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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Endometriosis: Focusing on Molecular and Cellular Research, 2nd Edition
edited by
submission deadline 30 Aug 2026 | 2 articles | Viewed by 2936
Keywords: endometriosis; reproductive system; endometrial cell; novel treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Discovery and Development of Functional Ingredients for Anti-Aging, Cognitive Enhancement and Skin Health
edited by and Jinbyung Park
submission deadline 30 Aug 2026 | 3 articles | Viewed by 2115
Keywords: bioactive compounds; anti-aging; cognitive performance; skin health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Human Endogenous Retrovirus Expression and Its Implications for Human Health and Disease submission deadline 30 Aug 2026 | 2 articles | Viewed by 1894
Keywords: human endogenous retrovirus; HERVs genes expression; HERV families; autoimmune diseases; degenerative diseases; physiological function; gene expression modulation; inflammation; immune response; molecular biology
(This special issue belongs to the Section Molecular Microbiology)
Cytotoxicity, Antioxidant, and Anticancer Activity of Natural Products, 3rd Edition
edited by
submission deadline 30 Aug 2026 | 3 articles | Viewed by 1585
Keywords: natural products; anticancer activity; apoptosis; immunomodulation; free radicals; proliferation; phytomolecules; nanoparticles; drug delivery
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Molecular Dynamics and Multiscale Modelling for Materials and Structures submission deadline 30 Aug 2026 | 1 articles | Viewed by 938
Keywords: molecular dynamics simulations; atomistic modeling; multiscale modeling; high-entropy alloys; grain boundaries and defects; machine-learning interatomic potentials; computational materials science
(This special issue belongs to the Section Materials Science)
Safety, Toxicity, and Therapeutic Potential of Natural Products and Complex Mixtures
edited by and Demetrios Kouretas
submission deadline 30 Aug 2026 | 1 articles | Viewed by 813
Keywords: natural products; complex mixtures; toxicity; safety assessment; antioxidant activity; bioactivity; redox biology; nutraceuticals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Latest Advances in Antiparasitic Agents
edited by Olga S. Koutsoni and
submission deadline 30 Aug 2026 | Viewed by 801
Keywords: parasite genomics; parasite proteomics; metabolic pathways; parasite–host interactions; drug targets; mechanisms of drug resistance
(This special issue belongs to the Section Molecular Pharmacology)
MiRNA Regulation in the Early PME/TME: The Role of Non-Cancer Cells and the ECM in Solid Tumours
edited by
submission deadline 30 Aug 2026 | 1 articles | Viewed by 516
Keywords: microRNAs; early tumor microenvironment (TME); stromal/ECM interaction; vascularization; ECM remodelling; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
Neurotransmitter Dysregulation in Brain Disease: Focus on Epilepsy and Its Comorbidities submission deadline 30 Aug 2026 | Viewed by 454
Keywords: neurotransmitter dysregulation; epilepsy; addiction; serotonin; GABA; molecular neuroscience; neuropharmacology; brain networks
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Biology of Placental Function and Pregnancy Complications
edited by
submission deadline 30 Aug 2026 | Viewed by 428
Keywords: placenta; placental dysfunction; pregnancy complications; preeclampsia; fetal growth restriction; placental immunology
(This special issue belongs to the Section Molecular Biology)
Iron Metabolism in Health and Disease
edited by
submission deadline 30 Aug 2026 | Viewed by 415
Keywords: iron metabolism; iron homeostasis; hepcidin; anemia; iron overload
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Pathways and Emerging Biomarkers in Inflammatory Diseases
edited by
submission deadline 30 Aug 2026 | Viewed by 381
Keywords: inflammation; resolution of inflammation; inflammatory diseases; cancer; biomarker; molecular pathways; mediators; signal transduction; transcription factors; gene regulation; modifications
(This special issue belongs to the Section Molecular Immunology)
Evolutionary Genetics of Pathogens
edited by Leonardo Gabriel Panunzi
submission deadline 30 Aug 2026 | Viewed by 377
Keywords: pathogenicity; genome evolution; horizontal gene transfer; virulence factors; comparative genomics; pangenome analysis mobile genetic elements; computational biology; machine learning; host–pathogen interactions
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Mechanisms Fueling Glioblastoma Progression and Resistance: Emerging Therapeutic Opportunities
edited by
submission deadline 30 Aug 2026 | Viewed by 369
Keywords: glioblastoma; cancer stem cells; radioresistance; chemoresistance; targeted therapies; tumor plasticity; tumor heterogeneity; invasion; immune escape
(This special issue belongs to the Section Molecular Neurobiology)
Cardioprotective Mechanisms in Myocardial Ischemia
edited by Virginia Pérez and Verónica D’annunzio
submission deadline 30 Aug 2026 | Viewed by 346
Keywords: myocardial ischemia; ischemia–reperfusion injury; cardioprotection; molecular signaling; oxidative stress; inflammation; cardiac remodeling; therapeutic targets; translational cardiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Graphene Nanocomposites
edited by Enrique Mejía-Ospino
submission deadline 30 Aug 2026 | Viewed by 325
Keywords: graphene derivatives; interface chemistry; dispersion; molecular mechanisms
(This special issue belongs to the Section Molecular Nanoscience)
Biomarkers and Early Detection Strategies of Ovarian Tumors: 2nd Edition
edited by Lukasz Szafron
submission deadline 30 Aug 2026 | Viewed by 320
Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment
(This special issue belongs to the Section Molecular Oncology)
Advances in Traditional Tree Breeding for Growth, Adaptation, and Genetic Improvement
edited by Huiyu Li
submission deadline 30 Aug 2026 | Viewed by 228
Keywords: tree breeding; genetic improvement; progeny testing; seed orchard; parental selection; growth adaptation; polyploid breeding; interspecific hybridization; forest genetics; climate resilience
(This special issue belongs to the Section Molecular Plant Sciences)
Protein Regulation and Targeted Therapeutics in Neurodegenerative Disorders
edited by
submission deadline 30 Aug 2026 | Viewed by 227
Keywords: neurodegeneration; protein regulation; protein aggregation; small molecules; therapeutic approaches
(This special issue belongs to the Section Molecular Neurobiology)
Hormone Replacement Therapy submission deadline 31 Aug 2026 | 3 articles | Viewed by 39003 | Submission Open
Keywords: hormone replacement therapy; molecular insights; endocrine signaling; precision medicine; gene expression; epigenetics; non-coding RNAs; personalized regimens
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition submission deadline 31 Aug 2026 | 6 articles | Viewed by 21870 | Submission Open
Keywords: biogenic amines (histamine, dopamine, serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies
(This special issue belongs to the Section Molecular Neurobiology)
Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers
edited by
submission deadline 31 Aug 2026 | 11 articles | Viewed by 17962 | Submission Open
Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis
(This special issue belongs to the Section Molecular Oncology)
Skin Microbiome and Skin Health: Molecular Interactions
edited by
submission deadline 31 Aug 2026 | 4 articles | Viewed by 14923 | Submission Open
Keywords: skin microbiota; human disease; human health; omics; microbiota–host interactions; microbiota manipulation; microbiota; virota; inflammatory diseases; dysbiosis
(This special issue belongs to the Section Molecular Immunology)
Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration: From Molecular Mechanisms to Therapeutic Applications
edited by Jordi Olloquequi and M. Emília Juan
submission deadline 31 Aug 2026 | 3 articles | Viewed by 10681 | Submission Open
Keywords: SASP; glial activation; age-related disorders; neurotherapeutics; molecular signaling
(This special issue belongs to the Section Molecular Neurobiology)
Exploring the Genetics in Rare Diseases: A Genomic Odyssey
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 6373 | Submission Open
Keywords: novel discoveries in rare disorders; polygenic risk scores; mosaicism; protein interaction; tools utilized to engineer DNA; somatic variants; patient advocacy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Developmental Biology: Computational and Experimental Approaches, 3rd Edition submission deadline 31 Aug 2026 | 7 articles | Viewed by 5036 | Submission Open
Keywords: animal; plant; fungus; biological organization hierarchy; evolutionary limitations; fertilization; zygote; cell cycle; stem cell; meristem; cell layer; tissue; embryo; multicellular organism; ontogenesis; morphogenesis; life cycle; molecular mechanism; signal transduction; gene regulation; gene networks; cellular process; differentiation; migration; segmentation; high-resolution 3D-map; real-time in silico simulator; developmental hourglass; transcriptome ontogenetic switch; developmental abnormality; premature aging; neurodegeneration; tumorigenesis; atherogenesis; autoimmunity; induced pluripotent cell; wound healing; regeneration; assisted reproductive technologies; epigenetic reprogramming; predictive preventive personalized participatory (4P) medicine
(This special issue belongs to the Section Molecular Biology)
Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease
edited by Sophia Lavrentiadou
submission deadline 31 Aug 2026 | 1 articles | Viewed by 4263 | Submission Open
Keywords: Alzheimer’s disease; neuroinflammation; anti-inflammatory strategies; cell models
(This special issue belongs to the Section Molecular Neurobiology)
Algae-Derived Bioactives: Key Molecular Interactions Govern High-Value Applications
edited by Evan Stephens and Kirsten Heimann
submission deadline 31 Aug 2026 | 4 articles | Viewed by 4206 | Submission Open
Keywords: microalgae; macroalgae; cyanobacteria; bioactive compounds; health and nutrition; algal food products; market analysis
(This special issue belongs to the Section Molecular Microbiology)
Genetic and Epigenetic Regulation of Ageing
edited by Hidekazu Yamada
submission deadline 31 Aug 2026 | 1 articles | Viewed by 3697 | Submission Open
Keywords: epigenetic clocks; biological resilience; DNA methylation; chromatin architecture; multi-omics integration; geroscience; cellular reprogramming; longevity interventions; immunosenescence; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Ruminant Physiology: Digestion, Metabolism, and Endocrine System
edited by Rui Hu
submission deadline 31 Aug 2026 | 1 articles | Viewed by 3424 | Submission Open
Keywords: ruminant physiology; digestive health; metabolic regulation; endocrine signaling; rumen microbiome; nutrient partitioning; methane mitigation; epigenetic modulation; nutritional stress adaptation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Role of Neuropeptides and Their GPCRs in the Neuroendocrine System
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 3363 | Submission Open
Keywords: neuropeptides; G-protein-coupled receptors (GPCRs); neuroendocrine system; signal transduction; hypothalamus
(This special issue belongs to the Section Molecular Neurobiology)
MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application—2nd Edition submission deadline 31 Aug 2026 | 3 articles | Viewed by 3299 | Submission Open
Keywords: microRNA; non-coding RNA; gene regulation; biomarkers; RNA therapeutics; extracellular vesicles; microarray; NGS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Sjogren's Disease: Multidimensional Perspectives on Pathogenesis, Clinical Manifestations, and Therapeutic Advancements (2nd Edition)
edited by
submission deadline 31 Aug 2026 | 5 articles | Viewed by 2866 | Submission Open
Keywords: Sjögren's disease; diagnosis; therapeutics; bioinformatics; pre-clinical; cytokine; lymphocytes; autoantibodies; exocrine glands
(This special issue belongs to the Section Molecular Immunology)
Exploring Melatonin and Related Indolic Agents
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 2808 | Submission Open
Keywords: aging; antioxidant; bioenergetic agent; biological clock; immunomodulation; indole-3-propionic acid; indole-3-propionamide; melatonin; senescence; tryptophan
(This special issue belongs to the Section Molecular Pharmacology)
Advanced In Vitro Systems for Mechanistic Toxicology submission deadline 31 Aug 2026 | 3 articles | Viewed by 2375 | Submission Open
Keywords: mechanistic toxicology; organ-on-chip; microphysiological systems; human iPSC models; organoids; AI/ML modeling; multi-omics; high-content screening; 3D cell cultures
(This special issue belongs to the Section Molecular Toxicology)
Role of Integrins in Cytokine Signaling
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 2372 | Submission Open
Keywords: integrins; cytokines; FGF1; CX3CL1; ternary-complex; antagonist; inside-out signaling; integrin-binding motif; cytokine-integrin crosstalk; ligand-induced activation
(This special issue belongs to the Section Molecular Biology)
Nutrition, Inflammation and Chronic Kidney Diseases submission deadline 31 Aug 2026 | 3 articles | Viewed by 2309 | Submission Open
Keywords: chronic kidney disease; nutrition; inflammation; bioimpedance; gut-kidney axis; uremic toxins; oxidative stress; protein-energy wasting; precision nutrition; biomarkers
(This special issue belongs to the Section Molecular Immunology)
DNA Methylation Dynamics Due to Environmental Factors and in Human Diseases submission deadline 31 Aug 2026 | 3 articles | Viewed by 2259 | Submission Open
Keywords: inflammatory diseases; mental diseases; tumour diseases; epidrugs; exposure biomarkers; epigenetic drugs
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in the Molecular Diagnosis and Treatment of Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2232 | Submission Open
Keywords: neurodegenerative disorders; biomarkers; treatment; omics; systems biology
(This special issue belongs to the Section Molecular Neurobiology)
Techniques and Applications of Forensic Molecular Biology: From Pathology to Clinical Practice
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2205 | Submission Open
Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro, in vivo, and in silico models; hypoxic–ischemic brain injury; pregnancy biomarkers; vitality
(This special issue belongs to the Section Molecular Biology)
The Toxicity of Bisphenol A and Its Analogs
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2178 | Submission Open
Keywords: bisphenols; endocrine disruptors; bisphenol A and analogs; toxicology
(This special issue belongs to the Section Molecular Toxicology)
Molecular and Cellular Mechanisms of Vaccine-Induced Immune Responses
edited by In Ohk Ouh
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1996 | Submission Open
Keywords: vaccine platforms; molecular mechanisms; innate immune sensing; adaptive immune responses; adjuvants and signaling pathways; antigen processing and presentation; immunological memory; systems immunology
(This special issue belongs to the Section Molecular Immunology)
Hydrogen Medicine: From Molecular Insights to Disease Intervention
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1987 | Submission Open
Keywords: hydrogen medicine; molecular hydrogen; oxidative stress; inflammation; mitochondrial function; gasotransmitters; ischemia–reperfusion injury; clinical trials; signal transduction; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation submission deadline 31 Aug 2026 | 3 articles | Viewed by 1929 | Submission Open
Keywords: intermittent hypoxia; cardiovascular and pulmonary effects; oxidative stress; autonomic dysfunction; neuroinflammation; renal effects; animal models
(This special issue belongs to the Section Molecular Biology)
Molecular Targets and Toxic Interactomes of Pathogenic Proteins in Neurodegeneration
edited by and Ichiro Kawahata
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1874 | Submission Open
Keywords: neurodegenerative diseases; tau protein; TDP-43; α-synuclein; endoplasmic reticulum stress; mitochondrial toxicity; liquid–liquid phase separation; toxic Interactomes
(This special issue belongs to the Section Molecular Neurobiology)
Degradable Polymers: Synthesis, Applications, and Environmental Impact
edited by Ce Sun and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1795 | Submission Open
Keywords: degradable polymer; synthesis; degradation mechanisms; sustainability
(This special issue belongs to the Section Macromolecules)
Feature Papers in ‘Physical Chemistry and Chemical Physics’: Fifth Edition
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1693 | Submission Open
Keywords: heterogeneous structures; alignment and surface phenomena; quantum theory; mathematical physics; statistical and classical mechanics; molecular structure; chemical kinetics; laser physics; dynamics; kinetics; photochemistry; spectroscopy; exciton dynamics; statistical mechanics; thermodynamics; electrochemistry; catalysis; surface science; quantum mechanics; theoretical developments; fundamental aspects of catalysis; solar energy conversion; polymer dynamics
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Recent Advances in Non-Coding RNAs in Human Research submission deadline 31 Aug 2026 | 3 articles | Viewed by 1597 | Submission Open
Keywords: microRNAs; lncRNAs; mRNA regulation; cell signaling pathways; RNA methylation; RNA phosphorylation; RNA deamidation; cell communication; chemoresistance; RNA inhibitors or activators
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advances in Vascular Function, Senescence and Remodeling: A New Direction for Therapeutic Approach to Prevent CVDs
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 1595 | Submission Open
Keywords: vascular dysfunction; senescence; endothelial cells; small molecules; anti-aging; cardiovascular diseases; sudden death
(This special issue belongs to the Section Molecular Biology)
Programmed Cell Death and Oxidative Stress: 4th Edition
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 1539 | Submission Open
Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress
(This special issue belongs to the Section Biochemistry)
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