From Basic Research to Clinical Application, Second Edition

edited by

Luca Lo Nigro

submission deadline 20 Dec 2025 | Viewed by 226 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers

(This special issue belongs to the Section Molecular Oncology)

Bioactives in Processed Foods: Profiling and Bioavailability Assessment

edited by Cong Wang

submission deadline 20 Dec 2025 | Viewed by 214 | Submission Open

Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 20 Dec 2025 | Viewed by 210 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 20 Dec 2025 | Viewed by 203 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 20 Dec 2025 | Viewed by 203 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Dec 2025 | Viewed by 198 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites

edited by

Jose Roberto Meyer-Fernandes

submission deadline 20 Dec 2025 | Viewed by 191 | Submission Open

Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation

(This special issue belongs to the Section Molecular Biology)

The Molecular Life of Sperm: New Horizons in Male Infertility

edited by

Mónica Vazquez-Levin

and

Robert John Aitken

submission deadline 20 Dec 2025 | Viewed by 189 | Submission Open

Keywords: human sperm; fertilization; infertility; biomarkers; genetics

(This special issue belongs to the Section Molecular Biology)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Dec 2025 | Viewed by 154 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition

edited by

Subhasis B. Biswas

submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

Male Reproduction: Unveiling the Molecular Revolution

edited by

Anthony Archibong

submission deadline 20 Dec 2025 | Viewed by 136 | Submission Open

Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research of Neonicotinoid Toxicity

edited by

Fatima Smagulova

submission deadline 20 Dec 2025 | Viewed by 134 | Submission Open

Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects

(This special issue belongs to the Section Molecular Toxicology)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Dec 2025 | Viewed by 120 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Dec 2025 | Viewed by 109 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Molecular Aspects of Tumor Radiotherapy

edited by

Johann Matschke

submission deadline 20 Dec 2025 | Viewed by 100 | Submission Open

Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies

(This special issue belongs to the Section Molecular Oncology)

Redox Physiology

edited by Mateusz Mołoń

submission deadline 21 Dec 2025 | Viewed by 407 | Submission Open

Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling

(This special issue belongs to the Section Molecular Biology)

Spectroscopic Techniques in Molecular Sciences

edited by

Angela Staicu

submission deadline 25 Dec 2025 | 5 articles | Viewed by 3394 | Submission Open

Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems

(This special issue belongs to the Section Molecular Biology)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 25 Dec 2025 | 3 articles | Viewed by 2535 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2196 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2168 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Therapeutic Horizons of Oligosaccharides: Molecular Mechanisms and Therapeutic Potential

edited by

Abdelali Daddaoua

and

María Núñez-Núñez

submission deadline 25 Dec 2025 | 2 articles | Viewed by 2028 | Submission Open

Keywords: oligosaccharides; bacterial infection; multidrug-resistant

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Genetic Advances in Plant Breeding

edited by Francesca Taranto

submission deadline 25 Dec 2025 | 2 articles | Viewed by 2018 | Submission Open

Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Plant Sciences)

Skin Cancer: From Molecular Pathophysiology to Novel Treatment

edited by Soon-Hyo Kwon

submission deadline 25 Dec 2025 | 2 articles | Viewed by 1942 | Submission Open

Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 451-500 on page 10 of 65.

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