Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 118
Special Issue Editor
Interests: mitochondrial dysfunction; oxidative stress; coenzyme Q10
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Coenzyme Q10 (CoQ10) is a vital molecule that exists in two bioactive states, ubiquinone (oxidized) and ubiquinol (reduced), and plays a crucial role in cellular energy production and antioxidant defense. This Special Issue will explore the central importance of the ubiquinone–ubiquinol redox cycle in maintaining cellular homeostasis and its implications for clinical practice. CoQ10 is essential in mitochondrial oxidative phosphorylation, shuttling electrons between mitochondrial respiratory chain complexes I and II and to complex III and protecting cellular membranes from oxidative damage. The redox state of CoQ10 influences the generation of reactive oxygen species (ROS) and the regulation of the cellular redox balance, impacting various physiological processes and disease states. Deficiencies in CoQ10 or disruptions to its redox cycle are linked to numerous conditions, including heart failure and neurodegenerative diseases. Clinical studies have shown that CoQ10 supplementation, particularly in combination with selenium, can improve outcomes in these conditions. However, the poor bioavailability of CoQ10 remains a challenge, prompting the development of new formulations to enhance its absorption and efficacy. This Special Issue of International Journal of Molecular Sciences will focus on the role of CoQ10 in the maintenance of cellular homeostasis and the development of effective therapeutic strategies to ameliorate CoQ10 deficiencies and restore cellular redox status. This Special Issue will also highlight the potential of CoQ10 in the treatment of diseases and the innovative delivery systems available that could improve its bioavailability.
Dr. Iain P. Hargreaves
Guest Editor
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Keywords
- coenzyme Q
- cellular homeostasis
- cellular energy production
- antioxidant defense
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